PEX3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEX3_HUMAN
• UniProt AC: P56589
• Protein Name: Peroxisomal biogenesis factor 3
• Gene Name: PEX3
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Peroxisome membrane ; Multi-pass membrane protein .
• Protein Description: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes..
• Protein Sequence: MLRSVWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKIREIQEREAAEYIAQARRQYHFESNQRTCNMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKIISFTRSTVAVYSTCMLVVLLRVQLNIIGGYIYLDNAAVGKNGTTILAPPDVQQQYLSSIQHLLGDGLTELITVIKQAVQKVLGSVSLKHSLSLLDLEQKLKEIRNLVEQHKSSSWINKDGSKPLLCHYMMPDEETPLAVQACGLSPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMAEFFRPTEQDLQHGNSMNSLSSVSLPLAKIIPIVNGQIHSVCSETPSHFVQDLLTMEQVKDFAANVYEAFSTPQQLEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	GTVLGGVYILGKYGQ CCHHHHHHHHHHHCH	8.16	-
48	Phosphorylation	QEREAAEYIAQARRQ HHHHHHHHHHHHHHH	9.24	-
75	Phosphorylation	TVLSMLPTLREALMQ HHHHCHHHHHHHHHH	34.19	-
100	Ubiquitination	LKNRPSNKLEIWEDL HHCCCCCCCHHHHCC	52.41	21890473
100	Malonylation	LKNRPSNKLEIWEDL HHCCCCCCCHHHHCC	52.41	26320211
100	Ubiquitination	LKNRPSNKLEIWEDL HHCCCCCCCHHHHCC	52.41	22817900
108	Ubiquitination	LEIWEDLKIISFTRS CHHHHCCEEEEECHH	50.76	21963094
189	Ubiquitination	VIKQAVQKVLGSVSL HHHHHHHHHHCCCCH	32.59	27667366
197	Ubiquitination	VLGSVSLKHSLSLLD HHCCCCHHHHHHHCC	24.52	29967540
199	Phosphorylation	GSVSLKHSLSLLDLE CCCCHHHHHHHCCHH	20.33	23312004
201	Phosphorylation	VSLKHSLSLLDLEQK CCHHHHHHHCCHHHH	29.87	28857561
208	Ubiquitination	SLLDLEQKLKEIRNL HHCCHHHHHHHHHHH	52.75	21906983
210	Ubiquitination	LDLEQKLKEIRNLVE CCHHHHHHHHHHHHH	59.12	22817900
220	Ubiquitination	RNLVEQHKSSSWINK HHHHHHHHHCCCCCC	52.29	29967540
221	Phosphorylation	NLVEQHKSSSWINKD HHHHHHHHCCCCCCC	27.72	24719451
227	Ubiquitination	KSSSWINKDGSKPLL HHCCCCCCCCCCCEE	55.09	27667366
230	Phosphorylation	SWINKDGSKPLLCHY CCCCCCCCCCEEEEE	41.03	24719451
254	Phosphorylation	AVQACGLSPRDITTI HHHHCCCCHHHHHHH	11.81	25159151
260	Phosphorylation	LSPRDITTIKLLNET CCHHHHHHHHHHHHH	19.22	-
262	Ubiquitination	PRDITTIKLLNETRD HHHHHHHHHHHHHHH	44.84	21890473
262	Ubiquitination	PRDITTIKLLNETRD HHHHHHHHHHHHHHH	44.84	23000965
302	Phosphorylation	MAEFFRPTEQDLQHG HHHHHCCCHHHHCCC	41.86	24275569
311	Phosphorylation	QDLQHGNSMNSLSSV HHHCCCCCCCCCCCC	24.75	24275569
314	Phosphorylation	QHGNSMNSLSSVSLP CCCCCCCCCCCCCCC	22.46	26471730
362	Phosphorylation	KDFAANVYEAFSTPQ HHHHHHHHHHHCCHH	11.01	27642862
367	Phosphorylation	NVYEAFSTPQQLEK- HHHHHHCCHHHHCC-	20.75	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEX3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEX3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX19_HUMAN	PEX19	physical	12096124
PEX19_HUMAN	PEX19	physical	25007327

Drug and Disease Associations

• Kegg Disease
• H00205: Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NAL
• OMIM Disease
• 614882: Peroxisome biogenesis disorder complementation group 12 (PBD-CG12)
• 614882: Peroxisome biogenesis disorder 10A (PBD10A)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.