NDUF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUF4_HUMAN
• UniProt AC: Q9P032
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
• Gene Name: NDUFAF4
• Organism: Homo sapiens (Human).
• Sequence Length: 175
• Subcellular Localization: Mitochondrion . Membrane ; Lipid-anchor .
• Protein Description: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion..
• Protein Sequence: MGALVIRGIRNFNLENRAEREISKMKPSVAPRHPSTNSLLREQISLYPEVKGEIARKDEKLLSFLKDVYVDSKDPVSSLQVKAAETCQEPKEFRLPKDHHFDMINIKSIPKGKISIVEALTLLNNHKLFPETWTAEKIMQEYQLEQKDVNSLLKYFVTFEVEIFPPEDKKAIRSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGALVIRGI ------CCCEEEECH	27.84	25255805
26	Ubiquitination	EREISKMKPSVAPRH HHHHHCCCCCCCCCC	37.57	24816145
28	Phosphorylation	EISKMKPSVAPRHPS HHHCCCCCCCCCCCC	25.95	22817900
35	Phosphorylation	SVAPRHPSTNSLLRE CCCCCCCCHHHHHHH	33.81	18179882
36	Phosphorylation	VAPRHPSTNSLLREQ CCCCCCCHHHHHHHH	33.02	23186163
38	Phosphorylation	PRHPSTNSLLREQIS CCCCCHHHHHHHHHH	28.95	23186163
45	Phosphorylation	SLLREQISLYPEVKG HHHHHHHHCCHHHCH	22.88	29978859
47	Phosphorylation	LREQISLYPEVKGEI HHHHHHCCHHHCHHH	7.20	27642862
51	Ubiquitination	ISLYPEVKGEIARKD HHCCHHHCHHHHCCC	49.52	21906983
57	Ubiquitination	VKGEIARKDEKLLSF HCHHHHCCCHHHHHH	62.31	22817900
60	Ubiquitination	EIARKDEKLLSFLKD HHHCCCHHHHHHHHH	65.93	21890473
63	Phosphorylation	RKDEKLLSFLKDVYV CCCHHHHHHHHHHCC	38.68	24719451
66	Ubiquitination	EKLLSFLKDVYVDSK HHHHHHHHHHCCCCC	43.04	21890473
69	Phosphorylation	LSFLKDVYVDSKDPV HHHHHHHCCCCCCCC	14.52	26270265
72	Phosphorylation	LKDVYVDSKDPVSSL HHHHCCCCCCCCCCH	28.99	26270265
73	Ubiquitination	KDVYVDSKDPVSSLQ HHHCCCCCCCCCCHH	62.68	21906983
77	Phosphorylation	VDSKDPVSSLQVKAA CCCCCCCCCHHHHHH	30.62	25599653
78	Phosphorylation	DSKDPVSSLQVKAAE CCCCCCCCHHHHHHH	24.05	26270265
82	Ubiquitination	PVSSLQVKAAETCQE CCCCHHHHHHHHCCC	28.99	23503661
91	Ubiquitination	AETCQEPKEFRLPKD HHHCCCCCCCCCCCC	69.59	21906983
91	Acetylation	AETCQEPKEFRLPKD HHHCCCCCCCCCCCC	69.59	23749302
97	Ubiquitination	PKEFRLPKDHHFDMI CCCCCCCCCCCCEEE	74.43	21906983
107	Ubiquitination	HFDMINIKSIPKGKI CCEEEECCCCCCCCE	37.53	21906983
111	Ubiquitination	INIKSIPKGKISIVE EECCCCCCCCEEHHH	71.77	22817900
113	Ubiquitination	IKSIPKGKISIVEAL CCCCCCCCEEHHHHH	39.13	23503661
137	Ubiquitination	PETWTAEKIMQEYQL CCCCCHHHHHHHHCC	40.80	29967540
147	Acetylation	QEYQLEQKDVNSLLK HHHCCHHHCHHHHHH	55.02	20167786
147	Ubiquitination	QEYQLEQKDVNSLLK HHHCCHHHCHHHHHH	55.02	22817900
151	Phosphorylation	LEQKDVNSLLKYFVT CHHHCHHHHHHHHHH	34.62	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUF4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUF4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUF4_HUMAN	NDUFAF4	physical	27499296
NDUF3_HUMAN	NDUFAF3	physical	27499296
NDUS7_HUMAN	NDUFS7	physical	27499296
ACAD9_HUMAN	ACAD9	physical	27499296
TIDC1_HUMAN	TIMMDC1	physical	27499296
NDUS8_HUMAN	NDUFS8	physical	27499296
HTRA2_HUMAN	HTRA2	physical	27499296
NDUS3_HUMAN	NDUFS3	physical	27499296
NDUB5_HUMAN	NDUFB5	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
NDUS2_HUMAN	NDUFS2	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
NDUA5_HUMAN	NDUFA5	physical	27499296
CIA30_HUMAN	NDUFAF1	physical	27499296
NUD19_HUMAN	NUDT19	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
PREP_HUMAN	PITRM1	physical	27499296
ATP5E_HUMAN	ATP5E	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
NDUBA_HUMAN	NDUFB10	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
WDR26_HUMAN	WDR26	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 252010: Mitochondrial complex I deficiency (MT-C1D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.