CX7A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CX7A2_HUMAN
• UniProt AC: P14406
• Protein Name: Cytochrome c oxidase subunit 7A2, mitochondrial
• Gene Name: COX7A2
• Organism: Homo sapiens (Human).
• Sequence Length: 83
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport..
• Protein Sequence: MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAIYELAVASFPKKQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Acetylation	NKVPEKQKLFQEDDE CCCCHHHHHCCCCCC	63.44	23954790
33	Ubiquitination	NKVPEKQKLFQEDDE CCCCHHHHHCCCCCC	63.44	21890473
44	Phosphorylation	EDDEIPLYLKGGVAD CCCCCCCHHCCCHHH	10.87	28152594
46	Ubiquitination	DEIPLYLKGGVADAL CCCCCHHCCCHHHHH	39.81	21890473
55	Phosphorylation	GVADALLYRATMILT CHHHHHHHHHHEEEE	10.07	21406692
65	Ubiquitination	TMILTVGGTAYAIYE HEEEEECHHHHHHHH	11.66	21890473
65	Acetylation	TMILTVGGTAYAIYE HEEEEECHHHHHHHH	11.66	-
71	Phosphorylation	GGTAYAIYELAVASF CHHHHHHHHHHHHHC	9.20	-
76	Phosphorylation	AIYELAVASFPKKQE HHHHHHHHHCCCCCC	10.39	-
78	Ubiquitination	YELAVASFPKKQE-- HHHHHHHCCCCCC--	8.09	21890473
87	Phosphorylation	KKQE----------- CCCC-----------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CX7A2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CX7A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CX7A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CX6B1_HUMAN	COX6B1	physical	28514442
NDUF7_HUMAN	NDUFAF7	physical	28514442
TOP3A_HUMAN	TOP3A	physical	28514442
DNLZ_HUMAN	DNLZ	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.