SUOX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUOX_HUMAN
• UniProt AC: P51687
• Protein Name: Sulfite oxidase, mitochondrial
• Gene Name: SUOX
• Organism: Homo sapiens (Human).
• Sequence Length: 545
• Subcellular Localization: Mitochondrion intermembrane space.
• Protein Sequence: MLLLHRAVVLRLQQACRLKSIPSRICIQACSTNDSFQPQRPSLTFSGDNSSTQGWRVMGTLLGLGAVLAYQDHRCRAAQESTHIYTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPGGPSKLMLAAGGPLEPFWALYAVHNQSHVRELLAQYKIGELNPEDKVAPTVETSDPYADDPVRHPALKVNSQRPFNAEPPPELLTENYITPNPIFFTRNHLPVPNLDPDTYRLHVVGAPGGQSLSLSLDDLHNFPRYEITVTLQCAGNRRSEMTQVKEVKGLEWRTGAISTARWAGARLCDVLAQAGHQLCETEAHVCFEGLDSDPTGTAYGASIPLARAMDPEAEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGARHVKWLGRVSVQPEESYSHWQRRDYKGFSPSVDWETVDFDSAPSIQELPVQSAITEPRDGETVESGEVTIKGYAWSGGGRAVIRVDVSLDGGLTWQVAKLDGEEQRPRKAWAWRLWQLKAPVPAGQKELNIVCKAVDDGYNVQPDTVAPIWNLRGVLSNAWHRVHVYVSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	SFQPQRPSLTFSGDN CCCCCCCEEEEECCC	42.08	27732954
44	Phosphorylation	QPQRPSLTFSGDNSS CCCCCEEEEECCCCC	21.79	27732954
46	Phosphorylation	QRPSLTFSGDNSSTQ CCCEEEEECCCCCCC	39.75	27732954
50	Phosphorylation	LTFSGDNSSTQGWRV EEEECCCCCCCCCCH	39.23	27732954
51	Phosphorylation	TFSGDNSSTQGWRVM EEECCCCCCCCCCHH	30.88	27732954
52	Phosphorylation	FSGDNSSTQGWRVMG EECCCCCCCCCCHHH	30.81	27732954
123	Phosphorylation	DLHPGGPSKLMLAAG ECCCCCCHHEEEECC	41.52	10519592
140	Phosphorylation	LEPFWALYAVHNQSH CCHHHHHHHHHCHHH	9.99	-
155	Phosphorylation	VRELLAQYKIGELNP HHHHHHHHCCCCCCC	10.04	-
165	Ubiquitination	GELNPEDKVAPTVET CCCCCHHCCCCCCCC	38.34	-
279	Acetylation	MTQVKEVKGLEWRTG CEEEEEECCCCCCCC	59.89	22424773
285	Phosphorylation	VKGLEWRTGAISTAR ECCCCCCCCCHHHHH	31.85	24719451
289	Phosphorylation	EWRTGAISTARWAGA CCCCCCHHHHHHHHH	18.58	28188228
330	Phosphorylation	SDPTGTAYGASIPLA CCCCCCCCCCCCCCH	17.05	22817900
391	Phosphorylation	VSVQPEESYSHWQRR EEECCCCCCCCHHHC	30.21	29083192
392	Phosphorylation	SVQPEESYSHWQRRD EECCCCCCCCHHHCC	14.08	29083192
393	Phosphorylation	VQPEESYSHWQRRDY ECCCCCCCCHHHCCC	27.77	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUOX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUOX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUOX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN576_HUMAN	ZNF576	physical	21988832
EST3_HUMAN	CES3	physical	28514442
FHOD1_HUMAN	FHOD1	physical	28514442
DJC11_HUMAN	DNAJC11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 272300: Isolated sulfite oxidase deficiency (ISOD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.