ZN576_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN576_HUMAN
• UniProt AC: Q9H609
• Protein Name: Zinc finger protein 576
• Gene Name: ZNF576
• Organism: Homo sapiens (Human).
• Sequence Length: 170
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MEDPNPEENMKQQDSPKERSPQSPGGNICHLGAPKCTRCLITFADSKFQERHMKREHPADFVAQKLQGVLFICFTCARSFPSSKALITHQRSHGPAAKPTLPVATTTAQPTFPCPDCGKTFGQAVSLRRHRQMHEVRAPPGTFACTECGQDFAQEAGLHQHYIRHARGEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	ENMKQQDSPKERSPQ HHHCCCCCCCCCCCC	33.27	24719451
20	Phosphorylation	QDSPKERSPQSPGGN CCCCCCCCCCCCCCC	28.51	25159151
23	Phosphorylation	PKERSPQSPGGNICH CCCCCCCCCCCCCCC	28.97	25159151
75	Phosphorylation	GVLFICFTCARSFPS HHHHHHHHCCCCCCC	10.80	25404012
79	Phosphorylation	ICFTCARSFPSSKAL HHHHCCCCCCCCHHH	24.00	28060719
82	Phosphorylation	TCARSFPSSKALITH HCCCCCCCCHHHHHC	42.32	28060719
83	Phosphorylation	CARSFPSSKALITHQ CCCCCCCCHHHHHCH	23.37	28060719
105	Phosphorylation	KPTLPVATTTAQPTF CCCCCEEECCCCCCC	25.55	30576142
107	Phosphorylation	TLPVATTTAQPTFPC CCCEEECCCCCCCCC	20.95	-
111	Phosphorylation	ATTTAQPTFPCPDCG EECCCCCCCCCCCCC	28.29	-
120	Phosphorylation	PCPDCGKTFGQAVSL CCCCCCCCHHHHHHH	20.48	22817900
126	Phosphorylation	KTFGQAVSLRRHRQM CCHHHHHHHHHHHHH	21.12	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN576_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN576_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN576_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POGZ_HUMAN	POGZ	physical	28514442
ZN618_HUMAN	ZNF618	physical	28514442
AJUBA_HUMAN	AJUBA	physical	28514442
ZBT40_HUMAN	ZBTB40	physical	28514442
ZBED1_HUMAN	ZBED1	physical	28514442
ZBT10_HUMAN	ZBTB10	physical	28514442
LIMD1_HUMAN	LIMD1	physical	28514442
RBBP6_HUMAN	RBBP6	physical	28514442
PDLI7_HUMAN	PDLIM7	physical	28514442
KAISO_HUMAN	ZBTB33	physical	28514442
ZN446_HUMAN	ZNF446	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-120 AND SER-126, ANDMASS SPECTROMETRY.
PubMed: 17081983