dbPTM

ZBT40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZBT40_HUMAN
UniProt AC	Q9NUA8
Protein Name	Zinc finger and BTB domain-containing protein 40
Gene Name	ZBTB40
Organism	Homo sapiens (Human).
Sequence Length	1239
Subcellular Localization	Nucleus .
Protein Description	May be involved in transcriptional regulation..
Protein Sequence	MELPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVVSPEEFALLLEMMYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTSLVNCSVQGQVVRDVSAPSSETFRKEPEKPQVEILSSEGAGEPHSSPELAATPGGPVKAETEEAAHSVSQEMSVNSPTAQESQRNAETPAETPTTAEACSPSPAVQTFSEAKKTSTEPGCERKHYQLNFLLENEGVFSDALMVTQDVLKKLEMCSEIKGPQKEMIVKCFEGEGGHSAFQRILGKVREESLDVQTVVSLLRLYQYSNPAVKTALLDRKPEDVDTVQPKGSTEEGKTLSVLLLEHKEDLIQCVTQLRPIMESLETAKEEFLTGTEKRVILNCCEGRTPKETIENLLHRMTEEKTLTAEGLVKLLQAVKTTFPNLGLLLEKLQKSATLPSTTVQPSPDDYGTELLRRYHENLSEIFTDNQILLKMISHMTSLAPGEREVMEKLVKRDSGSGGFNSLISAVLEKQTLSATAIWQLLLVVQETKTCPLDLLMEEIRREPGADAFFRAVTTPEHATLETILRHNQLILEAIQQKIEYKLFTSEEEHLAETVKEILSIPSETASPEASLRAVLSRAMEKSVPAIEICHLLCSVHKSFPGLQPVMQELAYIGVLTKEDGEKETWKVSNKFHLEANNKEDEKAAKEDSQPGEQNDQGETGSLPGQQEKEASASPDPAKKSFICKACDKSFHFYCRLKVHMKRCRVAKSKQVQCKECSETKDSKKELDKHQLEAHGAGGEPDAPKKKKKRLPVTCDLCGREFAHASGMQYHKLTEHFDEKPFSCEECGAKFAANSTLKNHLRLHTGDRPFMCKHCLMTFTQASALAYHTKKKHSEGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQVFVTLPDSQASQASSELVAVTVEDLLDGTVTLICGEAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	AASLLFKTLLDNTDT HHHHHHHHHHCCCCE	25.81	22210691
56	Phosphorylation	FKTLLDNTDTISIDA HHHHHCCCCEEEEEC	33.90	22210691
58	Phosphorylation	TLLDNTDTISIDASV HHHCCCCEEEEECCC	18.00	23532336
79	Phosphorylation	ALLLEMMYTGKLPVG HHHHHHHHHCCCCCC	15.84	23532336
150	Phosphorylation	KPQVEILSSEGAGEP CCCEEEECCCCCCCC	31.82	20873877
151	Phosphorylation	PQVEILSSEGAGEPH CCEEEECCCCCCCCC	36.28	30177828
159	Phosphorylation	EGAGEPHSSPELAAT CCCCCCCCCHHHCCC	59.30	20873877
160	Phosphorylation	GAGEPHSSPELAATP CCCCCCCCHHHCCCC	21.25	20873877
166	Phosphorylation	SSPELAATPGGPVKA CCHHHCCCCCCCCCC	19.50	20873877
172	Sumoylation	ATPGGPVKAETEEAA CCCCCCCCCCCHHHH	43.57	-
175	Phosphorylation	GGPVKAETEEAAHSV CCCCCCCCHHHHHHH	43.94	23927012
181	Phosphorylation	ETEEAAHSVSQEMSV CCHHHHHHHHHHHCC	20.81	23927012
183	Phosphorylation	EEAAHSVSQEMSVNS HHHHHHHHHHHCCCC	24.36	17525332
187	Phosphorylation	HSVSQEMSVNSPTAQ HHHHHHHCCCCCCHH	19.86	30266825
190	Phosphorylation	SQEMSVNSPTAQESQ HHHHCCCCCCHHHHH	22.82	23401153
192	Phosphorylation	EMSVNSPTAQESQRN HHCCCCCCHHHHHHH	40.57	30266825
196	Phosphorylation	NSPTAQESQRNAETP CCCCHHHHHHHCCCC	23.51	23927012
202	Phosphorylation	ESQRNAETPAETPTT HHHHHCCCCCCCCCC	25.95	30576142
206	Phosphorylation	NAETPAETPTTAEAC HCCCCCCCCCCHHHC	28.21	30266825
208	Phosphorylation	ETPAETPTTAEACSP CCCCCCCCCHHHCCC	46.16	30266825
209	Phosphorylation	TPAETPTTAEACSPS CCCCCCCCHHHCCCC	24.57	30266825
214	Phosphorylation	PTTAEACSPSPAVQT CCCHHHCCCCHHHHH	35.15	30266825
216	Phosphorylation	TAEACSPSPAVQTFS CHHHCCCCHHHHHHH	14.81	30266825
221	Phosphorylation	SPSPAVQTFSEAKKT CCCHHHHHHHHHHCC	23.64	30108239
223	Phosphorylation	SPAVQTFSEAKKTST CHHHHHHHHHHCCCC	39.78	28450419
228	Phosphorylation	TFSEAKKTSTEPGCE HHHHHHCCCCCCCCC	39.93	-
229	Phosphorylation	FSEAKKTSTEPGCER HHHHHCCCCCCCCCC	39.39	-
230	Phosphorylation	SEAKKTSTEPGCERK HHHHCCCCCCCCCCH	51.97	-
264	Ubiquitination	VTQDVLKKLEMCSEI HCHHHHHHHHHHHHC	45.58	-
272	Ubiquitination	LEMCSEIKGPQKEMI HHHHHHCCCCCCEEE	61.56	-
276	Ubiquitination	SEIKGPQKEMIVKCF HHCCCCCCEEEEECC	53.00	-
281	Ubiquitination	PQKEMIVKCFEGEGG CCCEEEEECCCCCCC	23.45	-
303	Phosphorylation	LGKVREESLDVQTVV HHHHHHHCCCHHHHH	25.72	22210691
308	Phosphorylation	EESLDVQTVVSLLRL HHCCCHHHHHHHHHH	23.79	21406692
311	Phosphorylation	LDVQTVVSLLRLYQY CCHHHHHHHHHHHHH	19.83	22210691
316	Phosphorylation	VVSLLRLYQYSNPAV HHHHHHHHHHCCHHH	10.04	27642862
318	Phosphorylation	SLLRLYQYSNPAVKT HHHHHHHHCCHHHHH	9.25	22210691
319	Phosphorylation	LLRLYQYSNPAVKTA HHHHHHHCCHHHHHH	22.32	27642862
324	Ubiquitination	QYSNPAVKTALLDRK HHCCHHHHHHHHCCC	30.13	-
337	Phosphorylation	RKPEDVDTVQPKGST CCCCCCCCCCCCCCC	22.38	18669648
374	Phosphorylation	QLRPIMESLETAKEE HHHHHHHHHHHHHHH	17.71	20068231
377	Phosphorylation	PIMESLETAKEEFLT HHHHHHHHHHHHHCC	48.61	20068231
388	Ubiquitination	EFLTGTEKRVILNCC HHCCCCCEEEEEECC	52.37	-
401	Ubiquitination	CCEGRTPKETIENLL CCCCCCCHHHHHHHH	67.86	-
412	Phosphorylation	ENLLHRMTEEKTLTA HHHHHHHCCCCCCCH	40.73	18669648
415	Ubiquitination	LHRMTEEKTLTAEGL HHHHCCCCCCCHHHH	42.47	-
416	Phosphorylation	HRMTEEKTLTAEGLV HHHCCCCCCCHHHHH	32.40	18669648
418	Phosphorylation	MTEEKTLTAEGLVKL HCCCCCCCHHHHHHH	28.09	18669648
424	Ubiquitination	LTAEGLVKLLQAVKT CCHHHHHHHHHHHHH	48.82	-
430	Ubiquitination	VKLLQAVKTTFPNLG HHHHHHHHHHCCCHH	44.88	-
442	Ubiquitination	NLGLLLEKLQKSATL CHHHHHHHHHHHCCC	57.07	-
445	Ubiquitination	LLLEKLQKSATLPST HHHHHHHHHCCCCCC	53.12	-
446	Phosphorylation	LLEKLQKSATLPSTT HHHHHHHHCCCCCCC	17.33	20068231
448	Phosphorylation	EKLQKSATLPSTTVQ HHHHHHCCCCCCCCC	46.41	20068231
451	Phosphorylation	QKSATLPSTTVQPSP HHHCCCCCCCCCCCC	39.56	28348404
452	Phosphorylation	KSATLPSTTVQPSPD HHCCCCCCCCCCCCC	29.10	28348404
453	Phosphorylation	SATLPSTTVQPSPDD HCCCCCCCCCCCCCC	22.83	28348404
457	Phosphorylation	PSTTVQPSPDDYGTE CCCCCCCCCCCHHHH	24.70	28348404
461	Phosphorylation	VQPSPDDYGTELLRR CCCCCCCHHHHHHHH	33.07	20068231
463	Phosphorylation	PSPDDYGTELLRRYH CCCCCHHHHHHHHHH	19.75	20068231
491	Phosphorylation	LKMISHMTSLAPGER HHHHHHHHHCCCCCH	18.37	24275569
503	Ubiquitination	GEREVMEKLVKRDSG CCHHHHHHHHHHCCC	40.25	-
610	Ubiquitination	EHLAETVKEILSIPS HHHHHHHHHHHCCCC	46.59	-
614	Phosphorylation	ETVKEILSIPSETAS HHHHHHHCCCCCCCC	37.81	20068231
617	Phosphorylation	KEILSIPSETASPEA HHHHCCCCCCCCHHH	46.00	20068231
619	Phosphorylation	ILSIPSETASPEASL HHCCCCCCCCHHHHH	36.45	28348404
621	Phosphorylation	SIPSETASPEASLRA CCCCCCCCHHHHHHH	30.60	21815630
625	Phosphorylation	ETASPEASLRAVLSR CCCCHHHHHHHHHHH	19.41	20068231
685	Ubiquitination	ETWKVSNKFHLEANN EEEEEECCEEEECCC	27.01	-
703	Phosphorylation	EKAAKEDSQPGEQND HHHHHHCCCCCCCCC	39.09	17525332
714	Phosphorylation	EQNDQGETGSLPGQQ CCCCCCCCCCCCCHH	38.61	27732954
716	Phosphorylation	NDQGETGSLPGQQEK CCCCCCCCCCCHHHH	38.52	27135362
726	Phosphorylation	GQQEKEASASPDPAK CHHHHHHCCCCCHHH	30.30	23403867
728	Phosphorylation	QEKEASASPDPAKKS HHHHHCCCCCHHHHC	27.60	28176443
744	Phosphorylation	ICKACDKSFHFYCRL HHHHCCCCEEHHHHH	15.65	28555341
772	Phosphorylation	QVQCKECSETKDSKK CCCCCCCCCCCCCHH	49.76	26657352
774	Phosphorylation	QCKECSETKDSKKEL CCCCCCCCCCCHHHH	24.69	26657352
777	Phosphorylation	ECSETKDSKKELDKH CCCCCCCCHHHHHHH	47.37	26657352
783	Ubiquitination	DSKKELDKHQLEAHG CCHHHHHHHHHHHCC	45.97	-
820	Phosphorylation	GREFAHASGMQYHKL CHHHHHHHCCCHHHH	25.57	-
824	Phosphorylation	AHASGMQYHKLTEHF HHHHCCCHHHHHHCC	7.63	-
834	Ubiquitination	LTEHFDEKPFSCEEC HHHCCCCCCCCHHHH	53.89	-
852	Ubiquitination	FAANSTLKNHLRLHT ECCCHHHHHHHHCCC	42.27	-
859	Phosphorylation	KNHLRLHTGDRPFMC HHHHHCCCCCCCCHH	45.42	28555341
893	Phosphorylation	KHSEGKMYACQYCDA CCCCCCCCHHHHHHH	14.01	22817900
897	Phosphorylation	GKMYACQYCDAVFAQ CCCCHHHHHHHHHHH	7.68	22817900
916	Phosphorylation	SRHVRTHTGDKPYVC HHHCHHCCCCCCEEE	46.60	28348404
961	Phosphorylation	KCRMSFPTLQDHRKH CCCCCCCCHHHHHHH	34.73	22199227
1004	Acetylation	VVTHVGGKPFSCGIC EEEEECCEECCCCCC	36.64	26051181
1066	Sumoylation	IEHKKHIKAEHADMK HHHHHHHCHHHCCCC	47.65	28112733
1152	Phosphorylation	TSQAQLDSHLESEHP CCHHHHHHHHHHCCC	38.27	-
1156	Phosphorylation	QLDSHLESEHPKVMS HHHHHHHHCCCCCCC	47.79	-
1163	Phosphorylation	SEHPKVMSTETQAAA HCCCCCCCHHHHHHH	26.53	-
1164	Phosphorylation	EHPKVMSTETQAAAS CCCCCCCHHHHHHHH	25.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZBT40_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZBT40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZBT40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZBT40_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZBT40_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-190 ANDSER-703, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-728, AND MASSSPECTROMETRY.	15302935 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-337; THR-412; THR-416AND THR-418, AND MASS SPECTROMETRY.	18669648 [Abstract]