ZN446_HUMAN - dbPTM
ZN446_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN446_HUMAN
UniProt AC Q9NWS9
Protein Name Zinc finger protein 446
Gene Name ZNF446
Organism Homo sapiens (Human).
Sequence Length 450
Subcellular Localization Nucleus .
Protein Description May be involved in transcriptional regulation..
Protein Sequence MPSPLGPPCLPVMDPETTLEEPETARLRFRGFCYQEVAGPREALARLRELCCQWLQPEAHSKEQMLEMLVLEQFLGTLPPEIQAWVRGQRPGSPEEAAALVEGLQHDPGQLLGWITAHVLKQEVLPAAQKTEEPLGSPHPSGTVESPGEGPQDTRIEGSVQLSCSVKEEPNVDGQEVAPSSPPLAAQSPEGNHGHQEPASTSFHPPRIQEEWGLLDRSQKELYWDAMLEKYGTVVSLGLPPHQPEAQAQSELGMLLTGTGVCRSLRSGNESEGPPGCPEAQPPQGPGPAAWEGLSGAATPAPTVRPGTPPVPTQPTPAETRLEPAATPRKPYTCEQCGRGFDWKSVFVIHHRTHTSGPGVQSPGLATGESTEKPPQGEVAFPHHPRRSLTGPRSYPCEECGCSFSWKSQLVIHRKSHTGQRRHFCSDCGRAFDWKSQLVIHRKGHRPEVP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPSPLGPPCL
-----CCCCCCCCCC		31.3030175587
17PhosphorylationLPVMDPETTLEEPET
CCCCCCCCCCCCCCH		41.9126074081
18PhosphorylationPVMDPETTLEEPETA
CCCCCCCCCCCCCHH		30.4326074081
24PhosphorylationTTLEEPETARLRFRG
CCCCCCCHHHHHCCC		28.0026074081
130SumoylationEVLPAAQKTEEPLGS
HHHCHHHCCCCCCCC		53.8528112733
131PhosphorylationVLPAAQKTEEPLGSP
HHCHHHCCCCCCCCC		33.2430266825
137PhosphorylationKTEEPLGSPHPSGTV
CCCCCCCCCCCCCCC		27.9329255136
141PhosphorylationPLGSPHPSGTVESPG
CCCCCCCCCCCCCCC		44.0223401153
143PhosphorylationGSPHPSGTVESPGEG
CCCCCCCCCCCCCCC		25.9930266825
146PhosphorylationHPSGTVESPGEGPQD
CCCCCCCCCCCCCCC		33.5929255136
154PhosphorylationPGEGPQDTRIEGSVQ
CCCCCCCCEEEEEEE		28.4429255136
159PhosphorylationQDTRIEGSVQLSCSV
CCCEEEEEEEEEEEE		8.2327251275
180PhosphorylationDGQEVAPSSPPLAAQ
CCCEECCCCCCCCCC		45.8223663014
181PhosphorylationGQEVAPSSPPLAAQS
CCEECCCCCCCCCCC		29.4930266825
188PhosphorylationSPPLAAQSPEGNHGH
CCCCCCCCCCCCCCC		21.8630266825
200PhosphorylationHGHQEPASTSFHPPR
CCCCCCCCCCCCCCH		34.9923663014
201PhosphorylationGHQEPASTSFHPPRI
CCCCCCCCCCCCCHH		37.2023663014
202PhosphorylationHQEPASTSFHPPRIQ
CCCCCCCCCCCCHHH		21.0423663014
218PhosphorylationEWGLLDRSQKELYWD
HHCCCCHHHHHHHHH		45.3228450419
220UbiquitinationGLLDRSQKELYWDAM
CCCCHHHHHHHHHHH		51.43-
295PhosphorylationPAAWEGLSGAATPAP
CCHHCCCCCCCCCCC		36.9226074081
299PhosphorylationEGLSGAATPAPTVRP
CCCCCCCCCCCCCCC		21.3226074081
303PhosphorylationGAATPAPTVRPGTPP
CCCCCCCCCCCCCCC		31.1126074081
308PhosphorylationAPTVRPGTPPVPTQP
CCCCCCCCCCCCCCC		27.4028112733
313PhosphorylationPGTPPVPTQPTPAET
CCCCCCCCCCCCCCC		47.6226074081
316PhosphorylationPPVPTQPTPAETRLE
CCCCCCCCCCCCCCC		25.8826074081
320PhosphorylationTQPTPAETRLEPAAT
CCCCCCCCCCCCCCC		42.5326074081
327PhosphorylationTRLEPAATPRKPYTC
CCCCCCCCCCCCCCC		26.2328985074
330SumoylationEPAATPRKPYTCEQC
CCCCCCCCCCCCCCC		43.51-
330SumoylationEPAATPRKPYTCEQC
CCCCCCCCCCCCCCC		43.5128112733
332PhosphorylationAATPRKPYTCEQCGR
CCCCCCCCCCCCCCC		27.3626074081
333PhosphorylationATPRKPYTCEQCGRG
CCCCCCCCCCCCCCC		20.3526074081
355PhosphorylationVIHHRTHTSGPGVQS
EEEECCCCCCCCCCC		34.4628555341
356PhosphorylationIHHRTHTSGPGVQSP
EEECCCCCCCCCCCC		35.0726425664
362PhosphorylationTSGPGVQSPGLATGE
CCCCCCCCCCCCCCC		20.6629978859
388PhosphorylationFPHHPRRSLTGPRSY
CCCCCCCCCCCCCCC		31.4029457462
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN446_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN446_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN446_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZSC16_HUMANZSCAN16physical
16189514
ZN496_HUMANZNF496physical
16189514
DGC6L_HUMANDGCR6Lphysical
16189514
ZN397_HUMANZNF397physical
20211142
ZN446_HUMANZNF446physical
25416956
ZKSC7_HUMANZKSCAN7physical
25416956
ZSC16_HUMANZSCAN16physical
25416956
ZN397_HUMANZNF397physical
25416956
LZTS2_HUMANLZTS2physical
25416956
PGBD1_HUMANPGBD1physical
25416956
ZN496_HUMANZNF496physical
25416956
K1C40_HUMANKRT40physical
25416956
ZN396_HUMANZNF396physical
25416956
ZSC22_HUMANZSCAN22physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
ZN165_HUMANZNF165physical
21516116
ZN397_HUMANZNF397physical
21516116
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN446_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND MASSSPECTROMETRY.

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