dbPTM

POGZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	POGZ_HUMAN
UniProt AC	Q7Z3K3
Protein Name	Pogo transposable element with ZNF domain
Gene Name	POGZ
Organism	Homo sapiens (Human).
Sequence Length	1410
Subcellular Localization	Nucleus. Chromosome. Cytoplasm. According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).
Protein Description	Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms..
Protein Sequence	MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTTVSVSQQPVSAPVPIAAHASVAGHLSTSTTVSSSGAQNSDSTKKTLVTLIANNNAGNPLVQQGGQPLILTQNPAPGLGTMVTQPVLRPVQVMQNANHVTSSPVASQPIFITTQGFPVRNVRPVQNAMNQVGIVLNVQQGQTVRPITLVPAPGTQFVKPTVGVPQVFSQMTPVRPGSTMPVRPTTNTFTTVIPATLTIRSTVPQSQSQQTKSTPSTSTTPTATQPTSLGQLAVQSPGQSNQTTNPKLAPSFPSPPAVSIASFVTVKRPGVTGENSNEVAKLVNTLNTIPSLGQSPGPVVVSNNSSAHGSQRTSGPESSMKVTSSIPVFDLQDGGRKICPRCNAQFRVTEALRGHMCYCCPEMVEYQKKGKSLDSEPSVPSAAKPPSPEKTAPVASTPSSTPIPALSPPTKVPEPNENVGDAVQTKLIMLVDDFYYGRDGGKVAQLTNFPKVATSFRCPHCTKRLKNNIRFMNHMKHHVELDQQNGEVDGHTICQHCYRQFSTPFQLQCHLENVHSPYESTTKCKICEWAFESEPLFLQHMKDTHKPGEMPYVCQVCQYRSSLYSEVDVHFRMIHEDTRHLLCPYCLKVFKNGNAFQQHYMRHQKRNVYHCNKCRLQFLFAKDKIEHKLQHHKTFRKPKQLEGLKPGTKVTIRASRGQPRTVPVSSNDTPPSALQEAAPLTSSMDPLPVFLYPPVQRSIQKRAVRKMSVMGRQTCLECSFEIPDFPNHFPTYVHCSLCRYSTCCSRAYANHMINNHVPRKSPKYLALFKNSVSGIKLACTSCTFVTSVGDAMAKHLVFNPSHRSSSILPRGLTWIAHSRHGQTRDRVHDRNVKNMYPPPSFPTNKAATVKSAGATPAEPEELLTPLAPALPSPASTATPPPTPTHPQALALPPLATEGAECLNVDDQDEGSPVTQEPELASGGGGSGGVGKKEQLSVKKLRVVLFALCCNTEQAAEHFRNPQRRIRRWLRRFQASQGENLEGKYLSFEAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSLEGGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKDVAENAGLFIDFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVGTGEPWCDVVLAILADGTVLPTLVFYRGQMDQPANMPDSILLEAKESGYSDDEIMELWSTRVWQKHTACQRSKGMLVMDCHRTHLSEEVLAMLSASSTLPAVVPAGCSSKIQPLDVCIKRTVKNFLHKKWKEQAREMADTACDSDVLLQLVLVWLGEVLGVIGDCPELVQRSFLVASVLPGPDGNINSPTRNADMQEELIASLEEQLKLSGEHSESSTPRPRSSPEETIEPESLHQLFEGESETESFYGFEEADLDLMEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LEPWQKISDVIEDSV CCHHHHHHHHHHHHH	32.62	26074081
28	Phosphorylation	ISDVIEDSVVEDYNS HHHHHHHHHCCCCCC	18.44	21712546
28 (in isoform 3)	Phosphorylation	-	18.44	27642862
33	Phosphorylation	EDSVVEDYNSVDKTT HHHHCCCCCCCCCCE	8.88	28796482
33 (in isoform 3)	Phosphorylation	-	8.88	27642862
35	Phosphorylation	SVVEDYNSVDKTTTV HHCCCCCCCCCCEEE	26.01	28796482
179	Phosphorylation	IVLNVQQGQTVRPIT EEEEECCCCEEECEE	14.18	32142685
183	Dimethylation	VQQGQTVRPITLVPA ECCCCEEECEEEEEC	21.94	-
183	Methylation	VQQGQTVRPITLVPA ECCCCEEECEEEEEC	21.94	52717217
191 (in isoform 2)	O-linked_Glycosylation	-	40.05	-
198 (in isoform 2)	Phosphorylation	-	27.32	-
205 (in isoform 2)	Phosphorylation	-	4.00	-
221	Phosphorylation	PGSTMPVRPTTNTFT CCCCCCCCCCCCCEE	19.58	32142685
221 (in isoform 2)	Phosphorylation	-	19.58	-
224	Ubiquitination	TMPVRPTTNTFTTVI CCCCCCCCCCEEEEE	34.64	29967540
229	Phosphorylation	PTTNTFTTVIPATLT CCCCCEEEEEEEEEE	16.55	19413330
229 (in isoform 2)	Phosphorylation	-	16.55	-
239	O-linked_Glycosylation	PATLTIRSTVPQSQS EEEEEEEECCCCCCC	29.88	20068230
240	O-linked_Glycosylation	ATLTIRSTVPQSQSQ EEEEEEECCCCCCCC	26.76	20068230
244	O-linked_Glycosylation	IRSTVPQSQSQQTKS EEECCCCCCCCCCCC	26.23	32574038
244	O-linked_Glycosylation	IRSTVPQSQSQQTKS EEECCCCCCCCCCCC	26.23	20068230
244	Phosphorylation	IRSTVPQSQSQQTKS EEECCCCCCCCCCCC	26.23	-
244 (in isoform 4)	O-linked_Glycosylation	-	26.23	-
246	O-linked_Glycosylation	STVPQSQSQQTKSTP ECCCCCCCCCCCCCC	29.51	20068230
249	O-linked_Glycosylation	PQSQSQQTKSTPSTS CCCCCCCCCCCCCCC	21.23	20068230
251	Phosphorylation	SQSQQTKSTPSTSTT CCCCCCCCCCCCCCC	49.27	19413330
251 (in isoform 4)	Phosphorylation	-	49.27	-
252	O-linked_Glycosylation	QSQQTKSTPSTSTTP CCCCCCCCCCCCCCC	23.86	20068230
252	Phosphorylation	QSQQTKSTPSTSTTP CCCCCCCCCCCCCCC	23.86	25159151
254	Phosphorylation	QQTKSTPSTSTTPTA CCCCCCCCCCCCCCC	34.77	30108239
255	Phosphorylation	QTKSTPSTSTTPTAT CCCCCCCCCCCCCCC	31.15	25262027
256	Phosphorylation	TKSTPSTSTTPTATQ CCCCCCCCCCCCCCC	34.32	25627689
257	Phosphorylation	KSTPSTSTTPTATQP CCCCCCCCCCCCCCC	36.56	25159151
257	Ubiquitination	KSTPSTSTTPTATQP CCCCCCCCCCCCCCC	36.56	29967540
258	Phosphorylation	STPSTSTTPTATQPT CCCCCCCCCCCCCCC	20.57	25159151
258 (in isoform 4)	Phosphorylation	-	20.57	-
260	Phosphorylation	PSTSTTPTATQPTSL CCCCCCCCCCCCCCC	40.00	25159151
262	Phosphorylation	TSTTPTATQPTSLGQ CCCCCCCCCCCCCCC	37.24	25262027
265	O-linked_Glycosylation	TPTATQPTSLGQLAV CCCCCCCCCCCCEEE	27.11	20068230
265	Phosphorylation	TPTATQPTSLGQLAV CCCCCCCCCCCCEEE	27.11	30108239
266	O-linked_Glycosylation	PTATQPTSLGQLAVQ CCCCCCCCCCCEEEC	36.87	20068230
266	Phosphorylation	PTATQPTSLGQLAVQ CCCCCCCCCCCEEEC	36.87	28450419
266	Ubiquitination	PTATQPTSLGQLAVQ CCCCCCCCCCCEEEC	36.87	29967540
274	O-linked_Glycosylation	LGQLAVQSPGQSNQT CCCEEECCCCCCCCC	25.13	20068230
274	Phosphorylation	LGQLAVQSPGQSNQT CCCEEECCCCCCCCC	25.13	25159151
274 (in isoform 4)	Phosphorylation	-	25.13	-
278	Phosphorylation	AVQSPGQSNQTTNPK EECCCCCCCCCCCCC	36.50	28450419
280 (in isoform 2)	Phosphorylation	-	55.75	-
281	Phosphorylation	SPGQSNQTTNPKLAP CCCCCCCCCCCCCCC	32.56	28450419
282	Phosphorylation	PGQSNQTTNPKLAPS CCCCCCCCCCCCCCC	39.50	28450419
282 (in isoform 4)	Phosphorylation	-	39.50	-
289	O-linked_Glycosylation	TNPKLAPSFPSPPAV CCCCCCCCCCCCCEE	44.15	20068230
289	Phosphorylation	TNPKLAPSFPSPPAV CCCCCCCCCCCCCEE	44.15	24732914
292	O-linked_Glycosylation	KLAPSFPSPPAVSIA CCCCCCCCCCEEEEE	41.32	20068230
292	Phosphorylation	KLAPSFPSPPAVSIA CCCCCCCCCCEEEEE	41.32	25159151
297	O-linked_Glycosylation	FPSPPAVSIASFVTV CCCCCEEEEEEEEEE	17.97	20068230
297	Phosphorylation	FPSPPAVSIASFVTV CCCCCEEEEEEEEEE	17.97	24732914
300	O-linked_Glycosylation	PPAVSIASFVTVKRP CCEEEEEEEEEEECC	20.69	20068230
300	Phosphorylation	PPAVSIASFVTVKRP CCEEEEEEEEEEECC	20.69	24732914
303	O-linked_Glycosylation	VSIASFVTVKRPGVT EEEEEEEEEECCCCC	20.49	20068230
303	Phosphorylation	VSIASFVTVKRPGVT EEEEEEEEEECCCCC	20.49	27251275
310	O-linked_Glycosylation	TVKRPGVTGENSNEV EEECCCCCCCCHHHH	44.70	20068230
310	Phosphorylation	TVKRPGVTGENSNEV EEECCCCCCCCHHHH	44.70	27251275
310	Ubiquitination	TVKRPGVTGENSNEV EEECCCCCCCCHHHH	44.70	29967540
314	Phosphorylation	PGVTGENSNEVAKLV CCCCCCCHHHHHHHH	30.02	25849741
319	Sumoylation	ENSNEVAKLVNTLNT CCHHHHHHHHHHHHC	59.13	28112733
319	Ubiquitination	ENSNEVAKLVNTLNT CCHHHHHHHHHHHHC	59.13	29967540
323	Phosphorylation	EVAKLVNTLNTIPSL HHHHHHHHHHCCCCC	17.57	28464451
326	Phosphorylation	KLVNTLNTIPSLGQS HHHHHHHCCCCCCCC	37.06	24732914
329	Phosphorylation	NTLNTIPSLGQSPGP HHHHCCCCCCCCCCC	41.08	23401153
330	Phosphorylation	TLNTIPSLGQSPGPV HHHCCCCCCCCCCCE	6.41	32142685
333	Phosphorylation	TIPSLGQSPGPVVVS CCCCCCCCCCCEEEC	29.99	25159151
333 (in isoform 4)	Phosphorylation	-	29.99	-
339	Phosphorylation	QSPGPVVVSNNSSAH CCCCCEEECCCCCCC	5.29	32142685
340	O-linked_Glycosylation	SPGPVVVSNNSSAHG CCCCEEECCCCCCCC	20.77	20068230
340	Phosphorylation	SPGPVVVSNNSSAHG CCCCEEECCCCCCCC	20.77	25159151
343	Phosphorylation	PVVVSNNSSAHGSQR CEEECCCCCCCCCCC	32.90	24732914
344	Phosphorylation	VVVSNNSSAHGSQRT EEECCCCCCCCCCCC	26.80	24732914
348	Phosphorylation	NNSSAHGSQRTSGPE CCCCCCCCCCCCCCC	13.46	24732914
350	Phosphorylation	SSAHGSQRTSGPESS CCCCCCCCCCCCCCC	32.34	32142685
351	Phosphorylation	SAHGSQRTSGPESSM CCCCCCCCCCCCCCC	30.33	26074081
352	Phosphorylation	AHGSQRTSGPESSMK CCCCCCCCCCCCCCE	55.32	26074081
359	Sumoylation	SGPESSMKVTSSIPV CCCCCCCEEEECCCE	44.29	28112733
361	O-linked_Glycosylation	PESSMKVTSSIPVFD CCCCCEEEECCCEEE	15.96	20068230
361	Phosphorylation	PESSMKVTSSIPVFD CCCCCEEEECCCEEE	15.96	23186163
362	Phosphorylation	ESSMKVTSSIPVFDL CCCCEEEECCCEEEC	29.29	23186163
363	O-linked_Glycosylation	SSMKVTSSIPVFDLQ CCCEEEECCCEEECC	22.88	20068230
363	Phosphorylation	SSMKVTSSIPVFDLQ CCCEEEECCCEEECC	22.88	18669648
363 (in isoform 2)	Phosphorylation	-	22.88	-
366 (in isoform 2)	Phosphorylation	-	5.78	-
370	Ubiquitination	SIPVFDLQDGGRKIC CCCEEECCCCCEEEC	49.50	23000965
372	Phosphorylation	PVFDLQDGGRKICPR CEEECCCCCEEECCC	25.50	32142685
372 (in isoform 2)	Phosphorylation	-	25.50	-
376 (in isoform 2)	Phosphorylation	-	3.63	-
381	Phosphorylation	RKICPRCNAQFRVTE EEECCCCCCCCCCCH	37.75	32142685
383	Phosphorylation	ICPRCNAQFRVTEAL ECCCCCCCCCCCHHH	16.82	32142685
392	Phosphorylation	RVTEALRGHMCYCCP CCCHHHCCCCCEECH	17.46	32142685
392 (in isoform 2)	Phosphorylation	-	17.46	-
394	Ubiquitination	TEALRGHMCYCCPEM CHHHCCCCCEECHHH	1.62	23000965
395 (in isoform 2)	Phosphorylation	-	1.63	-
396	Phosphorylation	ALRGHMCYCCPEMVE HHCCCCCEECHHHHH	6.90	30576142
404	Phosphorylation	CCPEMVEYQKKGKSL ECHHHHHHHHCCCCC	17.77	30576142
410	Phosphorylation	EYQKKGKSLDSEPSV HHHHCCCCCCCCCCC	46.18	23927012
413	Phosphorylation	KKGKSLDSEPSVPSA HCCCCCCCCCCCCCC	57.61	23927012
416	Phosphorylation	KSLDSEPSVPSAAKP CCCCCCCCCCCCCCC	42.48	23927012
419	Phosphorylation	DSEPSVPSAAKPPSP CCCCCCCCCCCCCCC	38.41	23927012
422	Sumoylation	PSVPSAAKPPSPEKT CCCCCCCCCCCCCCC	58.12	28112733
425	Phosphorylation	PSAAKPPSPEKTAPV CCCCCCCCCCCCCCC	54.97	29255136
427	Ubiquitination	AAKPPSPEKTAPVAS CCCCCCCCCCCCCCC	68.33	23000965
429	Phosphorylation	KPPSPEKTAPVASTP CCCCCCCCCCCCCCC	34.23	23927012
434	Phosphorylation	EKTAPVASTPSSTPI CCCCCCCCCCCCCCC	40.88	25159151
435	Phosphorylation	KTAPVASTPSSTPIP CCCCCCCCCCCCCCC	19.90	25159151
436	Phosphorylation	TAPVASTPSSTPIPA CCCCCCCCCCCCCCC	24.64	32142685
436	Ubiquitination	TAPVASTPSSTPIPA CCCCCCCCCCCCCCC	24.64	23000965
437	Phosphorylation	APVASTPSSTPIPAL CCCCCCCCCCCCCCC	47.10	30278072
438	Phosphorylation	PVASTPSSTPIPALS CCCCCCCCCCCCCCC	39.13	23927012
439	Phosphorylation	VASTPSSTPIPALSP CCCCCCCCCCCCCCC	29.58	25159151
439 (in isoform 2)	Phosphorylation	-	29.58	-
440 (in isoform 2)	Phosphorylation	-	32.30	-
445	Phosphorylation	STPIPALSPPTKVPE CCCCCCCCCCCCCCC	30.82	25159151
448	Phosphorylation	IPALSPPTKVPEPNE CCCCCCCCCCCCCCC	48.32	30278072
449	Sumoylation	PALSPPTKVPEPNEN CCCCCCCCCCCCCCC	62.66	28112733
463	Phosphorylation	NVGDAVQTKLIMLVD CCHHHHHHHHEEEEC	22.63	22115753
473	Phosphorylation	IMLVDDFYYGRDGGK EEEECCEEECCCCCC	16.41	20068231
480	Ubiquitination	YYGRDGGKVAQLTNF EECCCCCCEEECCCC	39.67	23000965
489	Sumoylation	AQLTNFPKVATSFRC EECCCCCCCCCCCCC	40.12	28112733
489	Ubiquitination	AQLTNFPKVATSFRC EECCCCCCCCCCCCC	40.12	23000965
492	Phosphorylation	TNFPKVATSFRCPHC CCCCCCCCCCCCCHH	31.24	22817900
493	Phosphorylation	NFPKVATSFRCPHCT CCCCCCCCCCCCHHH	10.85	22817900
496	Ubiquitination	KVATSFRCPHCTKRL CCCCCCCCCHHHHHH	2.25	23000965
554	Phosphorylation	CHLENVHSPYESTTK EECCCCCCCCCCCCC	25.54	28555341
559	Phosphorylation	VHSPYESTTKCKICE CCCCCCCCCCCEECH	20.52	25627689
560	Phosphorylation	HSPYESTTKCKICEW CCCCCCCCCCEECHH	43.66	25627689
565	Ubiquitination	STTKCKICEWAFESE CCCCCEECHHHHHCC	1.87	33845483
571	Ubiquitination	ICEWAFESEPLFLQH ECHHHHHCCCCCHHH	37.75	29967540
576	Ubiquitination	FESEPLFLQHMKDTH HHCCCCCHHHCCCCC	4.50	29967540
582	Ubiquitination	FLQHMKDTHKPGEMP CHHHCCCCCCCCCCC	26.70	29967540
588	Ubiquitination	DTHKPGEMPYVCQVC CCCCCCCCCCHHHHC	3.44	29967540
598	Ubiquitination	VCQVCQYRSSLYSEV HHHHCCCCHHHHCEE	8.22	33845483
604	Ubiquitination	YRSSLYSEVDVHFRM CCHHHHCEECEEEEE	29.22	29967540
607	Ubiquitination	SLYSEVDVHFRMIHE HHHCEECEEEEECCC	5.77	33845483
609	Ubiquitination	YSEVDVHFRMIHEDT HCEECEEEEECCCCH	5.95	29967540
613	Ubiquitination	DVHFRMIHEDTRHLL CEEEEECCCCHHHCH	19.96	29967540
615	Ubiquitination	HFRMIHEDTRHLLCP EEEECCCCHHHCHHH	34.57	29967540
618	Ubiquitination	MIHEDTRHLLCPYCL ECCCCHHHCHHHHHH	25.83	29967540
621	Ubiquitination	EDTRHLLCPYCLKVF CCHHHCHHHHHHHHH	2.58	29967540
624	Ubiquitination	RHLLCPYCLKVFKNG HHCHHHHHHHHHHCC	1.47	29967540
629	Sumoylation	PYCLKVFKNGNAFQQ HHHHHHHHCCCHHHH	67.92	28112733
630	Ubiquitination	YCLKVFKNGNAFQQH HHHHHHHCCCHHHHH	37.17	29967540
651	Phosphorylation	RNVYHCNKCRLQFLF CCCEECCHHHHEEEE	26.57	32645325
651	Ubiquitination	RNVYHCNKCRLQFLF CCCEECCHHHHEEEE	26.57	33845483
651 (in isoform 2)	Phosphorylation	-	26.57	-
654 (in isoform 2)	Phosphorylation	-	6.22	-
657	Ubiquitination	NKCRLQFLFAKDKIE CHHHHEEEECHHHHH	2.35	29967540
660	Ubiquitination	RLQFLFAKDKIEHKL HHEEEECHHHHHHHH	52.82	33845483
662	Ubiquitination	QFLFAKDKIEHKLQH EEEECHHHHHHHHHH	49.65	29967540
666	Ubiquitination	AKDKIEHKLQHHKTF CHHHHHHHHHHCCCC	36.73	29967540
668	Ubiquitination	DKIEHKLQHHKTFRK HHHHHHHHHCCCCCC	41.25	29967540
671	Ubiquitination	EHKLQHHKTFRKPKQ HHHHHHCCCCCCHHH	47.43	29967540
674	Ubiquitination	LQHHKTFRKPKQLEG HHHCCCCCCHHHCCC	60.65	29967540
677	Sumoylation	HKTFRKPKQLEGLKP CCCCCCHHHCCCCCC	71.23	28112733
677	Ubiquitination	HKTFRKPKQLEGLKP CCCCCCHHHCCCCCC	71.23	29967540
679	Ubiquitination	TFRKPKQLEGLKPGT CCCCHHHCCCCCCCC	7.61	22817900
682	Ubiquitination	KPKQLEGLKPGTKVT CHHHCCCCCCCCEEE	4.40	21890473
683	Acetylation	PKQLEGLKPGTKVTI HHHCCCCCCCCEEEE	52.86	25953088
683	Ubiquitination	PKQLEGLKPGTKVTI HHHCCCCCCCCEEEE	52.86	29967540
684	Phosphorylation	KQLEGLKPGTKVTIR HHCCCCCCCCEEEEE	61.81	32645325
686	Phosphorylation	LEGLKPGTKVTIRAS CCCCCCCCEEEEEEC	30.76	22817900
689	Phosphorylation	LKPGTKVTIRASRGQ CCCCCEEEEEECCCC	13.29	24719451
693	Phosphorylation	TKVTIRASRGQPRTV CEEEEEECCCCCCEE	27.39	32645325
699	O-linked_Glycosylation	ASRGQPRTVPVSSND ECCCCCCEECCCCCC	35.53	20068230
699	Phosphorylation	ASRGQPRTVPVSSND ECCCCCCEECCCCCC	35.53	22199227
703	Phosphorylation	QPRTVPVSSNDTPPS CCCEECCCCCCCCCH	19.84	28464451
703	Ubiquitination	QPRTVPVSSNDTPPS CCCEECCCCCCCCCH	19.84	22817900
704	Phosphorylation	PRTVPVSSNDTPPSA CCEECCCCCCCCCHH	38.67	22199227
706	Acetylation	TVPVSSNDTPPSALQ EECCCCCCCCCHHHH	63.64	19608861
706	Ubiquitination	TVPVSSNDTPPSALQ EECCCCCCCCCHHHH	63.64	21890473
706 (in isoform 5)	Ubiquitination	-	63.64	21890473
707	O-linked_Glycosylation	VPVSSNDTPPSALQE ECCCCCCCCCHHHHH	41.15	20068230
707	Phosphorylation	VPVSSNDTPPSALQE ECCCCCCCCCHHHHH	41.15	28176443
710	Phosphorylation	SSNDTPPSALQEAAP CCCCCCCHHHHHHCC	42.70	22199227
719	O-linked_Glycosylation	LQEAAPLTSSMDPLP HHHHCCCCCCCCCCC	20.07	20068230
719	Phosphorylation	LQEAAPLTSSMDPLP HHHHCCCCCCCCCCC	20.07	22199227
720	Phosphorylation	QEAAPLTSSMDPLPV HHHCCCCCCCCCCCC	31.20	22199227
721	O-linked_Glycosylation	EAAPLTSSMDPLPVF HHCCCCCCCCCCCCC	23.21	20068230
721	Phosphorylation	EAAPLTSSMDPLPVF HHCCCCCCCCCCCCC	23.21	22199227
730	Phosphorylation	DPLPVFLYPPVQRSI CCCCCCCCCCCCHHH	8.27	20068231
736	Ubiquitination	LYPPVQRSIQKRAVR CCCCCCHHHHHHHHH	16.57	22817900
737	Phosphorylation	YPPVQRSIQKRAVRK CCCCCHHHHHHHHHH	6.44	32645325
739	Acetylation	PVQRSIQKRAVRKMS CCCHHHHHHHHHHHC	40.43	19608861
739	Ubiquitination	PVQRSIQKRAVRKMS CCCHHHHHHHHHHHC	40.43	21890473
745	Ubiquitination	QKRAVRKMSVMGRQT HHHHHHHHCCCCCCC	2.27	22817900
746	Phosphorylation	KRAVRKMSVMGRQTC HHHHHHHCCCCCCCH	16.40	23401153
748	Ubiquitination	AVRKMSVMGRQTCLE HHHHHCCCCCCCHHH	2.62	21890473
748	Acetylation	AVRKMSVMGRQTCLE HHHHHCCCCCCCHHH	2.62	19608861
748	Ubiquitination	AVRKMSVMGRQTCLE HHHHHCCCCCCCHHH	2.62	21890473
748 (in isoform 2)	Acetylation	-	2.62	-
748 (in isoform 2)	Ubiquitination	-	2.62	21890473
749	Ubiquitination	VRKMSVMGRQTCLEC HHHHCCCCCCCHHHE	19.18	22817900
752	Ubiquitination	MSVMGRQTCLECSFE HCCCCCCCHHHEEEE	20.07	21890473
757 (in isoform 3)	Ubiquitination	-	19.28	21890473
780	Phosphorylation	CSLCRYSTCCSRAYA CHHHCCCHHCHHHHH	14.48	-
789	Ubiquitination	CSRAYANHMINNHVP CHHHHHHHHHHCCCC	15.44	22817900
792	Ubiquitination	AYANHMINNHVPRKS HHHHHHHHCCCCCCC	25.61	21890473
792	Acetylation	AYANHMINNHVPRKS HHHHHHHHCCCCCCC	25.61	19608861
792	Ubiquitination	AYANHMINNHVPRKS HHHHHHHHCCCCCCC	25.61	21890473
792 (in isoform 4)	Ubiquitination	-	25.61	21890473
798	Acetylation	INNHVPRKSPKYLAL HHCCCCCCCHHHHHH	66.11	25953088
798	Ubiquitination	INNHVPRKSPKYLAL HHCCCCCCCHHHHHH	66.11	22817900
799	Phosphorylation	NNHVPRKSPKYLALF HCCCCCCCHHHHHHH	28.09	24260401
801	Ubiquitination	HVPRKSPKYLALFKN CCCCCCHHHHHHHCC	61.05	21890473
801	Sumoylation	HVPRKSPKYLALFKN CCCCCCHHHHHHHCC	61.05	-
801	Acetylation	HVPRKSPKYLALFKN CCCCCCHHHHHHHCC	61.05	19608861
801	Sumoylation	HVPRKSPKYLALFKN CCCCCCHHHHHHHCC	61.05	28112733
801	Ubiquitination	HVPRKSPKYLALFKN CCCCCCHHHHHHHCC	61.05	22817900
801 (in isoform 1)	Ubiquitination	-	61.05	21890473
805	Ubiquitination	KSPKYLALFKNSVSG CCHHHHHHHCCCCCC	6.07	22817900
807	Acetylation	PKYLALFKNSVSGIK HHHHHHHCCCCCCCC	49.52	25953088
808	Ubiquitination	KYLALFKNSVSGIKL HHHHHHCCCCCCCCE	40.07	21890473
832	Acetylation	SVGDAMAKHLVFNPS CHHHHHHHHHCCCCC	25.12	25953088
844	Phosphorylation	NPSHRSSSILPRGLT CCCCCCCCCCCCCCE	29.41	23532336
856	Phosphorylation	GLTWIAHSRHGQTRD CCEEEEECCCCCCCC	19.56	23401153
871	Acetylation	RVHDRNVKNMYPPPS CCCCCCCCCCCCCCC	39.28	25953088
883	Acetylation	PPSFPTNKAATVKSA CCCCCCCCCCCHHCC	41.71	20167786
883	Sumoylation	PPSFPTNKAATVKSA CCCCCCCCCCCHHCC	41.71	28112733
913	Phosphorylation	PALPSPASTATPPPT CCCCCCCCCCCCCCC	23.20	26074081
914	Phosphorylation	ALPSPASTATPPPTP CCCCCCCCCCCCCCC	36.33	26074081
916	Phosphorylation	PSPASTATPPPTPTH CCCCCCCCCCCCCCC	36.09	26074081
920	Phosphorylation	STATPPPTPTHPQAL CCCCCCCCCCCCCHH	46.74	26074081
922	Phosphorylation	ATPPPTPTHPQALAL CCCCCCCCCCCHHCC	48.98	26074081
935	Ubiquitination	ALPPLATEGAECLNV CCCCCCCCCCCCCCC	51.29	29967540
949	Phosphorylation	VDDQDEGSPVTQEPE CCCCCCCCCCCCCCC	17.72	22817901
958	Ubiquitination	VTQEPELASGGGGSG CCCCCCCCCCCCCCC	12.41	32015554
964	Phosphorylation	LASGGGGSGGVGKKE CCCCCCCCCCCCHHH	35.33	24275569
968	Ubiquitination	GGGSGGVGKKEQLSV CCCCCCCCHHHHCCH	38.30	29967540
976	Acetylation	KKEQLSVKKLRVVLF HHHHCCHHHHHHHHH	42.59	25953088
977	Ubiquitination	KEQLSVKKLRVVLFA HHHCCHHHHHHHHHH	39.09	29967540
991	Ubiquitination	ALCCNTEQAAEHFRN HHHCCHHHHHHHCCC	43.78	32015554
1000	Ubiquitination	AEHFRNPQRRIRRWL HHHCCCHHHHHHHHH	51.32	32015554
1013	Phosphorylation	WLRRFQASQGENLEG HHHHHHHHCCCCCCC	28.12	21815630
1021	Acetylation	QGENLEGKYLSFEAE CCCCCCCCCCCCHHH	33.37	26051181
1021	Ubiquitination	QGENLEGKYLSFEAE CCCCCCCCCCCCHHH	33.37	29967540
1030	Ubiquitination	LSFEAEEKLAEWVLT CCCHHHHHHHHHHHH	44.49	29967540
1044	Ubiquitination	TQREQQLPVNEETLF HHHHHCCCCCHHHHH	23.66	32015554
1053	Acetylation	NEETLFQKATKIGRS CHHHHHHHHHHHCHH	51.17	25953088
1053	Ubiquitination	NEETLFQKATKIGRS CHHHHHHHHHHHCHH	51.17	32015554
1056	Ubiquitination	TLFQKATKIGRSLEG HHHHHHHHHCHHCCC	48.28	-
1082	Phosphorylation	FMLRHHLTPHARRAV HHHHHCCCHHHHHHH	14.52	-
1120	Ubiquitination	HNQDLPLSMIVAIDE HCCCCCHHHEEEEEE	12.43	29967540
1153	Ubiquitination	ALQTVGTGEPWCDVV HHHHCCCCCCHHHHH	32.80	29967540
1162	Ubiquitination	PWCDVVLAILADGTV CHHHHHHHHHCCCCE	5.33	29967540
1169 (in isoform 2)	Phosphorylation	-	8.03	-
1174	Ubiquitination	GTVLPTLVFYRGQMD CCEEEEEEEECCCCC	4.33	29967540
1183 (in isoform 2)	Phosphorylation	-	22.72	-
1200	Phosphorylation	EAKESGYSDDEIMEL HHHHHCCCHHHHHHH	41.95	28348404
1206	Ubiquitination	YSDDEIMELWSTRVW CCHHHHHHHHHHHHH	53.39	29967540
1206 (in isoform 2)	Phosphorylation	-	53.39	-
1207	Ubiquitination	SDDEIMELWSTRVWQ CHHHHHHHHHHHHHH	2.12	29967540
1215	Ubiquitination	WSTRVWQKHTACQRS HHHHHHHHHHHHHHC	27.49	29967540
1216	Ubiquitination	STRVWQKHTACQRSK HHHHHHHHHHHHHCC	12.00	29967540
1222	Phosphorylation	KHTACQRSKGMLVMD HHHHHHHCCCEEEEE	14.00	20068231
1223	Ubiquitination	HTACQRSKGMLVMDC HHHHHHCCCEEEEEC	50.99	-
1233	Phosphorylation	LVMDCHRTHLSEEVL EEEECCCCCCCHHHH	11.96	20068231
1236	Phosphorylation	DCHRTHLSEEVLAML ECCCCCCCHHHHHHH	24.89	20068231
1244	Phosphorylation	EEVLAMLSASSTLPA HHHHHHHHHHCCCCE	17.02	20068231
1246	Phosphorylation	VLAMLSASSTLPAVV HHHHHHHHCCCCEEE	22.08	20068231
1247	Phosphorylation	LAMLSASSTLPAVVP HHHHHHHCCCCEEEC	33.41	20068231
1248	Phosphorylation	AMLSASSTLPAVVPA HHHHHHCCCCEEECC	33.98	20068231
1258	Phosphorylation	AVVPAGCSSKIQPLD EEECCCCCCCCCCHH	33.48	20068231
1259	Phosphorylation	VVPAGCSSKIQPLDV EECCCCCCCCCCHHH	37.54	20068231
1260	Ubiquitination	VPAGCSSKIQPLDVC ECCCCCCCCCCHHHH	29.12	29967540
1269	Phosphorylation	QPLDVCIKRTVKNFL CCHHHHHHHHHHHHH	36.57	33259812
1269	Ubiquitination	QPLDVCIKRTVKNFL CCHHHHHHHHHHHHH	36.57	29967540
1273	Acetylation	VCIKRTVKNFLHKKW HHHHHHHHHHHHHHH	41.17	26051181
1285 (in isoform 2)	Phosphorylation	-	33.64	-
1302	Phosphorylation	DVLLQLVLVWLGEVL HHHHHHHHHHHHHHH	2.88	33259812
1307 (in isoform 2)	Phosphorylation	-	32.19	-
1311	Phosphorylation	WLGEVLGVIGDCPEL HHHHHHHHHCCCHHH	3.75	33259812
1311 (in isoform 2)	Phosphorylation	-	3.75	-
1313 (in isoform 2)	Phosphorylation	-	28.23	-
1315 (in isoform 2)	Phosphorylation	-	2.08	-
1322	Phosphorylation	CPELVQRSFLVASVL CHHHHHHHHHHEECC	13.07	23403867
1327	Phosphorylation	QRSFLVASVLPGPDG HHHHHHEECCCCCCC	19.39	29255136
1338	Phosphorylation	GPDGNINSPTRNADM CCCCCCCCCCCCHHH	24.69	29255136
1340	Phosphorylation	DGNINSPTRNADMQE CCCCCCCCCCHHHHH	36.05	30266825
1352	Phosphorylation	MQEELIASLEEQLKL HHHHHHHHHHHHHHH	29.35	27067055
1355	Phosphorylation	ELIASLEEQLKLSGE HHHHHHHHHHHHCCC	67.51	33259812
1360	Phosphorylation	LEEQLKLSGEHSESS HHHHHHHCCCCCCCC	40.31	23927012
1364	Phosphorylation	LKLSGEHSESSTPRP HHHCCCCCCCCCCCC	34.57	29255136
1366	O-linked_Glycosylation	LSGEHSESSTPRPRS HCCCCCCCCCCCCCC	42.39	20068230
1366	Phosphorylation	LSGEHSESSTPRPRS HCCCCCCCCCCCCCC	42.39	29255136
1367	Phosphorylation	SGEHSESSTPRPRSS CCCCCCCCCCCCCCC	38.08	29255136
1368	O-linked_Glycosylation	GEHSESSTPRPRSSP CCCCCCCCCCCCCCC	32.37	20068230
1368	Phosphorylation	GEHSESSTPRPRSSP CCCCCCCCCCCCCCC	32.37	29255136
1373	Phosphorylation	SSTPRPRSSPEETIE CCCCCCCCCCCCCCC	53.58	29997176
1374	Phosphorylation	STPRPRSSPEETIEP CCCCCCCCCCCCCCH	37.30	29997176
1378	Phosphorylation	PRSSPEETIEPESLH CCCCCCCCCCHHHHH	29.04	29997176
1383	Phosphorylation	EETIEPESLHQLFEG CCCCCHHHHHHHHCC	41.70	24275569
1392	Phosphorylation	HQLFEGESETESFYG HHHHCCCCCCCCCCC	61.75	28112733
1394	Phosphorylation	LFEGESETESFYGFE HHCCCCCCCCCCCCC	46.32	29997176
1396	Phosphorylation	EGESETESFYGFEEA CCCCCCCCCCCCCHH	31.05	29997176

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1392	S	Phosphorylation	Kinase	CK2	-	Uniprot
1396	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of POGZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of POGZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
BANP_HUMAN	BANP	physical	25416956
ZXDC_HUMAN	ZXDC	physical	25416956
PR20E_HUMAN	PRR20A	physical	25416956
PR20C_HUMAN	PRR20A	physical	25416956
PR20D_HUMAN	PRR20A	physical	25416956
PR20B_HUMAN	PRR20A	physical	25416956
PR20A_HUMAN	PRR20A	physical	25416956
CBX1_HUMAN	CBX1	physical	20850016
HDGR2_HUMAN	HDGFRP2	physical	20850016
MD2L2_HUMAN	MAD2L2	physical	20850016
CBX5_HUMAN	CBX5	physical	20850016
CHAP1_HUMAN	CHAMP1	physical	20850016
ZMYM4_HUMAN	ZMYM4	physical	20850016
CBX3_HUMAN	CBX3	physical	20850016

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
0000269\|PubMed	Note=Defects in POGZ may be associated with neuropsychiatric disorders such as autism spectrum disorders (ASD), bipolar affective disorders and early dementia onset. ASD are characterized by impairments in reciprocal social interaction and communication as well as restricted and stereotyped patterns of interest and activities. ASD include forms with moderate to severe cognitive impairment and milder forms with higher cognitive ability (Asperger syndrome). {ECO
616364
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of POGZ_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-801, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-439 AND SER-445, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251; THR-258; SER-274;THR-282; SER-425; SER-445; THR-448 AND SER-1338, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-425 ANDSER-1338, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1364, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419 AND SER-1364, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, AND MASSSPECTROMETRY.	15302935 [Abstract]