dbPTM

ZMYM4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZMYM4_HUMAN
UniProt AC	Q5VZL5
Protein Name	Zinc finger MYM-type protein 4
Gene Name	ZMYM4
Organism	Homo sapiens (Human).
Sequence Length	1548
Subcellular Localization
Protein Description	Plays a role in the regulation of cell morphology and cytoskeletal organization..
Protein Sequence	MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNEDEQDFSSKDNLVSSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYEREKRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLDKIKDEPDNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLFYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQPTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSIVAVEPRSLIQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQESSEPGCRVRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPDKLTVGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDVELSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEREVESG ------CCCCCCCCC	35.54	19413330
8	Phosphorylation	MAEREVESGPRKRFE CCCCCCCCCCCHHHH	60.31	21406692
21	Ubiquitination	FEQKSGAVFDEIVEN HHHHHCHHHHHHHHH	7.68	22817900
22	Ubiquitination	EQKSGAVFDEIVENC HHHHCHHHHHHHHHC	7.46	22817900
26	Ubiquitination	GAVFDEIVENCGGIM CHHHHHHHHHCCCCC	3.99	21963094
26 (in isoform 3)	Ubiquitination	-	3.99	21890473
46	Phosphorylation	EDIDHNLTPTLDSMS CCCCCCCCCCCCHHC	21.39	26074081
48	Phosphorylation	IDHNLTPTLDSMSYG CCCCCCCCCCHHCCC	37.65	26074081
87	Phosphorylation	AGIPVVGSDNEDEQD CCCCCCCCCCCCCCC	26.17	23879269
90	Phosphorylation	PVVGSDNEDEQDFSS CCCCCCCCCCCCCCC	68.84	32142685
103	Phosphorylation	SSKDNLVSSIHTDDS CCCCCCEEEECCCCH	27.09	30266825
103	Ubiquitination	SSKDNLVSSIHTDDS CCCCCCEEEECCCCH	27.09	22817900
104	Phosphorylation	SKDNLVSSIHTDDSL CCCCCEEEECCCCHH	15.77	30266825
104	Ubiquitination	SKDNLVSSIHTDDSL CCCCCEEEECCCCHH	15.77	22817900
107	Phosphorylation	NLVSSIHTDDSLEVE CCEEEECCCCHHHHH	39.57	30266825
108	Ubiquitination	LVSSIHTDDSLEVER CEEEECCCCHHHHHH	29.37	21890473
108 (in isoform 4)	Ubiquitination	-	29.37	21890473
110	Phosphorylation	SSIHTDDSLEVERRV EEECCCCHHHHHHHH	29.28	30266825
118	Phosphorylation	LEVERRVTQHESDNE HHHHHHHCCCCCCCC	23.54	22167270
122	Phosphorylation	RRVTQHESDNENEIQ HHHCCCCCCCCCHHH	43.54	29255136
125	Phosphorylation	TQHESDNENEIQIQN CCCCCCCCCHHHHHH	62.32	32142685
133	Ubiquitination	NEIQIQNKLKKDFPK CHHHHHHHHHHCCCC	45.36	29967540
135	Ubiquitination	IQIQNKLKKDFPKQF HHHHHHHHHCCCCCC	52.48	22817900
136	Ubiquitination	QIQNKLKKDFPKQFD HHHHHHHHCCCCCCC	75.04	22817900
137	Ubiquitination	IQNKLKKDFPKQFDQ HHHHHHHCCCCCCCC	64.59	22817900
138	Ubiquitination	QNKLKKDFPKQFDQV HHHHHHCCCCCCCCH	12.82	22817900
139	Ubiquitination	NKLKKDFPKQFDQVS HHHHHCCCCCCCCHH	39.41	22817900
140	Sumoylation	KLKKDFPKQFDQVSV HHHHCCCCCCCCHHH	64.69	28112733
140	Ubiquitination	KLKKDFPKQFDQVSV HHHHCCCCCCCCHHH	64.69	21890473
140 (in isoform 1)	Ubiquitination	-	64.69	21890473
140 (in isoform 2)	Ubiquitination	-	64.69	21890473
142	Ubiquitination	KKDFPKQFDQVSVFK HHCCCCCCCCHHHHH	9.90	21890473
143	Ubiquitination	KDFPKQFDQVSVFKS HCCCCCCCCHHHHHH	45.54	21890473
149	Acetylation	FDQVSVFKSIRKDFS CCCHHHHHHHHHHHH	42.70	26051181
149	Sumoylation	FDQVSVFKSIRKDFS CCCHHHHHHHHHHHH	42.70	28112733
150	Ubiquitination	DQVSVFKSIRKDFSL CCHHHHHHHHHHHHH	19.03	32015554
156	Phosphorylation	KSIRKDFSLVRENSK HHHHHHHHHHHCCCC	35.77	23403867
162	Phosphorylation	FSLVRENSKETFSGK HHHHHCCCCCCCCCC	27.41	23401153
165	Phosphorylation	VRENSKETFSGKEKN HHCCCCCCCCCCHHC	27.17	29255136
167	Phosphorylation	ENSKETFSGKEKNRD CCCCCCCCCCHHCCC	57.27	23403867
169	Acetylation	SKETFSGKEKNRDLT CCCCCCCCHHCCCCC	65.40	23749302
185	Acetylation	EREKRLDKPHKDLDS HHHHCCCCCCCCHHH	54.32	25953088
185	Phosphorylation	EREKRLDKPHKDLDS HHHHCCCCCCCCHHH	54.32	32142685
195	Sumoylation	KDLDSRLKSSFFDKA CCHHHHHHHHHHHHH	42.83	-
195	Methylation	KDLDSRLKSSFFDKA CCHHHHHHHHHHHHH	42.83	83055549
195	Sumoylation	KDLDSRLKSSFFDKA CCHHHHHHHHHHHHH	42.83	28112733
195	Ubiquitination	KDLDSRLKSSFFDKA CCHHHHHHHHHHHHH	42.83	29967540
196	Phosphorylation	DLDSRLKSSFFDKAA CHHHHHHHHHHHHHH	36.65	23186163
197	Phosphorylation	LDSRLKSSFFDKAAN HHHHHHHHHHHHHHH	28.48	21815630
201	Sumoylation	LKSSFFDKAANQVEE HHHHHHHHHHHHHHH	44.22	28112733
209	Phosphorylation	AANQVEETLHTHLPQ HHHHHHHHHHHCCCC	15.44	29255136
212	Phosphorylation	QVEETLHTHLPQTPE HHHHHHHHCCCCCCC	28.37	29255136
217	Phosphorylation	LHTHLPQTPETNFRD HHHCCCCCCCCCCCC	22.58	23401153
220	Phosphorylation	HLPQTPETNFRDSSY CCCCCCCCCCCCCCC	40.64	30266825
232	Acetylation	SSYPFANKESIGSEL CCCCCCCHHHHHCCC	49.78	26051181
232	Sumoylation	SSYPFANKESIGSEL CCCCCCCHHHHHCCC	49.78	28112733
232	Ubiquitination	SSYPFANKESIGSEL CCCCCCCHHHHHCCC	49.78	29967540
234	Phosphorylation	YPFANKESIGSELGN CCCCCHHHHHCCCCC	33.58	23403867
237	Phosphorylation	ANKESIGSELGNSFA CCHHHHHCCCCCCHH	28.16	25627689
242	Phosphorylation	IGSELGNSFASNIRI HHCCCCCCHHHCCEE	22.01	25159151
245	Phosphorylation	ELGNSFASNIRIKEE CCCCCHHHCCEEECC	30.68	23403867
250	Sumoylation	FASNIRIKEEPLDDE HHHCCEEECCCCCCH	46.29	-
250	Sumoylation	FASNIRIKEEPLDDE HHHCCEEECCCCCCH	46.29	25114211
250	Ubiquitination	FASNIRIKEEPLDDE HHHCCEEECCCCCCH	46.29	29967540
257	Ubiquitination	KEEPLDDEYDKAMAP ECCCCCCHHHHHHCH	56.13	22817900
257 (in isoform 4)	Ubiquitination	-	56.13	21890473
258	Phosphorylation	EEPLDDEYDKAMAPQ CCCCCCHHHHHHCHH	29.73	28796482
260	Sumoylation	PLDDEYDKAMAPQQG CCCCHHHHHHCHHCC	38.88	28112733
271	Sumoylation	PQQGLLDKIKDEPDN HHCCHHHHHCCCCCC	52.18	28112733
273	Sumoylation	QGLLDKIKDEPDNAQ CCHHHHHCCCCCCHH	62.88	-
273	Sumoylation	QGLLDKIKDEPDNAQ CCHHHHHCCCCCCHH	62.88	28112733
289	Sumoylation	YSHGQQQKTQEGELK CCCCCCEECCCCCEE	48.08	28112733
289	Ubiquitination	YSHGQQQKTQEGELK CCCCCCEECCCCCEE	48.08	21906983
289 (in isoform 1)	Ubiquitination	-	48.08	21890473
289 (in isoform 2)	Ubiquitination	-	48.08	21890473
291	Ubiquitination	HGQQQKTQEGELKIS CCCCEECCCCCEEEE	64.83	22817900
292	Ubiquitination	GQQQKTQEGELKISA CCCEECCCCCEEEEE	60.92	22817900
302	Phosphorylation	LKISAVFSVSGSPLA EEEEEEEEECCCCCC	14.58	26074081
304	Phosphorylation	ISAVFSVSGSPLAPQ EEEEEEECCCCCCCC	32.15	22210691
306	Phosphorylation	AVFSVSGSPLAPQLT EEEEECCCCCCCCCC	14.83	26074081
313	Phosphorylation	SPLAPQLTTGFQPSL CCCCCCCCCCCCHHH	21.45	28102081
313	Ubiquitination	SPLAPQLTTGFQPSL CCCCCCCCCCCCHHH	21.45	22817900
314	Phosphorylation	PLAPQLTTGFQPSLA CCCCCCCCCCCHHHH	44.59	28102081
314	Ubiquitination	PLAPQLTTGFQPSLA CCCCCCCCCCCHHHH	44.59	22817900
318	Ubiquitination	QLTTGFQPSLASSGM CCCCCCCHHHHCCCH	29.11	21963094
318 (in isoform 4)	Ubiquitination	-	29.11	21890473
319	Phosphorylation	LTTGFQPSLASSGMN CCCCCCHHHHCCCHH	26.28	28102081
327	Sumoylation	LASSGMNKMLPSVPA HHCCCHHHCCCCCCC	32.68	28112733
331	Phosphorylation	GMNKMLPSVPATAVR CHHHCCCCCCCEEEE	36.45	21406692
335	Phosphorylation	MLPSVPATAVRVSCS CCCCCCCEEEEEECC	21.44	21406692
345	Ubiquitination	RVSCSGCKKILQKGQ EEECCCHHHHHHCCC	46.50	22817900
346	Ubiquitination	VSCSGCKKILQKGQT EECCCHHHHHHCCCC	53.37	22817900
347	Ubiquitination	SCSGCKKILQKGQTA ECCCHHHHHHCCCCH	2.77	22817900
348	Ubiquitination	CSGCKKILQKGQTAY CCCHHHHHHCCCCHH	6.21	22817900
349	Ubiquitination	SGCKKILQKGQTAYQ CCHHHHHHCCCCHHH	51.83	22817900
350	Sumoylation	GCKKILQKGQTAYQR CHHHHHHCCCCHHHC	49.92	-
350	Sumoylation	GCKKILQKGQTAYQR CHHHHHHCCCCHHHC	49.92	-
350	Ubiquitination	GCKKILQKGQTAYQR CHHHHHHCCCCHHHC	49.92	27667366
350 (in isoform 1)	Ubiquitination	-	49.92	21890473
350 (in isoform 2)	Ubiquitination	-	49.92	21890473
352	Ubiquitination	KKILQKGQTAYQRKG HHHHHCCCCHHHCCC	29.96	21963094
353	Ubiquitination	KILQKGQTAYQRKGS HHHHCCCCHHHCCCC	35.68	21963094
360	Phosphorylation	TAYQRKGSTQLFCST CHHHCCCCHHHEEEE	18.93	27251275
361	Phosphorylation	AYQRKGSTQLFCSTL HHHCCCCHHHEEEEH	37.65	27251275
390	Phosphorylation	PLTKKTCSSCSKDIL CCCCCCCCCCCCCCC	39.34	30576142
394	Acetylation	KTCSSCSKDILNPKD CCCCCCCCCCCCHHH	53.79	26051181
396	Ubiquitination	CSSCSKDILNPKDVI CCCCCCCCCCHHHHH	4.62	32015554
400	Sumoylation	SKDILNPKDVISAQF CCCCCCHHHHHHHCC	64.65	28112733
400	Ubiquitination	SKDILNPKDVISAQF CCCCCCHHHHHHHCC	64.65	29967540
410	Phosphorylation	ISAQFENTTTSKDFC HHHCCCCCCCCHHHC	25.01	30576142
411	Phosphorylation	SAQFENTTTSKDFCS HHCCCCCCCCHHHCC	40.42	30576142
425	Phosphorylation	SQSCLSTYELKKKPI CHHHHCHHHCCCCCC	18.85	30576142
428	Sumoylation	CLSTYELKKKPIVTI HHCHHHCCCCCCEEE	46.97	28112733
428	Ubiquitination	CLSTYELKKKPIVTI HHCHHHCCCCCCEEE	46.97	32015554
429	Ubiquitination	LSTYELKKKPIVTIN HCHHHCCCCCCEEEC	76.14	29967540
430	Sumoylation	STYELKKKPIVTINT CHHHCCCCCCEEECC	38.09	-
430	Sumoylation	STYELKKKPIVTINT CHHHCCCCCCEEECC	38.09	28112733
430	Ubiquitination	STYELKKKPIVTINT CHHHCCCCCCEEECC	38.09	29967540
431	Ubiquitination	TYELKKKPIVTINTN HHHCCCCCCEEECCC	34.85	32015554
434	Phosphorylation	LKKKPIVTINTNSIS CCCCCCEEECCCCCC	14.83	30576142
439	Phosphorylation	IVTINTNSISTKCSM CEEECCCCCCCCCHH	18.84	20860994
442	Phosphorylation	INTNSISTKCSMCQK ECCCCCCCCCHHHCC	34.11	30576142
442	Ubiquitination	INTNSISTKCSMCQK ECCCCCCCCCHHHCC	34.11	32015554
465	Ubiquitination	NYQNVVHKLCSDACF CHHHHHHHHHCHHHH	39.31	29967540
474	Acetylation	CSDACFSKFRSANNL HCHHHHHHHHCCCCC	25.25	25953088
474	Ubiquitination	CSDACFSKFRSANNL HCHHHHHHHHCCCCC	25.25	32015554
477	Ubiquitination	ACFSKFRSANNLTMN HHHHHHHCCCCCCCC	38.18	32015554
511	Acetylation	QIEGQSKKFCSSSCI EEECCCCEECCHHHH	57.77	25953088
525	Phosphorylation	ITAYKQKSAKITPCA HHHHHHCCCCCCHHH	32.09	21406692
529	Phosphorylation	KQKSAKITPCALCKS HHCCCCCCHHHHHHH	16.17	21406692
535	2-Hydroxyisobutyrylation	ITPCALCKSLRSSAE CCHHHHHHHHHHHHH	54.07	-
536	Phosphorylation	TPCALCKSLRSSAEM CHHHHHHHHHHHHHH	28.19	21406692
581	Phosphorylation	GVQVQCNSCKTSAIP CEEEECCCCCCCCCC	25.31	29083192
595	Phosphorylation	PQYHLAMSDGSIRNF CCCEEECCCCCHHHH	32.96	30108239
598	Phosphorylation	HLAMSDGSIRNFCSY EEECCCCCHHHHHHH	24.30	30108239
600	Dimethylation	AMSDGSIRNFCSYSC ECCCCCHHHHHHHHH	31.69	-
600	Methylation	AMSDGSIRNFCSYSC ECCCCCHHHHHHHHH	31.69	24376893
697	Sumoylation	CNRLFATKPELLDYK CCCEECCCHHHHHCC	32.82	-
697	Acetylation	CNRLFATKPELLDYK CCCEECCCHHHHHCC	32.82	26051181
697	Sumoylation	CNRLFATKPELLDYK CCCEECCCHHHHHCC	32.82	-
697	Ubiquitination	CNRLFATKPELLDYK CCCEECCCHHHHHCC	32.82	29967540
704	Ubiquitination	KPELLDYKGKMFQFC CHHHHHCCCCCHHHC	52.28	29967540
706	Sumoylation	ELLDYKGKMFQFCGK HHHHCCCCCHHHCCC	32.18	-
706	Sumoylation	ELLDYKGKMFQFCGK HHHHCCCCCHHHCCC	32.18	-
711	Ubiquitination	KGKMFQFCGKNCSDE CCCCHHHCCCCCCHH	5.43	33845483
739	Sumoylation	CKIEKIVKETVRFSG CCHHHHHHHHCCCCC	51.66	-
739	Sumoylation	CKIEKIVKETVRFSG CCHHHHHHHHCCCCC	51.66	-
740	Ubiquitination	KIEKIVKETVRFSGA CHHHHHHHHCCCCCC	41.46	21890473
744	Ubiquitination	IVKETVRFSGADKSF HHHHHCCCCCCCHHH	7.40	22817900
749	Ubiquitination	VRFSGADKSFCSEGC CCCCCCCHHHCHHHH	44.92	29967540
756	Ubiquitination	KSFCSEGCKLLYKHD HHHCHHHHHHHHHHH	2.17	32015554
761	Ubiquitination	EGCKLLYKHDLAKRW HHHHHHHHHHHHHHH	30.52	29967540
773	Acetylation	KRWGNHCKMCSYCLQ HHHCCCCHHCHHHHH	35.08	26051181
777	Phosphorylation	NHCKMCSYCLQTSPK CCCHHCHHHHHCCHH	7.70	32142685
781	Phosphorylation	MCSYCLQTSPKLVQN HCHHHHHCCHHHHHC	33.76	25627689
782	Phosphorylation	CSYCLQTSPKLVQNN CHHHHHCCHHHHHCC	13.69	25159151
803	Ubiquitination	EFCCEECMSKYTVLF HHHHHHHHHHHHHHH	4.36	21890473
803 (in isoform 3)	Ubiquitination	-	4.36	21890473
807	Ubiquitination	EECMSKYTVLFYQMA HHHHHHHHHHHHHHH	17.92	22817900
811	Phosphorylation	SKYTVLFYQMAKCDA HHHHHHHHHHHCCHH	8.01	25884760
824	Sumoylation	DACKRQGKLSESLKW HHHHHCCCCCHHHHH	40.27	-
824	Sumoylation	DACKRQGKLSESLKW HHHHHCCCCCHHHHH	40.27	-
828	Phosphorylation	RQGKLSESLKWRGEM HCCCCCHHHHHHHHH	31.69	-
882	Phosphorylation	PPSLRKDSTPVIANV CCHHCCCCCCEEEEH	37.33	26657352
883	Phosphorylation	PSLRKDSTPVIANVV CHHCCCCCCEEEEHH	31.54	28348404
891	Phosphorylation	PVIANVVSLASAPAA CEEEEHHHHHCCCCC	17.59	28122231
894	Phosphorylation	ANVVSLASAPAAQPT EEHHHHHCCCCCCCC	39.83	28122231
949	Acetylation	KNKALLCKPITQTKA CCCEEEEECCCCCCC	39.15	25953088
954	Ubiquitination	LCKPITQTKATSCKP EEECCCCCCCCCCCC	17.62	21890473
957	Ubiquitination	PITQTKATSCKPHTQ CCCCCCCCCCCCCCC	35.89	22817900
1003	Ubiquitination	LYTQYAPVPFGIPVP EECCCCCCCCCCCCC	4.70	33845483
1017	Ubiquitination	PMPVPMLIPSSMDSE CCCCCEECCCCCCCC	2.24	21890473
1017 (in isoform 3)	Ubiquitination	-	2.24	21890473
1020	Ubiquitination	VPMLIPSSMDSEDKV CCEECCCCCCCCCHH	22.66	22817900
1028	Phosphorylation	MDSEDKVTESIEDIK CCCCCHHHHCHHHHH	29.74	27732954
1030	Phosphorylation	SEDKVTESIEDIKEK CCCHHHHCHHHHHHH	23.16	29255136
1035	Sumoylation	TESIEDIKEKLPTHP HHCHHHHHHHCCCCC	62.20	-
1035	Sumoylation	TESIEDIKEKLPTHP HHCHHHHHHHCCCCC	62.20	28112733
1035	Ubiquitination	TESIEDIKEKLPTHP HHCHHHHHHHCCCCC	62.20	32015554
1037	Ubiquitination	SIEDIKEKLPTHPFE CHHHHHHHCCCCCCH	55.56	29967540
1038	Ubiquitination	IEDIKEKLPTHPFEA HHHHHHHCCCCCCHH	6.58	33845483
1038 (in isoform 2)	Ubiquitination	-	6.58	21890473
1048	Ubiquitination	HPFEADLLEMAEMIA CCCHHHHHHHHHHHH	4.32	32015554
1061	Sumoylation	IAEDEEKKTLSQGES HHCCHHHHCCCCCCC	58.96	28112733
1061	Ubiquitination	IAEDEEKKTLSQGES HHCCHHHHCCCCCCC	58.96	29967540
1062	Phosphorylation	AEDEEKKTLSQGESQ HCCHHHHCCCCCCCC	42.59	23927012
1064	Phosphorylation	DEEKKTLSQGESQTS CHHHHCCCCCCCCCC	41.17	17525332
1068	Phosphorylation	KTLSQGESQTSEHEL HCCCCCCCCCCCEEE	45.65	23401153
1069	Phosphorylation	TLSQGESQTSEHELF CCCCCCCCCCCEEEE	44.75	32142685
1070	Phosphorylation	LSQGESQTSEHELFL CCCCCCCCCCEEEEE	45.41	30266825
1071	Phosphorylation	SQGESQTSEHELFLD CCCCCCCCCEEEEEE	29.35	17525332
1079	Phosphorylation	EHELFLDTKIFEKDQ CEEEEEEEEEEECCC	28.34	23403867
1080	Sumoylation	HELFLDTKIFEKDQG EEEEEEEEEEECCCC	45.10	28112733
1080	Ubiquitination	HELFLDTKIFEKDQG EEEEEEEEEEECCCC	45.10	32015554
1083	Ubiquitination	FLDTKIFEKDQGSTY EEEEEEEECCCCCCC	60.23	32015554
1084	Acetylation	LDTKIFEKDQGSTYS EEEEEEECCCCCCCC	44.60	26051181
1084	Ubiquitination	LDTKIFEKDQGSTYS EEEEEEECCCCCCCC	44.60	29967540
1088	Phosphorylation	IFEKDQGSTYSGDLE EEECCCCCCCCCCCC	20.66	30108239
1089	Phosphorylation	FEKDQGSTYSGDLES EECCCCCCCCCCCCC	28.65	30108239
1090	Phosphorylation	EKDQGSTYSGDLESE ECCCCCCCCCCCCCC	16.62	30108239
1091	Phosphorylation	KDQGSTYSGDLESEA CCCCCCCCCCCCCCE	26.39	25159151
1095	Ubiquitination	STYSGDLESEAVSTP CCCCCCCCCCEECCC	51.80	21890473
1095 (in isoform 4)	Ubiquitination	-	51.80	21890473
1096	Phosphorylation	TYSGDLESEAVSTPH CCCCCCCCCEECCCC	37.85	28450419
1099	Ubiquitination	GDLESEAVSTPHSWE CCCCCCEECCCCCHH	6.01	22817900
1100	Phosphorylation	DLESEAVSTPHSWEE CCCCCEECCCCCHHH	43.18	28450419
1101	Phosphorylation	LESEAVSTPHSWEEE CCCCEECCCCCHHHH	20.58	25159151
1104	Phosphorylation	EAVSTPHSWEEELNH CEECCCCCHHHHHHH	37.07	25159151
1112	Phosphorylation	WEEELNHYALKSNAV HHHHHHHHHHHCHHH	16.74	28450419
1115	Ubiquitination	ELNHYALKSNAVQEA HHHHHHHHCHHHHHH	33.23	29967540
1116	Phosphorylation	LNHYALKSNAVQEAD HHHHHHHCHHHHHHH	30.76	20068231
1124	Phosphorylation	NAVQEADSELKQFSK HHHHHHHHHHHHHCC	52.45	20068231
1127	Sumoylation	QEADSELKQFSKGET HHHHHHHHHHCCCCC	45.29	-
1127	Sumoylation	QEADSELKQFSKGET HHHHHHHHHHCCCCC	45.29	28112733
1127	Ubiquitination	QEADSELKQFSKGET HHHHHHHHHHCCCCC	45.29	22817900
1127 (in isoform 1)	Ubiquitination	-	45.29	21890473
1129	Ubiquitination	ADSELKQFSKGETEQ HHHHHHHHCCCCCHH	8.56	21890473
1130	Ubiquitination	DSELKQFSKGETEQD HHHHHHHCCCCCHHH	36.94	21890473
1131	Ubiquitination	SELKQFSKGETEQDL HHHHHHCCCCCHHHH	63.15	22817900
1133	Ubiquitination	LKQFSKGETEQDLEA HHHHCCCCCHHHHHC	53.56	22817900
1134	Ubiquitination	KQFSKGETEQDLEAD HHHCCCCCHHHHHCC	47.84	22817900
1144	Phosphorylation	DLEADFPSDSFDPLN HHHCCCCCCCCCCCC	45.97	27251275
1146	Phosphorylation	EADFPSDSFDPLNKG HCCCCCCCCCCCCCC	35.57	27251275
1152	Ubiquitination	DSFDPLNKGQGIQAR CCCCCCCCCCCCHHH	61.36	29967540
1155	Ubiquitination	DPLNKGQGIQARSRT CCCCCCCCCHHHHHC	23.73	32015554
1179	Ubiquitination	QPRRRGRKKSIVAVE CCCCCCCCCEEEEEC	54.41	-
1180	Sumoylation	PRRRGRKKSIVAVEP CCCCCCCCEEEEECC	44.01	-
1180	Sumoylation	PRRRGRKKSIVAVEP CCCCCCCCEEEEECC	44.01	-
1180	Ubiquitination	PRRRGRKKSIVAVEP CCCCCCCCEEEEECC	44.01	29967540
1181	Phosphorylation	RRRGRKKSIVAVEPR CCCCCCCEEEEECCH	25.90	29255136
1188	Methylation	SIVAVEPRSLIQGAF EEEEECCHHHHCCCC	30.50	115920425
1204	Phosphorylation	GCSVSGMTLKYMYGV CCCCCCHHHHHHHHH	24.51	20068231
1218	Phosphorylation	VNAWKNWVQWKNAKE HCHHHHHHHHCCHHH	7.32	33259812
1221	Ubiquitination	WKNWVQWKNAKEEQG HHHHHHHCCHHHHCC	29.90	29967540
1224	Sumoylation	WVQWKNAKEEQGDLK HHHHCCHHHHCCCCC	71.78	-
1224	Sumoylation	WVQWKNAKEEQGDLK HHHHCCHHHHCCCCC	71.78	-
1231	Ubiquitination	KEEQGDLKCGGVEQA HHHCCCCCCCCCCCC	35.26	29967540
1239	Phosphorylation	CGGVEQASSSPRSDP CCCCCCCCCCCCCCC	30.92	23401153
1240	Phosphorylation	GGVEQASSSPRSDPL CCCCCCCCCCCCCCC	47.58	30266825
1241	Phosphorylation	GVEQASSSPRSDPLG CCCCCCCCCCCCCCC	23.10	23401153
1244	Phosphorylation	QASSSPRSDPLGSTQ CCCCCCCCCCCCCCH	47.14	30266825
1249	Phosphorylation	PRSDPLGSTQDHALS CCCCCCCCCHHHHHH	30.49	30266825
1250	Phosphorylation	RSDPLGSTQDHALSQ CCCCCCCCHHHHHHH	35.90	29255136
1252 (in isoform 2)	Ubiquitination	-	29.17	21890473
1256	Phosphorylation	STQDHALSQESSEPG CCHHHHHHHHCCCCC	32.46	17525332
1259	Phosphorylation	DHALSQESSEPGCRV HHHHHHHCCCCCCEE	32.15	23663014
1260	Phosphorylation	HALSQESSEPGCRVR HHHHHHCCCCCCEEC	47.24	23663014
1268	Phosphorylation	EPGCRVRSIKLKEDI CCCCEECEEECCHHH	22.63	-
1309	Ubiquitination	YDPDSILYLCLGIQQ CCHHHHHHHHHHHHH	8.16	21890473
1309 (in isoform 4)	Ubiquitination	-	8.16	21890473
1312	Ubiquitination	DSILYLCLGIQQYLF HHHHHHHHHHHHHHH	6.63	22817900
1340	Phosphorylation	SRFMIELTKLLKIWE HHHHHHHHHHHHHHC	13.57	-
1341	Ubiquitination	RFMIELTKLLKIWEP HHHHHHHHHHHHHCC	65.53	22817900
1341 (in isoform 1)	Ubiquitination	-	65.53	21890473
1343	Ubiquitination	MIELTKLLKIWEPTI HHHHHHHHHHHCCEE	3.94	21890473
1344	Ubiquitination	IELTKLLKIWEPTIL HHHHHHHHHHCCEEC	57.09	21890473
1346	Ubiquitination	LTKLLKIWEPTILPN HHHHHHHHCCEECCC	12.15	22817900
1347	Ubiquitination	TKLLKIWEPTILPNG HHHHHHHCCEECCCC	35.72	22817900
1374	Phosphorylation	ECKQLGAYSPIVLLN HHHHCCCCCHHHHHH	17.12	30576142
1375	Phosphorylation	CKQLGAYSPIVLLNT HHHCCCCCHHHHHHH	13.96	30576142
1382	Phosphorylation	SPIVLLNTLLFFNTK CHHHHHHHHHHCCCC	25.47	-
1394	Ubiquitination	NTKYFQLKNVTEHLK CCCCEECCCHHHHHH	38.29	29967540
1403	Phosphorylation	VTEHLKLSFAHVMRR HHHHHHHHHHHHHHH	20.85	22210691
1416	Phosphorylation	RRTRTLKYSTKMTYL HHHCCCCCCCCCEEH	25.37	21964256
1418	Phosphorylation	TRTLKYSTKMTYLRF HCCCCCCCCCEEHHC	23.03	21964256
1419	Ubiquitination	RTLKYSTKMTYLRFF CCCCCCCCCEEHHCC	24.25	29967540
1422	Phosphorylation	KYSTKMTYLRFFPPL CCCCCCEEHHCCCCC	7.74	-
1431	Sumoylation	RFFPPLQKQESEPDK HCCCCCCCCCCCCCC	64.81	-
1431	Sumoylation	RFFPPLQKQESEPDK HCCCCCCCCCCCCCC	64.81	28112733
1431	Ubiquitination	RFFPPLQKQESEPDK HCCCCCCCCCCCCCC	64.81	29967540
1434	Phosphorylation	PPLQKQESEPDKLTV CCCCCCCCCCCCCCC	52.51	28270605
1438	Acetylation	KQESEPDKLTVGKRK CCCCCCCCCCCCCCC	57.69	23749302
1440	Phosphorylation	ESEPDKLTVGKRKRN CCCCCCCCCCCCCCC	32.71	28270605
1443	Acetylation	PDKLTVGKRKRNEDD CCCCCCCCCCCCCCC	50.87	25953088
1443	Ubiquitination	PDKLTVGKRKRNEDD CCCCCCCCCCCCCCC	50.87	29967540
1447	Ubiquitination	TVGKRKRNEDDEVPV CCCCCCCCCCCCCCC	61.15	32015554
1479	Ubiquitination	LYEFYLSKCSESVKQ HHHHHHHHCCHHHHH	38.90	32015554
1482	Ubiquitination	FYLSKCSESVKQRND HHHHHCCHHHHHCCC	69.86	32015554
1510	Phosphorylation	SPMWYSTFPIDPGTL CCCCEECCCCCCCCH	4.03	33259812
1519	Phosphorylation	IDPGTLDTMLTRILM CCCCCHHHHHHHHHH	19.72	15302935
1536	Ubiquitination	EVHEELAKAKSEDSD HHHHHHHHHHCCCCC	69.81	29967540
1539	Phosphorylation	EELAKAKSEDSDVEL HHHHHHHCCCCCCCC	52.04	25159151
1542	Phosphorylation	AKAKSEDSDVELSD- HHHHCCCCCCCCCC-	39.23	25159151
1545	Phosphorylation	KSEDSDVELSD---- HCCCCCCCCCC----	47.77	33259812
1547	Phosphorylation	EDSDVELSD------ CCCCCCCCC------	27.98	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZMYM4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZMYM4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZMYM4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CTCF_HUMAN	CTCF	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZMYM4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-1241, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1181, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-1241, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122; SER-1539; SER-1542AND SER-1547, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1181, AND MASSSPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1068; SER-1071 ANDSER-1256, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122; SER-162; SER-1542AND SER-1547, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1241, AND MASSSPECTROMETRY.	15302935 [Abstract]