ZBED1_HUMAN - dbPTM
ZBED1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZBED1_HUMAN
UniProt AC O96006
Protein Name Zinc finger BED domain-containing protein 1
Gene Name ZBED1
Organism Homo sapiens (Human).
Sequence Length 694
Subcellular Localization Nucleus . In granular structures.
Protein Description Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity..
Protein Sequence MENKSLESSQTDLKLVAHPRAKSKVWKYFGFDTNAEGCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHPEEFCEFVKSNTEQMREAFATAFSKLKPESSQQPGQDALAVKAGHGYDSKKQQELTAAVLGLICEGLYPASIVDEPTFKVLLKTADPRYELPSRKYISTKAIPEKYGAVREVILKELAEATWCGISTDMWRSENQNRAYVTLAAHFLGLGAPNCLSMGSRCLKTFEVPEENTAETITRVLYEVFIEWGISAKVFGATTNYGKDIVKACSLLDVAVHMPCLGHTFNAGIQQAFQLPKLGALLSRCRKLVEYFQQSAVAMYMLYEKQKQQNVAHCMLVSNRVSWWGSTLAMLQRLKEQQFVIAGVLVEDSNNHHLMLEASEWATIEGLVELLQPFKQVAEMLSASRYPTISMVKPLLHMLLNTTLNIKETDSKELSMAKEVIAKELSKTYQETPEIDMFLNVATFLDPRYKRLPFLSAFERQQVENRVVEEAKGLLDKVKDGGYRPAEDKIFPVPEEPPVKKLMRTSTPPPASVINNMLAEIFCQTGGVEDQEEWHAQVVEELSNFKSQKVLGLNEDPLKWWSDRLALFPLLPKVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLYENARSGAEAEPEDQDEGEWGLDQEQVFSLGDGVSGGFFGIRDSSFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MENKSLESSQTD
---CCCCCCCCCHHC		49.2925159151
8PhosphorylationMENKSLESSQTDLKL
CCCCCCCCCHHCHHH		32.7928450419
9PhosphorylationENKSLESSQTDLKLV
CCCCCCCCHHCHHHH		27.9425159151
11PhosphorylationKSLESSQTDLKLVAH
CCCCCCHHCHHHHCC		45.2930108239
14UbiquitinationESSQTDLKLVAHPRA
CCCHHCHHHHCCHHH		43.66-
43UbiquitinationEGCILQWKKIYCRIC
CCCEEEHHHHHHHHH		19.14-
80AcetylationEEFCEFVKSNTEQMR
HHHHHHHHHCHHHHH		43.2226051181
80UbiquitinationEEFCEFVKSNTEQMR
HHHHHHHHHCHHHHH		43.22-
96AcetylationAFATAFSKLKPESSQ
HHHHHHHHCCCCCCC		54.8226051181
96UbiquitinationAFATAFSKLKPESSQ
HHHHHHHHCCCCCCC		54.82-
98AcetylationATAFSKLKPESSQQP
HHHHHHCCCCCCCCC		50.9426051181
98UbiquitinationATAFSKLKPESSQQP
HHHHHHCCCCCCCCC		50.94-
102PhosphorylationSKLKPESSQQPGQDA
HHCCCCCCCCCCCCC		31.0428555341
113UbiquitinationGQDALAVKAGHGYDS
CCCCCHHHCCCCCCH		42.9421890473
154UbiquitinationPTFKVLLKTADPRYE
CCCEEEEECCCCCCC		37.19-
167PhosphorylationYELPSRKYISTKAIP
CCCCCCCCCCCCCCH		10.0519664994
170PhosphorylationPSRKYISTKAIPEKY
CCCCCCCCCCCHHHH		18.2219664994
171AcetylationSRKYISTKAIPEKYG
CCCCCCCCCCHHHHC		37.2126051181
171UbiquitinationSRKYISTKAIPEKYG
CCCCCCCCCCHHHHC		37.21-
176UbiquitinationSTKAIPEKYGAVREV
CCCCCHHHHCHHHHH		43.56-
210PhosphorylationSENQNRAYVTLAAHF
CCCCCHHHHHHHHHH		7.25-
212PhosphorylationNQNRAYVTLAAHFLG
CCCHHHHHHHHHHHC		9.67-
227PhosphorylationLGAPNCLSMGSRCLK
CCCCCHHHCCCCCEE		24.25-
268PhosphorylationSAKVFGATTNYGKDI
CEEECCCCCCCHHHH		18.8921406692
269PhosphorylationAKVFGATTNYGKDIV
EEECCCCCCCHHHHH		26.3821406692
271PhosphorylationVFGATTNYGKDIVKA
ECCCCCCCHHHHHHH		24.3821406692
273UbiquitinationGATTNYGKDIVKACS
CCCCCCHHHHHHHHH		33.64-
313PhosphorylationPKLGALLSRCRKLVE
HHHHHHHHHHHHHHH		30.1325348772
317AcetylationALLSRCRKLVEYFQQ
HHHHHHHHHHHHHHH		61.5819811495
416PhosphorylationEMLSASRYPTISMVK
HHHHCCCCCCHHHHH		11.3930266825
418PhosphorylationLSASRYPTISMVKPL
HHCCCCCCHHHHHHH		19.4230266825
420PhosphorylationASRYPTISMVKPLLH
CCCCCCHHHHHHHHH		21.7230266825
453UbiquitinationMAKEVIAKELSKTYQ
HHHHHHHHHHHHHHC		48.33-
502UbiquitinationNRVVEEAKGLLDKVK
HHHHHHHHHHHHHHH		54.06-
509UbiquitinationKGLLDKVKDGGYRPA
HHHHHHHHCCCCCCC		57.29-
519UbiquitinationGYRPAEDKIFPVPEE
CCCCCCCCCCCCCCC		37.44-
519AcetylationGYRPAEDKIFPVPEE
CCCCCCCCCCCCCCC		37.4426051181
530UbiquitinationVPEEPPVKKLMRTST
CCCCCCHHHHHCCCC		46.06-
535PhosphorylationPVKKLMRTSTPPPAS
CHHHHHCCCCCCCHH		24.0024275569
536PhosphorylationVKKLMRTSTPPPASV
HHHHHCCCCCCCHHH		28.6627251275
537PhosphorylationKKLMRTSTPPPASVI
HHHHCCCCCCCHHHH		38.9227251275
542PhosphorylationTSTPPPASVINNMLA
CCCCCCHHHHHHHHH		29.3324275569
579UbiquitinationLSNFKSQKVLGLNED
HHCCCCCCCCCCCCC		46.66-
607AcetylationLLPKVLQKYWCVTAT
HHHHHHHHCCCCCCE		36.2426051181
607UbiquitinationLLPKVLQKYWCVTAT
HHHHHHHHCCCCCCE		36.2421890473
632UbiquitinationAANVVSAKRNRLAPA
HHHHHHHHCCCCCCC		42.57-
648PhosphorylationVDEQVFLYENARSGA
CCCHHHHCCCCCCCC		8.8227642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZBED1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZBED1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZBED1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPEF1_HUMANSPEF1physical
16189514
NIF3L_HUMANNIF3L1physical
16189514
GPN1_HUMANGPN1physical
16189514
NUD18_HUMANNUDT18physical
16189514
GPSM1_HUMANGPSM1physical
16189514
NIP7_HUMANNIP7physical
16189514
VINEX_HUMANSORBS3physical
16189514
ZBED1_HUMANZBED1physical
25416956
UCHL5_HUMANUCHL5physical
25416956
AMOL2_HUMANAMOTL2physical
25416956
CA109_HUMANC1orf109physical
25416956
LRC20_HUMANLRRC20physical
25416956
KLH40_HUMANKLHL40physical
25416956
CSTF1_HUMANCSTF1physical
28514442
CREG1_HUMANCREG1physical
28514442
UBP22_HUMANUSP22physical
28514442
P66B_HUMANGATAD2Bphysical
28514442
JIP4_HUMANSPAG9physical
28514442
TPC2A_HUMANTRAPPC2physical
28514442
TPC2B_HUMANTRAPPC2physical
28514442
CDK7_HUMANCDK7physical
28514442
MBD3_HUMANMBD3physical
28514442
MTA2_HUMANMTA2physical
28514442
GDAP2_HUMANGDAP2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZBED1_HUMAN

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Related Literatures of Post-Translational Modification

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