GDAP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDAP2_HUMAN
• UniProt AC: Q9NXN4
• Protein Name: Ganglioside-induced differentiation-associated protein 2
• Gene Name: GDAP2
• Organism: Homo sapiens (Human).
• Sequence Length: 497
• Protein Sequence: MDPLGAPSQFVDVDTLPSWGDSCQDELNSSDTTAEIFQEDTVRSPFLYNKDVNGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLKGCRTGEAKLTKGFNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGETIEKVVFAVSDLEEGTYQKLLPLYFPRSLKEENRSLPYLPADIGNAEGEPVVPERQIRISEKPGAPEDNQEEEDEGLGVDLSFIGSHAFARMEGDIDKQRKLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLHQLFSAISPEQIDFPPFVLEYDARENGPYYTSYPPSPDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Ubiquitination	RSPFLYNKDVNGKVV CCCCEEEECCCCCEE	49.88	32015554
57	Ubiquitination	KDVNGKVVLWKGDVA ECCCCCEEEEECCEE	6.34	23503661
69	Phosphorylation	DVALLNCTAIVNTSN CEEEEECEEEEECCC	20.53	-
116	Ubiquitination	TGEAKLTKGFNLAAR CCCCCCCCCCHHHHH	72.45	27667366
136	Ubiquitination	VGPKYKSRYRTAAES CCCCHHHHHHHHHHH	22.32	22817900
139	Ubiquitination	KYKSRYRTAAESSLY CHHHHHHHHHHHHHH	22.68	21890473
153	Ubiquitination	YSCYRNVLQLAKEQS HHHHHHHHHHHHHCC	3.84	21890473
160	Phosphorylation	LQLAKEQSMSSVGFC HHHHHHCCCCCCEEE	23.02	-
162	Phosphorylation	LAKEQSMSSVGFCVI HHHHCCCCCCEEEEE	27.41	-
163	Phosphorylation	AKEQSMSSVGFCVIN HHHCCCCCCEEEEEC	20.02	-
171	Phosphorylation	VGFCVINSAKRGYPL CEEEEECCCCCCCCH	24.84	-
178	Ubiquitination	SAKRGYPLEDATHIA CCCCCCCHHHHHHHH	7.57	23000965
208	Phosphorylation	EKVVFAVSDLEEGTY EEEEEEEECCCCCCC	32.80	-
217	Ubiquitination	LEEGTYQKLLPLYFP CCCCCCHHHHHHHCC	41.39	23503661
217 (in isoform 2)	Ubiquitination	-	41.39	-
222	Phosphorylation	YQKLLPLYFPRSLKE CHHHHHHHCCCCCCC	15.03	22817900
247	Ubiquitination	DIGNAEGEPVVPERQ CCCCCCCCCCCCHHH	26.82	23000965
248	Ubiquitination	IGNAEGEPVVPERQI CCCCCCCCCCCHHHE	43.17	23000965
260	Ubiquitination	RQIRISEKPGAPEDN HHEEEECCCCCCCCC	41.79	29967540
280	Phosphorylation	EGLGVDLSFIGSHAF CCCCCCHHHHCHHHH	15.45	25159151
296	Ubiquitination	RMEGDIDKQRKLILQ HCCCCHHHHHHHHHH	52.95	22817900
299	Ubiquitination	GDIDKQRKLILQGQL CCHHHHHHHHHHHHC	37.07	22817900
299 (in isoform 1)	Ubiquitination	-	37.07	21890473
299 (in isoform 2)	Ubiquitination	-	37.07	21890473
307	Phosphorylation	LILQGQLSEAALQKQ HHHHHHCCHHHHHHH	19.80	27251275
313 (in isoform 1)	Ubiquitination	-	51.07	21890473
313 (in isoform 2)	Ubiquitination	-	51.07	21890473
313	Ubiquitination	LSEAALQKQHQRNYN CCHHHHHHHHHHHHH	51.07	23000965
338	Ubiquitination	LSDIASLKALYQTGV HHHHHHHHHHHHHCC	33.57	23000965
338 (in isoform 2)	Ubiquitination	-	33.57	-
407	Ubiquitination	HLDSDFLKKLYDVVD CCCHHHHHHHHHHHC	40.50	23000965
408	Ubiquitination	LDSDFLKKLYDVVDV CCHHHHHHHHHHHCH	55.19	23000965
425	Phosphorylation	KRNLKAVYFVHPTFR CCCCEEEEEECHHHH	12.54	26074081
430	Phosphorylation	AVYFVHPTFRSKVST EEEEECHHHHHHCCC	19.46	26074081
433	Phosphorylation	FVHPTFRSKVSTWFF EECHHHHHHCCCCEE	32.97	26074081
436	Phosphorylation	PTFRSKVSTWFFTTF HHHHHHCCCCEEEEE	24.53	26074081
437	Phosphorylation	TFRSKVSTWFFTTFS HHHHHCCCCEEEEEE	29.31	26074081
441	Phosphorylation	KVSTWFFTTFSVSGL HCCCCEEEEEEECCC	19.91	26074081
442	Phosphorylation	VSTWFFTTFSVSGLK CCCCEEEEEEECCCC	14.57	26074081
444	Phosphorylation	TWFFTTFSVSGLKDK CCEEEEEEECCCCHH	17.18	24702127
446	Phosphorylation	FFTTFSVSGLKDKIH EEEEEEECCCCHHHE	36.89	29514088
466	Phosphorylation	HQLFSAISPEQIDFP HHHHHCCCHHHCCCC	23.31	-
485 (in isoform 2)	Phosphorylation	-	13.56	-
486 (in isoform 2)	Phosphorylation	-	30.45	-
487	Phosphorylation	DARENGPYYTSYPPS ECCCCCCCCCCCCCC	22.30	-
488	Phosphorylation	ARENGPYYTSYPPSP CCCCCCCCCCCCCCC	7.73	-
490	Phosphorylation	ENGPYYTSYPPSPDL CCCCCCCCCCCCCCC	21.37	-
491	Phosphorylation	NGPYYTSYPPSPDL- CCCCCCCCCCCCCC-	16.03	-
494	Phosphorylation	YYTSYPPSPDL---- CCCCCCCCCCC----	26.92	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDAP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDAP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDAP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEP76_HUMAN	CEP76	physical	25416956
URFB1_HUMAN	UHRF1BP1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.