CREG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CREG1_HUMAN
• UniProt AC: O75629
• Protein Name: Protein CREG1
• Gene Name: CREG1
• Organism: Homo sapiens (Human).
• Sequence Length: 220
• Subcellular Localization: Secreted .
• Protein Description: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R..
• Protein Sequence: MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLSLSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKVNETEMDIAKHSLFIRHPEMKTWPSSHNWFFAKLNITNIWVLDYFGGPKIVTPEEYYNVTVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAGLSRGSARALLAA CCCCCHHHHHHHHHH	17.30	-
19	Phosphorylation	LLAALLASTLLALLV HHHHHHHHHHHHHHH	21.40	-
27	Phosphorylation	TLLALLVSPARGRGG HHHHHHHCCCCCCCC	16.89	-
153	Phosphorylation	LCVHIMLSGTVTKVN EEEEEEEECCEEECC	18.29	22210691
160	N-linked_Glycosylation	SGTVTKVNETEMDIA ECCEEECCHHHHHHH	52.61	19159218
162	O-linked_Glycosylation	TVTKVNETEMDIAKH CEEECCHHHHHHHHH	31.26	30059200
162	Phosphorylation	TVTKVNETEMDIAKH CEEECCHHHHHHHHH	31.26	22210691
168	Ubiquitination	ETEMDIAKHSLFIRH HHHHHHHHHEEECCC	33.78	29967540
193	N-linked_Glycosylation	NWFFAKLNITNIWVL CCEEEEECEEEEEEE	38.03	19159218
216	N-linked_Glycosylation	VTPEEYYNVTVQ--- CCHHHHCCCCCC---	23.29	19159218

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CREG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CREG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CREG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBP_HUMAN	TBP	physical	9710587
RB_HUMAN	RB1	physical	9710587
RBL1_HUMAN	RBL1	physical	9710587

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160; ASN-193 AND ASN-216,AND MASS SPECTROMETRY.
PubMed: 19159218