| UniProt ID | KLH40_HUMAN | |
|---|---|---|
| UniProt AC | Q2TBA0 | |
| Protein Name | Kelch-like protein 40 {ECO:0000305} | |
| Gene Name | KLHL40 {ECO:0000312|HGNC:HGNC:30372} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 621 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, myofibril, sarcomere, A band . Cytoplasm, myofibril, sarcomere, I band . | |
| Protein Description | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. [PubMed: 23746549 The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity] | |
| Protein Sequence | MALGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREIAYAAGATFLPVRLNVLCLTKM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 266 | Phosphorylation | DAHEGRITTLRKKKK HHCCCCCCEEEECCC | 26437602 | ||
| 267 | Phosphorylation | AHEGRITTLRKKKKG HCCCCCCEEEECCCC | - | ||
| 400 | Phosphorylation | LGMPPLPSPRCLFGL CCCCCCCCCCEECCH | 24719451 | ||
| 439 | Phosphorylation | VMCYDRLSFKWGESD CCEECCEEECCCCCC | 24719451 | ||
| 501 | Phosphorylation | APMQTARSLFGATVH CCHHHHHHHHCCEEE | 30576142 | ||
| 524 | Phosphorylation | GVTDTGLTSSAEVYS EECCCCCCCCCEEEE | 17929957 | ||
| 525 | Phosphorylation | VTDTGLTSSAEVYSI ECCCCCCCCCEEEEC | 30576142 | ||
| 530 | Phosphorylation | LTSSAEVYSITDNKW CCCCCEEEECCCCCC | 17929957 | ||
| 548 | Phosphorylation | EAFPQERSSLSLVSL HHCCCCCCHHHHHHH | - | ||
| 572 | Phosphorylation | FATLETESGELVPTE EEEEEECCCCCCCCC | - | ||
| 578 | Phosphorylation | ESGELVPTELNDIWR CCCCCCCCCHHHHHC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KLH40_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KLH40_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KLH40_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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