UniProt ID | ZBTB5_HUMAN | |
---|---|---|
UniProt AC | O15062 | |
Protein Name | Zinc finger and BTB domain-containing protein 5 | |
Gene Name | ZBTB5 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 677 | |
Subcellular Localization | Nucleus . | |
Protein Description | May be involved in transcriptional regulation.. | |
Protein Sequence | MDFPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFSVAEGDQTMNMIQLDSEVVTAEAFAALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMSPPSERVQEQSARMQRSFMLQQLGLSIVSSALNSSQNGEEQPAPMSSSMRSNLDQRTPFPMRRLHKRKQSAEERARQRLRPSIDESAISDVTPENGPSGVHSREEFFSPDSLKIVDNPKADGMTDNQEDSAIMFDQSFGTQEDAQVPSQSDNSAGNMAQLSMASRATQVETSFDQEAAPEKSSFQCENPEVGLGEKEHMRVVVKSEPLSSPEPQDEVSDVTSQAEGSESVEVEGVVVSAEKIDLSPESSDRSFSDPQSSTDRVGDIHILEVTNNLEHKSTFSISNFLNKSRGNNFTANQNNDDNIPNTTSDCRLESEAPYLLSPEAGPAGGPSSAPGSHVENPFSEPADSHFVRPMQEVMGLPCVQTSGYQGGEQFGMDFSRSGLGLHSSFSRVMIGSPRGGASNFPYYRRIAPKMPVVTSVRSSQIPENSTSSQLMMNGATSSFENGHPSQPGPPQLTRASADVLSKCKKALSEHNVLVVEGARKYACKICCKTFLTLTDCKKHIRVHTGEKPYACLKCGKRFSQSSHLYKHSKTTCLRWQSSNLPSTLL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
118 | Phosphorylation | VVKACKHYLTTRTLP HHHHHHHHHHHCCCC | 7.40 | - | |
123 | Phosphorylation | KHYLTTRTLPMSPPS HHHHHHCCCCCCCCH | 32.87 | 23403867 | |
127 | Phosphorylation | TTRTLPMSPPSERVQ HHCCCCCCCCHHHHH | 31.55 | 20044836 | |
130 | Phosphorylation | TLPMSPPSERVQEQS CCCCCCCHHHHHHHH | 41.23 | 23403867 | |
143 | Phosphorylation | QSARMQRSFMLQQLG HHHHHHHHHHHHHHH | 9.71 | 22210691 | |
155 | Phosphorylation | QLGLSIVSSALNSSQ HHHHHHHHHHHHCCC | 14.28 | 22210691 | |
173 | Phosphorylation | EQPAPMSSSMRSNLD CCCCCCCHHHHCCCC | 23.15 | 22210691 | |
183 | Phosphorylation | RSNLDQRTPFPMRRL HCCCCCCCCCCHHHH | 24.53 | 28555341 | |
208 | Phosphorylation | ARQRLRPSIDESAIS HHHHHCCCCCHHHHC | 35.92 | 28450419 | |
212 | Phosphorylation | LRPSIDESAISDVTP HCCCCCHHHHCCCCC | 27.44 | 25394399 | |
215 | Phosphorylation | SIDESAISDVTPENG CCCHHHHCCCCCCCC | 26.24 | 20873877 | |
218 | Phosphorylation | ESAISDVTPENGPSG HHHHCCCCCCCCCCC | 29.85 | 20873877 | |
224 | Phosphorylation | VTPENGPSGVHSREE CCCCCCCCCCCCCCC | 55.64 | 20873877 | |
228 | Phosphorylation | NGPSGVHSREEFFSP CCCCCCCCCCCCCCC | 38.69 | 20873877 | |
234 | Phosphorylation | HSREEFFSPDSLKIV CCCCCCCCCCCCEEC | 32.87 | 30266825 | |
237 | Phosphorylation | EEFFSPDSLKIVDNP CCCCCCCCCEECCCC | 34.64 | 30266825 | |
239 | Sumoylation | FFSPDSLKIVDNPKA CCCCCCCEECCCCCC | 44.64 | 28112733 | |
239 | Ubiquitination | FFSPDSLKIVDNPKA CCCCCCCEECCCCCC | 44.64 | 21906983 | |
245 | Sumoylation | LKIVDNPKADGMTDN CEECCCCCCCCCCCC | 66.42 | - | |
297 | Phosphorylation | SRATQVETSFDQEAA HHHHCCCCCCCCCCC | 35.52 | 29978859 | |
298 | Phosphorylation | RATQVETSFDQEAAP HHHCCCCCCCCCCCC | 17.20 | 21815630 | |
307 | Ubiquitination | DQEAAPEKSSFQCEN CCCCCCCCCCCCCCC | 50.79 | - | |
308 | Phosphorylation | QEAAPEKSSFQCENP CCCCCCCCCCCCCCC | 34.42 | 25627689 | |
309 | Phosphorylation | EAAPEKSSFQCENPE CCCCCCCCCCCCCCC | 30.33 | 25627689 | |
322 | Sumoylation | PEVGLGEKEHMRVVV CCCCCCCCCCEEEEE | 51.63 | 28112733 | |
322 | Ubiquitination | PEVGLGEKEHMRVVV CCCCCCCCCCEEEEE | 51.63 | - | |
330 | Sumoylation | EHMRVVVKSEPLSSP CCEEEEEECCCCCCC | 37.18 | 28112733 | |
335 | Phosphorylation | VVKSEPLSSPEPQDE EEECCCCCCCCCCCC | 55.34 | - | |
371 | Phosphorylation | SAEKIDLSPESSDRS EEEEEECCCCCCCCC | 23.91 | 23401153 | |
374 | Phosphorylation | KIDLSPESSDRSFSD EEECCCCCCCCCCCC | 40.71 | 20873877 | |
375 | Phosphorylation | IDLSPESSDRSFSDP EECCCCCCCCCCCCC | 35.07 | 20873877 | |
378 | Phosphorylation | SPESSDRSFSDPQSS CCCCCCCCCCCCCCC | 33.81 | 21815630 | |
380 | Phosphorylation | ESSDRSFSDPQSSTD CCCCCCCCCCCCCCC | 50.02 | 27732954 | |
384 | Phosphorylation | RSFSDPQSSTDRVGD CCCCCCCCCCCCCCC | 40.36 | 27732954 | |
385 | Phosphorylation | SFSDPQSSTDRVGDI CCCCCCCCCCCCCCE | 29.13 | 27732954 | |
386 | Phosphorylation | FSDPQSSTDRVGDIH CCCCCCCCCCCCCEE | 32.83 | 27732954 | |
404 | Sumoylation | VTNNLEHKSTFSISN EECCCCCCCCEEHHH | 41.64 | 28112733 | |
408 | Phosphorylation | LEHKSTFSISNFLNK CCCCCCEEHHHHHHH | 25.79 | 28555341 | |
415 | Ubiquitination | SISNFLNKSRGNNFT EHHHHHHHCCCCCCC | 43.61 | - | |
415 | Sumoylation | SISNFLNKSRGNNFT EHHHHHHHCCCCCCC | 43.61 | 28112733 | |
493 | Phosphorylation | MGLPCVQTSGYQGGE HCCCEEECCCCCCCH | 12.06 | 24043423 | |
494 | Phosphorylation | GLPCVQTSGYQGGEQ CCCEEECCCCCCCHH | 20.57 | 24043423 | |
496 | Phosphorylation | PCVQTSGYQGGEQFG CEEECCCCCCCHHCC | 12.07 | 24043423 | |
507 | Phosphorylation | EQFGMDFSRSGLGLH HHCCCCCCCCCCCCC | 22.67 | 24043423 | |
509 | Phosphorylation | FGMDFSRSGLGLHSS CCCCCCCCCCCCCCC | 36.85 | 23186163 | |
515 | Phosphorylation | RSGLGLHSSFSRVMI CCCCCCCCCCEEEEE | 37.81 | 28450419 | |
516 | Phosphorylation | SGLGLHSSFSRVMIG CCCCCCCCCEEEEEC | 19.25 | 23403867 | |
518 | Phosphorylation | LGLHSSFSRVMIGSP CCCCCCCEEEEECCC | 26.39 | 23186163 | |
524 | Phosphorylation | FSRVMIGSPRGGASN CEEEEECCCCCCCCC | 10.66 | 28985074 | |
526 | Methylation | RVMIGSPRGGASNFP EEEECCCCCCCCCCC | 58.85 | 54560775 | |
541 | Sumoylation | YYRRIAPKMPVVTSV HHHHCCCCCCEEEEE | 46.98 | - | |
541 | Sumoylation | YYRRIAPKMPVVTSV HHHHCCCCCCEEEEE | 46.98 | 28112733 | |
594 | Sumoylation | ASADVLSKCKKALSE HHHHHHHHHHHHHHH | 46.01 | 28112733 | |
594 | Ubiquitination | ASADVLSKCKKALSE HHHHHHHHHHHHHHH | 46.01 | - | |
597 | Ubiquitination | DVLSKCKKALSEHNV HHHHHHHHHHHHCCE | 65.12 | - | |
597 | Sumoylation | DVLSKCKKALSEHNV HHHHHHHHHHHHCCE | 65.12 | 28112733 | |
636 | Phosphorylation | KKHIRVHTGEKPYAC HHHEEEECCCCCEEE | 44.15 | 29214152 | |
641 | Phosphorylation | VHTGEKPYACLKCGK EECCCCCEEEECCCC | 22.48 | 21253578 | |
645 | Sumoylation | EKPYACLKCGKRFSQ CCCEEEECCCCCCCC | 40.60 | 28112733 | |
645 | Sumoylation | EKPYACLKCGKRFSQ CCCEEEECCCCCCCC | 40.60 | - | |
658 | Sumoylation | SQSSHLYKHSKTTCL CCCHHHHHCCCCCHH | 48.00 | 28112733 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZBTB5_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZBTB5_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZBTB5_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
CC85B_HUMAN | CCDC85B | physical | 16189514 | |
JADE2_HUMAN | JADE2 | physical | 20211142 | |
SWP70_HUMAN | SWAP70 | physical | 25416956 | |
ZBT7B_HUMAN | ZBTB7B | physical | 25416956 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371, AND MASSSPECTROMETRY. |