KLH41_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH41_HUMAN
• UniProt AC: O60662
• Protein Name: Kelch-like protein 41
• Gene Name: KLHL41
• Organism: Homo sapiens (Human).
• Sequence Length: 606
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, pseudopodium . Cell projection, ruffle . Cytoplasm, myofibril, sarcomere, M line . Sarcoplasmic reticulum membrane . Endoplasmic reticulum membrane . Predominantly cytoplasmic but can colocalize
• Protein Description: Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells..
• Protein Sequence: MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSQRELAEE -----CHHHHHHHHH		-
14	Phosphorylation	LAEELRLYQSTLLQD HHHHHHHHHHHHHHH		27067055
16	Phosphorylation	EELRLYQSTLLQDGL HHHHHHHHHHHHHHH		27067055
17	Phosphorylation	ELRLYQSTLLQDGLK HHHHHHHHHHHHHHH		27067055
244	Phosphorylation	EKDDIIKSNPDLQKK CHHHHHHCCHHHHHH		26437602
267	Phosphorylation	AGKLPEPSKNAAKTG CCCCCCCCCCCHHCC		28111955
438	Phosphorylation	KKLPIKVYGHNVISH CCCCEEEECCCEEEC		26437602
446	Acetylation	GHNVISHKGMIYCLG CCCEEECCCEEEECC		7367225
486	Phosphorylation	APMKIPRSMFGVAVH CCCCCCHHHCEEEEE		-
573 (in isoform 2)	Ubiquitination	-		21890473
583	Ubiquitination	KEWAGMLKEIRYASG HHHHHHHHHHHHHHH		22817900
583 (in isoform 1)	Ubiquitination	-		21890473
587	Phosphorylation	GMLKEIRYASGASCL HHHHHHHHHHHHHHH		22817900
589	Phosphorylation	LKEIRYASGASCLAT HHHHHHHHHHHHHHH		29052541
592	Phosphorylation	IRYASGASCLATRLN HHHHHHHHHHHHHHH		29052541
596	Phosphorylation	SGASCLATRLNLFKL HHHHHHHHHHHHHHH		29052541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH41_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH41_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH41_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_HUMAN	CUL3	physical	15983046
RBX1_HUMAN	RBX1	physical	15983046
ZN363_HUMAN	RCHY1	physical	25416956
KLH41_HUMAN	KLHL41	physical	15983046

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615731: Nemaline myopathy 9 (NEM9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.