LMOD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMOD3_HUMAN
• UniProt AC: Q0VAK6
• Protein Name: Leiomodin-3
• Gene Name: LMOD3
• Organism: Homo sapiens (Human).
• Sequence Length: 560
• Subcellular Localization: Cytoplasm . Cytoplasm, myofibril, sarcomere, M line . Cytoplasm, myofibril, sarcomere, A band . Cytoplasm, cytoskeleton . Highly expressed in nonstriated areas of developing myotubes, where it shows a granular cytoplasmic pattern. In sarcomeres, high
• Protein Description: Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. [PubMed: 25250574 Increases the rate of actin polymerization]
• Protein Sequence: MSEHSRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLKEKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQIRNCENNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDPKKLALDTSFLKVSTRPSGNQTDLDGSLRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADENVAFALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEIARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQEEQKQQQLKEQKKLIAMLENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPFSQRSEMMKKPSQAPKYRTDPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLNDIRHSSVAYLKPVQLPKELA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSEHSRNSDQEE ---CCCCCCCCCHHH	29.16	22673903
8	Phosphorylation	MSEHSRNSDQEELLD CCCCCCCCCHHHHHH	39.29	22673903
37	Phosphorylation	EELKELQSEMEVMAP HHHHHHHHHCHHCCC	52.08	26074081
47	Phosphorylation	EVMAPDPSLPVGMIQ HHCCCCCCCCCCEEC	53.32	26074081
134	Phosphorylation	IVANKRESKGSSNIQ HHHCCCCCCCCCCCC	46.48	26437602
225	Phosphorylation	PKKLALDTSFLKVST HHHHHHCCCEEEEEC	23.41	23403867
226	Phosphorylation	KKLALDTSFLKVSTR HHHHHCCCEEEEECC	28.40	24719451
250	Ubiquitination	GSLRRVRKNDPDMKE CHHHHHHHCCCCHHH	63.95	30230243
375	Phosphorylation	NTLLKMGYHFELPGP CCEEEECCCCCCCCC	10.39	21214269
517	Phosphorylation	NLKDVIKTLKPVPRN CHHHHHHHCCCCCCC	28.96	-
546	Phosphorylation	LNDIRHSSVAYLKPV HHHHCCCCCCCCCCC	12.49	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMOD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMOD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMOD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLH40_HUMAN	KLHL40	physical	24960163

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.