MCM8_HUMAN - dbPTM
MCM8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MCM8_HUMAN
UniProt AC Q9UJA3
Protein Name DNA helicase MCM8
Gene Name MCM8
Organism Homo sapiens (Human).
Sequence Length 840
Subcellular Localization Nucleus . Localizes to nuclear foci and colocalizes with RAD51.
Protein Description Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle..
Protein Sequence MNGEYRGRGFGRGRFQSWKRGRGGGNFSGKWREREHRPDLSKTTGKRTSEQTPQFLLSTKTPQSMQSTLDRFIPYKGWKLYFSEVYSDSSPLIEKIQAFEKFFTRHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Methylation--MNGEYRGRGFGRG
--CCCCCCCCCCCCC		24.83115483027
43PhosphorylationHRPDLSKTTGKRTSE
CCCCCCCCCCCCCCC		37.0925690035
44PhosphorylationRPDLSKTTGKRTSEQ
CCCCCCCCCCCCCCC		44.4325690035
49PhosphorylationKTTGKRTSEQTPQFL
CCCCCCCCCCCCCCH		31.5728555341
58PhosphorylationQTPQFLLSTKTPQSM
CCCCCHHCCCCCHHH		29.9724719451
59PhosphorylationTPQFLLSTKTPQSMQ
CCCCHHCCCCCHHHH		38.6224114839
60UbiquitinationPQFLLSTKTPQSMQS
CCCHHCCCCCHHHHH		55.63-
86PhosphorylationKLYFSEVYSDSSPLI
EEEEEECCCCCCHHH		11.6018083107
89PhosphorylationFSEVYSDSSPLIEKI
EEECCCCCCHHHHHH		28.1023401153
90PhosphorylationSEVYSDSSPLIEKIQ
EECCCCCCHHHHHHH		28.8123401153
101UbiquitinationEKIQAFEKFFTRHID
HHHHHHHHHHHHHCC		39.05-
112UbiquitinationRHIDLYDKDEIERKG
HHCCCCCHHHHHHCC		43.64-
118UbiquitinationDKDEIERKGSILVDF
CHHHHHHCCEEEEEH		44.19-
199PhosphorylationPHIHARVYNYEPLTQ
CCEEEEECCCCCCHH		13.38-
201PhosphorylationIHARVYNYEPLTQLK
EEEEECCCCCCHHCC		10.96-
208UbiquitinationYEPLTQLKNVRANYY
CCCCHHCCCEEHHHC		43.51-
214PhosphorylationLKNVRANYYGKYIAL
CCCEEHHHCCCEEEE		16.77-
215PhosphorylationKNVRANYYGKYIALR
CCEEHHHCCCEEEEE		13.62-
218PhosphorylationRANYYGKYIALRGTV
EHHHCCCEEEEECEE		6.25-
229PhosphorylationRGTVVRVSNIKPLCT
ECEEEEECCCHHHHH		23.4424719451
232UbiquitinationVVRVSNIKPLCTKMA
EEEECCCHHHHHHHH		35.87-
236PhosphorylationSNIKPLCTKMAFLCA
CCCHHHHHHHHHHHH		31.3824719451
263UbiquitinationGKYSLPTKCPVPVCR
CCCCCCCCCCCCCCC		34.30-
273PhosphorylationVPVCRGRSFTALRSS
CCCCCCCCEEECCCC		29.7624719451
275PhosphorylationVCRGRSFTALRSSPL
CCCCCCEEECCCCCE		26.4830576142
280PhosphorylationSFTALRSSPLTVTMD
CEEECCCCCEEEEEE		19.9330576142
386PhosphorylationHGMLMEFSLKDLYAI
CCCEEEEEHHHHHHH		22.6224719451
439UbiquitinationSQKYADDKNRIPIRG
CHHCCCCCCCCCCCC		48.99-
460UbiquitinationVGDPGLGKSQMLQAA
ECCCCCCHHHHHHHH		42.42-
476PhosphorylationNVAPRGVYVCGNTTT
CCCCCCEEECCCCCC		7.8928842319
481PhosphorylationGVYVCGNTTTTSGLT
CEEECCCCCCCCCEE		15.7128842319
543UbiquitinationQQSISLAKAGVVCSL
HHCHHHHHCCEEEEC		51.47-
549PhosphorylationAKAGVVCSLPARTSI
HHCCEEEECCCCCEE		26.2724719451
569UbiquitinationPVGGHYNKAKTVSEN
CCCCCCCCCCCHHHH		44.06-
571UbiquitinationGGHYNKAKTVSENLK
CCCCCCCCCHHHHHH		51.58-
572PhosphorylationGHYNKAKTVSENLKM
CCCCCCCCHHHHHHH		33.8426437602
574PhosphorylationYNKAKTVSENLKMGS
CCCCCCHHHHHHHHH		26.4626437602
578UbiquitinationKTVSENLKMGSALLS
CCHHHHHHHHHHHHH		53.44-
581PhosphorylationSENLKMGSALLSRFD
HHHHHHHHHHHHHCC		16.5523312004
585PhosphorylationKMGSALLSRFDLVFI
HHHHHHHHHCCEEEE		31.5823312004
619PhosphorylationIRAGKQRTISSATVA
EECCCCCEECCEEEE		23.79-
630PhosphorylationATVARMNSQDSNTSV
EEEEHHHCCCCCCCE		26.4825159151
633PhosphorylationARMNSQDSNTSVLEV
EHHHCCCCCCCEEEE		34.0829116813
635PhosphorylationMNSQDSNTSVLEVVS
HHCCCCCCCEEEEEE		24.9429978859
636PhosphorylationNSQDSNTSVLEVVSE
HCCCCCCCEEEEEEC		29.0228464451
642PhosphorylationTSVLEVVSEKPLSER
CCEEEEEECCCHHHC		45.1129978859
644UbiquitinationVLEVVSEKPLSERLK
EEEEEECCCHHHCCE		43.69-
647PhosphorylationVVSEKPLSERLKVVP
EEECCCHHHCCEECC		29.2429978859
651UbiquitinationKPLSERLKVVPGETI
CCHHHCCEECCCCCC		47.62-
668UbiquitinationIPHQLLRKYIGYARQ
CCHHHHHHHHHHHHH		40.98-
715PhosphorylationITTRQLESLIRLTEA
CCHHHHHHHHHHHHH		37.3720068231
734UbiquitinationELREEATKEDAEDIV
HHHHHHCHHHHHHHH		61.72-
747PhosphorylationIVEIMKYSMLGTYSD
HHHHHHHHHHCCCCC		11.3030576142
752PhosphorylationKYSMLGTYSDEFGNL
HHHHHCCCCCCCCCC		16.6030576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MCM8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MCM8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MCM8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC6_HUMANCDC6physical
15684404
ORC2_HUMANORC2physical
15684404
MCM8_HUMANMCM8physical
22771115
MCM9_HUMANMCM9physical
26215093
MLH1_HUMANMLH1physical
26300262
MSH2_HUMANMSH2physical
26300262
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612885Premature ovarian failure 10 (POF10)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MCM8_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory