UniProt ID | MCM8_HUMAN | |
---|---|---|
UniProt AC | Q9UJA3 | |
Protein Name | DNA helicase MCM8 | |
Gene Name | MCM8 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 840 | |
Subcellular Localization | Nucleus . Localizes to nuclear foci and colocalizes with RAD51. | |
Protein Description | Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.. | |
Protein Sequence | MNGEYRGRGFGRGRFQSWKRGRGGGNFSGKWREREHRPDLSKTTGKRTSEQTPQFLLSTKTPQSMQSTLDRFIPYKGWKLYFSEVYSDSSPLIEKIQAFEKFFTRHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
6 | Methylation | --MNGEYRGRGFGRG --CCCCCCCCCCCCC | 24.83 | 115483027 | |
43 | Phosphorylation | HRPDLSKTTGKRTSE CCCCCCCCCCCCCCC | 37.09 | 25690035 | |
44 | Phosphorylation | RPDLSKTTGKRTSEQ CCCCCCCCCCCCCCC | 44.43 | 25690035 | |
49 | Phosphorylation | KTTGKRTSEQTPQFL CCCCCCCCCCCCCCH | 31.57 | 28555341 | |
58 | Phosphorylation | QTPQFLLSTKTPQSM CCCCCHHCCCCCHHH | 29.97 | 24719451 | |
59 | Phosphorylation | TPQFLLSTKTPQSMQ CCCCHHCCCCCHHHH | 38.62 | 24114839 | |
60 | Ubiquitination | PQFLLSTKTPQSMQS CCCHHCCCCCHHHHH | 55.63 | - | |
86 | Phosphorylation | KLYFSEVYSDSSPLI EEEEEECCCCCCHHH | 11.60 | 18083107 | |
89 | Phosphorylation | FSEVYSDSSPLIEKI EEECCCCCCHHHHHH | 28.10 | 23401153 | |
90 | Phosphorylation | SEVYSDSSPLIEKIQ EECCCCCCHHHHHHH | 28.81 | 23401153 | |
101 | Ubiquitination | EKIQAFEKFFTRHID HHHHHHHHHHHHHCC | 39.05 | - | |
112 | Ubiquitination | RHIDLYDKDEIERKG HHCCCCCHHHHHHCC | 43.64 | - | |
118 | Ubiquitination | DKDEIERKGSILVDF CHHHHHHCCEEEEEH | 44.19 | - | |
199 | Phosphorylation | PHIHARVYNYEPLTQ CCEEEEECCCCCCHH | 13.38 | - | |
201 | Phosphorylation | IHARVYNYEPLTQLK EEEEECCCCCCHHCC | 10.96 | - | |
208 | Ubiquitination | YEPLTQLKNVRANYY CCCCHHCCCEEHHHC | 43.51 | - | |
214 | Phosphorylation | LKNVRANYYGKYIAL CCCEEHHHCCCEEEE | 16.77 | - | |
215 | Phosphorylation | KNVRANYYGKYIALR CCEEHHHCCCEEEEE | 13.62 | - | |
218 | Phosphorylation | RANYYGKYIALRGTV EHHHCCCEEEEECEE | 6.25 | - | |
229 | Phosphorylation | RGTVVRVSNIKPLCT ECEEEEECCCHHHHH | 23.44 | 24719451 | |
232 | Ubiquitination | VVRVSNIKPLCTKMA EEEECCCHHHHHHHH | 35.87 | - | |
236 | Phosphorylation | SNIKPLCTKMAFLCA CCCHHHHHHHHHHHH | 31.38 | 24719451 | |
263 | Ubiquitination | GKYSLPTKCPVPVCR CCCCCCCCCCCCCCC | 34.30 | - | |
273 | Phosphorylation | VPVCRGRSFTALRSS CCCCCCCCEEECCCC | 29.76 | 24719451 | |
275 | Phosphorylation | VCRGRSFTALRSSPL CCCCCCEEECCCCCE | 26.48 | 30576142 | |
280 | Phosphorylation | SFTALRSSPLTVTMD CEEECCCCCEEEEEE | 19.93 | 30576142 | |
386 | Phosphorylation | HGMLMEFSLKDLYAI CCCEEEEEHHHHHHH | 22.62 | 24719451 | |
439 | Ubiquitination | SQKYADDKNRIPIRG CHHCCCCCCCCCCCC | 48.99 | - | |
460 | Ubiquitination | VGDPGLGKSQMLQAA ECCCCCCHHHHHHHH | 42.42 | - | |
476 | Phosphorylation | NVAPRGVYVCGNTTT CCCCCCEEECCCCCC | 7.89 | 28842319 | |
481 | Phosphorylation | GVYVCGNTTTTSGLT CEEECCCCCCCCCEE | 15.71 | 28842319 | |
543 | Ubiquitination | QQSISLAKAGVVCSL HHCHHHHHCCEEEEC | 51.47 | - | |
549 | Phosphorylation | AKAGVVCSLPARTSI HHCCEEEECCCCCEE | 26.27 | 24719451 | |
569 | Ubiquitination | PVGGHYNKAKTVSEN CCCCCCCCCCCHHHH | 44.06 | - | |
571 | Ubiquitination | GGHYNKAKTVSENLK CCCCCCCCCHHHHHH | 51.58 | - | |
572 | Phosphorylation | GHYNKAKTVSENLKM CCCCCCCCHHHHHHH | 33.84 | 26437602 | |
574 | Phosphorylation | YNKAKTVSENLKMGS CCCCCCHHHHHHHHH | 26.46 | 26437602 | |
578 | Ubiquitination | KTVSENLKMGSALLS CCHHHHHHHHHHHHH | 53.44 | - | |
581 | Phosphorylation | SENLKMGSALLSRFD HHHHHHHHHHHHHCC | 16.55 | 23312004 | |
585 | Phosphorylation | KMGSALLSRFDLVFI HHHHHHHHHCCEEEE | 31.58 | 23312004 | |
619 | Phosphorylation | IRAGKQRTISSATVA EECCCCCEECCEEEE | 23.79 | - | |
630 | Phosphorylation | ATVARMNSQDSNTSV EEEEHHHCCCCCCCE | 26.48 | 25159151 | |
633 | Phosphorylation | ARMNSQDSNTSVLEV EHHHCCCCCCCEEEE | 34.08 | 29116813 | |
635 | Phosphorylation | MNSQDSNTSVLEVVS HHCCCCCCCEEEEEE | 24.94 | 29978859 | |
636 | Phosphorylation | NSQDSNTSVLEVVSE HCCCCCCCEEEEEEC | 29.02 | 28464451 | |
642 | Phosphorylation | TSVLEVVSEKPLSER CCEEEEEECCCHHHC | 45.11 | 29978859 | |
644 | Ubiquitination | VLEVVSEKPLSERLK EEEEEECCCHHHCCE | 43.69 | - | |
647 | Phosphorylation | VVSEKPLSERLKVVP EEECCCHHHCCEECC | 29.24 | 29978859 | |
651 | Ubiquitination | KPLSERLKVVPGETI CCHHHCCEECCCCCC | 47.62 | - | |
668 | Ubiquitination | IPHQLLRKYIGYARQ CCHHHHHHHHHHHHH | 40.98 | - | |
715 | Phosphorylation | ITTRQLESLIRLTEA CCHHHHHHHHHHHHH | 37.37 | 20068231 | |
734 | Ubiquitination | ELREEATKEDAEDIV HHHHHHCHHHHHHHH | 61.72 | - | |
747 | Phosphorylation | IVEIMKYSMLGTYSD HHHHHHHHHHCCCCC | 11.30 | 30576142 | |
752 | Phosphorylation | KYSMLGTYSDEFGNL HHHHHCCCCCCCCCC | 16.60 | 30576142 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MCM8_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MCM8_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MCM8_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
CDC6_HUMAN | CDC6 | physical | 15684404 | |
ORC2_HUMAN | ORC2 | physical | 15684404 | |
MCM8_HUMAN | MCM8 | physical | 22771115 | |
MCM9_HUMAN | MCM9 | physical | 26215093 | |
MLH1_HUMAN | MLH1 | physical | 26300262 | |
MSH2_HUMAN | MSH2 | physical | 26300262 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
612885 | Premature ovarian failure 10 (POF10) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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