MCM9_HUMAN - dbPTM
MCM9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MCM9_HUMAN
UniProt AC Q9NXL9
Protein Name DNA helicase MCM9
Gene Name MCM9
Organism Homo sapiens (Human).
Sequence Length 1143
Subcellular Localization Nucleus. Localizes to nuclear foci and colocalizes with RAD51..
Protein Description Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart..
Protein Sequence MNSDQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPVVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRRSALTILQSLSQPEAVSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADFEQYYTFCRPSSCPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFWEYYKSDPFAGRNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQGGALLGGVNALHTSFPENPGEQYQRQCELILEKLELQSLLSEELRRLERLQNQSVHQSQPRVLEVETTPGSLRNGPGEESNFRTSSQQEINYSTHIFSPGGSPEGSPVLDPPPHLEPNRSTSRKHSAQHKNNRDDSLDWFDFMATHQSEPKNTVVVSPHPKTSGENMASKISNSTSQGKEKSEPGQRSKVDIGLLPSPGETGVPWRADNVESNKKKRLALDSEAAVSADKPDSVLTHHVPRNLQKLCKERAQKLCRNSTRVPAQCTVPSHPQSTPVHSPDRMLDSPKRKRPKSLAQVEEPAIENVKPPGSPVAKLAKFTFKQKSKLIHSFEDHSHVSPGATKIAVHSPKISQRRTRRDAALPVKRPGKLTSTPGNQISSQPQGETKEVSQQPPEKHGPREKVMCAPEKRIIQPELELGNETGCAHLTCEGDKKEEVSGSNKSGKVHACTLARLANFCFTPPSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKLIVSKESLFTLPELGDEAFDCDWDEEMRKKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
79PhosphorylationALRRSALTILQSLSQ
HHHHHHHHHHHHCCC		21.2524719451
83PhosphorylationSALTILQSLSQPEAV
HHHHHHHHCCCHHHH		26.9224719451
85PhosphorylationLTILQSLSQPEAVSM
HHHHHHCCCHHHHHC		49.27-
91PhosphorylationLSQPEAVSMKQNLHA
CCCHHHHHCCCCHHH		27.5824719451
93UbiquitinationQPEAVSMKQNLHARI
CHHHHHCCCCHHHHH		28.64-
137UbiquitinationVIRTSLVKVLEFERD
EEEHHHHHHHHHHHH		46.53-
191PhosphorylationTCLSGLSSSPTRCRD
EECCCCCCCCCCCCC		45.4325627689
192PhosphorylationCLSGLSSSPTRCRDY
ECCCCCCCCCCCCCH		27.2425627689
215PhosphorylationVQRLSVGSIPRSMKV
HHHHCCCCCCCCCEE		27.5428188228
249UbiquitinationGIVMQRWKPFQQDVR
EEEECCCCCCCCCCC		37.84-
296 (in isoform 2)Ubiquitination-47.7021906983
296UbiquitinationEDFWEYYKSDPFAGR
HHHHHHHHCCCCCCC		47.702190698
296 (in isoform 1)Ubiquitination-47.7021906983
309PhosphorylationGRNVILASLCPQVFG
CCCHHHHHHCHHHHH		27.36-
318PhosphorylationCPQVFGMYLVKLAVA
CHHHHHHHHHHHHHH		14.55-
346PhosphorylationGTRVRGESHLLLVGD
CCEEECEEEEEEEEC		23.4322210691
356PhosphorylationLLVGDPGTGKSQFLK
EEEECCCCCHHHHHH		46.9922210691
358UbiquitinationVGDPGTGKSQFLKYA
EECCCCCHHHHHHHH		40.70-
367UbiquitinationQFLKYAAKITPRSVL
HHHHHHCCCCCCCCE		38.65-
372PhosphorylationAAKITPRSVLTTGIG
HCCCCCCCCEECCCC		23.7628270605
375PhosphorylationITPRSVLTTGIGSTS
CCCCCCEECCCCCCC		22.3328270605
376PhosphorylationTPRSVLTTGIGSTSA
CCCCCEECCCCCCCC		23.7328270605
380PhosphorylationVLTTGIGSTSAGLTV
CEECCCCCCCCCEEE		19.7828270605
381PhosphorylationLTTGIGSTSAGLTVT
EECCCCCCCCCEEEE		19.8628270605
382PhosphorylationTTGIGSTSAGLTVTA
ECCCCCCCCCEEEEE		23.2628270605
425PhosphorylationSLKEHDRTSIHEAME
CCCCCCCCCHHHHHH		37.7821888424
426PhosphorylationLKEHDRTSIHEAMEQ
CCCCCCCCHHHHHHH		23.8821888424
440UbiquitinationQQTISVAKAGLVCKL
HHCHHHHHHCEEEEE		40.61-
446UbiquitinationAKAGLVCKLNTRTTI
HHHCEEEEECCCCEE		36.97-
502PhosphorylationEDWDRIISSFILENK
CCHHHHHHHHHHHCC		19.4727461979
503PhosphorylationDWDRIISSFILENKG
CHHHHHHHHHHHCCC		13.0927461979
509UbiquitinationSSFILENKGYPSKSE
HHHHHHCCCCCCHHH		50.90-
511PhosphorylationFILENKGYPSKSEKL
HHHHCCCCCCHHHHH		13.1227461979
513PhosphorylationLENKGYPSKSEKLWS
HHCCCCCCHHHHHCC		40.0927461979
515PhosphorylationNKGYPSKSEKLWSME
CCCCCCHHHHHCCHH		44.28-
659PhosphorylationLERLQNQSVHQSQPR
HHHHHHCCCCCCCCC		29.1727732954
663PhosphorylationQNQSVHQSQPRVLEV
HHCCCCCCCCCEEEE		27.5527732954
672PhosphorylationPRVLEVETTPGSLRN
CCEEEEECCCCCCCC		43.3930001349
673PhosphorylationRVLEVETTPGSLRNG
CEEEEECCCCCCCCC		16.4921815630
676PhosphorylationEVETTPGSLRNGPGE
EEECCCCCCCCCCCC		25.9230001349
698PhosphorylationSQQEINYSTHIFSPG
CCCEEEEEEEEECCC		14.7130175587
703PhosphorylationNYSTHIFSPGGSPEG
EEEEEEECCCCCCCC		23.2526074081
707PhosphorylationHIFSPGGSPEGSPVL
EEECCCCCCCCCCCC		26.2026074081
711PhosphorylationPGGSPEGSPVLDPPP
CCCCCCCCCCCCCCC		15.3530175587
741PhosphorylationHKNNRDDSLDWFDFM
CCCCCCCCCCHHHHH		32.3028348404
762PhosphorylationPKNTVVVSPHPKTSG
CCCEEEECCCCCCCC		13.0925159151
777PhosphorylationENMASKISNSTSQGK
CCHHHHHHCCCCCCC		28.5923403867
779PhosphorylationMASKISNSTSQGKEK
HHHHHHCCCCCCCCC		23.7323403867
780PhosphorylationASKISNSTSQGKEKS
HHHHHCCCCCCCCCC		29.3523403867
781PhosphorylationSKISNSTSQGKEKSE
HHHHCCCCCCCCCCC		36.4323403867
802PhosphorylationVDIGLLPSPGETGVP
EEEEECCCCCCCCCC		45.5729978859
806PhosphorylationLLPSPGETGVPWRAD
ECCCCCCCCCCCCCC		49.7727732954
871PhosphorylationTRVPAQCTVPSHPQS
CCCCCCCCCCCCCCC		24.3027732954
874PhosphorylationPAQCTVPSHPQSTPV
CCCCCCCCCCCCCCC		43.3929978859
878PhosphorylationTVPSHPQSTPVHSPD
CCCCCCCCCCCCCCC		38.8525159151
879PhosphorylationVPSHPQSTPVHSPDR
CCCCCCCCCCCCCCC		24.8825159151
883PhosphorylationPQSTPVHSPDRMLDS
CCCCCCCCCCCCCCC		28.8225159151
890PhosphorylationSPDRMLDSPKRKRPK
CCCCCCCCCCCCCCC		28.4927422710
898PhosphorylationPKRKRPKSLAQVEEP
CCCCCCCCHHHCCCH		31.4625159151
915PhosphorylationENVKPPGSPVAKLAK
HCCCCCCCHHHHHHE		23.2130266825
934PhosphorylationQKSKLIHSFEDHSHV
CCCCEEEEECCCCCC		24.2826425664
939PhosphorylationIHSFEDHSHVSPGAT
EEEECCCCCCCCCCC		37.6028348404
942PhosphorylationFEDHSHVSPGATKIA
ECCCCCCCCCCCEEE		16.5225159151
946PhosphorylationSHVSPGATKIAVHSP
CCCCCCCCEEEEECC		28.9722468782
952PhosphorylationATKIAVHSPKISQRR
CCEEEEECCCHHCCC		22.6829396449
975PhosphorylationVKRPGKLTSTPGNQI
CCCCCCCCCCCCCCC		33.7628270605
976PhosphorylationKRPGKLTSTPGNQIS
CCCCCCCCCCCCCCC		42.9425627689
977PhosphorylationRPGKLTSTPGNQISS
CCCCCCCCCCCCCCC		29.9428985074
983PhosphorylationSTPGNQISSQPQGET
CCCCCCCCCCCCCCC		17.1028270605
984PhosphorylationTPGNQISSQPQGETK
CCCCCCCCCCCCCCC		47.7328270605
990PhosphorylationSSQPQGETKEVSQQP
CCCCCCCCCCHHCCC		39.0528270605
994PhosphorylationQGETKEVSQQPPEKH
CCCCCCHHCCCCHHC		24.9628270605
1013AcetylationKVMCAPEKRIIQPEL
HCCCCCCCCEECCCH		48.0825953088
1064PhosphorylationRLANFCFTPPSESKS
HHHHHCCCCCCCCCC		35.1625159151
1067PhosphorylationNFCFTPPSESKSKSP
HHCCCCCCCCCCCCC		56.5625627689
1069PhosphorylationCFTPPSESKSKSPPP
CCCCCCCCCCCCCCC		46.7118669648
1071PhosphorylationTPPSESKSKSPPPER
CCCCCCCCCCCCCCC		47.8724719451
1073PhosphorylationPSESKSKSPPPERKN
CCCCCCCCCCCCCCC		50.1328985074
1087PhosphorylationNRGERGPSSPPTTTA
CCCCCCCCCCCCCCC		59.3030266825
1088PhosphorylationRGERGPSSPPTTTAP
CCCCCCCCCCCCCCC		37.7223401153
1091PhosphorylationRGPSSPPTTTAPMRV
CCCCCCCCCCCCCCC		39.9130266825
1092PhosphorylationGPSSPPTTTAPMRVS
CCCCCCCCCCCCCCC		27.0830266825
1093PhosphorylationPSSPPTTTAPMRVSK
CCCCCCCCCCCCCCC		31.1030266825
1103PhosphorylationMRVSKRKSFQLRGST
CCCCCCCCEECCCCC		23.4323186163
1107MethylationKRKSFQLRGSTEKLI
CCCCEECCCCCCEEE		26.66115483033
1109PhosphorylationKSFQLRGSTEKLIVS
CCEECCCCCCEEEEE		27.2725849741
1110PhosphorylationSFQLRGSTEKLIVSK
CEECCCCCCEEEEEH		39.7128450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MCM9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MCM9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MCM9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MCM8_HUMANMCM8physical
26186194
MCM8_HUMANMCM8physical
28514442
MCM9_HUMANMCM9physical
22771115
MSH6_HUMANMSH6physical
26870752
PMS1_HUMANPMS1physical
26870752
MLH1_HUMANMLH1physical
26870752
MSH3_HUMANMSH3physical
26870752
MSH2_HUMANMSH2physical
26870752
RFC2_HUMANRFC2physical
26870752
RFC3_HUMANRFC3physical
26870752
RFC4_HUMANRFC4physical
26870752
RFC5_HUMANRFC5physical
26870752
MCM8_HUMANMCM8physical
26870752
RUVB1_HUMANRUVBL1physical
26870752
SK2L2_HUMANSKIV2L2physical
26870752
NOP56_HUMANNOP56physical
26870752
DDX47_HUMANDDX47physical
26870752
NOP58_HUMANNOP58physical
26870752
API5_HUMANAPI5physical
26870752
SF3B6_HUMANSF3B6physical
26870752
PFKAP_HUMANPFKPphysical
26870752
HORM1_HUMANHORMAD1physical
26870752
NFIL3_HUMANNFIL3physical
26870752
PSDE_HUMANPSMD14physical
26870752
WRIP1_HUMANWRNIP1physical
26870752
MCM8_HUMANMCM8physical
26215093
NBN_HUMANNBNphysical
26215093
MRE11_HUMANMRE11Aphysical
26215093
RAD50_HUMANRAD50physical
26215093
MCM8_HUMANMCM8physical
26300262
MSH2_HUMANMSH2physical
26300262
RFC4_HUMANRFC4physical
26300262
MLH1_HUMANMLH1physical
26300262
PMS1_HUMANPMS1physical
26300262
RFC2_HUMANRFC2physical
26300262
RFC3_HUMANRFC3physical
26300262
RFC5_HUMANRFC5physical
26300262
RUVB1_HUMANRUVBL1physical
26300262
WRIP1_HUMANWRNIP1physical
26300262
HORM1_HUMANHORMAD1physical
26300262
SF3B6_HUMANSF3B6physical
26300262
PFKAP_HUMANPFKPphysical
26300262
NOP58_HUMANNOP58physical
26300262
DDX47_HUMANDDX47physical
26300262
API5_HUMANAPI5physical
26300262
NOP56_HUMANNOP56physical
26300262
PSDE_HUMANPSMD14physical
26300262
NFIL3_HUMANNFIL3physical
26300262
MSH3_HUMANMSH3physical
26300262
SK2L2_HUMANSKIV2L2physical
26300262
MSH6_HUMANMSH6physical
26300262
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616185Ovarian dysgenesis 4 (ODG4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MCM9_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1088, AND MASSSPECTROMETRY.

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