HORM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HORM1_HUMAN
• UniProt AC: Q86X24
• Protein Name: HORMA domain-containing protein 1 {ECO:0000312|HGNC:HGNC:25245}
• Gene Name: HORMAD1 {ECO:0000312|HGNC:HGNC:25245}
• Organism: Homo sapiens (Human).
• Sequence Length: 394
• Subcellular Localization: Nucleus . Chromosome . Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 i
• Protein Description: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes..
• Protein Sequence: MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPLMDFISKNQSNESSMLSTDTKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMENIDSTILSPKQIKTPFQKILRDKDVEDEQEHYTSDDLDIETKMEEQEKNPASSELEEPSLVCEEDEIMRSKESPDLSISHSQVEQLVNKTSELDMSESKTRSGKVFQNKMANGNQPVKSSKENRKRSQHESGRIVLHHFDSSSQESVPKRRKFSEPKEHI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ATAQLQRTPMSALVF CCCCCCCCCCCEEEC	15.47	23403867
12	Phosphorylation	QLQRTPMSALVFPNK CCCCCCCCEEECCCC	21.47	23403867
21	Phosphorylation	LVFPNKISTEHQSLV EECCCCCCHHHHHHH	29.38	23532336
22	Phosphorylation	VFPNKISTEHQSLVL ECCCCCCHHHHHHHH	40.74	26270265
26	Phosphorylation	KISTEHQSLVLVKRL CCCHHHHHHHHHHHH	23.50	26270265
136	Phosphorylation	DFISKNQSNESSMLS HHHHCCCCCCCCCCC	52.54	29083192
139	Phosphorylation	SKNQSNESSMLSTDT HCCCCCCCCCCCCCC	25.87	29083192
140	Phosphorylation	KNQSNESSMLSTDTK CCCCCCCCCCCCCCH	19.98	29083192
143	Phosphorylation	SNESSMLSTDTKKAS CCCCCCCCCCCHHHH	18.65	29083192
144	Phosphorylation	NESSMLSTDTKKASI CCCCCCCCCCHHHHH	43.67	29083192
146	Phosphorylation	SSMLSTDTKKASILL CCCCCCCCHHHHHHH	34.24	29083192
150	Phosphorylation	STDTKKASILLIRKI CCCCHHHHHHHHHHH	23.73	-
239	Phosphorylation	RMENIDSTILSPKQI HHHCCCCCCCCHHHC	23.38	28348404
242	Phosphorylation	NIDSTILSPKQIKTP CCCCCCCCHHHCCCC	26.63	21815630
304	Phosphorylation	EEDEIMRSKESPDLS CHHHHHHCCCCCCCC	24.32	23663014
307	Phosphorylation	EIMRSKESPDLSISH HHHHCCCCCCCCCCH	27.70	23663014
311	Phosphorylation	SKESPDLSISHSQVE CCCCCCCCCCHHHHH	29.44	23663014
313	Phosphorylation	ESPDLSISHSQVEQL CCCCCCCCHHHHHHH	17.45	23663014
315	Phosphorylation	PDLSISHSQVEQLVN CCCCCCHHHHHHHHH	29.18	23663014
365	Phosphorylation	RKRSQHESGRIVLHH HCCCCHHCCCEEEEC	31.11	-
375	Phosphorylation	IVLHHFDSSSQESVP EEEECCCCCCCCCCC	30.83	27732954
376	Phosphorylation	VLHHFDSSSQESVPK EEECCCCCCCCCCCC	37.57	27732954
377	Phosphorylation	LHHFDSSSQESVPKR EECCCCCCCCCCCCC	41.75	27732954
380	Phosphorylation	FDSSSQESVPKRRKF CCCCCCCCCCCCCCC	35.76	27732954
388	Phosphorylation	VPKRRKFSEPKEHI- CCCCCCCCCCCCCC-	56.90	29214152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HORM1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
377	S	Phosphorylation	Phosphorylated at Ser-377 in a SPO11-dependent manner.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HORM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	25184681

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.