| UniProt ID | PMS1_HUMAN | |
|---|---|---|
| UniProt AC | P54277 | |
| Protein Name | PMS1 protein homolog 1 | |
| Gene Name | PMS1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 932 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Probably involved in the repair of mismatches in DNA.. | |
| Protein Sequence | MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEGIKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQYVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLTYLPETT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Ubiquitination | ------MKQLPAATV ------CCCCCHHHH | 61.62 | - | |
| 8 | Phosphorylation | MKQLPAATVRLLSSS CCCCCHHHHHHHCHH | 14.31 | - | |
| 13 | Phosphorylation | AATVRLLSSSQIITS HHHHHHHCHHHHHHH | 32.32 | - | |
| 14 | Phosphorylation | ATVRLLSSSQIITSV HHHHHHCHHHHHHHH | 26.65 | - | |
| 43 | Ubiquitination | GATSVDVKLENYGFD CCCEEEEEEECCCCC | 45.69 | 21906983 | |
| 51 | Ubiquitination | LENYGFDKIEVRDNG EECCCCCEEEEEECC | 38.21 | - | |
| 62 | Ubiquitination | RDNGEGIKAVDAPVM EECCCCCEECCCCEE | 53.89 | - | |
| 72 | Ubiquitination | DAPVMAMKYYTSKIN CCCEEEHHHHHHCCC | 26.10 | - | |
| 77 | Ubiquitination | AMKYYTSKINSHEDL EHHHHHHCCCCHHHH | 37.80 | - | |
| 147 | Ubiquitination | GTTVTALRLFKNLPV CCCHHHHHHHHCCCH | 35.30 | 21906983 | |
| 150 | Ubiquitination | VTALRLFKNLPVRKQ HHHHHHHHCCCHHHH | 63.27 | - | |
| 156 | Ubiquitination | FKNLPVRKQFYSTAK HHCCCHHHHHHHHHH | 45.02 | - | |
| 200 | Ubiquitination | NKAVIWQKSRVSDHK CCEEEEECCCCCHHH | 25.82 | - | |
| 204 | Phosphorylation | IWQKSRVSDHKMALM EEECCCCCHHHHHHH | 32.65 | - | |
| 270 | Ubiquitination | NSRPVHQKDILKLIR CCCCCCHHHHHHHHH | 31.68 | - | |
| 274 | Succinylation | VHQKDILKLIRHHYN CCHHHHHHHHHHHCC | 42.05 | 27452117 | |
| 274 | Acetylation | VHQKDILKLIRHHYN CCHHHHHHHHHHHCC | 42.05 | 25953088 | |
| 280 | Phosphorylation | LKLIRHHYNLKCLKE HHHHHHHCCHHHHHH | 18.96 | - | |
| 283 | Ubiquitination | IRHHYNLKCLKESTR HHHHCCHHHHHHCCC | 33.61 | - | |
| 311 | Phosphorylation | ADVDVNLTPDKSQVL CCCCCCCCCCHHHHH | 25.00 | 25159151 | |
| 314 | Ubiquitination | DVNLTPDKSQVLLQN CCCCCCCHHHHHHCC | 43.95 | - | |
| 315 | Phosphorylation | VNLTPDKSQVLLQNK CCCCCCHHHHHHCCC | 32.66 | 24961811 | |
| 354 | Phosphorylation | ENNKTDVSAADIVLS CCCCCCCCHHHHHCC | 22.13 | 28555341 | |
| 362 | Ubiquitination | AADIVLSKTAETDVL HHHHHCCCCCCCHHH | 47.82 | 21906983 | |
| 372 | Sumoylation | ETDVLFNKVESSGKN CCHHHHHHHHCCCCC | 39.79 | - | |
| 372 | Sumoylation | ETDVLFNKVESSGKN CCHHHHHHHHCCCCC | 39.79 | - | |
| 372 | Ubiquitination | ETDVLFNKVESSGKN CCHHHHHHHHCCCCC | 39.79 | - | |
| 378 | Ubiquitination | NKVESSGKNYSNVDT HHHHCCCCCCCCCCC | 55.44 | - | |
| 380 | Phosphorylation | VESSGKNYSNVDTSV HHCCCCCCCCCCCCE | 12.71 | 27642862 | |
| 416 (in isoform 4) | Phosphorylation | - | 7.38 | 29083192 | |
| 419 (in isoform 4) | Phosphorylation | - | 18.72 | 29083192 | |
| 442 | Phosphorylation | AFQDISMSNVSWENS HCHHHCCCCCCCCCC | 27.56 | 28450419 | |
| 445 | Phosphorylation | DISMSNVSWENSQTE HHCCCCCCCCCCCCC | 32.68 | 28450419 | |
| 449 | Phosphorylation | SNVSWENSQTEYSKT CCCCCCCCCCCEECE | 27.28 | 28450419 | |
| 451 | Phosphorylation | VSWENSQTEYSKTCF CCCCCCCCCEECEEE | 36.39 | 28450419 | |
| 453 | Phosphorylation | WENSQTEYSKTCFIS CCCCCCCEECEEEEE | 20.89 | 28450419 | |
| 454 | Phosphorylation | ENSQTEYSKTCFISS CCCCCCEECEEEEEE | 18.43 | 28450419 | |
| 505 | Sumoylation | WSRGNILKNSVGENI HHHCCHHHCCCCCCC | 43.30 | - | |
| 505 | Ubiquitination | WSRGNILKNSVGENI HHHCCHHHCCCCCCC | 43.30 | - | |
| 505 | Methylation | WSRGNILKNSVGENI HHHCCHHHCCCCCCC | 43.30 | 110871769 | |
| 505 | Sumoylation | WSRGNILKNSVGENI HHHCCHHHCCCCCCC | 43.30 | - | |
| 507 | Phosphorylation | RGNILKNSVGENIEP HCCHHHCCCCCCCCC | 29.88 | 25159151 | |
| 517 | Ubiquitination | ENIEPVKILVPEKSL CCCCCEEEEEECCCC | 4.83 | 21906983 | |
| 522 | Acetylation | VKILVPEKSLPCKVS EEEEEECCCCCCCCC | 51.74 | 23749302 | |
| 563 | Phosphorylation | KSGKVTAYDLLSNRV CCCCEEHHHHHHCCC | 9.58 | 28796482 | |
| 567 | Phosphorylation | VTAYDLLSNRVIKKP EEHHHHHHCCCCCCC | 29.86 | 28796482 | |
| 620 | Phosphorylation | SEEEKLKYEEKATKD CHHHHHHHHHHHHHH | 39.49 | - | |
| 626 | Methylation | KYEEKATKDLERYNS HHHHHHHHHHHHHHH | 66.24 | 116252439 | |
| 631 (in isoform 2) | Phosphorylation | - | 15.13 | 29083192 | |
| 634 (in isoform 2) | Phosphorylation | - | 37.47 | 29083192 | |
| 645 | Sulfoxidation | AIEQESQMSLKDGRK HHHHHHHCCHHCCCC | 7.64 | 21406390 | |
| 670 | Phosphorylation | AQKHKLKTSLSNQPK HHHHCCCHHHCCCCC | 45.39 | 28450419 | |
| 671 | Phosphorylation | QKHKLKTSLSNQPKL HHHCCCHHHCCCCCH | 28.36 | 28450419 | |
| 673 | Phosphorylation | HKLKTSLSNQPKLDE HCCCHHHCCCCCHHH | 32.94 | 28450419 | |
| 684 | Phosphorylation | KLDELLQSQIEKRRS CHHHHHHHHHHHHHH | 32.85 | 29523821 | |
| 688 | Ubiquitination | LLQSQIEKRRSQNIK HHHHHHHHHHHCCCE | 55.53 | 21906983 | |
| 702 | Phosphorylation | KMVQIPFSMKNLKIN EEEEECCCCCCCEEC | 24.40 | 24719451 | |
| 721 | Ubiquitination | NKVDLEEKDEPCLIH CCCCCCCCCCCCEEE | 59.00 | - | |
| 802 | Phosphorylation | MTADDQRYSGSTYLS EECCCCCCCCCCCCC | 16.26 | 23663014 | |
| 803 | Phosphorylation | TADDQRYSGSTYLSD ECCCCCCCCCCCCCC | 28.58 | 23663014 | |
| 805 | Phosphorylation | DDQRYSGSTYLSDPR CCCCCCCCCCCCCCC | 14.13 | 23663014 | |
| 806 | Phosphorylation | DQRYSGSTYLSDPRL CCCCCCCCCCCCCCE | 31.82 | 23663014 | |
| 807 | Phosphorylation | QRYSGSTYLSDPRLT CCCCCCCCCCCCCEE | 13.10 | 23663014 | |
| 809 | Phosphorylation | YSGSTYLSDPRLTAN CCCCCCCCCCCEECC | 34.84 | 23663014 | |
| 863 | Acetylation | AILNRNAKEVYECRP HHHCCCCCHHHHCCC | 51.79 | 7662953 | |
| 875 | Phosphorylation | CRPRKVISYLEGEAV CCCHHHHHHHHHHHH | 27.01 | - | |
| 885 | Phosphorylation | EGEAVRLSRQLPMYL HHHHHHHHHHHCCCC | 13.86 | - | |
| 891 | Phosphorylation | LSRQLPMYLSKEDIQ HHHHHCCCCCHHHHH | 13.09 | - | |
| 893 | Phosphorylation | RQLPMYLSKEDIQDI HHHCCCCCHHHHHHH | 19.26 | - | |
| 894 | Acetylation | QLPMYLSKEDIQDII HHCCCCCHHHHHHHH | 57.73 | 20167786 | |
| 894 | Ubiquitination | QLPMYLSKEDIQDII HHCCCCCHHHHHHHH | 57.73 | 2190698 | |
| 905 | Acetylation | QDIIYRMKHQFGNEI HHHHHHHHHHHCHHH | 25.84 | 20167786 | |
| 913 | Ubiquitination | HQFGNEIKECVHGRP HHHCHHHHHHHCCCC | 38.59 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PMS1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PMS1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PMS1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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