PSD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD2_HUMAN
• UniProt AC: Q9BQI7
• Protein Name: PH and SEC7 domain-containing protein 2
• Gene Name: PSD2
• Organism: Homo sapiens (Human).
• Sequence Length: 771
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Cell projection, ruffle membrane . Cleavage furrow . In interphase associated with the plasma membrane, in particular with membrane ruffling regions. In cells undergoing cytokinesis, transiently found ar
• Protein Sequence: MEEDKLLSAVPEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADTEEPTKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAEDPQLGLDGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPLTPLIQQRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSLMAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIKVGSDDLERIEARLATLEGDDPSLRKTHSSPALSQGHVTGSKTTKDATGPDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEEDKLLSAVPEEGD CCHHHHHHCCCCCCC	37.34	27251275
17	Phosphorylation	VPEEGDATRDPGPEP CCCCCCCCCCCCCCC	40.10	27251275
155	Phosphorylation	ELLRGTQYSSLDSLD HHHCCCCCCCCCCCC	10.48	29759185
156	Phosphorylation	LLRGTQYSSLDSLDG HHCCCCCCCCCCCCC	18.01	29759185
157	Phosphorylation	LRGTQYSSLDSLDGL HCCCCCCCCCCCCCC	31.12	29759185
191	Phosphorylation	IQQRARDSPEPGAGL HHHHHHCCCCCCCCC	26.13	25921289
220	Phosphorylation	GGDGELGSPLRRSIS CCCCCCCCCCHHHHC	33.13	25921289
225	Phosphorylation	LGSPLRRSISSSRSE CCCCCHHHHCCCCCH	22.01	23312004
227	Phosphorylation	SPLRRSISSSRSENV CCCHHHHCCCCCHHH	24.41	24275569
228	Phosphorylation	PLRRSISSSRSENVL CCHHHHCCCCCHHHH	28.27	23312004
229	Phosphorylation	LRRSISSSRSENVLS CHHHHCCCCCHHHHH	32.79	23312004
231	Phosphorylation	RSISSSRSENVLSRL HHHCCCCCHHHHHHH	35.16	23312004
272	Phosphorylation	DTDKLLNSASDPSLK HHHHHHHHCCCHHHC	29.17	29970186
274	Phosphorylation	DKLLNSASDPSLKDG HHHHHHCCCHHHCCC	50.29	26846344
277	Phosphorylation	LNSASDPSLKDGLSD HHHCCCHHHCCCCCC	53.71	25022875
476	Phosphorylation	DEDELRKSLSELVDD CHHHHHHHHHHHHHC	30.60	19664994
478	Phosphorylation	DELRKSLSELVDDKF HHHHHHHHHHHHCCC	35.66	30266825
487	Phosphorylation	LVDDKFGTGTKKVTR HHHCCCCCCCCEEEE	44.82	30266825
489	Phosphorylation	DDKFGTGTKKVTRIL HCCCCCCCCEEEEEC	27.77	23312004
493	Phosphorylation	GTGTKKVTRILDGGN CCCCCEEEEECCCCC	22.37	23312004
523	Phosphorylation	HGVLTRKTHADMDGK CCEEECCCCCCCCCC	21.00	24719451
532	Phosphorylation	ADMDGKRTPRGRRGW CCCCCCCCCCCCCHH	22.33	24719451
552	Phosphorylation	VLKGTILYLQKDEYR HHHHHEEEEECCCCC	11.84	20049867
628	Phosphorylation	NLVAAIFSAPAFPAA HHHHHHHHCCCCHHH	27.51	-
637	Phosphorylation	PAFPAAVSSMKKFCR CCCHHHHHHHHHHHH	21.71	-
638	Phosphorylation	AFPAAVSSMKKFCRP CCHHHHHHHHHHHHH	28.20	-
649	Phosphorylation	FCRPLLPSCTTRLCQ HHHHHCCHHHHHHHH	24.86	-
651	Phosphorylation	RPLLPSCTTRLCQEE HHHCCHHHHHHHHHH	21.20	-
652	Phosphorylation	PLLPSCTTRLCQEEQ HHCCHHHHHHHHHHH	26.43	-
671	Phosphorylation	ENKLRQLTAELAEHR HHHHHHHHHHHHHHC	15.11	18452278
735	Phosphorylation	RIEARLATLEGDDPS HHHHHHHHHCCCCHH	29.90	29978859
742	Phosphorylation	TLEGDDPSLRKTHSS HHCCCCHHHHHCCCC	48.04	29978859
746	Phosphorylation	DDPSLRKTHSSPALS CCHHHHHCCCCCCCC	22.13	29978859
748	Phosphorylation	PSLRKTHSSPALSQG HHHHHCCCCCCCCCC	43.16	29978859
749	Phosphorylation	SLRKTHSSPALSQGH HHHHCCCCCCCCCCC	13.44	29978859
753	Phosphorylation	THSSPALSQGHVTGS CCCCCCCCCCCCCCC	35.90	29978859
758	Phosphorylation	ALSQGHVTGSKTTKD CCCCCCCCCCCCCCC	30.02	29978859
760	Phosphorylation	SQGHVTGSKTTKDAT CCCCCCCCCCCCCCC	19.91	29978859
762	Phosphorylation	GHVTGSKTTKDATGP CCCCCCCCCCCCCCC	40.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PSD2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.