dbPTM

RFC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RFC1_HUMAN
UniProt AC	P35251
Protein Name	Replication factor C subunit 1
Gene Name	RFC1
Organism	Homo sapiens (Human).
Sequence Length	1148
Subcellular Localization	Nucleus.
Protein Description	The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.; Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair..
Protein Sequence	MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAIETDAMIKKKTKSSKPSKPEKDKEPRKGKGKSSKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	KFFGVIPSGKKLVSE HHCCCCCCCCCHHHH	52.71	25159151
14	2-Hydroxyisobutyrylation	FGVIPSGKKLVSETV CCCCCCCCCHHHHHH	47.47	-
14	Acetylation	FGVIPSGKKLVSETV CCCCCCCCCHHHHHH	47.47	25953088
14	Ubiquitination	FGVIPSGKKLVSETV CCCCCCCCCHHHHHH	47.47	27667366
15	Acetylation	GVIPSGKKLVSETVK CCCCCCCCHHHHHHH	58.61	25953088
27	Phosphorylation	TVKKNEKTKSDEETL HHHHCCCCCCHHHHH	29.60	28176443
29	Phosphorylation	KKNEKTKSDEETLKA HHCCCCCCHHHHHHH	56.33	25849741
33	Phosphorylation	KTKSDEETLKAKKGI CCCCHHHHHHHHHCC	31.35	28176443
41	Acetylation	LKAKKGIKEIKVNSS HHHHHCCCEEECCCC	63.15	25953088
50	Sumoylation	IKVNSSRKEDDFKQK EECCCCCCCCCCCCC	68.40	25772364
55	Ubiquitination	SRKEDDFKQKQPSKK CCCCCCCCCCCCCCC	64.68	24816145
60	Phosphorylation	DFKQKQPSKKKRIIY CCCCCCCCCCCCEEE	55.39	26074081
67	Phosphorylation	SKKKRIIYDSDSESE CCCCCEEECCCCCCH	13.66	29255136
67 (in isoform 2)	Phosphorylation	-	13.66	-
69	Phosphorylation	KKRIIYDSDSESEET CCCEEECCCCCCHHH	26.51	29255136
69 (in isoform 2)	Phosphorylation	-	26.51	-
71	Phosphorylation	RIIYDSDSESEETLQ CEEECCCCCCHHHHC	47.15	29255136
71 (in isoform 2)	Phosphorylation	-	47.15	-
73	Phosphorylation	IYDSDSESEETLQVK EECCCCCCHHHHCCC	44.69	29255136
73 (in isoform 2)	Phosphorylation	-	44.69	-
76	Phosphorylation	SDSESEETLQVKNAK CCCCCHHHHCCCCCC	20.59	30266825
76 (in isoform 2)	Phosphorylation	-	20.59	-
92	Phosphorylation	PPEKLPVSSKPGKIS CCHHCCCCCCCCCCC	30.61	25627689
93	Phosphorylation	PEKLPVSSKPGKISR CHHCCCCCCCCCCCC	43.00	28555341
94	Acetylation	EKLPVSSKPGKISRQ HHCCCCCCCCCCCCC	50.73	25953088
97	Acetylation	PVSSKPGKISRQDPV CCCCCCCCCCCCCCC	46.14	25953088
97	Ubiquitination	PVSSKPGKISRQDPV CCCCCCCCCCCCCCC	46.14	29967540
99	Phosphorylation	SSKPGKISRQDPVTY CCCCCCCCCCCCCCE	27.63	20068231
99 (in isoform 2)	Phosphorylation	-	27.63	-
105	Phosphorylation	ISRQDPVTYISETDE CCCCCCCCEEECCCC	22.11	30266825
105 (in isoform 2)	Phosphorylation	-	22.11	-
106	Phosphorylation	SRQDPVTYISETDEE CCCCCCCEEECCCCC	11.59	30266825
108	Phosphorylation	QDPVTYISETDEEDD CCCCCEEECCCCCCC	24.83	22167270
108 (in isoform 2)	Phosphorylation	-	24.83	-
110	Phosphorylation	PVTYISETDEEDDFM CCCEEECCCCCCCHH	41.75	22167270
110 (in isoform 2)	Phosphorylation	-	41.75	-
123	Phosphorylation	FMCKKAASKSKENGR HHHHHHHHCCHHCCC	42.18	20860994
131	Phosphorylation	KSKENGRSTNSHLGT CCHHCCCCCCCCCCC	33.08	-
134	Phosphorylation	ENGRSTNSHLGTSNM HCCCCCCCCCCCCCC	21.85	30576142
138	Phosphorylation	STNSHLGTSNMKKNE CCCCCCCCCCCCCCC	24.24	25627689
139	Phosphorylation	TNSHLGTSNMKKNEE CCCCCCCCCCCCCCC	32.88	25159151
142	Acetylation	HLGTSNMKKNEENTK CCCCCCCCCCCCCCC	57.61	25953088
148	Phosphorylation	MKKNEENTKTKNKPL CCCCCCCCCCCCCCC	43.29	30576142
149	Acetylation	KKNEENTKTKNKPLS CCCCCCCCCCCCCCC	69.91	30585933
150	Phosphorylation	KNEENTKTKNKPLSP CCCCCCCCCCCCCCC	37.50	26074081
153	Acetylation	ENTKTKNKPLSPIKL CCCCCCCCCCCCCCC	49.22	30585939
156	Phosphorylation	KTKNKPLSPIKLTPT CCCCCCCCCCCCCCC	32.86	25159151
156 (in isoform 2)	Phosphorylation	-	32.86	-
161	Phosphorylation	PLSPIKLTPTSVLDY CCCCCCCCCCCHHHH	21.37	23927012
161 (in isoform 2)	Phosphorylation	-	21.37	-
163	Phosphorylation	SPIKLTPTSVLDYFG CCCCCCCCCHHHHHC	26.65	23927012
163 (in isoform 2)	Phosphorylation	-	26.65	-
164	Phosphorylation	PIKLTPTSVLDYFGT CCCCCCCCHHHHHCC	23.14	25159151
164 (in isoform 2)	Phosphorylation	-	23.14	-
168	Phosphorylation	TPTSVLDYFGTGSVQ CCCCHHHHHCCCCCC	10.35	23927012
168 (in isoform 2)	Phosphorylation	-	10.35	-
171	Phosphorylation	SVLDYFGTGSVQRSN CHHHHHCCCCCCCCC	19.18	23927012
171 (in isoform 2)	Phosphorylation	-	19.18	-
173	Phosphorylation	LDYFGTGSVQRSNKK HHHHCCCCCCCCCHH	18.21	25159151
173 (in isoform 2)	Phosphorylation	-	18.21	-
177	Phosphorylation	GTGSVQRSNKKMVAS CCCCCCCCCHHHHHH	35.59	25159151
185	Ubiquitination	NKKMVASKRKELSQN CHHHHHHHHHHHHCC	58.72	24816145
190	Phosphorylation	ASKRKELSQNTDESG HHHHHHHHCCCCCCC	23.60	29255136
190 (in isoform 2)	Phosphorylation	-	23.60	-
193	Phosphorylation	RKELSQNTDESGLND HHHHHCCCCCCCCCH	33.24	30266825
193 (in isoform 2)	Phosphorylation	-	33.24	-
196	Phosphorylation	LSQNTDESGLNDEAI HHCCCCCCCCCHHHH	51.93	30266825
217	Ubiquitination	DEDAELERQLHEDEE CCHHHHHHHHHCCHH	57.92	21963094
234	Ubiquitination	RTLAMLDEEPKTKKA HHHHHHCCCCCCCCC	72.70	22817900
237	Ubiquitination	AMLDEEPKTKKARKD HHHCCCCCCCCCCCC	76.02	21906983
237 (in isoform 1)	Ubiquitination	-	76.02	21890473
237 (in isoform 2)	Ubiquitination	-	76.02	21890473
239	Ubiquitination	LDEEPKTKKARKDTE HCCCCCCCCCCCCCC	51.03	22817900
240	Ubiquitination	DEEPKTKKARKDTEA CCCCCCCCCCCCCCC	59.67	22817900
243	Ubiquitination	PKTKKARKDTEAGET CCCCCCCCCCCCHHC	74.08	21906983
243 (in isoform 1)	Ubiquitination	-	74.08	21890473
243 (in isoform 2)	Ubiquitination	-	74.08	21890473
245	Phosphorylation	TKKARKDTEAGETFS CCCCCCCCCCHHCHH	30.67	26133373
245	Ubiquitination	TKKARKDTEAGETFS CCCCCCCCCCHHCHH	30.67	27667366
250	Phosphorylation	KDTEAGETFSSVQAN CCCCCHHCHHHHHHH	28.09	28555341
253	Phosphorylation	EAGETFSSVQANLSK CCHHCHHHHHHHHHH	17.66	28555341
259	Phosphorylation	SSVQANLSKAEKHKY HHHHHHHHHHHHCCC	29.63	21712546
260	Acetylation	SVQANLSKAEKHKYP HHHHHHHHHHHCCCC	64.83	25953088
260	Ubiquitination	SVQANLSKAEKHKYP HHHHHHHHHHHCCCC	64.83	21906983
260 (in isoform 1)	Ubiquitination	-	64.83	21890473
260 (in isoform 2)	Ubiquitination	-	64.83	21890473
263	Ubiquitination	ANLSKAEKHKYPHKV HHHHHHHHCCCCCCC	50.70	22817900
265	Ubiquitination	LSKAEKHKYPHKVKT HHHHHHCCCCCCCEE	72.11	22817900
271	Ubiquitination	HKYPHKVKTAQVSDE CCCCCCCEECCCCCC	42.84	27667366
272	Phosphorylation	KYPHKVKTAQVSDER CCCCCCEECCCCCCC	25.88	21712546
276	Phosphorylation	KVKTAQVSDERKSYS CCEECCCCCCCCCCC	22.98	21712546
281	Phosphorylation	QVSDERKSYSPRKQS CCCCCCCCCCCCHHH	36.74	26055452
281 (in isoform 2)	Phosphorylation	-	36.74	-
282	Phosphorylation	VSDERKSYSPRKQSK CCCCCCCCCCCHHHH	26.23	20068231
283	Phosphorylation	SDERKSYSPRKQSKY CCCCCCCCCCHHHHH	25.89	26055452
283 (in isoform 2)	Phosphorylation	-	25.89	-
302	Phosphorylation	ESQQHSKSSADKIGE HHHHHCHHHHHHHHC	33.50	24732914
303	Phosphorylation	SQQHSKSSADKIGEV HHHHCHHHHHHHHCC	44.20	24732914
306	Acetylation	HSKSSADKIGEVSSP HCHHHHHHHHCCCCC	52.94	25953088
306	Ubiquitination	HSKSSADKIGEVSSP HCHHHHHHHHCCCCC	52.94	-
311	Phosphorylation	ADKIGEVSSPKASSK HHHHHCCCCCCHHHH	36.30	23401153
312	Phosphorylation	DKIGEVSSPKASSKL HHHHCCCCCCHHHHH	35.28	29255136
312 (in isoform 2)	Phosphorylation	-	35.28	-
313	Ubiquitination	KIGEVSSPKASSKLA HHHCCCCCCHHHHHH	28.82	24816145
316	Phosphorylation	EVSSPKASSKLAIMK CCCCCCHHHHHHHHH	33.85	26074081
317	Phosphorylation	VSSPKASSKLAIMKR CCCCCHHHHHHHHHC	36.23	26074081
318	Acetylation	SSPKASSKLAIMKRK CCCCHHHHHHHHHCC	39.17	25953088
318	Ubiquitination	SSPKASSKLAIMKRK CCCCHHHHHHHHHCC	39.17	29967540
323	Methylation	SSKLAIMKRKEESSY HHHHHHHHCCCCCCC	54.96	116252259
325	Ubiquitination	KLAIMKRKEESSYKE HHHHHHCCCCCCCCC	61.38	-
328	Phosphorylation	IMKRKEESSYKEIEP HHHCCCCCCCCCCCC	39.81	28796482
329	Phosphorylation	MKRKEESSYKEIEPV HHCCCCCCCCCCCCC	43.43	28796482
330	Phosphorylation	KRKEESSYKEIEPVA HCCCCCCCCCCCCCC	23.17	28796482
331	Acetylation	RKEESSYKEIEPVAS CCCCCCCCCCCCCCC	54.91	26051181
331	Ubiquitination	RKEESSYKEIEPVAS CCCCCCCCCCCCCCC	54.91	-
339	Acetylation	EIEPVASKRKENAIK CCCCCCCCCHHHCCC	58.72	25953088
339	Ubiquitination	EIEPVASKRKENAIK CCCCCCCCCHHHCCC	58.72	24816145
353	Phosphorylation	KLKGETKTPKKTKSS CCCCCCCCCCCCCCC	48.00	24719451
357	Phosphorylation	ETKTPKKTKSSPAKK CCCCCCCCCCCCCCC	42.14	26074081
359	Phosphorylation	KTPKKTKSSPAKKES CCCCCCCCCCCCCCC	46.95	18669648
359 (in isoform 2)	Phosphorylation	-	46.95	-
360	Phosphorylation	TPKKTKSSPAKKESV CCCCCCCCCCCCCCC	30.36	28985074
366	Phosphorylation	SSPAKKESVSPEDSE CCCCCCCCCCHHHHH	36.45	30266825
368	Phosphorylation	PAKKESVSPEDSEKK CCCCCCCCHHHHHHH	31.67	29255136
368 (in isoform 2)	Phosphorylation	-	31.67	-
372	Phosphorylation	ESVSPEDSEKKRTNY CCCCHHHHHHHHHHH	50.05	22167270
379	Phosphorylation	SEKKRTNYQAYRSYL HHHHHHHHHHHHHHH	8.23	-
382	Phosphorylation	KRTNYQAYRSYLNRE HHHHHHHHHHHHCCC	5.65	-
384	Phosphorylation	TNYQAYRSYLNREGP HHHHHHHHHHCCCCC	22.69	28555341
396	Phosphorylation	EGPKALGSKEIPKGA CCCCCCCCCCCCCCH	28.15	20363803
432	Ubiquitination	EAKSLIERYGGKVTG HHHHHHHHHCCEEEC	28.53	22817900
435	Ubiquitination	SLIERYGGKVTGNVS HHHHHHCCEEECCCC	16.60	22817900
436	Ubiquitination	LIERYGGKVTGNVSK HHHHHCCEEECCCCC	32.06	-
442	Ubiquitination	GKVTGNVSKKTNYLV CEEECCCCCCCCEEE	32.22	33845483
443	Acetylation	KVTGNVSKKTNYLVM EEECCCCCCCCEEEE	60.37	12656497
447	Phosphorylation	NVSKKTNYLVMGRDS CCCCCCCEEEEECCC	13.10	22210691
454	Phosphorylation	YLVMGRDSGQSKSDK EEEEECCCCCCHHHH	37.05	22210691
457	Phosphorylation	MGRDSGQSKSDKAAA EECCCCCCHHHHHHH	37.34	22210691
458	Ubiquitination	GRDSGQSKSDKAAAL ECCCCCCHHHHHHHH	55.58	22817900
459	Phosphorylation	RDSGQSKSDKAAALG CCCCCCHHHHHHHHC	49.98	27251275
461	Acetylation	SGQSKSDKAAALGTK CCCCHHHHHHHHCCE	47.19	25953088
461	Ubiquitination	SGQSKSDKAAALGTK CCCCHHHHHHHHCCE	47.19	22817900
461 (in isoform 1)	Ubiquitination	-	47.19	21890473
461 (in isoform 2)	Ubiquitination	-	47.19	21890473
467	Phosphorylation	DKAAALGTKIIDEDG HHHHHHCCEEECCCC	21.66	27251275
468	Ubiquitination	KAAALGTKIIDEDGL HHHHHCCEEECCCCH	35.55	21906983
468 (in isoform 1)	Ubiquitination	-	35.55	21890473
468 (in isoform 2)	Ubiquitination	-	35.55	21890473
486	Acetylation	IRTMPGKKSKYEIAV HHCCCCCCCHHEEEE	59.08	7261903
488	Acetylation	TMPGKKSKYEIAVET CCCCCCCHHEEEEEC	56.64	7261913
488	Ubiquitination	TMPGKKSKYEIAVET CCCCCCCHHEEEEEC	56.64	24816145
489	Phosphorylation	MPGKKSKYEIAVETE CCCCCCHHEEEEECH	21.47	20068231
498	Sumoylation	IAVETEMKKESKLER EEEECHHHHHHHCCC	47.35	-
498	Ubiquitination	IAVETEMKKESKLER EEEECHHHHHHHCCC	47.35	-
506	Phosphorylation	KESKLERTPQKNVQG HHHHCCCCCCCCCCC	22.24	23401153
506 (in isoform 2)	Phosphorylation	-	22.24	-
509	Acetylation	KLERTPQKNVQGKRK HCCCCCCCCCCCCCC	61.36	7664335
514	Acetylation	PQKNVQGKRKISPSK CCCCCCCCCCCCCCH	33.17	2380553
514	Ubiquitination	PQKNVQGKRKISPSK CCCCCCCCCCCCCCH	33.17	24816145
518	Phosphorylation	VQGKRKISPSKKESE CCCCCCCCCCHHHCC	26.59	28102081
518 (in isoform 2)	Phosphorylation	-	26.59	-
520	Phosphorylation	GKRKISPSKKESESK CCCCCCCCHHHCCCC	49.96	23403867
520 (in isoform 2)	Phosphorylation	-	49.96	-
525	Ubiquitination	SPSKKESESKKSRPT CCCHHHCCCCCCCCC	68.61	21890473
530	Ubiquitination	ESESKKSRPTSKRDS HCCCCCCCCCCHHHH	47.60	22817900
537	Phosphorylation	RPTSKRDSLAKTIKK CCCCHHHHHHHHHHH	33.97	28176443
542	Ubiquitination	RDSLAKTIKKETDVF HHHHHHHHHHHHHHH	6.22	33845483
551	Ubiquitination	KETDVFWKSLDFKEQ HHHHHHHHHCCHHHH	29.67	22817900
551 (in isoform 1)	Ubiquitination	-	29.67	21890473
551 (in isoform 2)	Ubiquitination	-	29.67	21890473
552	Phosphorylation	ETDVFWKSLDFKEQV HHHHHHHHCCHHHHH	24.62	29978859
556	Sumoylation	FWKSLDFKEQVAEET HHHHCCHHHHHHHHC	47.07	-
556	Ubiquitination	FWKSLDFKEQVAEET HHHHCCHHHHHHHHC	47.07	21906983
556 (in isoform 1)	Ubiquitination	-	47.07	21890473
556 (in isoform 2)	Ubiquitination	-	47.07	21890473
563	Phosphorylation	KEQVAEETSGDSKAR HHHHHHHCCCCHHHH	29.52	25850435
564	Phosphorylation	EQVAEETSGDSKARN HHHHHHCCCCHHHHH	43.83	25849741
567	Phosphorylation	AEETSGDSKARNLAD HHHCCCCHHHHHCCC	31.57	25850435
568	Sumoylation	EETSGDSKARNLADD HHCCCCHHHHHCCCC	56.98	-
568	Sumoylation	EETSGDSKARNLADD HHCCCCHHHHHCCCC	56.98	-
568	Ubiquitination	EETSGDSKARNLADD HHCCCCHHHHHCCCC	56.98	21906983
568 (in isoform 1)	Ubiquitination	-	56.98	21890473
568 (in isoform 2)	Ubiquitination	-	56.98	21890473
572	Ubiquitination	GDSKARNLADDSSEN CCHHHHHCCCCCCCC	4.63	21890473
576	Phosphorylation	ARNLADDSSENKVEN HHHCCCCCCCCCHHH	39.85	20873877
577	Phosphorylation	RNLADDSSENKVENL HHCCCCCCCCCHHHH	52.78	20873877
580	Acetylation	ADDSSENKVENLLWV CCCCCCCCHHHHEEE	47.04	26051181
580	Ubiquitination	ADDSSENKVENLLWV CCCCCCCCHHHHEEE	47.04	29967540
589	Ubiquitination	ENLLWVDKYKPTSLK HHHEEECCCCCCCHH	45.62	29967540
596	Ubiquitination	KYKPTSLKTIIGQQG CCCCCCHHHHCCCCC	37.13	29967540
597	Phosphorylation	YKPTSLKTIIGQQGD CCCCCHHHHCCCCCC	24.10	27732954
606	Phosphorylation	IGQQGDQSCANKLLR CCCCCCHHHHHHHHH	21.67	27732954
610	Acetylation	GDQSCANKLLRWLRN CCHHHHHHHHHHHHH	30.30	23749302
610	Ubiquitination	GDQSCANKLLRWLRN CCHHHHHHHHHHHHH	30.30	-
618	Ubiquitination	LLRWLRNWQKSSSED HHHHHHHHHHCCHHH	10.67	21890473
619	Ubiquitination	LRWLRNWQKSSSEDK HHHHHHHHHCCHHHH	39.02	21890473
633	Acetylation	KKHAAKFGKFSGKDD HHHHHHHHCCCCCCC	29.41	19608861
633 (in isoform 2)	Acetylation	-	29.41	-
634	Acetylation	KHAAKFGKFSGKDDG HHHHHHHCCCCCCCC	39.22	19608861
636	Phosphorylation	AAKFGKFSGKDDGSS HHHHHCCCCCCCCCC	48.71	28555341
638	Acetylation	KFGKFSGKDDGSSFK HHHCCCCCCCCCCHH	51.99	23749302
638	Ubiquitination	KFGKFSGKDDGSSFK HHHCCCCCCCCCCHH	51.99	29967540
644	Ubiquitination	GKDDGSSFKAALLSG CCCCCCCHHHHHHHC	7.17	21890473
644 (in isoform 2)	Ubiquitination	-	7.17	21890473
645	Methylation	KDDGSSFKAALLSGP CCCCCCHHHHHHHCC	34.40	42366681
645	Ubiquitination	KDDGSSFKAALLSGP CCCCCCHHHHHHHCC	34.40	22817900
645 (in isoform 1)	Ubiquitination	-	34.40	21890473
656	Ubiquitination	LSGPPGVGKTTTASL HHCCCCCCHHHHHHH	27.75	27667366
664	Ubiquitination	KTTTASLVCQELGYS HHHHHHHHHHHHCCC	2.68	24816145
670	Phosphorylation	LVCQELGYSYVELNA HHHHHHCCCEEEECC	14.95	17053785
672	Phosphorylation	CQELGYSYVELNASD HHHHCCCEEEECCCC	6.89	17053785
675	Ubiquitination	LGYSYVELNASDTRS HCCCEEEECCCCCCC	4.65	24816145
687	Ubiquitination	TRSKSSLKAIVAESL CCCHHHHHHHHHHHC	37.71	-
693	Phosphorylation	LKAIVAESLNNTSIK HHHHHHHHCCCCCCC	27.02	21406692
697	Phosphorylation	VAESLNNTSIKGFYS HHHHCCCCCCCCCCC	30.65	21406692
698	Phosphorylation	AESLNNTSIKGFYSN HHHCCCCCCCCCCCC	25.15	21406692
700	Ubiquitination	SLNNTSIKGFYSNGA HCCCCCCCCCCCCCC	42.61	-
703	Phosphorylation	NTSIKGFYSNGAASS CCCCCCCCCCCCCCC	15.19	22210691
709	Phosphorylation	FYSNGAASSVSTKHA CCCCCCCCCCCCCCE	30.64	22210691
710	Phosphorylation	YSNGAASSVSTKHAL CCCCCCCCCCCCCEE	18.50	22210691
713	Phosphorylation	GAASSVSTKHALIMD CCCCCCCCCCEEEEC	25.37	25367160
715	Ubiquitination	ASSVSTKHALIMDEV CCCCCCCCEEEECCC	26.34	21890473
716	Ubiquitination	SSVSTKHALIMDEVD CCCCCCCEEEECCCC	10.59	21890473
741	Ubiquitination	IQELIGLIKHTKIPI HHHHHHHHHCCCCCE	2.31	21890473
741 (in isoform 2)	Ubiquitination	-	2.31	21890473
742	Acetylation	QELIGLIKHTKIPII HHHHHHHHCCCCCEE	50.71	25953088
742	Ubiquitination	QELIGLIKHTKIPII HHHHHHHHCCCCCEE	50.71	21890473
742 (in isoform 1)	Ubiquitination	-	50.71	21890473
799	Ubiquitination	GLKIPPPAMNEIILG CCCCCCCHHHHHHHC	21.14	27667366
800	Ubiquitination	LKIPPPAMNEIILGA CCCCCCHHHHHHHCC	5.96	27667366
807	Ubiquitination	MNEIILGANQDIRQV HHHHHHCCCHHHHHH	13.68	24816145
808	Ubiquitination	NEIILGANQDIRQVL HHHHHCCCHHHHHHH	37.95	24816145
818	Ubiquitination	IRQVLHNLSMWCARS HHHHHHHHHHHHHHC	2.30	24816145
819	Ubiquitination	RQVLHNLSMWCARSK HHHHHHHHHHHHHCC	18.63	24816145
825	Ubiquitination	LSMWCARSKALTYDQ HHHHHHHCCCCCHHH	12.07	27667366
826	Ubiquitination	SMWCARSKALTYDQA HHHHHHCCCCCHHHH	41.69	27667366
833	Ubiquitination	KALTYDQAKADSHRA CCCCHHHHHHHHHHH	13.20	24816145
834	Ubiquitination	ALTYDQAKADSHRAK CCCHHHHHHHHHHHH	47.28	24816145
844	Ubiquitination	SHRAKKDIKMGPFDV HHHHHCCCCCCHHHH	4.55	24816145
845	Ubiquitination	HRAKKDIKMGPFDVA HHHHCCCCCCHHHHH	48.19	24816145
909	Phosphorylation	KKHLMLLSRAADSIC HHHHHHHHHHHHHHC	18.86	-
914	Phosphorylation	LLSRAADSICDGDLV HHHHHHHHHCCCCCC	22.01	20873877
932	Phosphorylation	IRSKQNWSLLPAQAI HHHHCCCCCCCHHHH	27.81	-
952	Phosphorylation	PGELMRGYMTQFPTF CHHHHCCHHCCCCCC	6.14	22210691
958	Phosphorylation	GYMTQFPTFPSWLGK CHHCCCCCCHHHCCC	49.84	22210691
958	Ubiquitination	GYMTQFPTFPSWLGK CHHCCCCCCHHHCCC	49.84	23503661
961	Ubiquitination	TQFPTFPSWLGKHSS CCCCCCHHHCCCCCC	30.64	25015289
964	Ubiquitination	PTFPSWLGKHSSTGK CCCHHHCCCCCCCCC	21.26	23503661
966	Ubiquitination	FPSWLGKHSSTGKHD CHHHCCCCCCCCCCH	25.78	25015289
968	Phosphorylation	SWLGKHSSTGKHDRI HHCCCCCCCCCCHHH	40.68	22210691
969	Phosphorylation	WLGKHSSTGKHDRIV HCCCCCCCCCCHHHH	53.95	22210691
970	Ubiquitination	LGKHSSTGKHDRIVQ CCCCCCCCCCHHHHH	27.52	23503661
986	Dimethylation	LALHMSLRTYSSKRT HHHHHHHHCCCCCCC	25.06	-
986	Methylation	LALHMSLRTYSSKRT HHHHHHHHCCCCCCC	25.06	115372793
991	Acetylation	SLRTYSSKRTVNMDY HHHCCCCCCCCCHHH	46.26	30585945
1047	Ubiquitination	EISSWGGKPSPFSKL HHHHCCCCCCCHHHC	38.08	-
1053	Ubiquitination	GKPSPFSKLDPKVKA CCCCCHHHCCHHHHH	58.24	-
1057	Ubiquitination	PFSKLDPKVKAAFTR CHHHCCHHHHHHHHH	56.91	-
1063	Phosphorylation	PKVKAAFTRAYNKEA HHHHHHHHHHHCCCC	15.06	20068231
1073	Phosphorylation	YNKEAHLTPYSLQAI HCCCCCCCHHHHHHH	15.43	25159151
1075	Phosphorylation	KEAHLTPYSLQAIKA CCCCCCHHHHHHHHH	19.44	28122231
1076	Phosphorylation	EAHLTPYSLQAIKAS CCCCCHHHHHHHHHH	18.40	25159151
1080	Ubiquitination	TPYSLQAIKASRHST CHHHHHHHHHHCCCC	2.18	29967540
1081	Acetylation	PYSLQAIKASRHSTS HHHHHHHHHHCCCCC	43.24	25953088
1081	Ubiquitination	PYSLQAIKASRHSTS HHHHHHHHHHCCCCC	43.24	29967540
1083	Phosphorylation	SLQAIKASRHSTSPS HHHHHHHHCCCCCCC	26.06	28555341
1086	Phosphorylation	AIKASRHSTSPSLDS HHHHHCCCCCCCCCH	29.48	30576142
1087	Phosphorylation	IKASRHSTSPSLDSE HHHHCCCCCCCCCHH	38.23	18452278
1087 (in isoform 2)	Phosphorylation	-	38.23	-
1088	Phosphorylation	KASRHSTSPSLDSEY HHHCCCCCCCCCHHH	18.59	30576142
1089 (in isoform 2)	Phosphorylation	-	38.71	-
1090	Phosphorylation	SRHSTSPSLDSEYNE HCCCCCCCCCHHHHH	44.57	27362937
1092 (in isoform 2)	Phosphorylation	-	43.70	-
1093	Phosphorylation	STSPSLDSEYNEELN CCCCCCCHHHHHHHC	47.47	28450419
1094 (in isoform 2)	Phosphorylation	-	52.63	-
1095	Phosphorylation	SPSLDSEYNEELNED CCCCCHHHHHHHCCC	31.65	28450419
1101	Ubiquitination	EYNEELNEDDSQSDE HHHHHHCCCCCCCCH	75.67	23503661
1102	Ubiquitination	YNEELNEDDSQSDEK HHHHHCCCCCCCCHH	60.84	23503661
1103 (in isoform 2)	Phosphorylation	-	42.26	-
1104	Phosphorylation	EELNEDDSQSDEKDQ HHHCCCCCCCCHHHH	43.86	20164059
1104	Ubiquitination	EELNEDDSQSDEKDQ HHHCCCCCCCCHHHH	43.86	25015289
1105	Ubiquitination	ELNEDDSQSDEKDQD HHCCCCCCCCHHHHH	62.99	25015289
1105 (in isoform 2)	Phosphorylation	-	62.99	-
1106	Phosphorylation	LNEDDSQSDEKDQDA HCCCCCCCCHHHHHH	52.25	25159151
1107	Ubiquitination	NEDDSQSDEKDQDAI CCCCCCCCHHHHHHH	60.37	23503661
1108	Ubiquitination	EDDSQSDEKDQDAIE CCCCCCCHHHHHHHH	64.87	23503661
1109	Ubiquitination	DDSQSDEKDQDAIET CCCCCCHHHHHHHHH	66.72	25015289
1110	Ubiquitination	DSQSDEKDQDAIETD CCCCCHHHHHHHHHH	49.93	25015289
1113	Ubiquitination	SDEKDQDAIETDAMI CCHHHHHHHHHHHHH	8.90	23503661
1114	Ubiquitination	DEKDQDAIETDAMIK CHHHHHHHHHHHHHH	8.67	23503661
1116	Phosphorylation	KDQDAIETDAMIKKK HHHHHHHHHHHHHHH	23.97	20873877
1127	Ubiquitination	IKKKTKSSKPSKPEK HHHHCCCCCCCCCCC	50.57	23503661
1128	Ubiquitination	KKKTKSSKPSKPEKD HHHCCCCCCCCCCCC	61.47	23503661
1130	Ubiquitination	KTKSSKPSKPEKDKE HCCCCCCCCCCCCCC	65.66	25015289
1131	Ubiquitination	TKSSKPSKPEKDKEP CCCCCCCCCCCCCCC	66.77	25015289
1133	Ubiquitination	SSKPSKPEKDKEPRK CCCCCCCCCCCCCCC	77.08	23503661
1133 (in isoform 2)	Ubiquitination	-	77.08	-
1134	Ubiquitination	SKPSKPEKDKEPRKG CCCCCCCCCCCCCCC	80.68	23503661
1135	Ubiquitination	KPSKPEKDKEPRKGK CCCCCCCCCCCCCCC	59.91	25015289
1136	Ubiquitination	PSKPEKDKEPRKGKG CCCCCCCCCCCCCCC	79.34	25015289
1139	Ubiquitination	PEKDKEPRKGKGKSS CCCCCCCCCCCCCCC	62.54	23503661
1140	Ubiquitination	EKDKEPRKGKGKSSK CCCCCCCCCCCCCCC	75.57	23503661
1145	Phosphorylation	PRKGKGKSSKK---- CCCCCCCCCCC----	56.93	-
1146	Phosphorylation	RKGKGKSSKK----- CCCCCCCCCC-----	48.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
506	T	Phosphorylation	Kinase	CDK1	P06493	PSP
506	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
518	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RFC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RFC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	12045192
BRD4_HUMAN	BRD4	physical	12192049
PCNA_HUMAN	PCNA	physical	12192049
PCNA_HUMAN	PCNA	physical	8861969
PCNA_HUMAN	PCNA	physical	8999859
P53_HUMAN	TP53	physical	12509469
TF65_HUMAN	RELA	physical	12509469
RAD17_HUMAN	RAD17	physical	18245774
CTF18_HUMAN	CHTF18	physical	18245774
RFC2_HUMAN	RFC2	physical	18245774
RFC3_HUMAN	RFC3	physical	18245774
RFC4_HUMAN	RFC4	physical	18245774
RFC5_HUMAN	RFC5	physical	18245774
SSBP3_HUMAN	SSBP3	physical	20211142
ZSCA1_HUMAN	ZSCAN1	physical	20211142
RAD17_HUMAN	RAD17	physical	12400013
RFC3_HUMAN	RFC3	physical	22939629
RFC2_HUMAN	RFC2	physical	22939629
RFC4_HUMAN	RFC4	physical	22939629
RFC5_HUMAN	RFC5	physical	22939629
WDR18_HUMAN	WDR18	physical	22939629
PCNA_HUMAN	PCNA	physical	9092549
PCNA_HUMAN	PCNA	physical	15225546
GLYR1_HUMAN	GLYR1	physical	26344197
PCNA_HUMAN	PCNA	physical	26344197
PDS5A_HUMAN	PDS5A	physical	26344197
RGAP1_HUMAN	RACGAP1	physical	26344197
RFC2_HUMAN	RFC2	physical	26344197
RFC3_HUMAN	RFC3	physical	26344197
RFC4_HUMAN	RFC4	physical	26344197
RFC5_HUMAN	RFC5	physical	26344197
SMC1A_HUMAN	SMC1A	physical	26344197
SMC2_HUMAN	SMC2	physical	26344197
SMC4_HUMAN	SMC4	physical	26344197
XRCC5_HUMAN	XRCC5	physical	26344197
XRCC6_HUMAN	XRCC6	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RFC1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-634, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-71; SER-156;THR-161; THR-163; SER-164 AND SER-173, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-67; SER-69; SER-71;SER-73 AND SER-312, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-71; SER-73;SER-108; THR-110; SER-156; THR-161; SER-164; THR-171; SER-173;SER-190; SER-281; SER-283 AND SER-312, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161 AND SER-173, ANDMASS SPECTROMETRY.	16565220 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-71 AND SER-73,AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-73 AND SER-156,AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-71; SER-108 ANDSER-190, AND MASS SPECTROMETRY.	15302935 [Abstract]
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-670 AND TYR-672, ANDMASS SPECTROMETRY.	17053785 [Abstract]