dbPTM

SMC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMC4_HUMAN
UniProt AC	Q9NTJ3
Protein Name	Structural maintenance of chromosomes protein 4
Gene Name	SMC4
Organism	Homo sapiens (Human).
Sequence Length	1288
Subcellular Localization	Nucleus . Cytoplasm . Chromosome . In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chro
Protein Description	Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases..
Protein Sequence	MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEEILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVAVNPKEIASKGLC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MPRKGTQPSTA ----CCCCCCCCCCC	76.63	116253841
6	Phosphorylation	--MPRKGTQPSTARR --CCCCCCCCCCCCC	40.10	25137130
22	Phosphorylation	EEGPPPPSPDGASSD CCCCCCCCCCCCCCC	41.20	29255136
27	Phosphorylation	PPSPDGASSDAEPEP CCCCCCCCCCCCCCC	33.99	29255136
28	Phosphorylation	PSPDGASSDAEPEPP CCCCCCCCCCCCCCC	40.06	29255136
36	Phosphorylation	DAEPEPPSGRTESPA CCCCCCCCCCCCCCC	52.18	30266825
39	Phosphorylation	PEPPSGRTESPATAA CCCCCCCCCCCCHHH	44.32	22167270
41	Phosphorylation	PPSGRTESPATAAET CCCCCCCCCCHHHHH	21.15	19664994
44	Phosphorylation	GRTESPATAAETASE CCCCCCCHHHHHHCH	29.77	19664994
48	Phosphorylation	SPATAAETASEELDN CCCHHHHHHCHHHCC	30.66	23927012
50	Phosphorylation	ATAAETASEELDNRS CHHHHHHCHHHCCCC	38.74	30266825
57	Phosphorylation	SEELDNRSLEEILNS CHHHCCCCHHHHHHC	46.52	20873877
85	Phosphorylation	GAPRLMITHIVNQNF CCCCEEEEHHHCCCH	7.50	-
93	Methylation	HIVNQNFKSYAGEKI HHHCCCHHHHCCCCC	50.54	100328913
93	Ubiquitination	HIVNQNFKSYAGEKI HHHCCCHHHHCCCCC	50.54	-
99	Ubiquitination	FKSYAGEKILGPFHK HHHHCCCCCCCCCCC	42.17	-
106	Acetylation	KILGPFHKRFSCIIG CCCCCCCCCEEEEEC	56.36	25953088
106	Ubiquitination	KILGPFHKRFSCIIG CCCCCCCCCEEEEEC	56.36	-
109	Phosphorylation	GPFHKRFSCIIGPNG CCCCCCEEEEECCCC	14.40	-
119	Methylation	IGPNGSGKSNVIDSM ECCCCCCCCCHHHHH	40.32	115980899
120	Phosphorylation	GPNGSGKSNVIDSML CCCCCCCCCHHHHHH	39.59	21406692
125	Phosphorylation	GKSNVIDSMLFVFGY CCCCHHHHHHHHHHH	13.27	21406692
132	Phosphorylation	SMLFVFGYRAQKIRS HHHHHHHHHHHHHHH	7.42	21406692
141	Ubiquitination	AQKIRSKKLSVLIHN HHHHHHCCEEEEEEC	47.44	-
143	Phosphorylation	KIRSKKLSVLIHNSD HHHHCCEEEEEECCC	24.61	25159151
149	Phosphorylation	LSVLIHNSDEHKDIQ EEEEEECCCCCCCHH	30.16	25159151
153	Ubiquitination	IHNSDEHKDIQSCTV EECCCCCCCHHHCEE	55.25	-
170	Ubiquitination	HFQKIIDKEGDDYEV EEEEHHHCCCCCCEE	53.86	-
175	Phosphorylation	IDKEGDDYEVIPNSN HHCCCCCCEECCCCC	19.48	25147952
184	Phosphorylation	VIPNSNFYVSRTACR ECCCCCEEEEEEEEC	11.19	29496907
188	Phosphorylation	SNFYVSRTACRDNTS CCEEEEEEEECCCCE	23.70	-
194	Phosphorylation	RTACRDNTSVYHISG EEEECCCCEEEEEEC	24.69	28152594
195	Phosphorylation	TACRDNTSVYHISGK EEECCCCEEEEEECC	27.25	28152594
197	Phosphorylation	CRDNTSVYHISGKKK ECCCCEEEEEECCCC	8.00	28152594
200	Phosphorylation	NTSVYHISGKKKTFK CCEEEEEECCCCCHH	31.11	28152594
202	2-Hydroxyisobutyrylation	SVYHISGKKKTFKDV EEEEEECCCCCHHHH	44.28	-
202	Acetylation	SVYHISGKKKTFKDV EEEEEECCCCCHHHH	44.28	25953088
202	Ubiquitination	SVYHISGKKKTFKDV EEEEEECCCCCHHHH	44.28	21890473
202 (in isoform 1)	Ubiquitination	-	44.28	21890473
202 (in isoform 2)	Ubiquitination	-	44.28	21890473
203	Ubiquitination	VYHISGKKKTFKDVG EEEEECCCCCHHHHH	61.65	-
204	Ubiquitination	YHISGKKKTFKDVGN EEEECCCCCHHHHHH	63.78	-
207	Acetylation	SGKKKTFKDVGNLLR ECCCCCHHHHHHHHH	57.65	25953088
207	Ubiquitination	SGKKKTFKDVGNLLR ECCCCCHHHHHHHHH	57.65	21890473
207 (in isoform 1)	Ubiquitination	-	57.65	21890473
207 (in isoform 2)	Ubiquitination	-	57.65	21890473
214	Methylation	KDVGNLLRSHGIDLD HHHHHHHHHCCCCCC	29.76	115917257
239	Ubiquitination	VEQIAMMKPKGQTEH EEEEEECCCCCCCCC	30.41	-
241	Ubiquitination	QIAMMKPKGQTEHDE EEEECCCCCCCCCCH	59.12	-
250	Sulfoxidation	QTEHDEGMLEYLEDI CCCCCHHHHHHHHHH	2.12	30846556
268	Acetylation	GRLNEPIKVLCRRVE CCCCHHHHHHHHHHH	39.61	23749302
268	Ubiquitination	GRLNEPIKVLCRRVE CCCCHHHHHHHHHHH	39.61	-
281	Methylation	VEILNEHRGEKLNRV HHHHHHCCCCCCCCC	49.11	115917261
284	Acetylation	LNEHRGEKLNRVKMV HHHCCCCCCCCCEEE	54.61	26051181
289	2-Hydroxyisobutyrylation	GEKLNRVKMVEKEKD CCCCCCCEEEHHHHH	33.71	-
293	Ubiquitination	NRVKMVEKEKDALEG CCCEEEHHHHHHHHC	59.67	-
319	2-Hydroxyisobutyrylation	ENEIFRKKNHVCQYY CHHHHHCCCCHHHHH	48.29	-
332	Ubiquitination	YYIYELQKRIAEMET HHHHHHHHHHHHHHH	59.40	-
341	Ubiquitination	IAEMETQKEKIHEDT HHHHHHHHHHHHHHH	69.28	-
343	Ubiquitination	EMETQKEKIHEDTKE HHHHHHHHHHHHHHH	57.30	-
348	Phosphorylation	KEKIHEDTKEINEKS HHHHHHHHHHHHHHH	27.82	20860994
349	Acetylation	EKIHEDTKEINEKSN HHHHHHHHHHHHHHC	69.76	23749302
349	Ubiquitination	EKIHEDTKEINEKSN HHHHHHHHHHHHHHC	69.76	-
354	2-Hydroxyisobutyrylation	DTKEINEKSNILSNE HHHHHHHHHCCCCHH	44.29	-
354	Acetylation	DTKEINEKSNILSNE HHHHHHHHHCCCCHH	44.29	19827019
354	Ubiquitination	DTKEINEKSNILSNE HHHHHHHHHCCCCHH	44.29	-
355	Phosphorylation	TKEINEKSNILSNEM HHHHHHHHCCCCHHH	23.95	19691289
363	Acetylation	NILSNEMKAKNKDVK CCCCHHHHHCCCCHH	50.45	25953088
363	Ubiquitination	NILSNEMKAKNKDVK CCCCHHHHHCCCCHH	50.45	-
381	Acetylation	KKLNKITKFIEENKE HHHHHHHHHHHHCHH	48.06	19608861
381	Ubiquitination	KKLNKITKFIEENKE HHHHHHHHHHHHCHH	48.06	19608861
387	Acetylation	TKFIEENKEKFTQLD HHHHHHCHHHHHCCC	66.61	25953088
389	Ubiquitination	FIEENKEKFTQLDLE HHHHCHHHHHCCCHH	56.15	21890473
389 (in isoform 1)	Ubiquitination	-	56.15	21890473
389 (in isoform 2)	Ubiquitination	-	56.15	21890473
409	Phosphorylation	EKLKHATSKAKKLEK HHHHHHHHHHHHHHH	31.25	25367160
413	Ubiquitination	HATSKAKKLEKQLQK HHHHHHHHHHHHHHH	67.73	21890473
413 (in isoform 1)	Ubiquitination	-	67.73	21890473
413 (in isoform 2)	Ubiquitination	-	67.73	21890473
416	Acetylation	SKAKKLEKQLQKDKE HHHHHHHHHHHHHHH	67.74	23749302
416	Ubiquitination	SKAKKLEKQLQKDKE HHHHHHHHHHHHHHH	67.74	-
434	Ubiquitination	EFKSIPAKSNNIINE HHHCCCCCCCCCCCC	48.65	-
444	Phosphorylation	NIINETTTRNNALEK CCCCCCCHHCHHHHH	38.53	21601212
464	Sulfoxidation	EKKLKEVMDSLKQET HHHHHHHHHHHHHHH	2.80	21406390
466	Phosphorylation	KLKEVMDSLKQETQG HHHHHHHHHHHHHHH	21.26	28985074
483	Acetylation	KEKESREKELMGFSK HHHHHHHHHHHHHHH	55.85	25953088
489	Phosphorylation	EKELMGFSKSVNEAR HHHHHHHHHHHHHHH	20.49	-
490	Acetylation	KELMGFSKSVNEARS HHHHHHHHHHHHHHH	57.04	25953088
511	Phosphorylation	SELDIYLSRHNTAVS HHHHHHHHCCCHHHH	17.96	30257219
515	Phosphorylation	IYLSRHNTAVSQLTK HHHHCCCHHHHHHHH	23.47	21406692
518	Phosphorylation	SRHNTAVSQLTKAKE HCCCHHHHHHHHHHH	19.60	21406692
521	Phosphorylation	NTAVSQLTKAKEALI CHHHHHHHHHHHHHH	22.71	21406692
522	2-Hydroxyisobutyrylation	TAVSQLTKAKEALIA HHHHHHHHHHHHHHH	67.08	-
522	Ubiquitination	TAVSQLTKAKEALIA HHHHHHHHHHHHHHH	67.08	-
524	2-Hydroxyisobutyrylation	VSQLTKAKEALIAAS HHHHHHHHHHHHHCH	45.11	-
531	Phosphorylation	KEALIAASETLKERK HHHHHHCHHHHHHHH	23.30	-
533	Phosphorylation	ALIAASETLKERKAA HHHHCHHHHHHHHHH	40.40	-
547	Ubiquitination	AIRDIEGKLPQTEQE HHHHHCCCCCHHHHH	44.17	-
551	Phosphorylation	IEGKLPQTEQELKEK HCCCCCHHHHHHHHH	37.38	25003641
564	Acetylation	EKEKELQKLTQEETN HHHHHHHHHHHHHHH	67.15	23236377
564	Ubiquitination	EKEKELQKLTQEETN HHHHHHHHHHHHHHH	67.15	-
573	2-Hydroxyisobutyrylation	TQEETNFKSLVHDLF HHHHHHHHHHHHHHH	44.97	-
573	Acetylation	TQEETNFKSLVHDLF HHHHHHHHHHHHHHH	44.97	23954790
573	Ubiquitination	TQEETNFKSLVHDLF HHHHHHHHHHHHHHH	44.97	-
574	Phosphorylation	QEETNFKSLVHDLFQ HHHHHHHHHHHHHHH	31.33	21712546
582	Acetylation	LVHDLFQKVEEAKSS HHHHHHHHHHHHHHH	44.26	25953088
582	Ubiquitination	LVHDLFQKVEEAKSS HHHHHHHHHHHHHHH	44.26	-
587	2-Hydroxyisobutyrylation	FQKVEEAKSSLAMNR HHHHHHHHHHHHCCC	43.80	-
587	Ubiquitination	FQKVEEAKSSLAMNR HHHHHHHHHHHHCCC	43.80	-
588	Phosphorylation	QKVEEAKSSLAMNRS HHHHHHHHHHHCCCC	37.32	20044836
589	Phosphorylation	KVEEAKSSLAMNRSR HHHHHHHHHHCCCCH	21.31	20044836
595	Phosphorylation	SSLAMNRSRGKVLDA HHHHCCCCHHHHHHH	40.14	20044836
598	2-Hydroxyisobutyrylation	AMNRSRGKVLDAIIQ HCCCCHHHHHHHHHH	38.22	-
598	Acetylation	AMNRSRGKVLDAIIQ HCCCCHHHHHHHHHH	38.22	30592473
598	Ubiquitination	AMNRSRGKVLDAIIQ HCCCCHHHHHHHHHH	38.22	-
607	2-Hydroxyisobutyrylation	LDAIIQEKKSGRIPG HHHHHHHHHCCCCCC	35.54	-
607	Acetylation	LDAIIQEKKSGRIPG HHHHHHHHHCCCCCC	35.54	23954790
607	Ubiquitination	LDAIIQEKKSGRIPG HHHHHHHHHCCCCCC	35.54	21906983
607 (in isoform 1)	Ubiquitination	-	35.54	21890473
607 (in isoform 2)	Ubiquitination	-	35.54	21890473
608	Acetylation	DAIIQEKKSGRIPGI HHHHHHHHCCCCCCC	58.34	30592485
616	Phosphorylation	SGRIPGIYGRLGDLG CCCCCCCCCCCCCCC	11.34	20068231
679	2-Hydroxyisobutyrylation	DKMAVWAKKMTEIQT HHHHHHHHHHCCCCC	27.62	-
679	Acetylation	DKMAVWAKKMTEIQT HHHHHHHHHHCCCCC	27.62	19608861
680	2-Hydroxyisobutyrylation	KMAVWAKKMTEIQTP HHHHHHHHHCCCCCC	43.22	-
680	Malonylation	KMAVWAKKMTEIQTP HHHHHHHHHCCCCCC	43.22	26320211
681	Sulfoxidation	MAVWAKKMTEIQTPE HHHHHHHHCCCCCCC	3.91	21406390
682	Phosphorylation	AVWAKKMTEIQTPEN HHHHHHHCCCCCCCC	38.52	22817900
686	Phosphorylation	KKMTEIQTPENTPRL HHHCCCCCCCCCCCC	37.93	22817900
690	Phosphorylation	EIQTPENTPRLFDLV CCCCCCCCCCCCHHE	14.23	29083192
698	Ubiquitination	PRLFDLVKVKDEKIR CCCCHHEEECCHHHH	51.36	-
709	Phosphorylation	EKIRQAFYFALRDTL HHHHHHHHHHHHHHH	7.31	22817900
739	Phosphorylation	DRRWRVVTLQGQIIE CCCEEEEEEECEEEE	15.54	24043423
748	Phosphorylation	QGQIIEQSGTMTGGG ECEEEEECCCCCCCC	24.36	24043423
750	Phosphorylation	QIIEQSGTMTGGGSK EEEEECCCCCCCCCC	19.46	24043423
752	Phosphorylation	IEQSGTMTGGGSKVM EEECCCCCCCCCCCC	32.29	24043423
756	Phosphorylation	GTMTGGGSKVMKGRM CCCCCCCCCCCCCCC	25.92	24043423
760	Ubiquitination	GGGSKVMKGRMGSSL CCCCCCCCCCCCCCE	46.48	-
765	Phosphorylation	VMKGRMGSSLVIEIS CCCCCCCCCEEEEEC	15.91	28450419
766	Phosphorylation	MKGRMGSSLVIEISE CCCCCCCCEEEEECH	22.41	28450419
787	Phosphorylation	ESQLQNDSKKAMQIQ HHHHHHHHHHHHHHH	43.54	28842319
789	Ubiquitination	QLQNDSKKAMQIQEQ HHHHHHHHHHHHHHH	53.71	-
797	Ubiquitination	AMQIQEQKVQLEERV HHHHHHHHHHHHHHH	31.06	-
820	Ubiquitination	EMRNTLEKFTASIQR HHHHHHHHHHHHHHH	51.64	-
822	Phosphorylation	RNTLEKFTASIQRLI HHHHHHHHHHHHHHH	30.48	23403867
853	2-Hydroxyisobutyrylation	VLATAPDKKKQKLLE HHCCCCCHHHHHHHH	61.89	-
853	Acetylation	VLATAPDKKKQKLLE HHCCCCCHHHHHHHH	61.89	25953088
853	Ubiquitination	VLATAPDKKKQKLLE HHCCCCCHHHHHHHH	61.89	-
855	Ubiquitination	ATAPDKKKQKLLEEN CCCCCHHHHHHHHHH	59.41	-
857	Acetylation	APDKKKQKLLEENVS CCCHHHHHHHHHHHH	65.01	25953088
857	Ubiquitination	APDKKKQKLLEENVS CCCHHHHHHHHHHHH	65.01	-
867	Ubiquitination	EENVSAFKTEYDAVA HHHHHHHHHHHHHHH	39.91	-
876	Acetylation	EYDAVAEKAGKVEAE HHHHHHHHHCCHHHH	53.34	25953088
876	Ubiquitination	EYDAVAEKAGKVEAE HHHHHHHHHCCHHHH	53.34	-
885	2-Hydroxyisobutyrylation	GKVEAEVKRLHNTIV CCHHHHHHHHHHHHH	40.52	-
898	Acetylation	IVEINNHKLKAQQDK HHHCCHHHHHHHHHH	54.53	25953088
898	Ubiquitination	IVEINNHKLKAQQDK HHHCCHHHHHHHHHH	54.53	-
905	Ubiquitination	KLKAQQDKLDKINKQ HHHHHHHHHHHHHHH	55.00	-
908	Acetylation	AQQDKLDKINKQLDE HHHHHHHHHHHHHHH	59.63	25953088
922	Ubiquitination	ECASAITKAQVAIKT HHHHHHHHHHHHHHH	30.61	-
928	2-Hydroxyisobutyrylation	TKAQVAIKTADRNLQ HHHHHHHHHHCHHHH	28.11	-
928	Acetylation	TKAQVAIKTADRNLQ HHHHHHHHHHCHHHH	28.11	25953088
928	Ubiquitination	TKAQVAIKTADRNLQ HHHHHHHHHHCHHHH	28.11	-
929	Phosphorylation	KAQVAIKTADRNLQK HHHHHHHHHCHHHHH	27.90	27174698
936	Ubiquitination	TADRNLQKAQDSVLR HHCHHHHHHHHHHHH	51.70	-
940	Phosphorylation	NLQKAQDSVLRTEKE HHHHHHHHHHHHHHH	15.80	30576142
944	Phosphorylation	AQDSVLRTEKEIKDT HHHHHHHHHHHHHHH	47.45	30576142
953	Ubiquitination	KEIKDTEKEVDDLTA HHHHHHHHHHHHHHH	66.19	-
963	Ubiquitination	DDLTAELKSLEDKAA HHHHHHHHHHHHHHH	44.49	-
968	2-Hydroxyisobutyrylation	ELKSLEDKAAEVVKN HHHHHHHHHHHHHHC	39.87	-
968	Acetylation	ELKSLEDKAAEVVKN HHHHHHHHHHHHHHC	39.87	25953088
968	Ubiquitination	ELKSLEDKAAEVVKN HHHHHHHHHHHHHHC	39.87	-
974	Ubiquitination	DKAAEVVKNTNAAEE HHHHHHHHCCCHHHH	64.33	-
976	Phosphorylation	AAEVVKNTNAAEESL HHHHHHCCCHHHHCH	22.10	23312004
982	Phosphorylation	NTNAAEESLPEIQKE CCCHHHHCHHHHHHH	40.50	25159151
988	Acetylation	ESLPEIQKEHRNLLQ HCHHHHHHHHHHHHH	62.24	26051181
988	Ubiquitination	ESLPEIQKEHRNLLQ HCHHHHHHHHHHHHH	62.24	-
998	Acetylation	RNLLQELKVIQENEH HHHHHHHHHHHHCHH	36.22	25953088
998	Ubiquitination	RNLLQELKVIQENEH HHHHHHHHHHHHCHH	36.22	-
1009	Acetylation	ENEHALQKDALSIKL HCHHHHHHHHHHHHH	45.90	23954790
1009	Ubiquitination	ENEHALQKDALSIKL HCHHHHHHHHHHHHH	45.90	-
1013	Phosphorylation	ALQKDALSIKLKLEQ HHHHHHHHHHHHHHH	21.28	-
1015	Ubiquitination	QKDALSIKLKLEQID HHHHHHHHHHHHHHC	35.87	-
1030	Phosphorylation	GHIAEHNSKIKYWHK CHHHHCCCCCCHHHH	37.35	25159151
1031	Acetylation	HIAEHNSKIKYWHKE HHHHCCCCCCHHHHH	48.84	25953088
1031	Ubiquitination	HIAEHNSKIKYWHKE HHHHCCCCCCHHHHH	48.84	-
1033	Ubiquitination	AEHNSKIKYWHKEIS HHCCCCCCHHHHHHC	46.13	-
1037	Acetylation	SKIKYWHKEISKISL CCCCHHHHHHCCCCC	42.47	19608861
1037	Ubiquitination	SKIKYWHKEISKISL CCCCHHHHHHCCCCC	42.47	19608861
1041	Ubiquitination	YWHKEISKISLHPIE HHHHHHCCCCCCCCC	41.81	-
1043	Phosphorylation	HKEISKISLHPIEDN HHHHCCCCCCCCCCC	25.10	24732914
1054 (in isoform 2)	Ubiquitination	-	41.08	21890473
1056	Phosphorylation	DNPIEEISVLSPEDL CCCCCEEEECCHHHH	21.93	25159151
1059	Phosphorylation	IEEISVLSPEDLEAI CCEEEECCHHHHHHH	24.88	25159151
1067	Ubiquitination	PEDLEAIKNPDSITN HHHHHHHCCCCHHHH	70.27	-
1071	Phosphorylation	EAIKNPDSITNQIAL HHHCCCCHHHHHHHH	32.35	24732914
1073	Phosphorylation	IKNPDSITNQIALLE HCCCCHHHHHHHHHH	25.64	24732914
1087	Acetylation	EARCHEMKPNLGAIA HHHHHHCCCCHHHHH	27.98	26051181
1087	Ubiquitination	EARCHEMKPNLGAIA HHHHHHCCCCHHHHH	27.98	-
1097	Ubiquitination	LGAIAEYKKKEELYL HHHHHHHHCHHHHHH	49.20	-
1098	Ubiquitination	GAIAEYKKKEELYLQ HHHHHHHCHHHHHHH	65.60	-
1099	Ubiquitination	AIAEYKKKEELYLQR HHHHHHCHHHHHHHH	52.87	-
1112	Ubiquitination	QRVAELDKITYERDS HHHHHHHHHHCCHHH	49.96	21890473
1112 (in isoform 1)	Ubiquitination	-	49.96	21890473
1115	Phosphorylation	AELDKITYERDSFRQ HHHHHHHCCHHHHHH	16.67	-
1129	Ubiquitination	QAYEDLRKQRLNEFM HHHHHHHHHHHHHHH	47.25	-
1129 (in isoform 2)	Ubiquitination	-	47.25	21890473
1145	Ubiquitination	GFYIITNKLKENYQM HHHHHHHHHHHCCEE	52.89	-
1187	Ubiquitination	PPKKSWKKIFNLSGG CCCCCHHHHHCCCCC	46.39	21890473
1187 (in isoform 1)	Ubiquitination	-	46.39	21890473
1192	Phosphorylation	WKKIFNLSGGEKTLS HHHHHCCCCCCHHHH	45.95	25367160
1209 (in isoform 2)	Ubiquitination	-	32.91	21890473
1213	Phosphorylation	ALHHYKPTPLYFMDE HHHHCCCCCEEEHHH	23.05	28787133
1215 (in isoform 2)	Ubiquitination	-	5.91	21890473
1222 (in isoform 2)	Ubiquitination	-	24.60	21890473
1227 (in isoform 2)	Ubiquitination	-	6.88	21890473
1266	Phosphorylation	SDRLIGIYKTYNITK HHHHHEEEECCCCCC	7.65	-
1267	Ubiquitination	DRLIGIYKTYNITKS HHHHEEEECCCCCCC	42.48	21890473
1267 (in isoform 1)	Ubiquitination	-	42.48	21890473
1273	Ubiquitination	YKTYNITKSVAVNPK EECCCCCCCEECCHH	38.85	21906983
1273 (in isoform 1)	Ubiquitination	-	38.85	21890473
1280	Ubiquitination	KSVAVNPKEIASKGL CCEECCHHHHHHCCC	57.45	2190698
1280 (in isoform 1)	Ubiquitination	-	57.45	21890473
1284	Phosphorylation	VNPKEIASKGLC--- CCHHHHHHCCCC---	32.68	28122231
1285	Acetylation	NPKEIASKGLC---- CHHHHHHCCCC----	47.05	25953088
1285	Ubiquitination	NPKEIASKGLC---- CHHHHHHCCCC----	47.05	-
1285 (in isoform 1)	Ubiquitination	-	47.05	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SMC4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SMC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMC2_HUMAN	SMC2	physical	9789013
CND2_HUMAN	NCAPH	physical	17268547
CNDH2_HUMAN	NCAPH2	physical	17268547
AP3S1_HUMAN	AP3S1	physical	22863883
CCAR2_HUMAN	CCAR2	physical	22863883
CND2_HUMAN	NCAPH	physical	22863883
RABL6_HUMAN	RABL6	physical	22863883
PLEC_HUMAN	PLEC	physical	22863883
TBCD4_HUMAN	TBC1D4	physical	22863883
KIF2C_HUMAN	KIF2C	physical	26344197
CND2_HUMAN	NCAPH	physical	26344197
SMC1A_HUMAN	SMC1A	physical	26344197
SMC2_HUMAN	SMC2	physical	26344197
HECD1_HUMAN	HECTD1	physical	26166704

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMC4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-381; LYS-679 AND LYS-1037,AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-28; THR-39;SER-41 AND SER-50, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND THR-39, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-39; SER-41 AND SER-50,AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-27, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-39 AND SER-982, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41 AND SER-1056, ANDMASS SPECTROMETRY.	16565220 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-28 AND SER-41,AND MASS SPECTROMETRY.	15302935 [Abstract]