dbPTM

TBCD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBCD4_HUMAN
UniProt AC	O60343
Protein Name	TBC1 domain family member 4
Gene Name	TBC1D4
Organism	Homo sapiens (Human).
Sequence Length	1298
Subcellular Localization	Cytoplasm . Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Protein Description	May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake..
Protein Sequence	MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPPSCIQ -------CCCCCCCC	60.54	19413330
4 (in isoform 4)	Phosphorylation	-	45.16	25159151
4 (in isoform 5)	Phosphorylation	-	45.16	25159151
6 (in isoform 4)	Phosphorylation	-	3.90	25159151
6 (in isoform 5)	Phosphorylation	-	3.90	25159151
44	Phosphorylation	RLWYVGGSCLDHRTT EEEEECCCCCCCCCH	12.94	28857561
66	Phosphorylation	MAEIRRRSQKPEAGG HHHHHHHCCCCCCCC	40.52	17494752
68	Ubiquitination	EIRRRSQKPEAGGCG HHHHHCCCCCCCCCC	46.18	-
102	Phosphorylation	PAPGAGASGGTSPSA ECCCCCCCCCCCCCC	36.52	23401153
105	Phosphorylation	GAGASGGTSPSATQP CCCCCCCCCCCCCCC	40.78	21712546
106	Phosphorylation	AGASGGTSPSATQPN CCCCCCCCCCCCCCC	21.82	25463755
108	Phosphorylation	ASGGTSPSATQPNPA CCCCCCCCCCCCCCE	43.65	25022875
110	Phosphorylation	GGTSPSATQPNPAVF CCCCCCCCCCCCEEE	49.23	25022875
133	Phosphorylation	ISRFIHNSHDLTYFA HHHHHHCCCCHHHEE	12.29	27732954
137	Phosphorylation	IHNSHDLTYFAYLIK HHCCCCHHHEEEEEC	23.73	27732954
138	Phosphorylation	HNSHDLTYFAYLIKA HCCCCHHHEEEEECC	8.10	27732954
141	Phosphorylation	HDLTYFAYLIKAQPD CCHHHEEEEECCCCC	10.08	27732954
172	Phosphorylation	SQVPDVISSIRQLSK HHCHHHHHHHHHHHH	21.40	24719451
173	Phosphorylation	QVPDVISSIRQLSKA HCHHHHHHHHHHHHH	15.63	25954137
215	2-Hydroxyisobutyrylation	GKVTVTHKKAPSSLI EEEEEEECCCCCHHH	41.06	-
220	Phosphorylation	THKKAPSSLIDDCME EECCCCCHHHHHHHH	28.43	28985074
226	Sulfoxidation	SSLIDDCMEKFSLHE CHHHHHHHHHCCHHH	8.91	21406390
228	Ubiquitination	LIDDCMEKFSLHEQQ HHHHHHHHCCHHHHH	17.23	-
238	Ubiquitination	LHEQQRLKIQGEQRG HHHHHHHHHCCHHCC	34.86	-
262	Phosphorylation	LEVVVPGSPGDCLPE CEEEECCCCCCCCCC	21.46	19276368
274	Phosphorylation	LPEEADGTDTHLGLP CCCCCCCCCCCCCCC	37.97	28387310
276	Phosphorylation	EEADGTDTHLGLPAG CCCCCCCCCCCCCCC	20.88	27251275
285	Phosphorylation	LGLPAGASQPALTSS CCCCCCCCCCCCCCC	35.46	20873877
290	Phosphorylation	GASQPALTSSRVCFP CCCCCCCCCCCCCCC	27.11	27251275
291	Phosphorylation	ASQPALTSSRVCFPE CCCCCCCCCCCCCCH	19.59	27251275
292	Phosphorylation	SQPALTSSRVCFPER CCCCCCCCCCCCCHH	24.40	27251275
304	Phosphorylation	PERILEDSGFDEQQE CHHHHHCCCCCHHHH	31.80	25159151
314	Phosphorylation	DEQQEFRSRCSSVTG CHHHHHHHHHHHHHC	42.85	21712546
317	Phosphorylation	QEFRSRCSSVTGVQR HHHHHHHHHHHCCHH	27.08	21712546
318	Phosphorylation	EFRSRCSSVTGVQRR HHHHHHHHHHCCHHH	27.59	23401153
320	Phosphorylation	RSRCSSVTGVQRRVH HHHHHHHHCCHHHHC	33.32	25262027
330	Phosphorylation	QRRVHEGSQKSQPRR HHHHCCCCCCCCCCC	31.30	24719451
341	Phosphorylation	QPRRRHASAPSHVQP CCCCCCCCCCCCCCC	34.29	29255136
344	Phosphorylation	RRHASAPSHVQPSDS CCCCCCCCCCCCCCC	35.69	22167270
349	Phosphorylation	APSHVQPSDSEKNRT CCCCCCCCCCCCCCE	36.36	23927012
351	Phosphorylation	SHVQPSDSEKNRTML CCCCCCCCCCCCEEE	55.60	23927012
356	Phosphorylation	SDSEKNRTMLFQVGR CCCCCCCEEEEEEEE	27.85	-
370	Phosphorylation	RFEINLISPDTKSVV EEEEEEECCCCCCEE	21.64	30266825
373	Phosphorylation	INLISPDTKSVVLEK EEEECCCCCCEEEEC	28.71	30266825
375	Phosphorylation	LISPDTKSVVLEKNF EECCCCCCEEEECCC	21.39	23312004
383	Acetylation	VVLEKNFKDISSCSQ EEEECCCCCHHHCCC	64.64	26051181
383	Ubiquitination	VVLEKNFKDISSCSQ EEEECCCCCHHHCCC	64.64	-
438	Phosphorylation	LTLKQAFSTAAALQS HHHHHHHHHHHHHHH	21.83	21406692
439	Phosphorylation	TLKQAFSTAAALQSA HHHHHHHHHHHHHHH	17.54	21406692
445	Phosphorylation	STAAALQSAKTQIKL HHHHHHHHHHHHHHH	32.36	21406692
448	Phosphorylation	AALQSAKTQIKLCEA HHHHHHHHHHHHHHH	34.93	21406692
477	Acetylation	GLYPPRAKLVIQRHL CCCCCHHHHHHHHHH	44.56	19608861
485	Phosphorylation	LVIQRHLSSLTDNEQ HHHHHHHHHCCCHHH	19.71	28348404
486	Phosphorylation	VIQRHLSSLTDNEQA HHHHHHHHCCCHHHH	41.47	25884760
488	Phosphorylation	QRHLSSLTDNEQADI HHHHHHCCCHHHHHH	38.43	28450419
542	Phosphorylation	GPSTISNSTIPENAT CCCCCCCCCCCCCCC	22.41	23312004
543	Phosphorylation	PSTISNSTIPENATS CCCCCCCCCCCCCCC	44.81	23312004
549	Phosphorylation	STIPENATSSGRFKL CCCCCCCCCCCCCCH	34.70	25159151
550	Phosphorylation	TIPENATSSGRFKLD CCCCCCCCCCCCCHH	28.52	26462736
551	Phosphorylation	IPENATSSGRFKLDI CCCCCCCCCCCCHHH	29.63	25159151
555	Ubiquitination	ATSSGRFKLDILKNK CCCCCCCCHHHHCHH	43.84	-
560	Ubiquitination	RFKLDILKNKAKRSL CCCHHHHCHHHHHHH	57.65	-
566	Phosphorylation	LKNKAKRSLTSSLEN HCHHHHHHHHHHHHH	34.98	26846344
568	Phosphorylation	NKAKRSLTSSLENIF HHHHHHHHHHHHHHH	19.95	29255136
569	Phosphorylation	KAKRSLTSSLENIFS HHHHHHHHHHHHHHH	37.91	29255136
570	Phosphorylation	AKRSLTSSLENIFSR HHHHHHHHHHHHHHH	34.17	29255136
576	Phosphorylation	SSLENIFSRGANRMR HHHHHHHHHCHHHHC	26.47	23927012
577	Methylation	SLENIFSRGANRMRG HHHHHHHHCHHHHCC	37.18	-
588	Phosphorylation	RMRGRLGSVDSFERS HHCCCCCCCCCCHHH	27.61	19664994
591	Phosphorylation	GRLGSVDSFERSNSL CCCCCCCCCHHHCCC	27.18	19664994
595	Phosphorylation	SVDSFERSNSLASEK CCCCCHHHCCCCCCC	24.47	22115753
597	Phosphorylation	DSFERSNSLASEKDY CCCHHHCCCCCCCCC	26.93	22617229
600	Phosphorylation	ERSNSLASEKDYSPG HHHCCCCCCCCCCCC	50.93	22617229
604	Phosphorylation	SLASEKDYSPGDSPP CCCCCCCCCCCCCCC	28.03	20873877
605	Phosphorylation	LASEKDYSPGDSPPG CCCCCCCCCCCCCCC	32.32	20873877
609	Phosphorylation	KDYSPGDSPPGTPPA CCCCCCCCCCCCCCC	38.62	26657352
613	Phosphorylation	PGDSPPGTPPASPPS CCCCCCCCCCCCCCC	31.69	20873877
617	Phosphorylation	PPGTPPASPPSSAWQ CCCCCCCCCCCCHHC	43.02	20873877
620	Phosphorylation	TPPASPPSSAWQTFP CCCCCCCCCHHCCCC	35.75	20873877
621	Phosphorylation	PPASPPSSAWQTFPE CCCCCCCCHHCCCCC	39.02	20873877
625	Phosphorylation	PPSSAWQTFPEEDSD CCCCHHCCCCCCCCC	30.38	20873877
631	Phosphorylation	QTFPEEDSDSPQFRR CCCCCCCCCCHHHHH	43.18	20873877
633	Phosphorylation	FPEEDSDSPQFRRRA CCCCCCCCHHHHHHH	25.26	20873877
642	Phosphorylation	QFRRRAHTFSHPPSS HHHHHHHHCCCCCCC	26.33	27273156
644	Phosphorylation	RRRAHTFSHPPSSTK HHHHHHCCCCCCCCC	35.92	27273156
648	Phosphorylation	HTFSHPPSSTKRKLN HHCCCCCCCCCCEEC	55.90	23401153
649	Phosphorylation	TFSHPPSSTKRKLNL HCCCCCCCCCCEECC	43.66	25159151
650	Phosphorylation	FSHPPSSTKRKLNLQ CCCCCCCCCCEECCC	38.92	25159151
666	Phosphorylation	GRAQGVRSPLLRQSS CCCCCCCCHHHHCCC	19.93	29255136
666 (in isoform 2)	Phosphorylation	-	19.93	25849741
672	Phosphorylation	RSPLLRQSSSEQCSN CCHHHHCCCHHHHCC	29.42	18669648
672 (in isoform 2)	Phosphorylation	-	29.42	23927012
673	Phosphorylation	SPLLRQSSSEQCSNL CHHHHCCCHHHHCCH	29.56	18669648
673 (in isoform 2)	Phosphorylation	-	29.56	23927012
674 (in isoform 2)	Phosphorylation	-	36.61	23927012
678	Phosphorylation	QSSSEQCSNLSSVRR CCCHHHHCCHHHHHH	40.26	18669648
678 (in isoform 2)	Phosphorylation	-	40.26	18669648
681	Phosphorylation	SEQCSNLSSVRRMYK HHHHCCHHHHHHHHH	30.91	24719451
686 (in isoform 2)	Phosphorylation	-	3.82	29116813
687 (in isoform 2)	Phosphorylation	-	15.14	29116813
688 (in isoform 2)	Phosphorylation	-	45.37	25849741
689 (in isoform 2)	Phosphorylation	-	37.35	25849741
691 (in isoform 2)	Phosphorylation	-	47.18	25849741
701	Phosphorylation	SSLPSLHTSFSAPSF CCCCCCCCCCCCCCC	36.44	21712546
702	Phosphorylation	SLPSLHTSFSAPSFT CCCCCCCCCCCCCCC	13.37	30576142
704	Phosphorylation	PSLHTSFSAPSFTAP CCCCCCCCCCCCCCH	38.75	22817900
707	Phosphorylation	HTSFSAPSFTAPSFL CCCCCCCCCCCHHHH	34.64	30576142
709	Phosphorylation	SFSAPSFTAPSFLKS CCCCCCCCCHHHHHH	41.83	30576142
712	Phosphorylation	APSFTAPSFLKSFYQ CCCCCCHHHHHHHHH	40.52	24719451
716	Phosphorylation	TAPSFLKSFYQNSGR CCHHHHHHHHHHCCC	31.19	26437602
716 (in isoform 3)	Phosphorylation	-	31.19	26437602
721 (in isoform 3)	Phosphorylation	-	15.12	22673903
725	Phosphorylation	YQNSGRLSPQYENEI HHHCCCCCHHHHHHH	14.48	26437602
725 (in isoform 3)	Phosphorylation	-	14.48	26437602
749	Phosphorylation	DGEGRKRTSSTCSNE CCCCCCCCCCCCCCC	30.02	23927012
750	Phosphorylation	GEGRKRTSSTCSNES CCCCCCCCCCCCCCC	27.90	23927012
751	Phosphorylation	EGRKRTSSTCSNESL CCCCCCCCCCCCCCC	32.59	23927012
752	Phosphorylation	GRKRTSSTCSNESLS CCCCCCCCCCCCCCC	21.52	23927012
754	Phosphorylation	KRTSSTCSNESLSVG CCCCCCCCCCCCCCC	43.66	25159151
757	Phosphorylation	SSTCSNESLSVGGTS CCCCCCCCCCCCCEE	30.14	23927012
759	Phosphorylation	TCSNESLSVGGTSVT CCCCCCCCCCCEECC	28.17	23927012
763	Phosphorylation	ESLSVGGTSVTPRRI CCCCCCCEECCCCCC	17.69	23927012
764	Phosphorylation	SLSVGGTSVTPRRIS CCCCCCEECCCCCCC	27.54	23927012
766	Phosphorylation	SVGGTSVTPRRISWR CCCCEECCCCCCCHH	15.73	23927012
771	Phosphorylation	SVTPRRISWRQRIFL ECCCCCCCHHHHHHH	17.88	24719451
782	Phosphorylation	RIFLRVASPMNKSPS HHHHHHCCCCCCCHH	23.09	26055452
787	Phosphorylation	VASPMNKSPSAMQQQ HCCCCCCCHHHHHHC	21.05	23401153
789	Phosphorylation	SPMNKSPSAMQQQDG CCCCCCHHHHHHCCC	43.39	29255136
791	Sulfoxidation	MNKSPSAMQQQDGLD CCCCHHHHHHCCCCC	4.30	21406390
806	Phosphorylation	RNELLPLSPLSPTME HHHCCCCCCCCCCCC	23.12	20068231
809	Phosphorylation	LLPLSPLSPTMEEEP CCCCCCCCCCCCCCC	23.00	28387310
811	Phosphorylation	PLSPLSPTMEEEPLV CCCCCCCCCCCCCEE	33.56	28464451
822	Phosphorylation	EPLVVFLSGEDDPEK CCEEEEECCCCCHHH	28.77	22468782
841	Phosphorylation	KKSKELRSLWRKAIH HHHHHHHHHHHHHHH	44.93	24719451
866	Phosphorylation	ENQKLEASRDELQSR HHHHHHHCHHHHHHC	30.78	27251275
872	Phosphorylation	ASRDELQSRKVKLDY HCHHHHHHCCCCCCH	46.85	27251275
892	Phosphorylation	CQKEVLITWDKKLLN CCEEEEEEECHHHHC	24.37	28509920
951	Phosphorylation	KQQPPDISYKELLKQ CCCCCCCCHHHHHHH	37.22	23828894
952	Phosphorylation	QQPPDISYKELLKQL CCCCCCCHHHHHHHH	14.60	23828894
1044	Phosphorylation	DLGFRKQYRPDMMSL HHCCCHHHCCCHHHH	27.44	23663014
1050	Phosphorylation	QYRPDMMSLQIQMYQ HHCCCHHHHHHHHHH	15.52	23401153
1056	Phosphorylation	MSLQIQMYQLSRLLH HHHHHHHHHHHHHHH	7.02	23663014
1059	Phosphorylation	QIQMYQLSRLLHDYH HHHHHHHHHHHHHHH	12.83	23663014
1065	Phosphorylation	LSRLLHDYHRDLYNH HHHHHHHHHHHHHHH	6.49	23401153
1122	Phosphorylation	VIFKVALSLLSSQET HHHHHHHHHHCCCCC	19.95	23401153
1125	Phosphorylation	KVALSLLSSQETLIM HHHHHHHCCCCCEEH	34.96	23401153
1126	Phosphorylation	VALSLLSSQETLIME HHHHHHCCCCCEEHH	31.82	23401153
1153	Phosphorylation	NTLPDMNTSEMEKII HHCCCCCHHHHHHHH	21.30	22210691
1154	Phosphorylation	TLPDMNTSEMEKIIT HCCCCCHHHHHHHHH	29.91	22210691
1189	Phosphorylation	LQDELQESSYSCEDS HHHHHHHCCCCCCCH	22.93	28122231
1190	Phosphorylation	QDELQESSYSCEDSE HHHHHHCCCCCCCHH	21.95	28122231
1191	Phosphorylation	DELQESSYSCEDSET HHHHHCCCCCCCHHH	26.98	22817900
1192	Phosphorylation	ELQESSYSCEDSETL HHHHCCCCCCCHHHH	16.99	28122231
1196	Phosphorylation	SSYSCEDSETLEKLE CCCCCCCHHHHHHHH	15.36	27690223
1198	Phosphorylation	YSCEDSETLEKLERA CCCCCHHHHHHHHHH	44.14	27690223
1207	Phosphorylation	EKLERANSQLKRQNM HHHHHHHHHHHHHCH	35.59	25159151
1246	Phosphorylation	TRETKMKSLIRTLEQ CHHHHHHHHHHHHHH	26.06	23917254
1250	Phosphorylation	KMKSLIRTLEQEKMA HHHHHHHHHHHHHHH	27.87	23186163
1255	Ubiquitination	IRTLEQEKMAYQKTV HHHHHHHHHHHHHHH	28.64	-
1267	Ubiquitination	KTVEQLRKLLPADAL HHHHHHHHHCCHHHH	64.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
318	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
318	S	Phosphorylation	Kinase	SGK1	O00141	PSP
318	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
318	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
341	S	Phosphorylation	Kinase	AKT1	P31749	PSP
341	S	Phosphorylation	Kinase	SGK1	O00141	PSP
341	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
485	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
568	T	Phosphorylation	Kinase	AKT1	P31749	PSP
568	T	Phosphorylation	Kinase	SGK1	O00141	PSP
568	T	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
570	S	Phosphorylation	Kinase	AKT1	P31749	PSP
570	S	Phosphorylation	Kinase	P90RSK	Q15418	PSP
570	S	Phosphorylation	Kinase	SGK1	O00141	PSP
570	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
588	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
588	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
588	S	Phosphorylation	Kinase	SGK1	O00141	PSP
588	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
588	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
588	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
595	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
642	T	Phosphorylation	Kinase	SGK1	O00141	PSP
642	T	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
642	T	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
642	T	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
642	T	Phosphorylation	Kinase	AKT1	P31749	Uniprot
642	T	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
650	T	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
666	S	Phosphorylation	Kinase	P90RSK	Q15418	PSP
666	S	Phosphorylation	Kinase	SGK1	O00141	PSP
666	S	Phosphorylation	Kinase	AKT1	P31749	PSP
751	S	Phosphorylation	Kinase	SGK1	O00141	PSP
751	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
751	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW11	Q9UKB1	PMID:25515538

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TBCD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBCD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SR140_HUMAN	U2SURP	physical	12421765
RBM12_HUMAN	RBM12	physical	12421765
EP400_HUMAN	EP400	physical	12421765
TET2_HUMAN	TET2	physical	12421765
TBD2A_HUMAN	TBC1D2	physical	22863883
TLE3_HUMAN	TLE3	physical	22863883
MEP50_HUMAN	WDR77	physical	22863883
RAB14_MOUSE	Rab14	physical	21454505
1433Z_HUMAN	YWHAZ	physical	25770209

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616087	Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBCD4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-570; SER-588; SER-591; THR-749; SER-751;THR-752; SER-754 AND THR-766, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-477, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-566; THR-568; SER-570;SER-588 AND SER-591, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-570; SER-588; SER-591; THR-749; SER-751;THR-752; SER-754 AND THR-766, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; SER-566; SER-570;SER-588; SER-591; SER-666; THR-752; SER-754 AND SER-757, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-551; SER-566; SER-570AND SER-588, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754, AND MASSSPECTROMETRY.	18187866 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588 AND SER-591, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344 AND SER-588, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, AND MASSSPECTROMETRY.	16083285 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754, AND MASSSPECTROMETRY.	15302935 [Abstract]
"A method to identify serine kinase substrates. Akt phosphorylates anovel adipocyte protein with a Rab GTPase-activating protein (GAP)domain."; Kane S., Sano H., Liu S.C.H., Asara J.M., Lane W.S., Garner C.C.,Lienhard G.E.; J. Biol. Chem. 277:22115-22118(2002). Cited for: PHOSPHORYLATION AT SER-588 AND THR-642.	11994271 [Abstract]
"Identification of a novel AS160 splice variant that regulates GLUT4translocation and glucose-uptake in rat muscle cells."; Baus D., Heermeier K., De Hoop M., Metz-Weidmann C., Gassenhuber J.,Dittrich W., Welte S., Tennagels N.; Cell. Signal. 20:2237-2246(2008). Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, SUBCELLULARLOCATION, TISSUE SPECIFICITY, AND PHOSPHORYLATION AT THR-642.	18771725 [Abstract]