dbPTM

SR140_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SR140_HUMAN
UniProt AC	O15042
Protein Name	U2 snRNP-associated SURP motif-containing protein
Gene Name	U2SURP
Organism	Homo sapiens (Human).
Sequence Length	1029
Subcellular Localization	Nucleus .
Protein Description
Protein Sequence	MADKTPGGSQKASSKTRSSDVHSSGSSDAHMDASGPSDSDMPSRTRPKSPRKHNYRNESARESLCDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEELKKKEDEKAAAEIYEEFLAAFEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIYKPSSRFADQKNPPNQSSNERPPSLLVIETKKPPLKKGEKEKKKSNLELFKEELKQIQEERDERHKTKGRLSRFEPPQSDSDGQRRSMDAPSRRNRSSGVLDDYAPGSHDVGDPSTTNLYLGNINPQMNEEMLCQEFGRFGPLASVKIMWPRTDEERARERNCGFVAFMNRRDAERALKNLNGKMIMSFEMKLGWGKAVPIPPHPIYIPPSMMEHTLPPPPSGLPFNAQPRERLKNPNAPMLPPPKNKEDFEKTLSQAIVKVVIPTERNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADKTPGGS ------CCCCCCCCC	38.01	22814378
4	Acetylation	----MADKTPGGSQK ----CCCCCCCCCCC	64.77	23749302
5	Phosphorylation	---MADKTPGGSQKA ---CCCCCCCCCCCC	27.93	25849741
9	Phosphorylation	ADKTPGGSQKASSKT CCCCCCCCCCCCCCC	34.13	29255136
11	Ubiquitination	KTPGGSQKASSKTRS CCCCCCCCCCCCCCC	52.51	24816145
13	Phosphorylation	PGGSQKASSKTRSSD CCCCCCCCCCCCCCC	39.13	18187866
14	Phosphorylation	GGSQKASSKTRSSDV CCCCCCCCCCCCCCC	42.79	18187866
16	Phosphorylation	SQKASSKTRSSDVHS CCCCCCCCCCCCCCC	37.42	29214152
18	Phosphorylation	KASSKTRSSDVHSSG CCCCCCCCCCCCCCC	35.80	30576142
19	Phosphorylation	ASSKTRSSDVHSSGS CCCCCCCCCCCCCCC	40.12	26552605
23	Phosphorylation	TRSSDVHSSGSSDAH CCCCCCCCCCCCCCC	35.92	30576142
24	Phosphorylation	RSSDVHSSGSSDAHM CCCCCCCCCCCCCCC	28.02	30576142
26	Phosphorylation	SDVHSSGSSDAHMDA CCCCCCCCCCCCCCC	27.30	30576142
27	Phosphorylation	DVHSSGSSDAHMDAS CCCCCCCCCCCCCCC	42.20	30576142
31	Sulfoxidation	SGSSDAHMDASGPSD CCCCCCCCCCCCCCC	5.02	21406390
34	Phosphorylation	SDAHMDASGPSDSDM CCCCCCCCCCCCCCC	47.15	26503892
37	Phosphorylation	HMDASGPSDSDMPSR CCCCCCCCCCCCCCC	53.95	26503892
39	Phosphorylation	DASGPSDSDMPSRTR CCCCCCCCCCCCCCC	39.90	30576142
43	Phosphorylation	PSDSDMPSRTRPKSP CCCCCCCCCCCCCCC	39.38	30576142
43	Ubiquitination	PSDSDMPSRTRPKSP CCCCCCCCCCCCCCC	39.38	21890473
45	Phosphorylation	DSDMPSRTRPKSPRK CCCCCCCCCCCCCCC	56.51	26074081
49	Phosphorylation	PSRTRPKSPRKHNYR CCCCCCCCCCCCCCC	32.40	26074081
52	Phosphorylation	TRPKSPRKHNYRNES CCCCCCCCCCCCCHH	39.32	32142685
54	Phosphorylation	PKSPRKHNYRNESAR CCCCCCCCCCCHHHH	40.26	32142685
55	Ubiquitination	KSPRKHNYRNESARE CCCCCCCCCCHHHHH	17.97	21890473
59	Phosphorylation	KHNYRNESARESLCD CCCCCCHHHHHHHCC	35.85	20873877
63	Phosphorylation	RNESARESLCDSPHQ CCHHHHHHHCCCCCC	28.83	23401153
67	Phosphorylation	ARESLCDSPHQNLSR HHHHHCCCCCCCCCH	24.24	29255136
67	Ubiquitination	ARESLCDSPHQNLSR HHHHHCCCCCCCCCH	24.24	21890473
73	Phosphorylation	DSPHQNLSRPLLENK CCCCCCCCHHHHHHH	39.13	23927012
76	Phosphorylation	HQNLSRPLLENKLKA CCCCCHHHHHHHHHH	10.21	32142685
78	Phosphorylation	NLSRPLLENKLKAFS CCCHHHHHHHHHHHH	61.06	32142685
79	Ubiquitination	LSRPLLENKLKAFSI CCHHHHHHHHHHHHH	55.73	21890473
80	Acetylation	SRPLLENKLKAFSIG CHHHHHHHHHHHHHH	41.82	23749302
80	Sumoylation	SRPLLENKLKAFSIG CHHHHHHHHHHHHHH	41.82	28112733
80	Ubiquitination	SRPLLENKLKAFSIG CHHHHHHHHHHHHHH	41.82	29967540
82	Methylation	PLLENKLKAFSIGKM HHHHHHHHHHHHHHH	49.33	115980525
82	Ubiquitination	PLLENKLKAFSIGKM HHHHHHHHHHHHHHH	49.33	-
85	Phosphorylation	ENKLKAFSIGKMSTA HHHHHHHHHHHHHHH	34.98	29496963
88	Acetylation	LKAFSIGKMSTAKRT HHHHHHHHHHHHHHH	28.18	25953088
88	Methylation	LKAFSIGKMSTAKRT HHHHHHHHHHHHHHH	28.18	115980541
88	Ubiquitination	LKAFSIGKMSTAKRT HHHHHHHHHHHHHHH	28.18	29967540
90	Phosphorylation	AFSIGKMSTAKRTLS HHHHHHHHHHHHHCC	28.79	20068231
91	Phosphorylation	FSIGKMSTAKRTLSK HHHHHHHHHHHHCCH	32.47	20068231
95	Phosphorylation	KMSTAKRTLSKKEQE HHHHHHHHCCHHHHH	34.38	20068231
97	Phosphorylation	STAKRTLSKKEQEEL HHHHHHCCHHHHHHH	40.86	20068231
97	Ubiquitination	STAKRTLSKKEQEEL HHHHHHCCHHHHHHH	40.86	21963094
98	Acetylation	TAKRTLSKKEQEELK HHHHHCCHHHHHHHH	64.54	19608861
98	Ubiquitination	TAKRTLSKKEQEELK HHHHHCCHHHHHHHH	64.54	22817900
102	Ubiquitination	TLSKKEQEELKKKED HCCHHHHHHHHHHHH	67.40	22817900
105	Acetylation	KKEQEELKKKEDEKA HHHHHHHHHHHHHHH	66.14	19608861
108	Ubiquitination	QEELKKKEDEKAAAE HHHHHHHHHHHHHHH	79.05	21963094
117	Phosphorylation	EKAAAEIYEEFLAAF HHHHHHHHHHHHHHH	10.83	28796482
121	Ubiquitination	AEIYEEFLAAFEGSD HHHHHHHHHHHCCCC	3.67	21963094
122	Ubiquitination	EIYEEFLAAFEGSDG HHHHHHHHHHCCCCC	18.54	22817900
126	Ubiquitination	EFLAAFEGSDGNKVK HHHHHHCCCCCCEEE	25.28	22817900
131	Ubiquitination	FEGSDGNKVKTFVRG HCCCCCCEEEEEEEC	51.11	29967540
132	Ubiquitination	EGSDGNKVKTFVRGG CCCCCCEEEEEEECC	9.06	21963094
133	Ubiquitination	GSDGNKVKTFVRGGV CCCCCEEEEEEECCC	37.54	-
137	Methylation	NKVKTFVRGGVVNAA CEEEEEEECCCCCHH	31.77	115917677
145	Sumoylation	GGVVNAAKEEHETDE CCCCCHHHHHCCCHH	62.31	-
145	Acetylation	GGVVNAAKEEHETDE CCCCCHHHHHCCCHH	62.31	26051181
145	Sumoylation	GGVVNAAKEEHETDE CCCCCHHHHHCCCHH	62.31	28112733
150	Phosphorylation	AAKEEHETDEKRGKI HHHHHCCCHHCCCCE	51.90	20068231
153	Acetylation	EEHETDEKRGKIYKP HHCCCHHCCCCEECC	70.07	26051181
153	Ubiquitination	EEHETDEKRGKIYKP HHCCCHHCCCCEECC	70.07	24816145
158	Phosphorylation	DEKRGKIYKPSSRFA HHCCCCEECCHHHCC	21.97	-
159	Ubiquitination	EKRGKIYKPSSRFAD HCCCCEECCHHHCCC	41.73	24816145
168	Acetylation	SSRFADQKNPPNQSS HHHCCCCCCCCCCCC	72.47	25953088
168	Sumoylation	SSRFADQKNPPNQSS HHHCCCCCCCCCCCC	72.47	28112733
168	Ubiquitination	SSRFADQKNPPNQSS HHHCCCCCCCCCCCC	72.47	-
174	Phosphorylation	QKNPPNQSSNERPPS CCCCCCCCCCCCCCC	41.60	20873877
175	Phosphorylation	KNPPNQSSNERPPSL CCCCCCCCCCCCCCE	32.71	20873877
175	Ubiquitination	KNPPNQSSNERPPSL CCCCCCCCCCCCCCE	32.71	21963094
181	Phosphorylation	SSNERPPSLLVIETK CCCCCCCCEEEEEEC	36.70	28655764
184	Ubiquitination	ERPPSLLVIETKKPP CCCCCEEEEEECCCC	4.51	22817900
187	Phosphorylation	PSLLVIETKKPPLKK CCEEEEEECCCCCCC	32.99	23312004
189	Ubiquitination	LLVIETKKPPLKKGE EEEEEECCCCCCCCH	60.32	21963094
199	Ubiquitination	LKKGEKEKKKSNLEL CCCCHHHHHHHHHHH	76.26	21963094
202	Phosphorylation	GEKEKKKSNLELFKE CHHHHHHHHHHHHHH	56.37	30266825
208	Sumoylation	KSNLELFKEELKQIQ HHHHHHHHHHHHHHH	64.00	-
208	Sumoylation	KSNLELFKEELKQIQ HHHHHHHHHHHHHHH	64.00	28112733
208	Ubiquitination	KSNLELFKEELKQIQ HHHHHHHHHHHHHHH	64.00	22817900
212	Ubiquitination	ELFKEELKQIQEERD HHHHHHHHHHHHHHH	48.94	33845483
213	Ubiquitination	LFKEELKQIQEERDE HHHHHHHHHHHHHHH	56.04	21963094
214	Ubiquitination	FKEELKQIQEERDER HHHHHHHHHHHHHHH	5.49	21963094
229	Phosphorylation	HKTKGRLSRFEPPQS HHCCCCHHHCCCCCC	33.30	28555341
231	Ubiquitination	TKGRLSRFEPPQSDS CCCCHHHCCCCCCCC	17.34	21890473
236	Phosphorylation	SRFEPPQSDSDGQRR HHCCCCCCCCCCCCC	44.87	30266825
238	Phosphorylation	FEPPQSDSDGQRRSM CCCCCCCCCCCCCCC	49.22	30266825
238	Ubiquitination	FEPPQSDSDGQRRSM CCCCCCCCCCCCCCC	49.22	21963094
243	Ubiquitination	SDSDGQRRSMDAPSR CCCCCCCCCCCCCCC	28.57	21890473
244	Phosphorylation	DSDGQRRSMDAPSRR CCCCCCCCCCCCCCC	24.17	21815630
249	Phosphorylation	RRSMDAPSRRNRSSG CCCCCCCCCCCCCCC	45.66	28102081
254	Phosphorylation	APSRRNRSSGVLDDY CCCCCCCCCCCCCCC	34.69	20068231
255	Phosphorylation	PSRRNRSSGVLDDYA CCCCCCCCCCCCCCC	29.68	20068231
260 (in isoform 2)	Phosphorylation	-	37.01	22210691
261	Phosphorylation	SSGVLDDYAPGSHDV CCCCCCCCCCCCCCC	17.86	20068231
265	Phosphorylation	LDDYAPGSHDVGDPS CCCCCCCCCCCCCCC	18.56	20068231
272	Phosphorylation	SHDVGDPSTTNLYLG CCCCCCCCCCCEEEC	53.24	20068231
272 (in isoform 2)	Phosphorylation	-	53.24	22210691
273	Phosphorylation	HDVGDPSTTNLYLGN CCCCCCCCCCEEECC	25.70	20068231
274	Phosphorylation	DVGDPSTTNLYLGNI CCCCCCCCCEEECCC	27.80	20068231
276 (in isoform 2)	Phosphorylation	-	3.33	22210691
277	Phosphorylation	DPSTTNLYLGNINPQ CCCCCCEEECCCCHH	18.03	20068231
285	Ubiquitination	LGNINPQMNEEMLCQ ECCCCHHCCHHHHHH	7.80	21963094
286	Ubiquitination	GNINPQMNEEMLCQE CCCCHHCCHHHHHHH	36.51	22817900
290	Ubiquitination	PQMNEEMLCQEFGRF HHCCHHHHHHHHCCC	2.85	22817900
296	Ubiquitination	MLCQEFGRFGPLASV HHHHHHCCCCCCEEE	38.37	21890473
315	Ubiquitination	PRTDEERARERNCGF CCCHHHHHHHHCCCE	22.44	32015554
322	Ubiquitination	ARERNCGFVAFMNRR HHHHCCCEEEECCHH	3.79	32015554
327	Ubiquitination	CGFVAFMNRRDAERA CCEEEECCHHHHHHH	29.40	32015554
339	Ubiquitination	ERALKNLNGKMIMSF HHHHHHCCCCEEEEE	58.39	32015554
346	Ubiquitination	NGKMIMSFEMKLGWG CCCEEEEEEEECCCC	6.18	32015554
351	Ubiquitination	MSFEMKLGWGKAVPI EEEEEECCCCCCCCC	26.10	32015554
363	Ubiquitination	VPIPPHPIYIPPSMM CCCCCCCCCCCHHHC	4.41	21963094
372	Ubiquitination	IPPSMMEHTLPPPPS CCHHHCCCCCCCCCC	18.14	22817900
377	Ubiquitination	MEHTLPPPPSGLPFN CCCCCCCCCCCCCCC	33.48	21963094
391	Ubiquitination	NAQPRERLKNPNAPM CCCHHHHCCCCCCCC	5.57	33845483
392	Ubiquitination	AQPRERLKNPNAPML CCHHHHCCCCCCCCC	76.27	33845483
396	Ubiquitination	ERLKNPNAPMLPPPK HHCCCCCCCCCCCCC	7.67	32015554
399	Ubiquitination	KNPNAPMLPPPKNKE CCCCCCCCCCCCCHH	5.84	32015554
402	Ubiquitination	NAPMLPPPKNKEDFE CCCCCCCCCCHHHHH	51.41	21963094
405	Acetylation	MLPPPKNKEDFEKTL CCCCCCCHHHHHHHH	65.86	26051181
409	Ubiquitination	PKNKEDFEKTLSQAI CCCHHHHHHHHHHHH	58.41	33845483
410	Ubiquitination	KNKEDFEKTLSQAIV CCHHHHHHHHHHHHH	55.55	33845483
418	Acetylation	TLSQAIVKVVIPTER HHHHHHHHHHCCCHH	25.35	26051181
420	Ubiquitination	SQAIVKVVIPTERNL HHHHHHHHCCCHHHH	3.43	32015554
423	Ubiquitination	IVKVVIPTERNLLAL HHHHHCCCHHHHHHH	36.13	32015554
445 (in isoform 3)	Ubiquitination	-	6.44	21890473
457 (in isoform 3)	Ubiquitination	-	20.85	21890473
458	Sulfoxidation	NREINNPMFRFLFEN CCCCCCHHHHHHHCC	4.01	21406390
466	Ubiquitination	FRFLFENQTPAHVYY HHHHHCCCCCCEEEE	41.48	24816145
467	Phosphorylation	RFLFENQTPAHVYYR HHHHCCCCCCEEEEE	33.74	28152594
467	Ubiquitination	RFLFENQTPAHVYYR HHHHCCCCCCEEEEE	33.74	24816145
472	Phosphorylation	NQTPAHVYYRWKLYS CCCCCEEEEEEEHHH	4.21	23186163
473	Phosphorylation	QTPAHVYYRWKLYSI CCCCEEEEEEEHHHH	14.65	23186163
475	Ubiquitination	PAHVYYRWKLYSILQ CCEEEEEEEHHHHHC	4.47	21890473
475 (in isoform 2)	Ubiquitination	-	4.47	21890473
476	Acetylation	AHVYYRWKLYSILQG CEEEEEEEHHHHHCC	28.66	26051181
476	Ubiquitination	AHVYYRWKLYSILQG CEEEEEEEHHHHHCC	28.66	21890473
476 (in isoform 1)	Ubiquitination	-	28.66	21890473
478	Phosphorylation	VYYRWKLYSILQGDS EEEEEEHHHHHCCCC	7.02	23403867
479	Phosphorylation	YYRWKLYSILQGDSP EEEEEHHHHHCCCCC	27.53	23401153
480	Ubiquitination	YRWKLYSILQGDSPT EEEEHHHHHCCCCCC	1.79	24816145
484	Phosphorylation	LYSILQGDSPTKWRT HHHHHCCCCCCCCCC	38.18	32142685
485	Phosphorylation	YSILQGDSPTKWRTE HHHHCCCCCCCCCCC	41.09	19664994
486	Phosphorylation	SILQGDSPTKWRTED HHHCCCCCCCCCCCC	42.61	32142685
487	Phosphorylation	ILQGDSPTKWRTEDF HHCCCCCCCCCCCCC	47.38	23401153
487	Ubiquitination	ILQGDSPTKWRTEDF HHCCCCCCCCCCCCC	47.38	21890473
487 (in isoform 2)	Ubiquitination	-	47.38	21890473
488	Acetylation	LQGDSPTKWRTEDFR HCCCCCCCCCCCCCE	37.75	25953088
488	Ubiquitination	LQGDSPTKWRTEDFR HCCCCCCCCCCCCCE	37.75	21963094
488 (in isoform 1)	Ubiquitination	-	37.75	21890473
490	Ubiquitination	GDSPTKWRTEDFRMF CCCCCCCCCCCCEEC	29.78	24816145
491	Phosphorylation	DSPTKWRTEDFRMFK CCCCCCCCCCCEECC	38.50	29759185
491	Ubiquitination	DSPTKWRTEDFRMFK CCCCCCCCCCCEECC	38.50	24816145
499	Phosphorylation	EDFRMFKNGSFWRPP CCCEECCCCCCCCCC	39.82	33259812
504	Ubiquitination	FKNGSFWRPPPLNPY CCCCCCCCCCCCCHH	31.66	24816145
510	Ubiquitination	WRPPPLNPYLHGMSE CCCCCCCHHHCCCCH	40.52	22817900
510 (in isoform 3)	Ubiquitination	-	40.52	21890473
515	Phosphorylation	LNPYLHGMSEEQETE CCHHHCCCCHHHHHH	2.95	32645325
515	Ubiquitination	LNPYLHGMSEEQETE CCHHHCCCCHHHHHH	2.95	22817900
516	Phosphorylation	NPYLHGMSEEQETEA CHHHCCCCHHHHHHH	42.44	28348404
521	Phosphorylation	GMSEEQETEAFVEEP CCCHHHHHHHHHCCC	32.10	28348404
523	Phosphorylation	SEEQETEAFVEEPSK CHHHHHHHHHCCCCC	22.62	33259812
529	Ubiquitination	EAFVEEPSKKGALKE HHHHCCCCCCCCCCH	50.72	21963094
530	Ubiquitination	AFVEEPSKKGALKEE HHHCCCCCCCCCCHH	66.98	21963094
531	Ubiquitination	FVEEPSKKGALKEEQ HHCCCCCCCCCCHHH	54.47	22817900
534	Ubiquitination	EPSKKGALKEEQRDK CCCCCCCCCHHHHHH	11.06	22817900
535	Ubiquitination	PSKKGALKEEQRDKL CCCCCCCCHHHHHHH	59.68	22817900
539	Phosphorylation	GALKEEQRDKLEEIL CCCCHHHHHHHHHHH	46.43	32645325
540	Ubiquitination	ALKEEQRDKLEEILR CCCHHHHHHHHHHHH	60.63	21963094
540 (in isoform 2)	Ubiquitination	-	60.63	21890473
541	2-Hydroxyisobutyrylation	LKEEQRDKLEEILRG CCHHHHHHHHHHHHC	61.05	-
541	Acetylation	LKEEQRDKLEEILRG CCHHHHHHHHHHHHC	61.05	25953088
541	Ubiquitination	LKEEQRDKLEEILRG CCHHHHHHHHHHHHC	61.05	21963094
541 (in isoform 1)	Ubiquitination	-	61.05	21890473
547	Methylation	DKLEEILRGLTPRKN HHHHHHHHCCCCCCC	43.68	115917681
550	Phosphorylation	EEILRGLTPRKNDIG HHHHHCCCCCCCCCC	24.70	24719451
582	Phosphorylation	DCITESLSILKTPLP HHHHHHHHHHCCCCC	34.84	24719451
607	Ubiquitination	DVLYNSSAKVANASY HHHHCCCCHHCCHHH	15.34	21963094
608	Ubiquitination	VLYNSSAKVANASYY HHHCCCCHHCCHHHH	43.77	21963094
613	Phosphorylation	SAKVANASYYRKFFE CCHHCCHHHHHHHHH	23.62	28152594
614	Phosphorylation	AKVANASYYRKFFET CHHCCHHHHHHHHHH	12.60	28152594
615	Phosphorylation	KVANASYYRKFFETK HHCCHHHHHHHHHHH	12.58	28152594
616	Ubiquitination	VANASYYRKFFETKL HCCHHHHHHHHHHHH	22.52	22817900
616 (in isoform 3)	Ubiquitination	-	22.52	21890473
617	Ubiquitination	ANASYYRKFFETKLC CCHHHHHHHHHHHHH	37.98	22817900
621	Ubiquitination	YYRKFFETKLCQIFS HHHHHHHHHHHHHHH	24.94	21963094
622	Ubiquitination	YRKFFETKLCQIFSD HHHHHHHHHHHHHHH	39.82	21963094
634	Phosphorylation	FSDLNATYRTIQGHL HHHHCHHHHHHHHHH	11.89	17360941
646	Ubiquitination	GHLQSENFKQRVMTC HHHHCCCHHHHHHHH	6.65	21963094
646 (in isoform 2)	Ubiquitination	-	6.65	21890473
647	Acetylation	HLQSENFKQRVMTCF HHHCCCHHHHHHHHH	49.10	25953088
647	Ubiquitination	HLQSENFKQRVMTCF HHHCCCHHHHHHHHH	49.10	21906983
647 (in isoform 1)	Ubiquitination	-	49.10	21890473
654	Ubiquitination	KQRVMTCFRAWEDWA HHHHHHHHHHHCCCC	4.37	24816145
655	Ubiquitination	QRVMTCFRAWEDWAI HHHHHHHHHHCCCCC	40.72	24816145
668	Ubiquitination	AIYPEPFLIKLQNIF CCCCCCHHHHHHHHH	5.03	24816145
719	Phosphorylation	DGIPIDATPIDDLDG CCCCCCCCCCCCCCC	19.61	24275569
729 (in isoform 3)	Ubiquitination	-	4.38	21890473
730	Sumoylation	DLDGVPIKSLDDDLD CCCCCCCCCCCCCCC	38.61	-
731	Phosphorylation	LDGVPIKSLDDDLDG CCCCCCCCCCCCCCC	37.44	28355574
744	Phosphorylation	DGVPLDATEDSKKNE CCCCCCCCCCHHCCC	39.74	25159151
747	Phosphorylation	PLDATEDSKKNEPIF CCCCCCCHHCCCCCE	39.02	25159151
747	Ubiquitination	PLDATEDSKKNEPIF CCCCCCCHHCCCCCE	39.02	32015554
748	Acetylation	LDATEDSKKNEPIFK CCCCCCHHCCCCCEE	72.45	26051181
748	Sumoylation	LDATEDSKKNEPIFK CCCCCCHHCCCCCEE	72.45	28112733
748	Ubiquitination	LDATEDSKKNEPIFK CCCCCCHHCCCCCEE	72.45	32015554
749	Acetylation	DATEDSKKNEPIFKV CCCCCHHCCCCCEEE	71.18	26051181
749	Sumoylation	DATEDSKKNEPIFKV CCCCCHHCCCCCEEE	71.18	28112733
754	Ubiquitination	SKKNEPIFKVAPSKW HHCCCCCEEECCCCC	8.34	32015554
755	Acetylation	KKNEPIFKVAPSKWE HCCCCCEEECCCCCE	37.90	25953088
755	Ubiquitination	KKNEPIFKVAPSKWE HCCCCCEEECCCCCE	37.90	32015554
759	Phosphorylation	PIFKVAPSKWEAVDE CCEEECCCCCEECCH	40.43	-
759	Ubiquitination	PIFKVAPSKWEAVDE CCEEECCCCCEECCH	40.43	32015554
759 (in isoform 2)	Ubiquitination	-	40.43	21890473
760	Sumoylation	IFKVAPSKWEAVDES CEEECCCCCEECCHH	48.25	-
760	Acetylation	IFKVAPSKWEAVDES CEEECCCCCEECCHH	48.25	19608861
760	Sumoylation	IFKVAPSKWEAVDES CEEECCCCCEECCHH	48.25	28112733
760	Ubiquitination	IFKVAPSKWEAVDES CEEECCCCCEECCHH	48.25	22817900
760 (in isoform 1)	Ubiquitination	-	48.25	21890473
767	Phosphorylation	KWEAVDESELEAQAV CCEECCHHHHHHHEE	42.91	20873877
788	Phosphorylation	LFDQHEESEEEENQN HHHHHHHHHHHHHHC	47.53	27362937
800	Phosphorylation	NQNQEEESEDEEDTQ HHCHHHHCCCHHHHH	54.34	27362937
806	Phosphorylation	ESEDEEDTQSSKSEE HCCCHHHHHHHHHHH	33.36	26074081
808	Phosphorylation	EDEEDTQSSKSEEHH CCHHHHHHHHHHHHH	41.65	26074081
809	Phosphorylation	DEEDTQSSKSEEHHL CHHHHHHHHHHHHHH	30.31	26074081
811	Phosphorylation	EDTQSSKSEEHHLYS HHHHHHHHHHHHHHC	50.60	30266825
817	Phosphorylation	KSEEHHLYSNPIKEE HHHHHHHHCCCCCHH	11.31	28796482
818	Phosphorylation	SEEHHLYSNPIKEEM HHHHHHHCCCCCHHH	42.35	28796482
822	Sumoylation	HLYSNPIKEEMTESK HHHCCCCCHHHHHHH	49.21	-
822	Sumoylation	HLYSNPIKEEMTESK HHHCCCCCHHHHHHH	49.21	28112733
828	Ubiquitination	IKEEMTESKFSKYSE CCHHHHHHHHHHHHH	29.81	32015554
829	Sumoylation	KEEMTESKFSKYSEM CHHHHHHHHHHHHHC	47.64	28112733
829	Ubiquitination	KEEMTESKFSKYSEM CHHHHHHHHHHHHHC	47.64	32015554
831	Phosphorylation	EMTESKFSKYSEMSE HHHHHHHHHHHHCCH	34.13	23403867
831	Ubiquitination	EMTESKFSKYSEMSE HHHHHHHHHHHHCCH	34.13	32015554
832	Sumoylation	MTESKFSKYSEMSEE HHHHHHHHHHHCCHH	56.80	-
832	Acetylation	MTESKFSKYSEMSEE HHHHHHHHHHHCCHH	56.80	25953088
832	Methylation	MTESKFSKYSEMSEE HHHHHHHHHHHCCHH	56.80	110877503
832	Sumoylation	MTESKFSKYSEMSEE HHHHHHHHHHHCCHH	56.80	28112733
832	Ubiquitination	MTESKFSKYSEMSEE HHHHHHHHHHHCCHH	56.80	32015554
833	Phosphorylation	TESKFSKYSEMSEEK HHHHHHHHHHCCHHH	14.52	28796482
834	Phosphorylation	ESKFSKYSEMSEEKR HHHHHHHHHCCHHHH	30.47	28796482
837	Phosphorylation	FSKYSEMSEEKRAKL HHHHHHCCHHHHHHH	38.25	23403867
840	Acetylation	YSEMSEEKRAKLREI HHHCCHHHHHHHHHH	54.31	25953088
850	Acetylation	KLREIELKVMKFQDE HHHHHHHHHHHHHHH	27.74	25953088
866	Acetylation	ESGKRPKKPGQSFQE HCCCCCCCCCCCHHH	58.00	26051181
866	Malonylation	ESGKRPKKPGQSFQE HCCCCCCCCCCCHHH	58.00	26320211
870	Phosphorylation	RPKKPGQSFQEQVEH CCCCCCCCHHHHHHH	34.51	28555341
881	Acetylation	QVEHYRDKLLQREKE HHHHHHHHHHHHHHH	41.94	26051181
898	Ubiquitination	LERERERDKKDKEKL HHHHHHHHHHHHHHH	58.57	24816145
899	Ubiquitination	ERERERDKKDKEKLE HHHHHHHHHHHHHHH	69.92	24816145
900	Ubiquitination	RERERDKKDKEKLES HHHHHHHHHHHHHHH	77.61	24816145
902	Acetylation	RERDKKDKEKLESRS HHHHHHHHHHHHHHC	66.67	20167786
904	Acetylation	RDKKDKEKLESRSKD HHHHHHHHHHHHCCC	64.39	7704089
907	Phosphorylation	KDKEKLESRSKDKKE HHHHHHHHHCCCHHH	52.90	29457462
910	Acetylation	EKLESRSKDKKEKDE HHHHHHCCCHHHCCC	72.89	20167786
912	Acetylation	LESRSKDKKEKDECT HHHHCCCHHHCCCCC	67.57	20167786
912	Ubiquitination	LESRSKDKKEKDECT HHHHCCCHHHCCCCC	67.57	24816145
913	Ubiquitination	ESRSKDKKEKDECTP HHHCCCHHHCCCCCC	78.94	24816145
919	Phosphorylation	KKEKDECTPTRKERK HHHCCCCCCCHHHHH	26.16	27794612
921	Phosphorylation	EKDECTPTRKERKRR HCCCCCCCHHHHHHH	35.90	27794612
930	Phosphorylation	KERKRRHSTSPSPSR HHHHHHCCCCCCCCC	28.86	27273156
931	Phosphorylation	ERKRRHSTSPSPSRS HHHHHCCCCCCCCCC	38.23	27273156
932	Phosphorylation	RKRRHSTSPSPSRSS HHHHCCCCCCCCCCC	26.79	27273156
934	Phosphorylation	RRHSTSPSPSRSSSG HHCCCCCCCCCCCCC	34.96	27273156
936	Phosphorylation	HSTSPSPSRSSSGRR CCCCCCCCCCCCCCC	49.48	27273156
938	Phosphorylation	TSPSPSRSSSGRRVK CCCCCCCCCCCCCCC	32.94	25884760
939	Phosphorylation	SPSPSRSSSGRRVKS CCCCCCCCCCCCCCC	35.38	29262532
940	Phosphorylation	PSPSRSSSGRRVKSP CCCCCCCCCCCCCCC	37.25	29262532
946	Phosphorylation	SSGRRVKSPSPKSER CCCCCCCCCCCCCHH	27.96	27273156
947	Phosphorylation	SGRRVKSPSPKSERS CCCCCCCCCCCCHHH	49.27	32645325
948	Phosphorylation	GRRVKSPSPKSERSE CCCCCCCCCCCHHHH	52.64	27273156
951	Phosphorylation	VKSPSPKSERSERSE CCCCCCCCHHHHHHH	41.44	23898821
954	Phosphorylation	PSPKSERSERSERSH CCCCCHHHHHHHHHH	33.05	30576142
957	Phosphorylation	KSERSERSERSHKES CCHHHHHHHHHHHHH	33.05	23312004
960	Phosphorylation	RSERSERSHKESSRS HHHHHHHHHHHHHHH	34.55	22817901
967	Phosphorylation	SHKESSRSRSSHKDS HHHHHHHHHCCCCCC	38.16	24719451
969	Phosphorylation	KESSRSRSSHKDSPR HHHHHHHCCCCCCHH	37.73	30576142
970	Phosphorylation	ESSRSRSSHKDSPRD HHHHHHCCCCCCHHH	33.18	30576142
974	Phosphorylation	SRSSHKDSPRDVSKK HHCCCCCCHHHHHHH	27.00	30576142
979	Phosphorylation	KDSPRDVSKKAKRSP CCCHHHHHHHHHCCC	32.50	21406692
985	Phosphorylation	VSKKAKRSPSGSRTP HHHHHHCCCCCCCCC	23.78	30576142
987	Phosphorylation	KKAKRSPSGSRTPKR HHHHCCCCCCCCCCC	51.12	30576142
989	Phosphorylation	AKRSPSGSRTPKRSR HHCCCCCCCCCCCCH	37.00	30576142
991	Phosphorylation	RSPSGSRTPKRSRRS CCCCCCCCCCCCHHC	34.55	30576142
1002	Phosphorylation	SRRSRSRSPKKSGKK CHHCCCCCCCCCCCC	42.17	22798277
1010	Phosphorylation	PKKSGKKSRSQSRSP CCCCCCCCCCCCCCC	40.42	25849741
1012	Phosphorylation	KSGKKSRSQSRSPHR CCCCCCCCCCCCCCH	39.33	25849741
1014	Phosphorylation	GKKSRSQSRSPHRSH CCCCCCCCCCCCHHC	35.65	25849741
1016	Phosphorylation	KSRSQSRSPHRSHKK CCCCCCCCCCHHCCH	30.24	25849741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SR140_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SR140_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SR140_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PR40A_HUMAN	PRPF40A	physical	22365833
SPF45_HUMAN	RBM17	physical	22365833
RBM10_HUMAN	RBM10	physical	22365833
RBM5_HUMAN	RBM5	physical	22365833
CTBL1_HUMAN	CTNNBL1	physical	22365833
DDX42_HUMAN	DDX42	physical	22365833
TRA2A_HUMAN	TRA2A	physical	22365833
PLOD1_HUMAN	PLOD1	physical	28514442
CSTFT_HUMAN	CSTF2T	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SR140_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-760, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485; SER-788 ANDSER-800, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-788 AND SER-800, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811; SER-946 ANDSER-948, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-946 AND SER-948, ANDMASS SPECTROMETRY.	15302935 [Abstract]