USP9Y_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USP9Y_HUMAN
• UniProt AC: O00507
• Protein Name: Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
• Gene Name: USP9Y
• Organism: Homo sapiens (Human).
• Sequence Length: 2555
• Subcellular Localization: Cytoplasm.
• Protein Description: May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity)..
• Protein Sequence: MTAITHGSPVGGNDSQGQVLDGQSQHLFQQNQTSSPDSSNENSVATPPPEEQGQGDAPPQHEDEEPAFPHTELANLDDMINRPRWVVPVLPKGELEVLLEAAIDLSVKGLDVKSEACQRFFRDGLTISFTKILMDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCELISSNAQLPEDELFARSSDPRSPKGWLVDLINKFGTLNGFQILHDRFFNGSALNIQIIAALIKPFGQCYEFLSQHTLKKYFIPVIEIVPHLLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRISGQDETIKNLEIFRLKMILRLLQISSFNGKMNALNEINKVISSVSYYTHRHSNPEEEEWLTAERMAEWIQQNNILSIVLQDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPGQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAQSDDVPVDIMDLALSAHIKILDYSCSQDRDAQKIQWIDHFIEELRTNDKWVIPALKQIREICSLFGEASQNLSQTQRSPHIFYRHDLINQLQQNHALVTLVAENLATYMNSIRLYAGDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCRERKLIAKRRSYMMDDLELIGLDYLWRVVIQSSDEIANRAIDLLKEIYTNLGPRLKANQVVIHEDFIQSCFDRLKASYDTLCVFDGDKNSINCARQEAIRMVRVLTVIKEYINECDSDYHKERMILPMSRAFRGKHLSLIVRFPNQGRQVDELDIWSHTNDTIGSVRRCIVNRIKANVAHKKIELFVGGELIDSEDDRKLIGQLNLKDKSLITAKLTQINFNMPSSPDSSSDSSTASPGNHRNHYNDGPNLEVESCLPGVIMSVHPRYISFLWQVADLGSNLNMPPLRDGARVLMKLMPPDRTAVEKLRAVCLDHAKLGEGKLSPPLDSLFFGPSASQVLYLTEVVYALLMPAGVPLTDGSSDFQVHFLKSGGLPLVLSMLIRNNFLPNTDMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPVVDGTDPITQINQVTHDQAVVLQSALQSIPNPSSECVLRNESILLAQEISNEASRYMPDICVIRAIQKIIWASACGALGLVFSPNEEITKIYQMTTNGSNKLEVEDEQVCCEALEVMTLCFALLPTALDALSKEKAWQTFIIDLLLHCPSKTVRQLAQEQFFLMCTRCCMGHRPLLFFITLLFTILGSTAREKGKYSGDYFTLLRHLLNYAYNGNINIPNAEVLLVSEIDWLKRIRDNVKNTGETGVEEPILEGHLGVTKELLAFQTSEKKYHFGCEKGGANLIKELIDDFIFPASKVYLQYLRSGELPAEQAIPVCSSPVTINAGFELLVALAIGCVRNLKQIVDCLTEMYYMGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDSESNVDPRDDVFGYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAILSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVKRLLIKKLPRVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMGPYTVAGVANLERDNVNSENELIEQKEQSDNETAGGTKYRLVGVLVHSGQASGGHYYSYIIQRNGKDDQTDHWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYEQMDMIDEDDEMIRYISELTIARPHQIIMSPAIERSVRKQNVKFMHNRLQYSLEYFQFVKKLLTCNGVYLNPAPGQDYLLPEAEEITMISIQLAARFLFTTGFHTKKIVRGPASDWYDALCVLLRHSKNVRFWFTHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGSCPSPFASPGPSSQACDNLSLSDHLLRATLNLLRREVSEHGHHLQQYFNLFVMYANLGVAEKTQLLKLNVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSTMQSSINGNPPLPNPFGDLNLSQPIMPIQQNVLDILFVRTSYVKKIIEDCSNSEDTIKLLRFCSWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLFQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYSYNNWSPPVQSNETANGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHEPSPSEDAPLYPHSPASQYQQNNHVHGQPYTGPAAHHLNNPQKTGQRTQENYEGNEEVSSPQMKDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Ubiquitination	SVKGLDVKSEACQRF HCCCCCCCHHHHHHH	42.09	32015554
128	Phosphorylation	FRDGLTISFTKILMD HCCCCEEEEEHHHHH	22.94	24719451
213	Phosphorylation	DELFARSSDPRSPKG HHHHCCCCCCCCCCC	46.19	17081983
219	Ubiquitination	SSDPRSPKGWLVDLI CCCCCCCCCHHHHHH	65.06	22817900
300	Acetylation	EELKKEAKNEAKNDA HHHHHHHHHHHHHHH	57.31	7430791
304	Acetylation	KEAKNEAKNDALSMI HHHHHHHHHHHHHHH	49.54	11794719
304	Malonylation	KEAKNEAKNDALSMI HHHHHHHHHHHHHHH	49.54	26320211
304	Ubiquitination	KEAKNEAKNDALSMI HHHHHHHHHHHHHHH	49.54	32015554
309	Phosphorylation	EAKNDALSMIIKSLK HHHHHHHHHHHHHHH	15.06	21712546
313	Acetylation	DALSMIIKSLKNLAS HHHHHHHHHHHHHHH	38.52	25953088
313	Ubiquitination	DALSMIIKSLKNLAS HHHHHHHHHHHHHHH	38.52	22817900
314	Phosphorylation	ALSMIIKSLKNLASR HHHHHHHHHHHHHHH	33.88	20068231
316	Acetylation	SMIIKSLKNLASRIS HHHHHHHHHHHHHHC	57.94	7430801
316	Ubiquitination	SMIIKSLKNLASRIS HHHHHHHHHHHHHHC	57.94	21890473
330	Ubiquitination	SGQDETIKNLEIFRL CCCCHHHHHHHHHHH	64.00	29967540
365	Phosphorylation	EINKVISSVSYYTHR HHHHHHHHHHHHCCC	12.17	28555341
367	Phosphorylation	NKVISSVSYYTHRHS HHHHHHHHHHCCCCC	17.86	21945579
368	Phosphorylation	KVISSVSYYTHRHSN HHHHHHHHHCCCCCC	15.38	21945579
369	Phosphorylation	VISSVSYYTHRHSNP HHHHHHHHCCCCCCH	6.64	21945579
370	Phosphorylation	ISSVSYYTHRHSNPE HHHHHHHCCCCCCHH	12.28	21945579
404	Phosphorylation	LSIVLQDSLHQPQYV HHHHHHCCCCCHHHH	18.13	-
410	Phosphorylation	DSLHQPQYVEKLEKI CCCCCHHHHHHHHHH	19.77	-
413	Acetylation	HQPQYVEKLEKILRF CCHHHHHHHHHHHHH	52.48	23236377
423	Ubiquitination	KILRFVIKEKALTLQ HHHHHHHHHCCCCHH	48.11	22817900
425	Ubiquitination	LRFVIKEKALTLQDL HHHHHHHCCCCHHHH	43.63	21890473
425 (in isoform 1)	Ubiquitination	-	43.63	21890473
425 (in isoform 2)	Ubiquitination	-	43.63	21890473
442	Ubiquitination	IWAAQAGKHEAIVKN HHHHHCCCHHHHHCC	41.09	32015554
448	Ubiquitination	GKHEAIVKNVHDLLA CCHHHHHCCHHHHHH	47.33	29967540
482	Ubiquitination	ASWTNASKKQREKLL HHCCCCCHHHHHHHH	50.98	22817900
483	Ubiquitination	SWTNASKKQREKLLE HCCCCCHHHHHHHHH	52.68	22817900
487	Ubiquitination	ASKKQREKLLELIRR CCHHHHHHHHHHHHH	61.64	21890473
487 (in isoform 1)	Ubiquitination	-	61.64	21890473
487 (in isoform 2)	Ubiquitination	-	61.64	21890473
500	Acetylation	RRLAEDDKDGVMAHK HHHHHCCCCCHHHHH	69.57	25953088
549	Ubiquitination	SQDRDAQKIQWIDHF CCCCCHHHHHHHHHH	38.29	29967540
561	Methylation	DHFIEELRTNDKWVI HHHHHHHHCCCCCHH	34.46	-
572	Ubiquitination	KWVIPALKQIREICS CCHHHHHHHHHHHHH	45.87	21890473
572 (in isoform 1)	Ubiquitination	-	45.87	21890473
572 (in isoform 2)	Ubiquitination	-	45.87	21890473
589	Phosphorylation	GEASQNLSQTQRSPH HHHHHCHHCCCCCCC	38.44	-
591	Phosphorylation	ASQNLSQTQRSPHIF HHHCHHCCCCCCCHH	23.67	-
631	Phosphorylation	YMNSIRLYAGDHEDY HHHHHEEECCCCCCC	9.93	23090842
638	Phosphorylation	YAGDHEDYDPQTVRL ECCCCCCCCCCCCCC	26.91	23090842
642	Phosphorylation	HEDYDPQTVRLGSRY CCCCCCCCCCCCCCC	17.00	23090842
647	Phosphorylation	PQTVRLGSRYSHVQE CCCCCCCCCCHHHHH	32.41	23090842
667	Ubiquitination	NFLRFLLKDGQLWLC HHHHHHHHCCCEEEE	63.06	-
679	Ubiquitination	WLCAPQAKQIWKCLA EEECHHHHHHHHHHH	36.75	-
683	Ubiquitination	PQAKQIWKCLAENAV HHHHHHHHHHHHCCE	22.47	32015554
702	Phosphorylation	REACFKWYSKLMGDE HHHHHHHHHHHHCCC	9.12	20068231
703	Phosphorylation	EACFKWYSKLMGDEP HHHHHHHHHHHCCCC	20.42	20068231
746	Acetylation	KCFERFFKAVNCRER HHHHHHHHHCCHHHH	49.03	26051181
746	Ubiquitination	KCFERFFKAVNCRER HHHHHHHHHCCHHHH	49.03	-
795	Ubiquitination	NRAIDLLKEIYTNLG HHHHHHHHHHHHHCC	49.73	21890473
795 (in isoform 1)	Ubiquitination	-	49.73	21890473
795 (in isoform 2)	Ubiquitination	-	49.73	21890473
798	Phosphorylation	IDLLKEIYTNLGPRL HHHHHHHHHHCCHHH	7.23	-
800	Ubiquitination	LLKEIYTNLGPRLKA HHHHHHHHCCHHHCC	26.48	21890473
825	Ubiquitination	QSCFDRLKASYDTLC HHHHHHHHHCCCEEE	35.86	29967540
838	Ubiquitination	LCVFDGDKNSINCAR EEEECCCCCCHHHHH	59.11	-
869	Phosphorylation	INECDSDYHKERMIL HHHCCCHHHHHHCHH	20.81	-
871	Ubiquitination	ECDSDYHKERMILPM HCCCHHHHHHCHHCC	40.56	-
879	Phosphorylation	ERMILPMSRAFRGKH HHCHHCCCHHHCCCE	20.65	20860994
885	Ubiquitination	MSRAFRGKHLSLIVR CCHHHCCCEEEEEEE	36.80	-
907	Phosphorylation	VDELDIWSHTNDTIG CCEEEECCCCCCCHH	22.29	24043423
909	Phosphorylation	ELDIWSHTNDTIGSV EEEECCCCCCCHHHH	29.31	24043423
912	Phosphorylation	IWSHTNDTIGSVRRC ECCCCCCCHHHHHHH	29.34	25954137
915	Phosphorylation	HTNDTIGSVRRCIVN CCCCCHHHHHHHHHH	14.48	25954137
957	Ubiquitination	LIGQLNLKDKSLITA HHHHCCCCCHHHHEE	63.14	32015554
959	2-Hydroxyisobutyrylation	GQLNLKDKSLITAKL HHCCCCCHHHHEEEE	45.64	-
959	Ubiquitination	GQLNLKDKSLITAKL HHCCCCCHHHHEEEE	45.64	-
965	Ubiquitination	DKSLITAKLTQINFN CHHHHEEEEEEEECC	43.34	-
1030	Phosphorylation	WQVADLGSNLNMPPL HHHHHCCCCCCCCCC	45.50	21406692
1046	Ubiquitination	DGARVLMKLMPPDRT CCHHHHHHHCCCCHH	37.16	22817900
1051	Ubiquitination	LMKLMPPDRTAVEKL HHHHCCCCHHHHHHH	55.48	22817900
1057	Ubiquitination	PDRTAVEKLRAVCLD CCHHHHHHHHHHHHH	36.35	-
1067	Ubiquitination	AVCLDHAKLGEGKLS HHHHHHHHCCCCCCC	54.31	29967540
1121	Phosphorylation	FQVHFLKSGGLPLVL CEEEEHHHCCHHHHH	39.99	-
1129	Phosphorylation	GGLPLVLSMLIRNNF CCHHHHHHHHHHCCC	12.22	25599653
1149	Phosphorylation	METRRGAYLNALKIA CCHHCHHHHHHHHHH	11.87	-
1154	Ubiquitination	GAYLNALKIAKLLLT HHHHHHHHHHHHHHH	37.90	21890473
1154 (in isoform 1)	Ubiquitination	-	37.90	21890473
1154 (in isoform 2)	Ubiquitination	-	37.90	21890473
1157	Ubiquitination	LNALKIAKLLLTAIG HHHHHHHHHHHHHHC	43.04	22817900
1159	Ubiquitination	ALKIAKLLLTAIGYG HHHHHHHHHHHHCCC	3.83	21890473
1162	Ubiquitination	IAKLLLTAIGYGHVR HHHHHHHHHCCCHHH	7.99	22817900
1219	Phosphorylation	ECVLRNESILLAQEI CCHHCCHHHHHHHHH	23.29	-
1227	Phosphorylation	ILLAQEISNEASRYM HHHHHHHCHHHHHCC	28.06	-
1231	Phosphorylation	QEISNEASRYMPDIC HHHCHHHHHCCCCHH	20.12	-
1233	Phosphorylation	ISNEASRYMPDICVI HCHHHHHCCCCHHHH	15.54	19664994
1269	Phosphorylation	NEEITKIYQMTTNGS CHHHHHHEEECCCCC	8.19	20860994
1272	Phosphorylation	ITKIYQMTTNGSNKL HHHHEEECCCCCCCE	11.11	20860994
1273	Phosphorylation	TKIYQMTTNGSNKLE HHHEEECCCCCCCEE	32.04	20860994
1276	Phosphorylation	YQMTTNGSNKLEVED EEECCCCCCCEEECC	32.63	20860994
1328	Ubiquitination	LLLHCPSKTVRQLAQ HHHCCCCHHHHHHHH	35.86	-
1343	Phosphorylation	EQFFLMCTRCCMGHR HHHHHHHHHHHCCCH	16.87	27174698
1372	Ubiquitination	STAREKGKYSGDYFT HHHHHCCCCCCCHHH	47.51	-
1417	Ubiquitination	KRIRDNVKNTGETGV HHHHHHCCCCCCCCC	55.86	-
1437	Ubiquitination	EGHLGVTKELLAFQT CCCCCCCHHHHHHCC	43.91	29967540
1447	Ubiquitination	LAFQTSEKKYHFGCE HHHCCCCCCCCCCCC	59.40	32015554
1448	Ubiquitination	AFQTSEKKYHFGCEK HHCCCCCCCCCCCCC	39.65	-
1455	Ubiquitination	KYHFGCEKGGANLIK CCCCCCCCCCHHHHH	67.72	29967540
1526	Phosphorylation	KQIVDCLTEMYYMGT HHHHHHHHHHHHHHH	25.66	24043423
1529	Phosphorylation	VDCLTEMYYMGTAIT HHHHHHHHHHHHHHH	5.53	24043423
1530	Phosphorylation	DCLTEMYYMGTAITT HHHHHHHHHHHHHHH	6.43	24043423
1533	Phosphorylation	TEMYYMGTAITTCEA HHHHHHHHHHHHHHH	9.80	24043423
1536	Phosphorylation	YYMGTAITTCEALTE HHHHHHHHHHHHHHC	23.95	24043423
1537	Phosphorylation	YMGTAITTCEALTEW HHHHHHHHHHHHHCC	11.39	24043423
1542	Phosphorylation	ITTCEALTEWEYLPP HHHHHHHHCCCCCCC	46.21	24043423
1546	Phosphorylation	EALTEWEYLPPVGPR HHHHCCCCCCCCCCC	26.11	24043423
1567	Phosphorylation	GLKNAGATCYMNSVI CCCCCCCCHHHCHHH	11.84	24719451
1578	Phosphorylation	NSVIQQLYMIPSIRN CHHHHHHHCCHHHHH	6.67	24719451
1582	Phosphorylation	QQLYMIPSIRNSILA HHHHCCHHHHHCEEE	24.21	24719451
1629	Ubiquitination	YPHQFEDKPALSKTE CCCCCCCCCCCCCCC	25.62	22817900
1634	Ubiquitination	EDKPALSKTEDRKEY CCCCCCCCCCCCHHH	57.70	33845483
1639	Ubiquitination	LSKTEDRKEYNIGVL CCCCCCCHHHCHHHH	76.50	21890473
1639 (in isoform 1)	Ubiquitination	-	76.50	21890473
1639 (in isoform 2)	Ubiquitination	-	76.50	21890473
1644	Ubiquitination	DRKEYNIGVLRHLQV CCHHHCHHHHHHHHH	14.58	21890473
1663	Phosphorylation	LAASQLQYYVPRGFW HHHHHCCHHCCCCHH	18.28	23917254
1671	Ubiquitination	YVPRGFWKQFRLWGE HCCCCHHHHHHHCCC	36.98	21890473
1671 (in isoform 1)	Ubiquitination	-	36.98	21890473
1671 (in isoform 2)	Ubiquitination	-	36.98	21890473
1676	Ubiquitination	FWKQFRLWGEPVNLR HHHHHHHCCCCCCHH	12.59	21890473
1724	Acetylation	GGSFADQKICQGCPH CCCHHCCCCCCCCCC	46.10	23954790
1724	Ubiquitination	GGSFADQKICQGCPH CCCHHCCCCCCCCCC	46.10	21890473
1724 (in isoform 1)	Ubiquitination	-	46.10	21890473
1724 (in isoform 2)	Ubiquitination	-	46.10	21890473
1729	Ubiquitination	DQKICQGCPHRYECE CCCCCCCCCCCCCCC	0.76	21890473
1738	Phosphorylation	HRYECEESFTTLNVD CCCCCCCCEEEECCC	12.95	28787133
1740	Phosphorylation	YECEESFTTLNVDIR CCCCCCEEEECCCCC	39.39	28787133
1782	Phosphorylation	KCDKKVDTVKRLLIK CCCCCCHHHHHHHHH	30.80	23403867
1784	2-Hydroxyisobutyrylation	DKKVDTVKRLLIKKL CCCCHHHHHHHHHHC	39.15	-
1800	Ubiquitination	RVLAIQLKRFDYDWE HHHEEEEECCCCCHH	34.34	23000965
1805	Ubiquitination	QLKRFDYDWERECAI EEECCCCCHHHHHEE	42.47	23000965
1813	Ubiquitination	WERECAIKFNDYFEF HHHHHEEEECCCCCC	21.42	22817900
1813 (in isoform 1)	Ubiquitination	-	21.42	21890473
1813 (in isoform 2)	Ubiquitination	-	21.42	21890473
1817	Phosphorylation	CAIKFNDYFEFPREL HEEEECCCCCCCCCC	13.20	28152594
1818	Ubiquitination	AIKFNDYFEFPRELD EEEECCCCCCCCCCC	9.70	21890473
1829	Phosphorylation	RELDMGPYTVAGVAN CCCCCCCCCCHHEEE	14.23	-
1830	Phosphorylation	ELDMGPYTVAGVANL CCCCCCCCCHHEEEC	13.65	-
1852	Ubiquitination	ENELIEQKEQSDNET HHHHHHHHHHCCCCC	44.95	29967540
1874	Phosphorylation	LVGVLVHSGQASGGH EEEEEEECCCCCCCE	25.72	28152594
1878	Phosphorylation	LVHSGQASGGHYYSY EEECCCCCCCEEEEE	37.10	28152594
1882	Phosphorylation	GQASGGHYYSYIIQR CCCCCCEEEEEEEEE	9.44	28152594
1883	Phosphorylation	QASGGHYYSYIIQRN CCCCCEEEEEEEEEC	6.85	28152594
1884	Phosphorylation	ASGGHYYSYIIQRNG CCCCEEEEEEEEECC	11.59	28152594
1885	Phosphorylation	SGGHYYSYIIQRNGK CCCEEEEEEEEECCC	5.97	28152594
1901	Ubiquitination	DQTDHWYKFDDGDVT CCCCCEEECCCCCCE	36.81	32015554
1911	Ubiquitination	DGDVTECKMDDDEEM CCCCEEEECCCCHHH	38.85	32015554
1937	Ubiquitination	EVFDHMMKRMSYRRQ HHHHHHHHHHHHHHH	37.06	22817900
1937 (in isoform 1)	Ubiquitination	-	37.06	21890473
1937 (in isoform 2)	Ubiquitination	-	37.06	21890473
1942	Ubiquitination	MMKRMSYRRQKRWWN HHHHHHHHHHHHHHH	27.52	22817900
1985	Phosphorylation	RPHQIIMSPAIERSV CCHHEEECHHHHHHH	10.77	20071362
2205	Phosphorylation	LKLNVPATFMLVSLD HCCCCCEEEEEEECC	11.96	-
2220	Ubiquitination	EGPGPPIKYQYAELG CCCCCCCEEEHHHHH	31.88	33845483
2228	Ubiquitination	YQYAELGKLYSVVSQ EEHHHHHHHHHHHHH	57.80	33845483
2361	Ubiquitination	HRIHNALKGIPDDRD HHHHHHHCCCCCCCC	53.00	21890473
2361 (in isoform 1)	Ubiquitination	-	53.00	21890473
2366	Ubiquitination	ALKGIPDDRDGLFDT HHCCCCCCCCCHHHH	45.26	21890473
2367	Methylation	LKGIPDDRDGLFDTI HCCCCCCCCCHHHHH	47.48	-
2444	Phosphorylation	QYSYNNWSPPVQSNE CCCCCCCCCCCCCCC	22.81	-
2461	O-linked_Glycosylation	NGYFLERSHSARMTL CCCCCCCCHHHHHHH	16.65	30379171
2461	Phosphorylation	NGYFLERSHSARMTL CCCCCCCCHHHHHHH	16.65	26074081
2463	Phosphorylation	YFLERSHSARMTLAK CCCCCCHHHHHHHHH	20.86	26074081
2467	Phosphorylation	RSHSARMTLAKACEL CCHHHHHHHHHHHHH	20.29	24719451
2533	Phosphorylation	HLNNPQKTGQRTQEN HCCCCCCCCCCCHHH	33.04	22210691
2541	Phosphorylation	GQRTQENYEGNEEVS CCCCHHHCCCCCCCC	25.18	-
2548	Phosphorylation	YEGNEEVSSPQMKDQ CCCCCCCCCCCCCCC	39.31	22210691
2549	Phosphorylation	EGNEEVSSPQMKDQ- CCCCCCCCCCCCCC-	25.07	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of USP9Y_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USP9Y_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USP9Y_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	23287719

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 19246359). {ECO: Note=USP9Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. However, AZFa deletions resulting in complete loss of USP9Y have also been found in normospermic men (PubMed
• 415000:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.