AKAP9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKAP9_HUMAN
• UniProt AC: Q99996
• Protein Name: A-kinase anchor protein 9
• Gene Name: AKAP9
• Organism: Homo sapiens (Human).
• Sequence Length: 3907
• Subcellular Localization: Golgi apparatus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasmic in parietal cells (PubMed:9915845). Recruited to the Golgi apparatus by GM130/GOLGA2 (PubMed:25657325). Localization at the centrosome vers
• Protein Description: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. [PubMed: 10202149]
• Protein Sequence: MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQFHAGMRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	"N6,N6-dimethyllysine"	EDEERQKKLEAGKAK CHHHHHHHHHHHHHH	43.13	-
9	Methylation	EDEERQKKLEAGKAK CHHHHHHHHHHHHHH	43.13	-
36	Acetylation	GQSPSKKQKKKRKTS CCCCCHHHHHHCCCC	42.30	-
39	Phosphorylation	PSKKQKKKRKTSSSK CCHHHHHHCCCCCCC	48.87	29052541
43	Phosphorylation	QKKKRKTSSSKHDVS HHHHCCCCCCCCCHH	36.35	22496350
45	Phosphorylation	KKRKTSSSKHDVSAH HHCCCCCCCCCHHHH	58.70	29052541
47	Acetylation	RKTSSSKHDVSAHHD CCCCCCCCCHHHHCC	72.23	-
49	Acetylation	TSSSKHDVSAHHDLN CCCCCCCHHHHCCCC	69.97	-
55	Phosphorylation	DVSAHHDLNIDQSQC CHHHHCCCCCCHHHH	35.33	67052803
57	Phosphorylation	SAHHDLNIDQSQCNE HHHCCCCCCHHHHCC	33.50	-
62	Phosphorylation	LNIDQSQCNEMYINS CCCCHHHHCCEECCC	28.13	28555341
78	Phosphorylation	QRVESTVIPESTIMR CCCEEECCCHHHHHE	7.26	-
78 (in isoform 6)	Phosphorylation	-	7.26	27642862
96	Sulfoxidation	SGEITSHEQGFSVEL CCCCCCCCCCEEEEE	2.44	21406390
146 (in isoform 2)	Phosphorylation	-	7.60	27251275
153	Phosphorylation	SEQGAQDSPTHLEMM CCCCCCCCHHHHHHH	10.05	24275569
153 (in isoform 2)	Phosphorylation	-	10.05	27251275
156	Phosphorylation	GAQDSPTHLEMMESE CCCCCHHHHHHHHHH	26.54	30108239
157	Phosphorylation	AQDSPTHLEMMESEL CCCCHHHHHHHHHHH	24.19	27251275
158	Phosphorylation	QDSPTHLEMMESELA CCCHHHHHHHHHHHC	27.65	30108239
165	Phosphorylation	EMMESELAGKQHEIE HHHHHHHCCCHHHHH	21.44	21712546
167	Phosphorylation	MESELAGKQHEIEEL HHHHHCCCHHHHHHH	42.94	28192239
174	Phosphorylation	KQHEIEELNRELEEM CHHHHHHHHHHHHHH	21.73	21712546
220	Phosphorylation	NLQQARREKDETMRE HHHHHHHHHHHHHHH	18.66	-
236	Phosphorylation	LELTEQSQKLQIQFQ HHHHHHHHHHHHHHH	31.49	21406692
244	Phosphorylation	KLQIQFQQLQASETL HHHHHHHHHHHHHHH	23.70	25599653
247	Phosphorylation	IQFQQLQASETLRNS HHHHHHHHHHHHHHC	24.05	25599653
255	Phosphorylation	SETLRNSTHSSTAAD HHHHHHCCCCCHHHH	27.05	20068231
257	Phosphorylation	TLRNSTHSSTAADLL HHHHCCCCCHHHHHH	2.98	20068231
260	Phosphorylation	NSTHSSTAADLLQAK HCCCCCHHHHHHHHH	20.39	25599653
262	Phosphorylation	THSSTAADLLQAKQQ CCCCHHHHHHHHHHH	28.64	25599653
266	Phosphorylation	TAADLLQAKQQILTH HHHHHHHHHHHHHHH	22.51	24275569
267	Phosphorylation	AADLLQAKQQILTHQ HHHHHHHHHHHHHHH	29.35	22496350
269	Phosphorylation	DLLQAKQQILTHQQQ HHHHHHHHHHHHHHH	29.49	22496350
270	Phosphorylation	LLQAKQQILTHQQQL HHHHHHHHHHHHHHH	17.92	20068231
271	Phosphorylation	LQAKQQILTHQQQLE HHHHHHHHHHHHHHH	28.95	20068231
320	Phosphorylation	DKKVENSNKEEIQEK HHCCCCCCHHHHHHH	12.45	-
386	Acetylation	ELTNSKQKERQSSEE HHCCHHHHHHHCHHH	50.68	20167786
390	Phosphorylation	SKQKERQSSEEIKQL HHHHHHHCHHHHHHH	4.54	18510355
391 (in isoform 2)	Phosphorylation	-	48.29	24719451
400 (in isoform 2)	Phosphorylation	-	49.03	24719451
402	Phosphorylation	KQLMGTVEELQKRNH HHHHHHHHHHHHHCC	46.03	18510355
403	Phosphorylation	QLMGTVEELQKRNHK HHHHHHHHHHHHCCC	30.80	24719451
412	Phosphorylation	QKRNHKDSQFETDIV HHHCCCCCCHHHHHH	15.69	24719451
489	Phosphorylation	TVNEDQIKLMNVAIN EECHHHHHHHHHHHH	33.49	-
490	Phosphorylation	VNEDQIKLMNVAINE ECHHHHHHHHHHHHH	10.17	-
491	Phosphorylation	NEDQIKLMNVAINEL CHHHHHHHHHHHHHH	24.01	-
494	Phosphorylation	QIKLMNVAINELNIK HHHHHHHHHHHHCHH	22.87	-
511 (in isoform 2)	Ubiquitination	-	24.14	-
513 (in isoform 2)	Ubiquitination	-	38.74	-
523	Ubiquitination	LGLILEEKCALQRQL HHHHHHHHHHHHHHH	72.41	-
525	Ubiquitination	LILEEKCALQRQLED HHHHHHHHHHHHHHH	61.28	-
583 (in isoform 2)	Ubiquitination	-	3.42	-
588 (in isoform 2)	Ubiquitination	-	2.69	-
595	Ubiquitination	KHEAEVTNYKIKLEM HHHHHHCCHHHHHHH	75.76	-
597 (in isoform 2)	Ubiquitination	-	11.94	-
600	Ubiquitination	VTNYKIKLEMLEKEK HCCHHHHHHHHHHHH	29.98	-
609	Ubiquitination	MLEKEKNAVLDRMAE HHHHHHHHHHHHHHH	35.12	-
666	Acetylation	LGIHYKQQIDGLQNE CCCCHHHHHHHHHHH	57.97	-
676	Acetylation	GLQNEMSQKIETMQF HHHHHHHHHHHHHHH	22.89	-
712	Phosphorylation	LQQSLVNSKSEEMTL HHHHHCCCCCHHHHH	23.66	68725397
718	Phosphorylation	NSKSEEMTLQINELQ CCCCHHHHHHHHHHH	40.73	18767875
724	Phosphorylation	MTLQINELQKEIEIL HHHHHHHHHHHHHHH	30.03	68725397
726 (in isoform 2)	Ubiquitination	-	38.31	-
730	Phosphorylation	ELQKEIEILRQEEKE HHHHHHHHHHHHHHH	20.84	18767875
736 (in isoform 2)	Ubiquitination	-	8.35	-
738	Ubiquitination	LRQEEKEKGTLEQEV HHHHHHHCCCHHHHH	73.59	-
748	Ubiquitination	LEQEVQELQLKTELL HHHHHHHHHHHHHHH	65.06	-
785 (in isoform 2)	Ubiquitination	-	6.37	21890473
785 (in isoform 3)	Ubiquitination	-	6.37	21890473
790	Phosphorylation	EKKTLEDMLKIHTPV HHCCHHHHHHHCCCC	22.32	25159151
795 (in isoform 2)	Phosphorylation	-	55.66	24719451
797	Ubiquitination	MLKIHTPVSQEERLI HHHHCCCCCHHHHHH	57.19	2189047
797 (in isoform 1)	Ubiquitination	-	57.19	21890473
797 (in isoform 4)	Ubiquitination	-	57.19	21890473
797 (in isoform 5)	Ubiquitination	-	57.19	21890473
797 (in isoform 6)	Ubiquitination	-	57.19	21890473
807	Phosphorylation	EERLIFLDSIKSKSK HHHHHHHHHHCCCCC	28.94	28857561
810	Phosphorylation	LIFLDSIKSKSKDSV HHHHHHHCCCCCCCC	32.83	23312004
824	Ubiquitination	VWEKEIEILIEENED CHHHHHHHHHHCCHH	57.43	-
824 (in isoform 6)	Ubiquitination	-	57.43	-
863	Phosphorylation	NFEVNYQELQEEYAC HHEECHHHHHHHHHH	22.85	24719451
873	Phosphorylation	EEYACLLKVKDDLED HHHHHHHHHCCCCCC	14.45	29759185
921 (in isoform 2)	Ubiquitination	-	21.27	-
925	Methylation	DEDKTFVAETLEMGE CCCCCEEEEEHHHCC	33.58	-
933	Ubiquitination	ETLEMGEVVEKDTTE EEHHHCCEECCCHHH	41.64	-
968	Phosphorylation	DLSEQLKQKHGEISF HHHHHHHHHHCCHHH	12.13	29083192
972	Phosphorylation	QLKQKHGEISFLNEE HHHHHHCCHHHCHHH	38.40	29083192
975	Phosphorylation	QKHGEISFLNEEVKS HHHCCHHHCHHHHHH	28.43	29083192
986	Phosphorylation	EVKSLKQEKEQVSLR HHHHHHHHHHHHHHH	21.27	28555341
994	Phosphorylation	KEQVSLRCRELEIII HHHHHHHHEECEEEE	46.07	24719451
1041 (in isoform 2)	Phosphorylation	-	38.89	24719451
1053	Phosphorylation	SKIMVEDKVSFENMT CCEEEEEECEECCCC	33.03	29496963
1058	Phosphorylation	EDKVSFENMTVGEES EEECEECCCCCCCHH	24.15	26270265
1078	Acetylation	ILDHLPSVTKESSLR HHHCCCCCCHHHHCC	62.22	-
1106	Ubiquitination	LNVLKSEQNDLRLQM HHHHHHHHCHHHHHH	65.48	-
1106 (in isoform 6)	Ubiquitination	-	65.48	-
1115	Ubiquitination	DLRLQMEAQRICLSL HHHHHHHHHHHHHHH	47.89	-
1115 (in isoform 6)	Ubiquitination	-	47.89	-
1159	Ubiquitination	FAQEEKIKELQKIHQ HCCHHHHHHHHHHHH	32.61	-
1159 (in isoform 6)	Ubiquitination	-	32.61	-
1175	Ubiquitination	ELQTMKTQETGDEGK HHHHCCCCCCCCCCC	55.57	-
1175 (in isoform 6)	Ubiquitination	-	55.57	-
1185	Ubiquitination	GDEGKPLHLLIGKLQ CCCCCCHHHHHHHHH	50.90	-
1185 (in isoform 6)	Ubiquitination	-	50.90	-
1194	Ubiquitination	LIGKLQKAVSEECSY HHHHHHHHHHHHHHH	42.21	-
1194 (in isoform 6)	Ubiquitination	-	42.21	-
1205	Ubiquitination	ECSYFLQTLCSVLGE HHHHHHHHHHHHHHH	62.28	-
1205 (in isoform 6)	Ubiquitination	-	62.28	-
1225	Phosphorylation	LKCEVNAEDKENSGD CEEEECCCCCCCCCC	15.73	-
1226	Phosphorylation	KCEVNAEDKENSGDY EEEECCCCCCCCCCC	11.27	-
1230 (in isoform 2)	Phosphorylation	-	7.40	27251275
1235 (in isoform 2)	Phosphorylation	-	18.47	24719451
1242	Phosphorylation	SENEDPELQDYRYEV CCCCCHHHHHHHHHH	33.85	26657352
1245	Phosphorylation	EDPELQDYRYEVQDF CCHHHHHHHHHHHHH	15.18	75261
1247	Phosphorylation	PELQDYRYEVQDFQE HHHHHHHHHHHHHHH	28.30	25159151
1257	Phosphorylation	QDFQENMHTLLNKVT HHHHHHHHHHHHHHH	11.35	75261
1259	Phosphorylation	FQENMHTLLNKVTEE HHHHHHHHHHHHHHH	17.77	23663014
1270	Phosphorylation	VTEEYNKLLVLQTRL HHHHHHHHHHHHHHH	23.36	23663014
1281	Ubiquitination	QTRLSKIWGQQTDGM HHHHHHHHCCCCCCC	42.15	-
1281 (in isoform 6)	Ubiquitination	-	42.15	-
1291	Ubiquitination	QTDGMKLEFGEENLP CCCCCEEECCCCCCC	47.25	-
1291 (in isoform 6)	Ubiquitination	-	47.25	-
1301	Acetylation	EENLPKEETEFLSIH CCCCCHHHHHHHHHH	50.85	-
1311	Acetylation	FLSIHSQMTNLEDID HHHHHHHCCCHHHCC	71.93	-
1312 (in isoform 2)	Phosphorylation	-	69.11	27251275
1318	Phosphorylation	MTNLEDIDVNHKSKL CCCHHHCCCCCHHHH	24.47	27251275
1321	Phosphorylation	LEDIDVNHKSKLSSL HHHCCCCCHHHHHCH	21.70	27251275
1324	Phosphorylation	IDVNHKSKLSSLQDL CCCCCHHHHHCHHHH	29.08	27251275
1327	Phosphorylation	NHKSKLSSLQDLEKT CCHHHHHCHHHHHHH	55.80	23186163
1327 (in isoform 2)	Phosphorylation	-	55.80	24719451
1335	Phosphorylation	LQDLEKTKLEEQVQE HHHHHHHHHHHHHHH	31.14	26074081
1336	Acetylation	QDLEKTKLEEQVQEL HHHHHHHHHHHHHHH	58.13	25953088
1338	Phosphorylation	LEKTKLEEQVQELES HHHHHHHHHHHHHHH	32.51	28450419
1339	Phosphorylation	EKTKLEEQVQELESL HHHHHHHHHHHHHHH	40.25	29255136
1346	Phosphorylation	QVQELESLISSLQQQ HHHHHHHHHHHHHHH	31.33	26074081
1382	Ubiquitination	VSESTVPPSLPVDSV HHHCCCCCCCCCCEE	41.97	-
1382 (in isoform 6)	Ubiquitination	-	41.97	-
1420	Ubiquitination	TIEFSGEFGVKEETN CEEECCCCCCCCCHH	38.44	-
1420 (in isoform 6)	Ubiquitination	-	38.44	-
1442	Ubiquitination	QYQEQLEEEVAKVIV HHHHHHHHHHHHHHH	43.49	-
1446	Ubiquitination	QLEEEVAKVIVSMSI HHHHHHHHHHHHHHH	55.03	-
1446 (in isoform 6)	Ubiquitination	-	55.03	-
1499	Phosphorylation	KLSQDQIGFQTFETV CCCHHHCCCCEEEEE	14.06	28796482
1527	Acetylation	ELGEHGKEILLSNSD HHHHHHCEEECCCCC	48.61	23236377
1527 (in isoform 6)	Malonylation	-	48.61	32601280
1531 (in isoform 2)	Phosphorylation	-	65.72	27251275
1538	Ubiquitination	SNSDPHDIPESKDCV CCCCCCCCCCCCCEE	43.41	-
1538 (in isoform 6)	Ubiquitination	-	43.41	-
1543	Phosphorylation	HDIPESKDCVLTISE CCCCCCCCEEEEEEH	30.73	25159151
1545	Phosphorylation	IPESKDCVLTISEEM CCCCCCEEEEEEHHH	49.49	25159151
1553	Phosphorylation	LTISEEMFSKDKTFI EEEEHHHHCCCCEEE	28.56	23312004
1564 (in isoform 2)	Phosphorylation	-	3.95	27251275
1566	Phosphorylation	FIVRQSIHDEISVSS EEEECCCCCCCCCCH	38.34	28192239
1576	Phosphorylation	ISVSSMDASRQLMLN CCCCHHHHHHHHHCC	16.01	22210691
1582	Phosphorylation	DASRQLMLNEEQLED HHHHHHHCCHHHHHH	17.56	22210691
1584	Phosphorylation	SRQLMLNEEQLEDMR HHHHHCCHHHHHHHH	17.10	27251275
1585	Phosphorylation	RQLMLNEEQLEDMRQ HHHHCCHHHHHHHHH	20.65	24275569
1589	Phosphorylation	LNEEQLEDMRQELVR CCHHHHHHHHHHHHH	19.12	22210691
1641 (in isoform 2)	Phosphorylation	-	40.63	27251275
1642 (in isoform 2)	Phosphorylation	-	2.87	24719451
1653	Phosphorylation	ENLVSERERVLLEEL CCCCCHHHHHHHHHH	21.40	23927012
1654	Phosphorylation	NLVSERERVLLEELE CCCCHHHHHHHHHHH	35.83	23927012
1676	Ubiquitination	AGREKLCCELRNSST CCHHHHHHHHCCCCC	57.13	-
1676 (in isoform 6)	Ubiquitination	-	57.13	-
1679	Phosphorylation	EKLCCELRNSSTQTQ HHHHHHHCCCCCCCC	17.43	24719451
1685	Ubiquitination	LRNSSTQTQNGNENQ HCCCCCCCCCCCCCC	45.52	-
1685 (in isoform 6)	Ubiquitination	-	45.52	-
1765	Phosphorylation	DRSSKSQSSASLIWR CCCCCCCCCCCCHHH	5.15	23186163
1765 (in isoform 2)	Phosphorylation	-	5.15	27251275
1775	Phosphorylation	SLIWRSEAEASVKSC CCHHHCHHHHHHHHH	36.92	24275569
1777	Phosphorylation	IWRSEAEASVKSCVH HHHCHHHHHHHHHHC	34.66	30576142
1778	Phosphorylation	WRSEAEASVKSCVHE HHCHHHHHHHHHHCC	17.78	28857561
1780	Phosphorylation	SEAEASVKSCVHEEH CHHHHHHHHHHCCCC	23.49	28857561
1803	Phosphorylation	PSYSGSDMPRNDINM CCCCCCCCCCCCCCH	30.66	-
1806	Phosphorylation	SGSDMPRNDINMWSK CCCCCCCCCCCHHHH	42.48	28555341
1809	Phosphorylation	DMPRNDINMWSKVTE CCCCCCCCHHHHCCH	30.20	23401153
1878	Phosphorylation	AKVTQTELMRESFRQ HHCHHHHHHHHHHHH	46.32	-
1882 (in isoform 2)	Phosphorylation	-	39.17	27251275
1894	Phosphorylation	QEATESLKCQEELRE HHHHHHHHHHHHHHH	18.50	27251275
1907 (in isoform 2)	Phosphorylation	-	8.15	27251275
1919	Phosphorylation	QLAVELSKAEGVIDG HHHHHHHHHCCCCCC	28.40	27251275
1977 (in isoform 2)	Phosphorylation	-	39.28	24719451
1989	Phosphorylation	AMKAEAGPVEQQLLQ HHHHHCCHHHHHHHH	45.34	24719451
2010	Phosphorylation	KEKLEVQCQAEKVRD HHHHHHHHHHHHHHH	26.01	23401153
2116	Phosphorylation	REVEQLANHLKEKTD HHHHHHHHHHHHHHH	35.39	-
2120	Phosphorylation	QLANHLKEKTDKCSE HHHHHHHHHHHHHHH	30.61	-
2160	Acetylation	VRELEQALLVSADTF HHHHHHHHHHCCCCC	60.00	-
2252	Phosphorylation	QELEQENKLFKDDME HHHHHHCCCCHHHHH	43.91	27282143
2341	Phosphorylation	LMSDQECVKRNREEE HHCCHHHHHHCHHHH	41.99	29978859
2348	Phosphorylation	VKRNREEEIEQLNEV HHHCHHHHHHHHHHH	24.16	29978859
2376 (in isoform 2)	Phosphorylation	-	12.58	27251275
2388	Phosphorylation	ADSLKHQLDVVIAEK HHHHHHHHHHHHHHH	31.05	25849741
2390	Phosphorylation	SLKHQLDVVIAEKLA HHHHHHHHHHHHHHH	36.08	23312004
2444	Phosphorylation	RESVEKIQSIPENSV HHHHHHHHCCCCCHH	45.68	24719451
2457	Phosphorylation	SVNVAIDHLSKDKPE HHHHHHHHHCCCCCC	43.51	28555341
2462	Phosphorylation	IDHLSKDKPELEVVL HHHHCCCCCCEEEEE	17.26	28555341
2471	Phosphorylation	ELEVVLTEDALKSLE CEEEEECHHHHHHHC	35.07	29888752
2476 (in isoform 2)	Phosphorylation	-	64.40	24719451
2485 (in isoform 2)	Phosphorylation	-	15.62	24719451
2488	Phosphorylation	TYFKSFEENGKGSII CHHHCHHHCCCCCEE	41.59	25849741
2493	Phosphorylation	FEENGKGSIINLETR HHHCCCCCEEEHHHH	42.37	-
2494	Phosphorylation	EENGKGSIINLETRL HHCCCCCEEEHHHHH	10.15	25159151
2497	Phosphorylation	GKGSIINLETRLLQL CCCCEEEHHHHHHHC	28.17	24719451
2505	Phosphorylation	ETRLLQLESTVSAKD HHHHHHCCCCCCHHH	24.63	-
2511	Phosphorylation	LESTVSAKDLELTQC CCCCCCHHHHHHHHH	29.77	25247763
2545	Phosphorylation	KKIVNLQKIVEEKVA HHHCCHHHHHHHHHH	28.16	27174698
2588	Phosphorylation	PERTNIQNLNQLRED CCHHCCCHHHHHCHH	29.13	28555341
2590	Phosphorylation	RTNIQNLNQLREDEL HHCCCHHHHHCHHCC	31.85	25627689
2591	Phosphorylation	TNIQNLNQLREDELG HCCCHHHHHCHHCCC	54.01	21815630
2621	Phosphorylation	QVVEMHTSLILEKEQ HHHHHHHHHHHCHHH	29.69	46161521
2633	Phosphorylation	KEQVEIAEKNVLEKE HHHHHHHHHHHHHHH	9.95	46161521
2665 (in isoform 2)	Phosphorylation	-	48.84	24719451
2677	Phosphorylation	EVLKTTTELFHSNEE HHHHHHHHHHCCCCC	35.47	20873877
2681 (in isoform 2)	Phosphorylation	-	4.64	27251275
2693	Phosphorylation	GFFNELEALRAESVA CCHHHHHHHHHHHHH	38.31	28348404
2740	Phosphorylation	LSQVRDHLAEAKEKL HHHHHHHHHHHHHHH	20.31	20860994
2746	Phosphorylation	HLAEAKEKLSILEKE HHHHHHHHHHHHCCC	36.44	28555341
2760	Phosphorylation	EDETEVQESKKACMF CCHHHHHHHHHHHCC	35.87	24719451
2777 (in isoform 2)	Phosphorylation	-	4.39	27251275
2787	Phosphorylation	SQTDGTLKISSSNQT HCCCCCEEECCCCCC	21.25	28348404
2789	Phosphorylation	TDGTLKISSSNQTPQ CCCCEEECCCCCCCE	21.73	27251275
2792	Phosphorylation	TLKISSSNQTPQILV CEEECCCCCCCEEEE	31.76	27251275
2794	O-linked_Glycosylation	KISSSNQTPQILVKN EECCCCCCCEEEEEC	33.62	30379171
2806	Phosphorylation	VKNAGIQINLQSECS EECCCEEEECCCCCC	22.78	28555341
2876 (in isoform 3)	Phosphorylation	-	3.52	25159151
2877 (in isoform 3)	Phosphorylation	-	61.12	26657352
2884 (in isoform 2)	Phosphorylation	-	40.21	25159151
2884 (in isoform 3)	Phosphorylation	-	40.21	27251275
2885 (in isoform 2)	Phosphorylation	-	13.52	26657352
2888 (in isoform 6)	Phosphorylation	-	17.37	25159151
2889 (in isoform 6)	Phosphorylation	-	2.04	26657352
2892 (in isoform 2)	Phosphorylation	-	21.88	27251275
2896 (in isoform 6)	Phosphorylation	-	6.17	27251275
2991	Phosphorylation	RKAYINTISSLKDLI HHHHHHHHHHHHHHH	9.57	-
2996	Phosphorylation	NTISSLKDLITKMQL HHHHHHHHHHHHHHH	27.81	24719451
2997	Phosphorylation	TISSLKDLITKMQLQ HHHHHHHHHHHHHHH	35.27	24719451
3014	Phosphorylation	AEVYDSSQSHESFSD HHHCCCCCCCCCCCH	11.12	-
3014 (in isoform 6)	Phosphorylation	-	11.12	27642862
3067	Glutathionylation	LLNCLEQRIQEQGVE HHHHHHHHHHHCCCH	4.46	22555962
3093	Phosphorylation	DRRSLLSEIQALHAQ HHHHHHHHHHHHHHH	34.26	-
3096	Phosphorylation	SLLSEIQALHAQMNG HHHHHHHHHHHHHCC	37.64	-
3107 (in isoform 2)	Phosphorylation	-	27.24	24719451
3111	Phosphorylation	RKITLKREQESEKPS CCCCCCHHHCCCCCC	29.30	24719451
3118	Phosphorylation	EQESEKPSQELLEYN HHCCCCCCHHHHHHH	51.09	29214152
3122	Phosphorylation	EKPSQELLEYNIQQK CCCCHHHHHHHHHHH	47.56	23312004
3128	Phosphorylation	LLEYNIQQKQSQMLE HHHHHHHHHHHHHHH	19.96	23312004
3135	Phosphorylation	QKQSQMLEMQVELSS HHHHHHHHHHHHHHH	25.29	20860994
3146	Phosphorylation	ELSSMKDRATELQEQ HHHHHHHHHHHHHHH	42.34	20860994
3175	Phosphorylation	LAQTKLELETTLKAQ HHHHHHHHHHHHHHH	31.80	28509920
3181	Phosphorylation	ELETTLKAQHKHLKE HHHHHHHHHHHHHHH	50.48	28509920
3182	Phosphorylation	LETTLKAQHKHLKEL HHHHHHHHHHHHHHH	19.52	28509920
3322	Dimethylation	TLDRERELHAQLQSS HCHHHHHHHHHHHCC	48.24	-
3328 (in isoform 2)	Phosphorylation	-	25.14	27251275
3332	Phosphorylation	QLQSSDGTGQSRPPL HHHCCCCCCCCCCCC	38.70	27251275
3373	Phosphorylation	TEKYKLDSLQTRQQM HHHHHHHHHHHHHHH	15.56	29978859
3377	Phosphorylation	KLDSLQTRQQMEKDR HHHHHHHHHHHHHHH	32.58	28509920
3380	Phosphorylation	SLQTRQQMEKDRQVH HHHHHHHHHHHHHHH	35.42	23403867
3431	Phosphorylation	QQVYKLDLEGQRLQG HHHHHHHHHHHHHHH	11.07	26074081
3449 (in isoform 6)	Ubiquitination	-	51.57	-
3465	Phosphorylation	RILYQNLNEPTTWSL HHHHHCCCCCCCEEC	7.93	21945579
3471 (in isoform 2)	Phosphorylation	-	33.77	24719451
3472	Phosphorylation	NEPTTWSLTSDRTRN CCCCCEECCCHHHCC	34.42	26434776
3473	Phosphorylation	EPTTWSLTSDRTRNW CCCCEECCCHHHCCH	24.62	20873877
3475	Phosphorylation	TTWSLTSDRTRNWVL CCEECCCHHHCCHHH	21.48	20873877
3477	Phosphorylation	WSLTSDRTRNWVLQQ EECCCHHHCCHHHHE	24.06	20873877
3478	Phosphorylation	SLTSDRTRNWVLQQK ECCCHHHCCHHHHEE	30.32	20873877
3481	Phosphorylation	SDRTRNWVLQQKIEG CHHHCCHHHHEEECC	33.09	26434776
3489 (in isoform 6)	Ubiquitination	-	29.75	-
3490 (in isoform 2)	Phosphorylation	-	7.75	24719451
3494	Phosphorylation	EGETKESNYAKLIEM CCCCCCCCCEEEEEC	51.47	24719451
3495 (in isoform 6)	Ubiquitination	-	55.64	-
3497	Phosphorylation	TKESNYAKLIEMNGG CCCCCCEEEEECCCC	36.37	30622161
3499	Phosphorylation	ESNYAKLIEMNGGGT CCCCEEEEECCCCCC	17.88	30622161
3529 (in isoform 6)	Ubiquitination	-	32.95	-
3569	Phosphorylation	QKLTGQQGEEPSLVS HHHHCCCCCCCCCCC	39.72	29255136
3573 (in isoform 2)	Phosphorylation	-	33.09	27251275
3576 (in isoform 2)	Phosphorylation	-	28.76	24719451
3577	Phosphorylation	EEPSLVSPSTSCGSL CCCCCCCCCCHHHHH	44.69	29255136
3580	Phosphorylation	SLVSPSTSCGSLTER CCCCCCCHHHHHHHH	20.58	29255136
3582	Phosphorylation	VSPSTSCGSLTERLL CCCCCHHHHHHHHHH	26.00	25262027
3583	Phosphorylation	SPSTSCGSLTERLLR CCCCHHHHHHHHHHH	31.27	25262027
3583 (in isoform 2)	Phosphorylation	-	31.27	27251275
3584	Phosphorylation	PSTSCGSLTERLLRQ CCCHHHHHHHHHHHH	22.33	25262027
3585 (in isoform 2)	Phosphorylation	-	4.32	24719451
3587	Phosphorylation	SCGSLTERLLRQNAE HHHHHHHHHHHHCHH	36.12	29255136
3589	Phosphorylation	GSLTERLLRQNAELT HHHHHHHHHHCHHHH	22.28	22199227
3619 (in isoform 6)	Ubiquitination	-	41.14	-
3627	Phosphorylation	IRWYRQTGAGRDNSS HHHHHHHCCCCCCCC	5.29	29978859
3641	Phosphorylation	SRFSLNGGANIEAII CCCCCCCCCCCEEEE	21.58	-
3668	Acetylation	TLQKSLKRAEAEVYK HHHHHHHHHHHHHHH	61.95	25953088
3668	Malonylation	TLQKSLKRAEAEVYK HHHHHHHHHHHHHHH	61.95	26320211
3668 (in isoform 6)	Malonylation	-	61.95	26320211
3678	Phosphorylation	AEVYKLKAELRNDSL HHHHHHHHHHCCCCH	11.34	29083192
3688	Phosphorylation	RNDSLLQTLSPDSEH CCCCHHHHCCCCCCC	34.23	20873877
3690	Phosphorylation	DSLLQTLSPDSEHVT CCHHHHCCCCCCCCC	4.18	23186163
3690 (in isoform 2)	Phosphorylation	-	4.18	24719451
3692	Phosphorylation	LLQTLSPDSEHVTLK HHHHCCCCCCCCCHH	29.22	29255136
3694	Phosphorylation	QTLSPDSEHVTLKRI HHCCCCCCCCCHHHH	30.01	29255136
3697	Phosphorylation	SPDSEHVTLKRIYGK CCCCCCCCHHHHHHH	32.74	29255136
3701	Phosphorylation	EHVTLKRIYGKYLRA CCCCHHHHHHHHHCH	28.59	25850435
3706	Phosphorylation	KRIYGKYLRAESFRK HHHHHHHHCHHHHHH	16.17	26074081
3709	Phosphorylation	YGKYLRAESFRKALI HHHHHCHHHHHHHHH	9.32	26074081
3714	Phosphorylation	RAESFRKALIYQKKY CHHHHHHHHHHHHHH	29.39	26074081
3721	Phosphorylation	ALIYQKKYLLLLLGG HHHHHHHHHHHHHCC	18.35	30622161
3740	Phosphorylation	EDATLALLARMGGQP HHHHHHHHHHCCCCC	25.53	-
3812 (in isoform 2)	Phosphorylation	-	64.41	27251275
3814	Phosphorylation	AEKTDSFYHSSGGLE CCCCCCCEECCCCEE	28.51	21945579
3816	Phosphorylation	KTDSFYHSSGGLELY CCCCCEECCCCEEEC	32.70	21945579
3816 (in isoform 2)	Phosphorylation	-	32.70	27251275
3816 (in isoform 6)	Phosphorylation	-	32.70	27642862
3818	Phosphorylation	DSFYHSSGGLELYGE CCCEECCCCEEECCC	12.54	21945579
3818 (in isoform 6)	Phosphorylation	-	12.54	27642862
3820	Phosphorylation	FYHSSGGLELYGEPR CEECCCCEEECCCCC	21.21	21945579
3820 (in isoform 6)	Phosphorylation	-	21.21	27642862
3821	Phosphorylation	YHSSGGLELYGEPRH EECCCCEEECCCCCC	24.46	21945579
3827	Phosphorylation	LELYGEPRHTTYRSR EEECCCCCCCCCCCH	15.29	21945579
3827 (in isoform 6)	Phosphorylation	-	15.29	27642862
3833 (in isoform 2)	Phosphorylation	-	27.14	24719451
3835 (in isoform 2)	Phosphorylation	-	14.03	24719451
3837	Phosphorylation	TYRSRSDLDYIRSPL CCCCHHHHCCCCCCC	26.23	23403867
3839	Phosphorylation	RSRSDLDYIRSPLPF CCHHHHCCCCCCCCC	43.71	27794612
3842	Phosphorylation	SDLDYIRSPLPFQNR HHHCCCCCCCCCCCC	41.63	23186163
3842 (in isoform 2)	Phosphorylation	-	41.63	24719451
3843	Phosphorylation	DLDYIRSPLPFQNRY HHCCCCCCCCCCCCC	12.92	30108239
3845	Methylation	DYIRSPLPFQNRYPG CCCCCCCCCCCCCCC	26.45	-
3846	Phosphorylation	YIRSPLPFQNRYPGT CCCCCCCCCCCCCCC	22.64	23401153
3853 (in isoform 2)	Phosphorylation	-	28.39	24719451
3854	Phosphorylation	QNRYPGTPADFNPGS CCCCCCCCCCCCCCC	17.35	26657352
3857	Phosphorylation	YPGTPADFNPGSLAC CCCCCCCCCCCCCHH	15.70	24719451
3865	Phosphorylation	NPGSLACSQLQNYDP CCCCCHHHHHCCCCC	17.66	17525332
3869	Phosphorylation	LACSQLQNYDPDRAL CHHHHHCCCCCCHHH	28.46	17525332
3874	Phosphorylation	LQNYDPDRALTDYIT HCCCCCCHHHHHHHH	18.85	-
3897	Phosphorylation	LGTIQSGSTTQFHAG HCCCCCCCCCCCCCC	2.66	23186163
3897 (in isoform 2)	Phosphorylation	-	2.66	24719451
3898 (in isoform 2)	Phosphorylation	-	41.39	27251275
3899	Phosphorylation	TIQSGSTTQFHAGMR CCCCCCCCCCCCCCC	30.75	28857561
3901	Phosphorylation	QSGSTTQFHAGMRR- CCCCCCCCCCCCCC-	33.26	28555341
3902	Phosphorylation	SGSTTQFHAGMRR-- CCCCCCCCCCCCC--	28.30	28857561
3903	Phosphorylation	GSTTQFHAGMRR--- CCCCCCCCCCCC---	30.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
43	S	Phosphorylation	Kinase	PKACA	P17612	PSP
43	S	Phosphorylation	Kinase	PRKACA	P05132	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKAP9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKAP9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FNBP1_HUMAN	FNBP1	physical	15047863
CIP4_HUMAN	TRIP10	physical	15047863
GCP3_HUMAN	TUBGCP3	physical	12221128
PKN1_HUMAN	PKN1	physical	10358086
KAP2_HUMAN	PRKAR2A	physical	10358086
KC1D_HUMAN	CSNK1D	physical	12270714
CCNE1_HUMAN	CCNE1	physical	15670215
KDM1A_HUMAN	KDM1A	physical	23455924
TYDP2_HUMAN	TDP2	physical	21988832
PCNT_HUMAN	PCNT	physical	16760425
SUV92_HUMAN	SUV39H2	physical	23455924
IKZF3_HUMAN	IKZF3	physical	25416956
WAC_HUMAN	WAC	physical	25416956
THAP1_HUMAN	THAP1	physical	25416956
PRD14_HUMAN	PRDM14	physical	25416956
USBP1_HUMAN	USHBP1	physical	25416956
CA094_HUMAN	C1orf94	physical	25416956
SAMD3_HUMAN	SAMD3	physical	25416956
GPC4_HUMAN	GPC4	physical	21516116
CA094_HUMAN	C1orf94	physical	21516116
BIRC6_HUMAN	BIRC6	physical	28514442
TPM2_HUMAN	TPM2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 611820: Long QT syndrome 11 (LQT11)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-3846, ANDMASS SPECTROMETRY.
PubMed: 19690332

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3869, AND MASSSPECTROMETRY.
PubMed: 17525332