SAMD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAMD3_HUMAN
• UniProt AC: Q8N6K7
• Protein Name: Sterile alpha motif domain-containing protein 3
• Gene Name: SAMD3
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Protein Sequence: METWSVEQVCSWLVEKNLGELVHRFQEEEVSGAALLALNDRMVQQLVKKIGHQAVLMDLIKKYKQNTQGLKSPENPKKAALVMQTEAARDYRDEESSSPARHGEQMPSFYPAENLDNGLIDQRVLKQRRNVKQILARSKALQWTKSYVLPEFPYDVKCMLAEQKCPDHSMRIRIIEFLQADMTKYLEGSLYPSTQQYNDVVNALLQAHPFLDEDGCGFFLWKRALKDRFKYVRRPIEDDEQVIRNKCKFGHRRGQTRKSLADIRFDEIKLVQIKEEAVCFDSELDEHIKWFQQEYVKTEKDWREIDKRMSQTLEIRRKMIGSRTPLKDILKLFPFLKCPYQMFREFQLLTRTDIYKKTRHILESYSENILTSFSVVDNPINIVLQEKMKHYTDEDMLKYMKMTATCLLLPDVFGDDPSLFVIMNEQVQVSTPVLEVKNPFNMEVCEFSLYLERERLTKVDDCVTALAALVAAFHVFRIECPRRLSQTFNFLETLIFDMHSPYFPSLKEKENEVGFQHPLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	RFQEEEVSGAALLAL HHHHHCCCHHHHHHH	26.45	-
108	Phosphorylation	RHGEQMPSFYPAENL CCCCCCCCCCCCHHC	31.88	-
259	Phosphorylation	RRGQTRKSLADIRFD CCCCCCHHHHHCCCC	26.04	27251275
283	Phosphorylation	EAVCFDSELDEHIKW EEEECCHHHHHHHHH	63.18	27251275
310	Phosphorylation	REIDKRMSQTLEIRR HHHHHHHHHHHHHHH	24.85	19664994
312	Phosphorylation	IDKRMSQTLEIRRKM HHHHHHHHHHHHHHH	21.03	19664994
318	Acetylation	QTLEIRRKMIGSRTP HHHHHHHHHHCCCCC	25.64	30592105
322	Phosphorylation	IRRKMIGSRTPLKDI HHHHHHCCCCCHHHH	23.27	-
403	Phosphorylation	MLKYMKMTATCLLLP HHHHHHHHHHHHHCC	17.19	22210691
405	Phosphorylation	KYMKMTATCLLLPDV HHHHHHHHHHHCCHH	8.43	22210691
418	Phosphorylation	DVFGDDPSLFVIMNE HHHCCCCCEEEEECC	41.24	22210691
520	Phosphorylation	VGFQHPLT------- CCCCCCCC-------	40.80	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAMD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAMD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAMD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
ANM1_HUMAN	PRMT1	physical	23455924
CF206_HUMAN	C6orf165	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.