dbPTM

PKN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKN1_HUMAN
UniProt AC	Q16512
Protein Name	Serine/threonine-protein kinase N1
Gene Name	PKN1
Organism	Homo sapiens (Human).
Sequence Length	942
Subcellular Localization	Cytoplasm . Nucleus . Endosome . Cell membrane Peripheral membrane protein . Cleavage furrow . Midbody . Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the
Protein Description	PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro..
Protein Sequence	MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASDAVQSE ------CCCHHHCCC	19.00	22814378
3	Phosphorylation	-----MASDAVQSEP -----CCCHHHCCCC	25.46	-
8	Phosphorylation	MASDAVQSEPRSWSL CCCHHHCCCCCHHHH	42.86	25850435
12	Phosphorylation	AVQSEPRSWSLLEQL HHCCCCCHHHHHHHH	31.56	24719451
14	Phosphorylation	QSEPRSWSLLEQLGL CCCCCHHHHHHHHCC	25.07	27251275
18 (in isoform 2)	Phosphorylation	-	40.58	24719451
51	Ubiquitination	REIRKELKLKEGAEN HHHHHHHHHHHHHHH	59.61	24816145
53	Ubiquitination	IRKELKLKEGAENLR HHHHHHHHHHHHHHH	53.14	-
57	Ubiquitination	LKLKEGAENLRRATT HHHHHHHHHHHHHHH	68.59	24816145
59 (in isoform 2)	Ubiquitination	-	2.70	-
63	Phosphorylation	AENLRRATTDLGRSL HHHHHHHHHHHHHHH	21.02	23403867
63	Ubiquitination	AENLRRATTDLGRSL HHHHHHHHHHHHHHH	21.02	24816145
64	Phosphorylation	ENLRRATTDLGRSLG HHHHHHHHHHHHHHC	28.39	10467162
69	Phosphorylation	ATTDLGRSLGPVELL HHHHHHHHHCHHHHH	35.56	22617229
75 (in isoform 2)	Phosphorylation	-	5.78	24719451
80	Phosphorylation	VELLLRGSSRRLDLL HHHHHCCCHHHHHHH	17.78	23186163
81	Phosphorylation	ELLLRGSSRRLDLLH HHHHCCCHHHHHHHH	25.01	23186163
86 (in isoform 2)	Phosphorylation	-	5.64	27251275
106	Phosphorylation	VLPDPAATHDGPQSP ECCCCCCCCCCCCCC	23.70	28464451
112	Phosphorylation	ATHDGPQSPGAGGPT CCCCCCCCCCCCCCC	28.56	28464451
118 (in isoform 2)	Phosphorylation	-	29.34	27251275
119	Phosphorylation	SPGAGGPTCSATNLS CCCCCCCCCCCCCHH	23.51	22210691
121	Phosphorylation	GAGGPTCSATNLSRV CCCCCCCCCCCHHHH	40.38	28122231
123	Phosphorylation	GGPTCSATNLSRVAG CCCCCCCCCHHHHCC	22.02	28122231
126	Phosphorylation	TCSATNLSRVAGLEK CCCCCCHHHHCCCCH	27.12	28122231
167 (in isoform 2)	Ubiquitination	-	24.79	-
173	Phosphorylation	AQQMLQDSKTKIDII HHHHHHCCCCHHHHH	29.30	22210691
175	Phosphorylation	QMLQDSKTKIDIIRM HHHHCCCCHHHHHHH	36.86	22210691
202	Phosphorylation	NQAAPDDTQGSPDLG CCCCCCCCCCCCCCC	42.06	28450419
205	Phosphorylation	APDDTQGSPDLGAVE CCCCCCCCCCCCCEE	12.86	21712546
233	Ubiquitination	HAVAEGAKNVLRLLS HHHHHHHHHHHHHHH	59.45	24816145
239	Ubiquitination	AKNVLRLLSAAKAPD HHHHHHHHHHCCCCC	2.37	24816145
240	Phosphorylation	KNVLRLLSAAKAPDR HHHHHHHHHCCCCCH	30.67	19664994
243	Acetylation	LRLLSAAKAPDRKAV HHHHHHCCCCCHHHH	61.23	25953088
243	Ubiquitination	LRLLSAAKAPDRKAV HHHHHHCCCCCHHHH	61.23	24816145
245	Ubiquitination	LLSAAKAPDRKAVSE HHHHCCCCCHHHHHH	41.03	24816145
246 (in isoform 2)	Phosphorylation	-	70.36	24719451
249	Ubiquitination	AKAPDRKAVSEAQEK CCCCCHHHHHHHHHH	15.80	24816145
255	Ubiquitination	KAVSEAQEKLTESNQ HHHHHHHHHHHHHHH	58.02	24816145
256	Ubiquitination	AVSEAQEKLTESNQK HHHHHHHHHHHHHHH	48.94	29967540
262	Ubiquitination	EKLTESNQKLGLLRE HHHHHHHHHHHHHHH	52.18	29967540
263	Ubiquitination	KLTESNQKLGLLREA HHHHHHHHHHHHHHH	49.09	22817900
263 (in isoform 1)	Ubiquitination	-	49.09	21890473
263	Ubiquitination	KLTESNQKLGLLREA HHHHHHHHHHHHHHH	49.09	21890473
269	Ubiquitination	QKLGLLREALERRLG HHHHHHHHHHHHHHC	58.54	21890473
269 (in isoform 2)	Ubiquitination	-	58.54	21890473
275	Ubiquitination	REALERRLGELPADH HHHHHHHHCCCCCCC	8.61	21890473
301	Phosphorylation	AASSAAFSTRLAGPF HHHHHHHHHHHCCCC	14.11	-
311	Phosphorylation	LAGPFPATHYSTLCK HCCCCCCCCCCCCCC	22.91	20873877
313	Phosphorylation	GPFPATHYSTLCKPA CCCCCCCCCCCCCCC	10.05	22210691
314	Phosphorylation	PFPATHYSTLCKPAP CCCCCCCCCCCCCCC	13.80	20873877
315	Phosphorylation	FPATHYSTLCKPAPL CCCCCCCCCCCCCCC	29.07	20873877
317 (in isoform 2)	Phosphorylation	-	5.13	27251275
323	Phosphorylation	LCKPAPLTGTLEVRV CCCCCCCCCEEEEEE	27.36	22210691
345	Phosphorylation	ETIPWNPTPSMGGPG CCCCCCCCCCCCCCC	25.45	26074081
347	Phosphorylation	IPWNPTPSMGGPGTP CCCCCCCCCCCCCCC	32.32	26074081
353	Phosphorylation	PSMGGPGTPDSRPPF CCCCCCCCCCCCCCC	27.36	17192257
356	Phosphorylation	GGPGTPDSRPPFLSR CCCCCCCCCCCCCCC	48.14	26074081
357	Methylation	GPGTPDSRPPFLSRP CCCCCCCCCCCCCCC	50.74	115386671
359 (in isoform 2)	Phosphorylation	-	41.52	24719451
362	Phosphorylation	DSRPPFLSRPARGLY CCCCCCCCCCCCCCC	36.28	28122231
366	Methylation	PFLSRPARGLYSRSG CCCCCCCCCCCCCCC	38.03	54558023
370	Phosphorylation	RPARGLYSRSGSLSG CCCCCCCCCCCCCCC	25.64	24719451
372	Phosphorylation	ARGLYSRSGSLSGRS CCCCCCCCCCCCCCH	27.13	28176443
374	Phosphorylation	GLYSRSGSLSGRSSL CCCCCCCCCCCCHHH	22.17	10467162
376	Phosphorylation	YSRSGSLSGRSSLKA CCCCCCCCCCHHHHE	33.58	28450419
379	Phosphorylation	SGSLSGRSSLKAEAE CCCCCCCHHHHEECC	43.48	28450419
380	Phosphorylation	GSLSGRSSLKAEAEN CCCCCCHHHHEECCC	32.31	10467162
382	Ubiquitination	LSGRSSLKAEAENTS CCCCHHHHEECCCCC	46.24	32015554
386 (in isoform 2)	Phosphorylation	-	53.17	24719451
388	Phosphorylation	LKAEAENTSEVSTVL HHEECCCCCCCCEEE	20.12	27251275
388	Ubiquitination	LKAEAENTSEVSTVL HHEECCCCCCCCEEE	20.12	32015554
389	Phosphorylation	KAEAENTSEVSTVLK HEECCCCCCCCEEEE	47.81	27251275
392	Phosphorylation	AENTSEVSTVLKLDN CCCCCCCCEEEEECC	14.56	27251275
393	Phosphorylation	ENTSEVSTVLKLDNT CCCCCCCEEEEECCE	34.73	27251275
445	Acetylation	QRGLCALKFLKLEDF CCCCCHHEEECHHHH	30.08	25953088
445	Ubiquitination	QRGLCALKFLKLEDF CCCCCHHEEECHHHH	30.08	-
448	Acetylation	LCALKFLKLEDFLDN CCHHEEECHHHHHCC	53.62	19608861
451 (in isoform 2)	Ubiquitination	-	60.90	-
454	Acetylation	LKLEDFLDNERHEVQ ECHHHHHCCCCCEEE	55.74	19608861
495	Phosphorylation	RRQKKIFSKQQGKAF HHHHHHCHHHHHHHH	32.78	23401153
496	Ubiquitination	RQKKIFSKQQGKAFQ HHHHHCHHHHHHHHH	35.57	-
501	Phosphorylation	FSKQQGKAFQRARQM CHHHHHHHHHHHHHC	16.78	32645325
501 (in isoform 2)	Phosphorylation	-	16.78	24719451
527	Phosphorylation	RRLIPNATGTGTFSP HHHCCCCCCCCCCCC	41.75	28555341
529	Phosphorylation	LIPNATGTGTFSPGA HCCCCCCCCCCCCCC	28.79	27134283
531	Phosphorylation	PNATGTGTFSPGASP CCCCCCCCCCCCCCC	22.30	29255136
533	Phosphorylation	ATGTGTFSPGASPGS CCCCCCCCCCCCCCC	23.43	29255136
535 (in isoform 2)	Phosphorylation	-	37.17	24719451
537	Phosphorylation	GTFSPGASPGSEART CCCCCCCCCCCCCCC	35.39	29255136
539	Phosphorylation	FSPGASPGSEARTTG CCCCCCCCCCCCCCC	35.31	32142685
539 (in isoform 2)	Phosphorylation	-	35.31	24719451
540	Phosphorylation	SPGASPGSEARTTGD CCCCCCCCCCCCCCC	31.31	29255136
543	Phosphorylation	ASPGSEARTTGDISV CCCCCCCCCCCCCCE	28.86	32142685
543 (in isoform 2)	Phosphorylation	-	28.86	24719451
544	Phosphorylation	SPGSEARTTGDISVE CCCCCCCCCCCCCEE	42.02	23312004
545	Phosphorylation	PGSEARTTGDISVEK CCCCCCCCCCCCEEE	27.57	23312004
549	Phosphorylation	ARTTGDISVEKLNLG CCCCCCCCEEECCCC	29.03	21815630
557	Phosphorylation	VEKLNLGTDSDSSPQ EEECCCCCCCCCCCC	35.18	22167270
559	O-linked_Glycosylation	KLNLGTDSDSSPQKS ECCCCCCCCCCCCCC	38.95	29351928
559	Phosphorylation	KLNLGTDSDSSPQKS ECCCCCCCCCCCCCC	38.95	22167270
561	O-linked_Glycosylation	NLGTDSDSSPQKSSR CCCCCCCCCCCCCCC	48.12	29351928
561	Phosphorylation	NLGTDSDSSPQKSSR CCCCCCCCCCCCCCC	48.12	29255136
562	Phosphorylation	LGTDSDSSPQKSSRD CCCCCCCCCCCCCCC	36.02	19664994
565	Ubiquitination	DSDSSPQKSSRDPPS CCCCCCCCCCCCCCC	54.50	24816145
565 (in isoform 2)	Phosphorylation	-	54.50	27251275
566	Phosphorylation	SDSSPQKSSRDPPSS CCCCCCCCCCCCCCC	25.92	23403867
567	Phosphorylation	DSSPQKSSRDPPSSP CCCCCCCCCCCCCCC	47.97	19413330
568 (in isoform 2)	Phosphorylation	-	68.49	24719451
571	Ubiquitination	QKSSRDPPSSPSSLS CCCCCCCCCCCHHCC	52.29	24816145
572	Phosphorylation	KSSRDPPSSPSSLSS CCCCCCCCCCHHCCC	61.34	23401153
573	Phosphorylation	SSRDPPSSPSSLSSP CCCCCCCCCHHCCCC	34.28	30278072
575	Phosphorylation	RDPPSSPSSLSSPIQ CCCCCCCHHCCCCCC	45.95	23401153
576	Phosphorylation	DPPSSPSSLSSPIQE CCCCCCHHCCCCCCC	35.34	30278072
577	Ubiquitination	PPSSPSSLSSPIQES CCCCCHHCCCCCCCC	7.44	24816145
578	Phosphorylation	PSSPSSLSSPIQEST CCCCHHCCCCCCCCC	35.70	23898821
579	Phosphorylation	SSPSSLSSPIQESTA CCCHHCCCCCCCCCC	31.17	30278072
579 (in isoform 2)	Phosphorylation	-	31.17	27251275
584	Phosphorylation	LSSPIQESTAPELPS CCCCCCCCCCCCCCC	17.31	30108239
585	Phosphorylation	SSPIQESTAPELPSE CCCCCCCCCCCCCCC	45.54	30206219
591	Phosphorylation	STAPELPSETQETPG CCCCCCCCCCCCCCC	66.94	28450419
593	Phosphorylation	APELPSETQETPGPA CCCCCCCCCCCCCCC	35.72	28464451
596	Phosphorylation	LPSETQETPGPALCS CCCCCCCCCCCCCCC	24.59	28450419
603	Phosphorylation	TPGPALCSPLRKSPL CCCCCCCCCCCCCCC	28.02	27050516
607	Ubiquitination	ALCSPLRKSPLTLED CCCCCCCCCCCCHHH	65.20	29967540
608	Phosphorylation	LCSPLRKSPLTLEDF CCCCCCCCCCCHHHH	20.78	28348404
611	Phosphorylation	PLRKSPLTLEDFKFL CCCCCCCCHHHHHHH	31.33	26074081
613	Ubiquitination	RKSPLTLEDFKFLAV CCCCCCHHHHHHHHE	57.05	29967540
613 (in isoform 2)	Ubiquitination	-	57.05	-
614 (in isoform 2)	Phosphorylation	-	55.97	27251275
644	Ubiquitination	SGELFAIKALKKGDI CCCEEEEEEHHHCCE	44.21	29967540
650	Ubiquitination	IKALKKGDIVARDEV EEEHHHCCEEEHHHH	40.86	29967540
650 (in isoform 2)	Ubiquitination	-	40.86	-
661	Sulfoxidation	RDEVESLMCEKRILA HHHHHHHHCHHHHHH	3.74	21406390
664	Ubiquitination	VESLMCEKRILAAVT HHHHHCHHHHHHHHH	39.55	24816145
670	Ubiquitination	EKRILAAVTSAGHPF HHHHHHHHHHCCCCC	3.46	24816145
670 (in isoform 2)	Ubiquitination	-	3.46	-
676	Ubiquitination	AVTSAGHPFLVNLFG HHHHCCCCCEEHHHC	24.29	24816145
742	Ubiquitination	KIVYRDLKLDNLLLD CEEECCCCCCCEEEC	59.07	22817900
748	Ubiquitination	LKLDNLLLDTEGYVK CCCCCEEECCCCCEE	9.61	22817900
754	Ubiquitination	LLDTEGYVKIADFGL EECCCCCEEHHHCCC	5.48	22817900
763	Ubiquitination	IADFGLCKEGMGYGD HHHCCCCCCCCCCCC	63.45	-
768	Phosphorylation	LCKEGMGYGDRTSTF CCCCCCCCCCCCCCC	13.63	22322096
772	Phosphorylation	GMGYGDRTSTFCGTP CCCCCCCCCCCCCCC	36.54	23401153
773	Phosphorylation	MGYGDRTSTFCGTPE CCCCCCCCCCCCCCH	22.00	22322096
774	Phosphorylation	GYGDRTSTFCGTPEF CCCCCCCCCCCCCHH	23.49	10467162
778	Phosphorylation	RTSTFCGTPEFLAPE CCCCCCCCCHHHCCH	22.33	21712546
778 (in isoform 2)	Phosphorylation	-	22.33	24719451
779	Phosphorylation	TSTFCGTPEFLAPEV CCCCCCCCHHHCCHH	18.67	32142685
779 (in isoform 2)	Phosphorylation	-	18.67	27251275
780	Phosphorylation	STFCGTPEFLAPEVL CCCCCCCHHHCCHHH	53.80	32142685
784	Phosphorylation	GTPEFLAPEVLTDTS CCCHHHCCHHHCCCC	34.08	32142685
788	Phosphorylation	FLAPEVLTDTSYTRA HHCCHHHCCCCCHHH	42.27	23403867
790	Phosphorylation	APEVLTDTSYTRAVD CCHHHCCCCCHHHHH	20.56	23403867
791	Phosphorylation	PEVLTDTSYTRAVDW CHHHCCCCCHHHHHH	27.58	23403867
792	Phosphorylation	EVLTDTSYTRAVDWW HHHCCCCCHHHHHHH	11.44	23403867
793	Phosphorylation	VLTDTSYTRAVDWWG HHCCCCCHHHHHHHH	16.36	23403867
847	Dimethylation	AEAIGIMRRLLRRNP HHHHHHHHHHHHHCH	24.95	-
847	Methylation	AEAIGIMRRLLRRNP HHHHHHHHHHHHHCH	24.95	115372699
869	Ubiquitination	ERDAEDVKKQPFFRT CCCHHHHHHCHHHHH	59.00	24816145
875	Ubiquitination	VKKQPFFRTLGWEAL HHHCHHHHHHCHHHH	29.44	24816145
875 (in isoform 2)	Ubiquitination	-	29.44	-
881	Ubiquitination	FRTLGWEALLARRLP HHHHCHHHHHHHCCC	11.02	24816145
896	Phosphorylation	PPFVPTLSGRTDVSN CCCCCCCCCCCCCCC	28.80	26074081
899	Phosphorylation	VPTLSGRTDVSNFDE CCCCCCCCCCCCCCH	44.25	23403867
902	Phosphorylation	LSGRTDVSNFDEEFT CCCCCCCCCCCHHHC	34.29	28176443
909	Phosphorylation	SNFDEEFTGEAPTLS CCCCHHHCCCCCCCC	37.07	28176443
914	Phosphorylation	EFTGEAPTLSPPRDA HHCCCCCCCCCCCCC	47.09	29255136
916	Phosphorylation	TGEAPTLSPPRDARP CCCCCCCCCCCCCCC	35.02	19664994
922	Phosphorylation	LSPPRDARPLTAAEQ CCCCCCCCCCCHHHH	30.93	32142685
922 (in isoform 2)	Phosphorylation	-	30.93	24719451
925	Phosphorylation	PRDARPLTAAEQAAF CCCCCCCCHHHHHHH	26.89	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
533	S	Phosphorylation	Kinase	CDK1	P06493	PSP
537	S	Phosphorylation	Kinase	CDK1	P06493	PSP
562	S	Phosphorylation	Kinase	CDK1	P06493	PSP
773	S	Phosphorylation	Kinase	PDPK1	O15530	GPS
774	T	Phosphorylation	Kinase	PDK1	Q15118	GPS
774	T	Phosphorylation	Kinase	PDK1	O15530	PSP
774	T	Phosphorylation	Kinase	PKN1	Q16512	PSP
916	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC85B_HUMAN	CCDC85B	physical	16189514
RHOA_HUMAN	RHOA	physical	9535835
NFL_HUMAN	NEFL	physical	8621664
NFH_HUMAN	NEFH	physical	8621664
ACTN1_HUMAN	ACTN1	physical	11802708
PLD1_HUMAN	PLD1	physical	11259428
VIME_HUMAN	VIM	physical	9175763
NDF2_HUMAN	NEUROD2	physical	10640683
RHOA_HUMAN	RHOA	physical	9446575
AKAP9_HUMAN	AKAP9	physical	10358086
PDPK1_HUMAN	PDPK1	physical	10764742
CDR2_HUMAN	CDR2	physical	9637778
HDAC5_HUMAN	HDAC5	physical	20188095
HDAC6_HUMAN	HDAC6	physical	19036992
H32_HUMAN	HIST2H3C	physical	18066052
ZN282_HUMAN	ZNF282	physical	21900206
SPR2D_HUMAN	SPRR2D	physical	21900206
TBA1A_HUMAN	TUBA1A	physical	12716939
TBB5_HUMAN	TUBB	physical	12716939
TRAF2_HUMAN	TRAF2	physical	14741690
PKN1_HUMAN	PKN1	physical	14741690
TM1L1_HUMAN	TOM1L1	physical	22939629
TAU_HUMAN	MAPT	physical	11104762
TRAF1_HUMAN	TRAF1	physical	18429822
TNR1B_HUMAN	TNFRSF1B	physical	18429822
MK12_HUMAN	MAPK12	physical	12761180
MK11_HUMAN	MAPK11	physical	12761180
MP2K3_HUMAN	MAP2K3	physical	12761180
MP2K6_HUMAN	MAP2K6	physical	12761180
RHOA_HUMAN	RHOA	physical	10619026
MARCS_HUMAN	MARCKS	physical	8557118
MPIP3_HUMAN	CDC25C	physical	15791647
MBP_HUMAN	MBP	physical	15791647
BUD23_HUMAN	WBSCR22	physical	21988832
H11_HUMAN	HIST1H1A	physical	21357687
VIME_HUMAN	VIM	physical	25416956
HOME3_HUMAN	HOMER3	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
WDR5_HUMAN	WDR5	physical	24793694
KMT2A_HUMAN	KMT2A	physical	24793694
RBBP5_HUMAN	RBBP5	physical	24793694
ASH2L_HUMAN	ASH2L	physical	24793694
PPM1A_HUMAN	PPM1A	physical	26344197
PPM1G_HUMAN	PPM1G	physical	26344197
HOME3_HUMAN	HOMER3	physical	21516116

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKN1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-533; SER-537; SER-559; SER-561; SER-562 ANDSER-916, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-448, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-533; SER-537;SER-559; SER-562; THR-914 AND SER-916, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-533; SER-537; SER-559; SER-561; SER-562 ANDSER-916, AND MASS SPECTROMETRY.	19413330 [Abstract]
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"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-778, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Phosphorylation of protein kinase N by phosphoinositide-dependentprotein kinase-1 mediates insulin signals to the actin cytoskeleton."; Dong L.Q., Landa L.R., Wick M.J., Zhu L., Mukai H., Ono Y., Liu F.; Proc. Natl. Acad. Sci. U.S.A. 97:5089-5094(2000). Cited for: PHOSPHORYLATION AT THR-774 BY PDPK1, AND INTERACTION WITH PDPK1.	10792047 [Abstract]