dbPTM

NFH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NFH_HUMAN
UniProt AC	P12036
Protein Name	Neurofilament heavy polypeptide
Gene Name	NEFH
Organism	Homo sapiens (Human).
Sequence Length	1026
Subcellular Localization	Cytoplasm .
Protein Description	Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins..
Protein Sequence	MMSFGGADALLGAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Ubiquitination	LHYALARKGGAGGTR HHHHHHHCCCCCCCC	56.97	-
39	Phosphorylation	GGAGGTRSAAGSSSG CCCCCCCCCCCCCCC	23.47	28857561
43	Phosphorylation	GTRSAAGSSSGFHSW CCCCCCCCCCCCCCC	19.32	28857561
44	Phosphorylation	TRSAAGSSSGFHSWT CCCCCCCCCCCCCCC	33.30	27732954
53	O-linked_Glycosylation	GFHSWTRTSVSSVSA CCCCCCCCEECCEEC	26.55	-
53	O-linked_Glycosylation	GFHSWTRTSVSSVSA CCCCCCCCEECCEEC	26.55	8702840
53	Phosphorylation	GFHSWTRTSVSSVSA CCCCCCCCEECCEEC	26.55	26434776
54	O-linked_Glycosylation	FHSWTRTSVSSVSAS CCCCCCCEECCEECC	19.40	30379171
54	Phosphorylation	FHSWTRTSVSSVSAS CCCCCCCEECCEECC	19.40	27732954
54	O-linked_Glycosylation	FHSWTRTSVSSVSAS CCCCCCCEECCEECC	19.40	8702840
56	O-linked_Glycosylation	SWTRTSVSSVSASPS CCCCCEECCEECCCC	25.45	30379171
56	O-linked_Glycosylation	SWTRTSVSSVSASPS CCCCCEECCEECCCC	25.45	8702840
56	Phosphorylation	SWTRTSVSSVSASPS CCCCCEECCEECCCC	25.45	26434776
57	Phosphorylation	WTRTSVSSVSASPSR CCCCEECCEECCCCC	20.24	26434776
59	Phosphorylation	RTSVSSVSASPSRFR CCEECCEECCCCCCC	25.61	30619164
61	Phosphorylation	SVSSVSASPSRFRGA EECCEECCCCCCCCC	18.85	28857561
63	Phosphorylation	SSVSASPSRFRGAGA CCEECCCCCCCCCCC	41.37	30619164
72	Phosphorylation	FRGAGAASSTDSLDT CCCCCCCCCCCCHHH	32.98	27732954
73	Phosphorylation	RGAGAASSTDSLDTL CCCCCCCCCCCHHHH	31.35	27732954
74	Phosphorylation	GAGAASSTDSLDTLS CCCCCCCCCCHHHHH	27.41	27732954
76	Phosphorylation	GAASSTDSLDTLSNG CCCCCCCCHHHHHCC	28.38	28857561
79	Phosphorylation	SSTDSLDTLSNGPEG CCCCCHHHHHCCCCC	37.06	28857561
81	Phosphorylation	TDSLDTLSNGPEGCM CCCHHHHHCCCCCEE	41.66	27732954
94	Phosphorylation	CMVAVATSRSEKEQL EEEEEECCCCHHHHH	24.87	24425749
98	Ubiquitination	VATSRSEKEQLQALN EECCCCHHHHHHHHH	52.59	21987572
111	Phosphorylation	LNDRFAGYIDKVRQL HHHHHHHHHHHHHHH	11.52	-
124	Phosphorylation	QLEAHNRSLEGEAAA HHHHHCCCHHHHHHH	35.77	27732954
229	Phosphorylation	ALQEECGYLRRHHQE HHHHHHCHHHHHHHH	14.53	29978859
264	Ubiquitination	AETRDALKCDVTSAL HHHHHHHHCHHHHHH	30.06	21987572
268	O-linked_Glycosylation	DALKCDVTSALREIR HHHHCHHHHHHHHHH	8.60	30379171
301	Phosphorylation	RVRLDRLSEAAKVNT HHHHHHHHHHHHCCH	26.53	23403867
336	Ubiquitination	TTELEALKSTKDSLE HHHHHHHHHHHHHHH	64.23	29967540
337	Phosphorylation	TELEALKSTKDSLER HHHHHHHHHHHHHHH	41.35	-
347	Phosphorylation	DSLERQRSELEDRHQ HHHHHHHHHHHHHHH	37.89	-
385	Phosphorylation	MAAQLREYQDLLNVK HHHHHHHHHHHHCHH	10.82	-
402	Phosphorylation	LDIEIAAYRKLLEGE HHHHHHHHHHHHCCC	10.16	-
412	Methylation	LLEGEECRIGFGPIP HHCCCCCEECCCCCC	35.03	-
421	Phosphorylation	GFGPIPFSLPEGLPK CCCCCCCCCCCCCCC	37.35	-
421	O-linked_Glycosylation	GFGPIPFSLPEGLPK CCCCCCCCCCCCCCC	37.35	30379171
431	Phosphorylation	EGLPKIPSVSTHIKV CCCCCCCCCCEEEEE	31.97	28857561
501	Phosphorylation	AEGGEEETKSPPAEE HCCCCCCCCCCCHHH	39.85	18510355
503	Phosphorylation	GGEEETKSPPAEEAA CCCCCCCCCCHHHHC	43.46	18510355
511	Phosphorylation	PPAEEAASPEKEAKS CCHHHHCCHHHHCCC	40.41	30177828
518	Phosphorylation	SPEKEAKSPVKEEAK CHHHHCCCCCCHHHC	41.81	18510355
526	Phosphorylation	PVKEEAKSPAEAKSP CCCHHHCCHHHHCCC	36.07	18510355
531	Ubiquitination	AKSPAEAKSPEKEEA HCCHHHHCCCCHHHC	59.03	-
532	Phosphorylation	KSPAEAKSPEKEEAK CCHHHHCCCCHHHCC	45.39	21955146
532	O-linked_Glycosylation	KSPAEAKSPEKEEAK CCHHHHCCCCHHHCC	45.39	30379171
540	Phosphorylation	PEKEEAKSPAEVKSP CCHHHCCCCCCCCCH	36.07	30177828
546	Phosphorylation	KSPAEVKSPEKAKSP CCCCCCCCHHHCCCC	43.39	22167270
552	Phosphorylation	KSPEKAKSPAKEEAK CCHHHCCCCCHHHHC	34.64	26657352
560	Phosphorylation	PAKEEAKSPPEAKSP CCHHHHCCCCCCCCC	53.38	20886841
565	Ubiquitination	AKSPPEAKSPEKEEA HCCCCCCCCCCHHHC	65.95	-
566	Phosphorylation	KSPPEAKSPEKEEAK CCCCCCCCCCHHHCC	45.39	20886841
574	Phosphorylation	PEKEEAKSPAEVKSP CCHHHCCCCCCCCCH	36.07	30177828
580	Phosphorylation	KSPAEVKSPEKAKSP CCCCCCCCHHHCCCC	43.39	22167270
586	Phosphorylation	KSPEKAKSPAKEEAK CCHHHCCCCCHHHCC	34.64	26657352
594	Phosphorylation	PAKEEAKSPAEAKSP CCHHHCCCHHHHCCH	36.07	23403867
600	Phosphorylation	KSPAEAKSPEKAKSP CCHHHHCCHHHCCCC	45.39	20815410
606	Phosphorylation	KSPEKAKSPVKEEAK CCHHHCCCCCCHHCC	39.52	18510355
614	Phosphorylation	PVKEEAKSPAEAKSP CCCHHCCCHHHHCCC	36.07	18510355
620	Phosphorylation	KSPAEAKSPVKEEAK CCHHHHCCCCCHHCC	41.81	23898821
628	Phosphorylation	PVKEEAKSPAEVKSP CCCHHCCCCCCCCCH	36.07	30177828
634	Phosphorylation	KSPAEVKSPEKAKSP CCCCCCCCHHHCCCC	43.39	22167270
640	Phosphorylation	KSPEKAKSPTKEEAK CCHHHCCCCCHHHHC	42.53	18510355
642	O-linked_Glycosylation	PEKAKSPTKEEAKSP HHHCCCCCHHHHCCH	59.17	30379171
648	Phosphorylation	PTKEEAKSPEKAKSP CCHHHHCCHHHCCCH	45.39	18510355
648	O-linked_Glycosylation	PTKEEAKSPEKAKSP CCHHHHCCHHHCCCH	45.39	30379171
654	Phosphorylation	KSPEKAKSPEKAKSP CCHHHCCCHHHHCCC	43.05	18510355
657	Acetylation	EKAKSPEKAKSPEKE HHCCCHHHHCCCCHH	65.58	18526003
659	Acetylation	AKSPEKAKSPEKEEA CCCHHHHCCCCHHHC	77.07	18526013
659	Ubiquitination	AKSPEKAKSPEKEEA CCCHHHHCCCCHHHC	77.07	-
660	Phosphorylation	KSPEKAKSPEKEEAK CCHHHHCCCCHHHCC	43.05	18510355
662	Phosphorylation	PEKAKSPEKEEAKSP HHHHCCCCHHHCCCH	78.99	18510355
663	Acetylation	EKAKSPEKEEAKSPE HHHCCCCHHHCCCHH	65.32	18526023
668	Phosphorylation	PEKEEAKSPEKAKSP CCHHHCCCHHHHCCC	45.39	18510355
674	Phosphorylation	KSPEKAKSPVKAEAK CCHHHHCCCCCCCCC	39.52	18510355
676	Phosphorylation	PEKAKSPVKAEAKSP HHHHCCCCCCCCCCH	13.65	18510355
682	Phosphorylation	PVKAEAKSPEKAKSP CCCCCCCCHHHCCCC	45.39	18510355
688	Phosphorylation	KSPEKAKSPVKAEAK CCHHHCCCCCCCCCC	39.52	18510355
690	Phosphorylation	PEKAKSPVKAEAKSP HHHCCCCCCCCCCCH	13.65	18510355
696	Phosphorylation	PVKAEAKSPEKAKSP CCCCCCCCHHHHCCC	45.39	18510355
702	Phosphorylation	KSPEKAKSPVKEEAK CCHHHHCCCCHHHHC	39.52	25072903
704	Phosphorylation	PEKAKSPVKEEAKSP HHHHCCCCHHHHCCH	18.40	18510355
710	Phosphorylation	PVKEEAKSPEKAKSP CCHHHHCCHHHHCCC	45.39	21955146
716	Phosphorylation	KSPEKAKSPVKEEAK CCHHHHCCCCHHHHC	39.52	25072903
718	Phosphorylation	PEKAKSPVKEEAKSP HHHHCCCCHHHHCCH	18.40	18510355
724	Phosphorylation	PVKEEAKSPEKAKSP CCHHHHCCHHHHCCC	45.39	21955146
730	Phosphorylation	KSPEKAKSPVKEEAK CCHHHHCCCCCHHCC	39.52	18510355
732	Phosphorylation	PEKAKSPVKEEAKTP HHHHCCCCCHHCCCH	18.40	18510355
738	Phosphorylation	PVKEEAKTPEKAKSP CCCHHCCCHHHHCCC	43.67	18510355
744	Phosphorylation	KTPEKAKSPVKEEAK CCHHHHCCCCHHHHC	39.52	18510355
746	Phosphorylation	PEKAKSPVKEEAKSP HHHHCCCCHHHHCCH	18.40	18510355
752	Phosphorylation	PVKEEAKSPEKAKSP CCHHHHCCHHHCCCH	45.39	21955146
758	Phosphorylation	KSPEKAKSPEKAKTL CCHHHCCCHHHHCCC	43.05	18510355
763	Phosphorylation	AKSPEKAKTLDVKSP CCCHHHHCCCCCCCC	61.77	18510355
769	Phosphorylation	AKTLDVKSPEAKTPA HCCCCCCCCCCCCCC	28.02	26033855
774	Phosphorylation	VKSPEAKTPAKEEAR CCCCCCCCCCHHHHC	35.21	21857030
776	Phosphorylation	SPEAKTPAKEEARSP CCCCCCCCHHHHCCH	36.80	27251275
782	Phosphorylation	PAKEEARSPADKFPE CCHHHHCCHHHHCCH	31.33	26033855
787	Phosphorylation	ARSPADKFPEKAKSP HCCHHHHCCHHHCCC	10.99	18510355
793	Phosphorylation	KFPEKAKSPVKEEVK HCCHHHCCCCCHHCC	39.52	28348404
795	Phosphorylation	PEKAKSPVKEEVKSP CHHHCCCCCHHCCCH	18.40	18510355
801	Phosphorylation	PVKEEVKSPEKAKSP CCCHHCCCHHHHCCC	43.39	30177828
807	Phosphorylation	KSPEKAKSPLKEDAK CCHHHHCCCCHHCCC	40.08	23312004
822	Phosphorylation	APEKEIPKKEEVKSP CCCCCCCCHHHCCCC	77.73	18510355
828	Phosphorylation	PKKEEVKSPVKEEEK CCHHHCCCCCCCCCC	39.85	18510355
889	Ubiquitination	EKKEPAVEKPKESKV CCCCCCCCCCCHHCC	66.79	29967540
894	Phosphorylation	AVEKPKESKVEAKKE CCCCCCHHCCHHHHH	48.40	25332170
905	Phosphorylation	AKKEEAEDKKKVPTP HHHHHHHHHCCCCCC	75.11	27251275
907	Acetylation	KEEAEDKKKVPTPEK HHHHHHHCCCCCCCC	71.91	7469317
908	Acetylation	EEAEDKKKVPTPEKE HHHHHHCCCCCCCCC	60.22	7469325
911	Phosphorylation	EDKKKVPTPEKEAPA HHHCCCCCCCCCCCC	47.25	20886841
942	Phosphorylation	AKKEPDDAKAKEPSK HHCCCCCHHHCCCCC	22.53	-
948	Phosphorylation	DAKAKEPSKPAEKKE CHHHCCCCCHHHHHH	52.98	21828286
993	Phosphorylation	KTLSKEPSKPKAEKA CCCCCCCCCHHHHHH	63.78	-
1005	Phosphorylation	EKAEKSSSTDQKDSK HHHHHCCCCCCCCCC	42.99	27794612
1006	Phosphorylation	KAEKSSSTDQKDSKP HHHHCCCCCCCCCCC	44.38	27794612
1011	Phosphorylation	SSTDQKDSKPPEKAT CCCCCCCCCCCHHHH	54.84	27794612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
503	S	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NFH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NFH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKN1_HUMAN	PKN1	physical	8621664
NFL_HUMAN	NEFL	physical	9388258
AINX_HUMAN	INA	physical	28514442
NFL_HUMAN	NEFL	physical	28514442
NFM_HUMAN	NEFM	physical	28514442
TARB1_HUMAN	TARBP1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
105400	Amyotrophic lateral sclerosis (ALS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NFH_HUMAN

Related Literatures of Post-Translational Modification