BUD23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BUD23_HUMAN
• UniProt AC: O43709
• Protein Name: Probable 18S rRNA (guanine-N(7))-methyltransferase {ECO:0000305}
• Gene Name: BUD23 {ECO:0000312|HGNC:HGNC:16405}
• Organism: Homo sapiens (Human).
• Sequence Length: 281
• Subcellular Localization: Nucleus . Nucleus, nucleoplasm . Cytoplasm, perinuclear region . Cytoplasm . Localized diffusely throughout the nucleus and the cytoplasm (PubMed:24488492). Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lyso
• Protein Description: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. [PubMed: 25851604 Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity]
• Protein Sequence: MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Sulfoxidation	KYVRNSRMIDIQTRM HHHHHHCCCCHHHHH		21406390
134	Ubiquitination	WLCNANKKSENPAKR HHHHCCCCCCCHHHH		29967540
135	Phosphorylation	LCNANKKSENPAKRL HHHCCCCCCCHHHHH		20860994
157	Phosphorylation	FSVLVRGSRAVLQLY HHHHHHCCHHHHHHC		24144214
164	Phosphorylation	SRAVLQLYPENSEQL CHHHHHHCCCCHHHE		24144214
168	Phosphorylation	LQLYPENSEQLELIT HHHCCCCHHHEEEEE		24144214
175	Phosphorylation	SEQLELITTQATKAG HHHEEEEEEHHHCCC		24144214
176	Phosphorylation	EQLELITTQATKAGF HHEEEEEEHHHCCCC		24144214
179	Phosphorylation	ELITTQATKAGFSGG EEEEEHHHCCCCCCC		24144214
180	Ubiquitination	LITTQATKAGFSGGM EEEEHHHCCCCCCCE		21906983
180	Ubiquitination	LITTQATKAGFSGGM EEEEHHHCCCCCCCE		-
180 (in isoform 1)	Ubiquitination	-		21890473
184	Phosphorylation	QATKAGFSGGMVVDY HHHCCCCCCCEEECC		23879269
191	Phosphorylation	SGGMVVDYPNSAKAK CCCEEECCCCCHHCC		24905233
194	Phosphorylation	MVVDYPNSAKAKKFY EEECCCCCHHCCEEE		23879269
196	Ubiquitination	VDYPNSAKAKKFYLC ECCCCCHHCCEEEEE		23000965
196	Ubiquitination	VDYPNSAKAKKFYLC ECCCCCHHCCEEEEE		-
196 (in isoform 1)	Ubiquitination	-		21890473
196	Acetylation	VDYPNSAKAKKFYLC ECCCCCHHCCEEEEE		25953088
198	Methylation	YPNSAKAKKFYLCLF CCCCHHCCEEEEECC		21684113
198	Ubiquitination	YPNSAKAKKFYLCLF CCCCHHCCEEEEECC		-
198	Ubiquitination	YPNSAKAKKFYLCLF CCCCHHCCEEEEECC		23000965
199	Ubiquitination	PNSAKAKKFYLCLFS CCCHHCCEEEEECCC		23000965
203	Ubiquitination	KAKKFYLCLFSGPST HCCEEEEECCCCCCC		22817900
219	Ubiquitination	IPEGLSENQDEVEPR CCCCCCCCCCCCCCC		23000965
221	Ubiquitination	EGLSENQDEVEPRES CCCCCCCCCCCCCHH		23000965
222	Ubiquitination	GLSENQDEVEPRESV CCCCCCCCCCCCHHH		23000965
228	Phosphorylation	DEVEPRESVFTNERF CCCCCCHHHCCCCCC		26074081
231	Phosphorylation	EPRESVFTNERFPLR CCCHHHCCCCCCCCC		23401153
240	Phosphorylation	ERFPLRMSRRGMVRK CCCCCCCCCCCCCCH		22617229
248	Phosphorylation	RRGMVRKSRAWVLEK CCCCCCHHHHHHHHH		25159151
255	Ubiquitination	SRAWVLEKKERHRRQ HHHHHHHHHHHHHHC		21890473
255 (in isoform 1)	Ubiquitination	-		21890473
255	Ubiquitination	SRAWVLEKKERHRRQ HHHHHHHHHHHHHHC		23000965
256	Ubiquitination	RAWVLEKKERHRRQG HHHHHHHHHHHHHCC		23000965
270	Phosphorylation	GREVRPDTQYTGRKR CCCCCCCCCCCCCCC		28152594
272	Ubiquitination	EVRPDTQYTGRKRKP CCCCCCCCCCCCCCC		23000965
272	Phosphorylation	EVRPDTQYTGRKRKP CCCCCCCCCCCCCCC		28152594
272	Nitration	EVRPDTQYTGRKRKP CCCCCCCCCCCCCCC		-
273	Ubiquitination	VRPDTQYTGRKRKPR CCCCCCCCCCCCCCC		23000965
273	Phosphorylation	VRPDTQYTGRKRKPR CCCCCCCCCCCCCCC		28152594
273	Ubiquitination	VRPDTQYTGRKRKPR CCCCCCCCCCCCCCC		-
278	Ubiquitination	QYTGRKRKPRF---- CCCCCCCCCCC----		23000965
279	Ubiquitination	YTGRKRKPRF----- CCCCCCCCCC-----		23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BUD23_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BUD23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BUD23_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR74_HUMAN	WDR74	physical	22939629
ZMYM3_HUMAN	ZMYM3	physical	22939629
TR112_HUMAN	TRMT112	physical	26186194
UBE2O_HUMAN	UBE2O	physical	26186194
H2A2B_HUMAN	HIST2H2AB	physical	26186194
FEN1_HUMAN	FEN1	physical	26344197
KIF2A_HUMAN	KIF2A	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
BUD23_HUMAN	WBSCR22	physical	26472760
TR112_HUMAN	TRMT112	physical	26472760
TR112_HUMAN	TRMT112	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
H2A2B_HUMAN	HIST2H2AB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.