TNR1B_HUMAN - dbPTM
TNR1B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TNR1B_HUMAN
UniProt AC P20333
Protein Name Tumor necrosis factor receptor superfamily member 1B
Gene Name TNFRSF1B
Organism Homo sapiens (Human).
Sequence Length 461
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein.
Isoform 2: Secreted.
Tumor necrosis factor-binding protein 2: Secreted.
Protein Description Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity..
Protein Sequence MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30O-linked_GlycosylationLPAQVAFTPYAPEPG
CCCEEEECCCCCCCC		12.9725456591
119PhosphorylationREQNRICTCRPGWYC
CCCCCEECCCCCCEE		14.8026356563
125PhosphorylationCTCRPGWYCALSKQE
ECCCCCCEEEEECCC		3.6126356563
129PhosphorylationPGWYCALSKQEGCRL
CCCEEEEECCCCCEE		17.4826356563
171N-linked_GlycosylationCAPGTFSNTTSSTDI
CCCCCCCCCCCCCCC		43.09UniProtKB CARBOHYD
193N-linked_GlycosylationNVVAIPGNASMDAVC
EEEEECCCCCCCEEE		24.40UniProtKB CARBOHYD
206O-linked_GlycosylationVCTSTSPTRSMAPGA
EEECCCCCCCCCCCC		34.8325456591
208O-linked_GlycosylationTSTSPTRSMAPGAVH
ECCCCCCCCCCCCCC		23.0555826319
221PhosphorylationVHLPQPVSTRSQHTQ
CCCCCCCCCCCCCCC		25.4518491316
221O-linked_GlycosylationVHLPQPVSTRSQHTQ
CCCCCCCCCCCCCCC		25.4518491316
222O-linked_GlycosylationHLPQPVSTRSQHTQP
CCCCCCCCCCCCCCC		34.2825456591
222PhosphorylationHLPQPVSTRSQHTQP
CCCCCCCCCCCCCCC		34.28-
239O-linked_GlycosylationEPSTAPSTSFLLPMG
CCCCCCCCCEEEECC		23.57OGP
311PhosphorylationPADKARGTQGPEQQH
CHHHHCCCCCCCCCE		25.4627080861
322PhosphorylationEQQHLLITAPSSSSS
CCCEEEEECCCCCCH		32.2728450419
325PhosphorylationHLLITAPSSSSSSLE
EEEEECCCCCCHHHH		40.1528450419
326PhosphorylationLLITAPSSSSSSLES
EEEECCCCCCHHHHH		32.9328450419
327PhosphorylationLITAPSSSSSSLESS
EEECCCCCCHHHHHH		38.2828450419
328PhosphorylationITAPSSSSSSLESSA
EECCCCCCHHHHHHH		26.3728450419
329PhosphorylationTAPSSSSSSLESSAS
ECCCCCCHHHHHHHH		40.6728450419
330PhosphorylationAPSSSSSSLESSASA
CCCCCCHHHHHHHHH		37.802166946
333PhosphorylationSSSSSLESSASALDR
CCCHHHHHHHHHHHH		36.1828450419
334PhosphorylationSSSSLESSASALDRR
CCHHHHHHHHHHHHC		19.5028450419
336PhosphorylationSSLESSASALDRRAP
HHHHHHHHHHHHCCC		31.1728450419
436PhosphorylationAFRSQLETPETLLGS
HHHHHCCCCHHHCCC		34.719535738
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseASB3Q9Y575
PMID:15899873
-KUbiquitinationE3 ubiquitin ligaseSMURF2Q9HAU4
PMID:18671942
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TNR1B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TNR1B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FACD2_HUMANFANCD2physical
14743216
TNFA_HUMANTNFphysical
14743216
TRAF2_HUMANTRAF2physical
14743216
TRAF2_HUMANTRAF2physical
7639698
CAV1_HUMANCAV1physical
11112773
TRAF2_HUMANTRAF2physical
11907088
K1C18_HUMANKRT18physical
10747083
TYDP2_HUMANTDP2physical
10764746
TRAF2_HUMANTRAF2physical
9162022
TRAF1_HUMANTRAF1physical
9162022
TNR1B_HUMANTNFRSF1Bphysical
10875917
TRI37_HUMANTRIM37physical
11279055
TRAIP_HUMANTRAIPphysical
9104814
TRAF2_HUMANTRAF2physical
18671942
SMUF2_HUMANSMURF2physical
18671942
ASB3_HUMANASB3physical
15899873
TRAF3_HUMANTRAF3physical
7859281
TRAF1_HUMANTRAF1physical
7859281
TNR1A_HUMANTNFRSF1Aphysical
19287455
IKKA_HUMANCHUKphysical
19287455
RIPK1_HUMANRIPK1physical
19287455
TRADD_HUMANTRADDphysical
19287455
TRAF1_HUMANTRAF1physical
9168896
TRAF2_HUMANTRAF2physical
9168896
TRAF1_HUMANTRAF1physical
8069916
TRAF2_HUMANTRAF2physical
8069916
PKN1_HUMANPKN1physical
18429822
TNFA_HUMANTNFphysical
7966397
KC1A_HUMANCSNK1A1physical
9109395
TNFA_HUMANTNFphysical
7930591
UBQL1_HUMANUBQLN1physical
21988832
ZN420_HUMANZNF420physical
21988832
KC1AL_HUMANCSNK1A1Lphysical
8051045
TNFA_HUMANTNFphysical
15173183
TNFA_HUMANTNFphysical
11448951
Drug and Disease Associations
Kegg Disease
H00084 Graft-versus-host disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TNR1B_HUMAN

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Related Literatures of Post-Translational Modification

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