KC1AL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KC1AL_HUMAN
• UniProt AC: Q8N752
• Protein Name: Casein kinase I isoform alpha-like
• Gene Name: CSNK1A1L
• Organism: Homo sapiens (Human).
• Sequence Length: 337
• Subcellular Localization: Cytoplasm.
• Protein Description: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity)..
• Protein Sequence: MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEDVAVKLESQKVKHPQLLYESKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLRAMTKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVKDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MTNNSGSKAELVVGG CCCCCCCCEEEEECC	49.78	-
53	Acetylation	KLESQKVKHPQLLYE EECCCCCCCCHHHHH	57.51	7966147
59	Phosphorylation	VKHPQLLYESKLYTI CCCCHHHHHHHHHHH	27.09	28331001
62	Acetylation	PQLLYESKLYTILQG CHHHHHHHHHHHHCC	33.31	7966155
83	Acetylation	MHWYGQEKDNNVLVM CCCCCCCCCCCEEEE	58.84	7966163
105	Phosphorylation	EDLFNFCSRRFTMKT HHHHHHHHHCCCHHH	23.50	19690332
109	Phosphorylation	NFCSRRFTMKTVLML HHHHHCCCHHHHHHH	18.88	22210691
126	Phosphorylation	QMISRIEYVHTKNFL HHHHHCEEEECCCCC	8.65	28102081
130	Ubiquitination	RIEYVHTKNFLHRDI HCEEEECCCCCCCCC	30.72	21890473
146	Phosphorylation	PDNFLMGTGRHCNKL CCCEECCCCCCCCEE	19.65	-
152	Ubiquitination	GTGRHCNKLFLIDFG CCCCCCCEEEEECHH	46.11	33845483
162	Ubiquitination	LIDFGLAKKYRDNRT EECHHCCHHHCCCCC	56.21	21906983
184	Phosphorylation	EDKHLIGTVRYASIN CCCCCCEEEEHHHHH	8.53	-
199	Phosphorylation	AHLGIEQSRRDDMES HHCCCCHHHHHHHHH	19.25	-
206	Phosphorylation	SRRDDMESLGYVFMY HHHHHHHHHCEEEHE	22.06	-
209	Phosphorylation	DDMESLGYVFMYFNR HHHHHHCEEEHEECC	8.87	-
213	Phosphorylation	SLGYVFMYFNRTSLP HHCEEEHEECCCCCC	6.04	-
228	Phosphorylation	WQGLRAMTKKQKYEK HHHHHHHHHHHHHHH	33.82	21406692
240	Ubiquitination	YEKISEKKMSTPVEV HHHHCCCCCCCCHHH	33.75	-
242	Phosphorylation	KISEKKMSTPVEVLC HHCCCCCCCCHHHHC	38.14	19860830
287	Phosphorylation	LFRILFRTLNHQYDY HHHHHHHHCCCCCCC	25.28	26356563
292	Phosphorylation	FRTLNHQYDYTFDWT HHHCCCCCCCCCCHH	11.90	26356563
294	Phosphorylation	TLNHQYDYTFDWTML HCCCCCCCCCCHHHH	12.36	26356563
295	Phosphorylation	LNHQYDYTFDWTMLK CCCCCCCCCCHHHHH	16.54	26356563
299	Phosphorylation	YDYTFDWTMLKQKAA CCCCCCHHHHHHHHH	17.92	26356563
302	Ubiquitination	TFDWTMLKQKAAQQA CCCHHHHHHHHHHHH	38.64	21906983
304	Ubiquitination	DWTMLKQKAAQQAAS CHHHHHHHHHHHHHH	44.07	33845483
311	Phosphorylation	KAAQQAASSSGQGQQ HHHHHHHHHCCCCHH	28.22	18691976
312	Phosphorylation	AAQQAASSSGQGQQA HHHHHHHHCCCCHHH	33.49	18691976
313	Phosphorylation	AQQAASSSGQGQQAQ HHHHHHHCCCCHHHH	32.42	19413330

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KC1AL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KC1AL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KC1AL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAM2_HUMAN	JAM2	physical	21988832
TNR1B_HUMAN	TNFRSF1B	physical	8051045
KC1AL_HUMAN	CSNK1A1L	physical	8051045
TNR1A_HUMAN	TNFRSF1A	physical	8051045

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.