NDF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDF2_HUMAN
• UniProt AC: Q15784
• Protein Name: Neurogenic differentiation factor 2
• Gene Name: NEUROD2
• Organism: Homo sapiens (Human).
• Sequence Length: 382
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity)..
• Protein Sequence: MLTRLFSEPGLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPARAAKPVPLRGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLTRLFSEPG -----CCCHHCCCCC	24.83	29083192
7	Phosphorylation	-MLTRLFSEPGLLSD -CCCHHCCCCCCCCC	47.69	32142685
13	Phosphorylation	FSEPGLLSDVPKFAS CCCCCCCCCCCCCCC	41.42	29083192
20	Phosphorylation	SDVPKFASWGDGEDD CCCCCCCCCCCCCCC	34.42	-
153	Ubiquitination	KVVPCYSKTQKLSKI HHHCCCCCCCCHHHH	28.62	32142685
156	Ubiquitination	PCYSKTQKLSKIETL CCCCCCCCHHHHHHH	61.02	-
159	Ubiquitination	SKTQKLSKIETLRLA CCCCCHHHHHHHHHH	55.81	32142685
169	Phosphorylation	TLRLAKNYIWALSEI HHHHHHHHHHHHHHH	9.35	25884760
212	Phosphorylation	AGCLQLNSRNFLTEQ HHHHHHHCCCCCCCC	36.87	-
325	Phosphorylation	DHEKSYHYSMHYSAL CCHHHHEEEEEEECC	10.23	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CDC20	Q12834	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDF2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NDF2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.