GPC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPC4_HUMAN
• UniProt AC: O75487
• Protein Name: Glypican-4
• Gene Name: GPC4
• Organism: Homo sapiens (Human).
• Sequence Length: 556
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; Secreted glypican-4: Secreted, extracellular space.
• Protein Description: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity)..
• Protein Sequence: MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	EVRRLYVSKGFNKND HHHHHHHCCCCCCCC	17.32	-
186	Phosphorylation	QYHFTDEYLECVSKY HCCCCHHHHHHHHHH	15.60	-
253	Phosphorylation	HALLKMIYCSHCRGL HHHHHHHHCCCCCCE	5.61	25219547
255	Phosphorylation	LLKMIYCSHCRGLVT HHHHHHCCCCCCEEE	14.51	25219547
357	Phosphorylation	GRISRSISESAFSAR CHHCCHHCHHHHHCC	27.09	9787072
362	Phosphorylation	SISESAFSARFRPHH HHCHHHHHCCCCCCC	20.46	28857561
375	O-linked_Glycosylation	HHPEERPTTAAGTSL CCCCCCCCCCCCCCH	34.98	55826857
376	O-linked_Glycosylation	HPEERPTTAAGTSLD CCCCCCCCCCCCCHH	19.72	55826863
387	Phosphorylation	TSLDRLVTDVKEKLK CCHHHHHHHHHHHHH	39.40	23090842
472	Phosphorylation	IMALRVMTSKMKNAY HHHHHHHHHHHHHCC	23.49	-
473	Phosphorylation	MALRVMTSKMKNAYN HHHHHHHHHHHHCCC	16.80	-
494	O-linked_Glycosylation	FDISDESSGEGSGSG EECCCCCCCCCCCCC	38.52	-
498	O-linked_Glycosylation	DESSGEGSGSGCEYQ CCCCCCCCCCCCCCC	26.03	-
500	O-linked_Glycosylation	SSGEGSGSGCEYQQC CCCCCCCCCCCCCCC	41.80	-
514	N-linked_Glycosylation	CPSEFDYNATDHAGK CCCCCCCCCCCCCCC	37.90	UniProtKB CARBOHYD
529	GPI-anchor	SANEKADSAGVRPGA CHHHHHHHCCCCCHH	31.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPC4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FGF2_HUMAN	FGF2	physical	11066092
AB17A_HUMAN	ABHD17A	physical	21516116
CCNC_HUMAN	CCNC	physical	21516116
GPC6_HUMAN	GPC6	physical	28514442
SPCS2_HUMAN	SPCS2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.