UniProt ID | GPC4_HUMAN | |
---|---|---|
UniProt AC | O75487 | |
Protein Name | Glypican-4 | |
Gene Name | GPC4 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 556 | |
Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor Extracellular side. Secreted glypican-4: Secreted, extracellular space. |
|
Protein Description | Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).. | |
Protein Sequence | MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
39 | Phosphorylation | EVRRLYVSKGFNKND HHHHHHHCCCCCCCC | 17.32 | - | |
186 | Phosphorylation | QYHFTDEYLECVSKY HCCCCHHHHHHHHHH | 15.60 | - | |
253 | Phosphorylation | HALLKMIYCSHCRGL HHHHHHHHCCCCCCE | 5.61 | 25219547 | |
255 | Phosphorylation | LLKMIYCSHCRGLVT HHHHHHCCCCCCEEE | 14.51 | 25219547 | |
357 | Phosphorylation | GRISRSISESAFSAR CHHCCHHCHHHHHCC | 27.09 | 9787072 | |
362 | Phosphorylation | SISESAFSARFRPHH HHCHHHHHCCCCCCC | 20.46 | 28857561 | |
375 | O-linked_Glycosylation | HHPEERPTTAAGTSL CCCCCCCCCCCCCCH | 34.98 | 55826857 | |
376 | O-linked_Glycosylation | HPEERPTTAAGTSLD CCCCCCCCCCCCCHH | 19.72 | 55826863 | |
387 | Phosphorylation | TSLDRLVTDVKEKLK CCHHHHHHHHHHHHH | 39.40 | 23090842 | |
472 | Phosphorylation | IMALRVMTSKMKNAY HHHHHHHHHHHHHCC | 23.49 | - | |
473 | Phosphorylation | MALRVMTSKMKNAYN HHHHHHHHHHHHCCC | 16.80 | - | |
494 | O-linked_Glycosylation | FDISDESSGEGSGSG EECCCCCCCCCCCCC | 38.52 | - | |
498 | O-linked_Glycosylation | DESSGEGSGSGCEYQ CCCCCCCCCCCCCCC | 26.03 | - | |
500 | O-linked_Glycosylation | SSGEGSGSGCEYQQC CCCCCCCCCCCCCCC | 41.80 | - | |
514 | N-linked_Glycosylation | CPSEFDYNATDHAGK CCCCCCCCCCCCCCC | 37.90 | UniProtKB CARBOHYD | |
529 | GPI-anchor | SANEKADSAGVRPGA CHHHHHHHCCCCCHH | 31.61 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GPC4_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPC4_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPC4_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
FGF2_HUMAN | FGF2 | physical | 11066092 | |
AB17A_HUMAN | ABHD17A | physical | 21516116 | |
CCNC_HUMAN | CCNC | physical | 21516116 | |
GPC6_HUMAN | GPC6 | physical | 28514442 | |
SPCS2_HUMAN | SPCS2 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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