GPC4_HUMAN - dbPTM
GPC4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPC4_HUMAN
UniProt AC O75487
Protein Name Glypican-4
Gene Name GPC4
Organism Homo sapiens (Human).
Sequence Length 556
Subcellular Localization Cell membrane
Lipid-anchor, GPI-anchor
Extracellular side.
Secreted glypican-4: Secreted, extracellular space.
Protein Description Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity)..
Protein Sequence MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
39PhosphorylationEVRRLYVSKGFNKND
HHHHHHHCCCCCCCC
17.32-
186PhosphorylationQYHFTDEYLECVSKY
HCCCCHHHHHHHHHH
15.60-
253PhosphorylationHALLKMIYCSHCRGL
HHHHHHHHCCCCCCE
5.6125219547
255PhosphorylationLLKMIYCSHCRGLVT
HHHHHHCCCCCCEEE
14.5125219547
357PhosphorylationGRISRSISESAFSAR
CHHCCHHCHHHHHCC
27.099787072
362PhosphorylationSISESAFSARFRPHH
HHCHHHHHCCCCCCC
20.4628857561
375O-linked_GlycosylationHHPEERPTTAAGTSL
CCCCCCCCCCCCCCH
34.9855826857
376O-linked_GlycosylationHPEERPTTAAGTSLD
CCCCCCCCCCCCCHH
19.7255826863
387PhosphorylationTSLDRLVTDVKEKLK
CCHHHHHHHHHHHHH
39.4023090842
472PhosphorylationIMALRVMTSKMKNAY
HHHHHHHHHHHHHCC
23.49-
473PhosphorylationMALRVMTSKMKNAYN
HHHHHHHHHHHHCCC
16.80-
494O-linked_GlycosylationFDISDESSGEGSGSG
EECCCCCCCCCCCCC
38.52-
498O-linked_GlycosylationDESSGEGSGSGCEYQ
CCCCCCCCCCCCCCC
26.03-
500O-linked_GlycosylationSSGEGSGSGCEYQQC
CCCCCCCCCCCCCCC
41.80-
514N-linked_GlycosylationCPSEFDYNATDHAGK
CCCCCCCCCCCCCCC
37.90UniProtKB CARBOHYD
529GPI-anchorSANEKADSAGVRPGA
CHHHHHHHCCCCCHH
31.61-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPC4_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPC4_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FGF2_HUMANFGF2physical
11066092
AB17A_HUMANABHD17Aphysical
21516116
CCNC_HUMANCCNCphysical
21516116
GPC6_HUMANGPC6physical
28514442
SPCS2_HUMANSPCS2physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPC4_HUMAN

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Related Literatures of Post-Translational Modification

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