AB17A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AB17A_HUMAN
• UniProt AC: Q96GS6
• Protein Name: Alpha/beta hydrolase domain-containing protein 17A {ECO:0000305}
• Gene Name: ABHD17A {ECO:0000312|HGNC:HGNC:28756}
• Organism: Homo sapiens (Human).
• Sequence Length: 310
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Endosome membrane ; Lipid-anchor ; Cytoplasmic side . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density .
• Protein Description: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. [PubMed: 26701913 Has depalmitoylating activity towards NRAS]
• Protein Sequence: MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPGPGGAGAAPLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFPTKSARGNRVSCMYVRCVPGARYTVLFSHGNAVDLGQMSSFYIGLGSRLHCNIFSYDYSGYGASSGRPSERNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MNGLSLSELCCL ---CCCCCHHHCHHH		46208651
7	Phosphorylation	-MNGLSLSELCCLFC -CCCCCHHHCHHHHH		46208655
35	Phosphorylation	FLPPEATYSLVPEPE CCCCCCEEEECCCCC		18083107
55	Phosphorylation	AGAAPLGTLRASSGA CCCCCCCCEEECCCC		46208659
67 (in isoform 2)	Ubiquitination	-		-
67	Ubiquitination	SGAPGRWKLHLTERA CCCCCCEEEEEEECC		-
78	Ubiquitination	TERADFQYSQRELDT EECCCCCCCCCCCCE		22817900
79	Ubiquitination	ERADFQYSQRELDTI ECCCCCCCCCCCCEE		22817900
92	Ubiquitination	TIEVFPTKSARGNRV EEEEEECCCCCCCEE		23000965
92 (in isoform 2)	Ubiquitination	-		-
226 (in isoform 3)	Ubiquitination	-		21906983
226 (in isoform 1)	Ubiquitination	-		21906983
226	Ubiquitination	RVAFPDTKKTYCFDA EEECCCCCCEEEECC		27667366
227	Ubiquitination	VAFPDTKKTYCFDAF EECCCCCCEEEECCC		22817900
277	Ubiquitination	CPKAVEPLWVEGAGH CCCCCCCEEECCCCC		27667366
277 (in isoform 2)	Ubiquitination	-		21906983
278	Ubiquitination	PKAVEPLWVEGAGHN CCCCCCEEECCCCCC		22817900
278 (in isoform 2)	Ubiquitination	-		-
302	Phosphorylation	ERLRRFISQELPSQR HHHHHHHHHHCCCCC		-
307	Phosphorylation	FISQELPSQRA---- HHHHHCCCCCC----		26701913

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AB17A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AB17A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AB17A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS28_HUMAN	VPS28	physical	26186194
TC1D2_HUMAN	TCTEX1D2	physical	26186194
RGS20_HUMAN	RGS20	physical	21516116
PNMA1_HUMAN	PNMA1	physical	21516116
TC1D2_HUMAN	TCTEX1D2	physical	28514442
VPS28_HUMAN	VPS28	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.