GPC6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPC6_HUMAN
• UniProt AC: Q9Y625
• Protein Name: Glypican-6
• Gene Name: GPC6
• Organism: Homo sapiens (Human).
• Sequence Length: 555
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; Secreted glypican-6: Secreted, extracellular space.
• Protein Description: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling..
• Protein Sequence: MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSWIGAVIL -----CCCHHHHHHH	29.99	-
212	Phosphorylation	RKLKIQVTRAFIAAR HHHHHHHHHHHHHHH	10.41	25278378
220	Phosphorylation	RAFIAARTFVQGLTV HHHHHHHHHHHCCCC	24.35	23403867
374	O-linked_Glycosylation	YNPEERPTTAAGTSL CCCCCCCCCCCCCCH	34.98	55826091
375	O-linked_Glycosylation	NPEERPTTAAGTSLD CCCCCCCCCCCCCHH	19.72	OGP
411	Phosphorylation	YTICKDESVTAGTSN CEEECCCCCCCCCCC	34.60	-
529	GPI-anchor	PDRREVDSSAAQRGH CCHHHCCCHHHHHCH	27.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPC6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPC6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPC6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GPC6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.