SF3B6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SF3B6_HUMAN
• UniProt AC: Q9Y3B4
• Protein Name: Splicing factor 3B subunit 6
• Gene Name: SF3B6
• Organism: Homo sapiens (Human).
• Sequence Length: 125
• Subcellular Localization: Nucleus .
• Protein Description: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. [PubMed: 27720643 SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA]
• Protein Sequence: MAMQAAKRANIRLPPEVNRILYIRNLPYKITAEEMYDIFGKYGPIRQIRVGNTPETRGTAYVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYNANRAFQKMDTKKKEEQLKLLKEKYGINTDPPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MAMQAAKRANIRLP -CCHHHHHHCCCCCC		33845483
7	2-Hydroxyisobutyrylation	-MAMQAAKRANIRLP -CCHHHHHHCCCCCC		-
7	Acetylation	-MAMQAAKRANIRLP -CCHHHHHHCCCCCC		25953088
7	Sumoylation	-MAMQAAKRANIRLP -CCHHHHHHCCCCCC		-
7	Sumoylation	-MAMQAAKRANIRLP -CCHHHHHHCCCCCC		-
28	Phosphorylation	LYIRNLPYKITAEEM EEECCCCCEEEHHHH		29496907
29	Ubiquitination	YIRNLPYKITAEEMY EECCCCCEEEHHHHH		21890473
29	Acetylation	YIRNLPYKITAEEMY EECCCCCEEEHHHHH		19608861
29	Sumoylation	YIRNLPYKITAEEMY EECCCCCEEEHHHHH		28112733
29	Ubiquitination	YIRNLPYKITAEEMY EECCCCCEEEHHHHH		23000965
36	Phosphorylation	KITAEEMYDIFGKYG EEEHHHHHHHHHCCC		27642862
41	Ubiquitination	EMYDIFGKYGPIRQI HHHHHHHCCCCEEEE		23000965
41	Ubiquitination	EMYDIFGKYGPIRQI HHHHHHHCCCCEEEE		21890473
41	Acetylation	EMYDIFGKYGPIRQI HHHHHHHCCCCEEEE		19608861
59	Phosphorylation	NTPETRGTAYVVYED CCCCCCCEEEEEEEC		29496907
61	Phosphorylation	PETRGTAYVVYEDIF CCCCCEEEEEEECCC		23822953
64	Phosphorylation	RGTAYVVYEDIFDAK CCEEEEEEECCCCHH		27642862
71	Acetylation	YEDIFDAKNACDHLS EECCCCHHHHHHHCC		26051181
71	Ubiquitination	YEDIFDAKNACDHLS EECCCCHHHHHHHCC		21906983
74	S-nitrosocysteine	IFDAKNACDHLSGFN CCCHHHHHHHCCCCC		-
83	S-nitrosocysteine	HLSGFNVCNRYLVVL HCCCCCCCCCEEEEE		-
86	Phosphorylation	GFNVCNRYLVVLYYN CCCCCCCEEEEEEEC		19060867
100	Ubiquitination	NANRAFQKMDTKKKE CCHHHHHHCCCHHHH		23000965
100	Acetylation	NANRAFQKMDTKKKE CCHHHHHHCCCHHHH		25953088
100	Ubiquitination	NANRAFQKMDTKKKE CCHHHHHHCCCHHHH		-
104	Ubiquitination	AFQKMDTKKKEEQLK HHHHCCCHHHHHHHH		23000965
105	Ubiquitination	FQKMDTKKKEEQLKL HHHCCCHHHHHHHHH		23000965
106	Ubiquitination	QKMDTKKKEEQLKLL HHCCCHHHHHHHHHH		23000965
111	Ubiquitination	KKKEEQLKLLKEKYG HHHHHHHHHHHHHHC		22817900
114	Ubiquitination	EEQLKLLKEKYGINT HHHHHHHHHHHCCCC		22817900
114	Acetylation	EEQLKLLKEKYGINT HHHHHHHHHHHCCCC		26051181
116	Ubiquitination	QLKLLKEKYGINTDP HHHHHHHHHCCCCCC		21906983
116	Acetylation	QLKLLKEKYGINTDP HHHHHHHHHCCCCCC		26051181
121	Phosphorylation	KEKYGINTDPPK--- HHHHCCCCCCCC---		28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SF3B6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SF3B6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SF3B6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SF3B1_HUMAN	SF3B1	physical	11500380
A4_HUMAN	APP	physical	21832049
SF3B1_HUMAN	SF3B1	physical	22939629
SF3B3_HUMAN	SF3B3	physical	22939629
SF3B5_HUMAN	SF3B5	physical	22939629
RU2A_HUMAN	SNRPA1	physical	22939629
SMD2_HUMAN	SNRPD2	physical	22939629
RU2B_HUMAN	SNRPB2	physical	22939629
SF3B2_HUMAN	SF3B2	physical	22939629
SMD1_HUMAN	SNRPD1	physical	22939629
SF3B4_HUMAN	SF3B4	physical	22939629
SRSF5_HUMAN	SRSF5	physical	22939629
U2AF2_HUMAN	U2AF2	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
SRSF7_HUMAN	SRSF7	physical	22939629
SRS11_HUMAN	SRSF11	physical	22939629
U5S1_HUMAN	EFTUD2	physical	22939629
PRP8_HUMAN	PRPF8	physical	22939629
ROA1_HUMAN	HNRNPA1	physical	22939629
SNUT2_HUMAN	USP39	physical	22939629
SPF27_HUMAN	BCAS2	physical	22939629
PRP19_HUMAN	PRPF19	physical	22939629
THOC6_HUMAN	THOC6	physical	22939629
SNUT1_HUMAN	SART1	physical	22939629
PUF60_HUMAN	PUF60	physical	22939629
PRKDC_HUMAN	PRKDC	physical	22939629
TOP1_HUMAN	TOP1	physical	22939629
ZN326_HUMAN	ZNF326	physical	22939629
UT14A_HUMAN	UTP14A	physical	22939629
S10A9_HUMAN	S100A9	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
SON_HUMAN	SON	physical	22939629
WDR18_HUMAN	WDR18	physical	22939629
ZCH18_HUMAN	ZC3H18	physical	22939629
VTNC_HUMAN	VTN	physical	22939629
TPR_HUMAN	TPR	physical	22939629
TRA2A_HUMAN	TRA2A	physical	22939629
TRI55_HUMAN	TRIM55	physical	22939629
RAN_HUMAN	RAN	physical	22939629
RCC1_HUMAN	RCC1	physical	22939629
SRP54_HUMAN	SRP54	physical	22939629
TR150_HUMAN	THRAP3	physical	22939629
SPB1_HUMAN	FTSJ3	physical	22939629
TPBG_HUMAN	TPBG	physical	22939629
SF3B1_HUMAN	SF3B1	physical	22365833
CCD97_HUMAN	CCDC97	physical	26344197
SAFB1_HUMAN	SAFB	physical	26344197
SF3B4_HUMAN	SF3B4	physical	26344197
SF3B5_HUMAN	SF3B5	physical	26344197
IFT22_HUMAN	IFT22	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.