SPB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPB1_HUMAN
• UniProt AC: Q8IY81
• Protein Name: pre-rRNA processing protein FTSJ3 {ECO:0000255|HAMAP-Rule:MF_03163}
• Gene Name: FTSJ3 {ECO:0000255|HAMAP-Rule:MF_03163}
• Organism: Homo sapiens (Human).
• Sequence Length: 847
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation..
• Protein Sequence: MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MGKKGKVGKSR ----CCCCCCCCCCH		24816145
10	Phosphorylation	KKGKVGKSRRDKFYH CCCCCCCCHHHHHHH		26029660
14	Acetylation	VGKSRRDKFYHLAKE CCCCHHHHHHHHHHH		26051181
14	Ubiquitination	VGKSRRDKFYHLAKE CCCCHHHHHHHHHHH		29967540
16	Phosphorylation	KSRRDKFYHLAKETG CCHHHHHHHHHHHHC		28152594
20	Acetylation	DKFYHLAKETGYRSR HHHHHHHHHHCCCCH		23236377
20	Ubiquitination	DKFYHLAKETGYRSR HHHHHHHHHHCCCCH		33845483
22	Phosphorylation	FYHLAKETGYRSRSA HHHHHHHHCCCCHHH		28555341
31	Acetylation	YRSRSAFKLIQLNRR CCCHHHHHHHHHHHH		25953088
31	Malonylation	YRSRSAFKLIQLNRR CCCHHHHHHHHHHHH		32601280
44	2-Hydroxyisobutyrylation	RRFQFLQKARALLDL HHHHHHHHHHHHHHH		-
44	Acetylation	RRFQFLQKARALLDL HHHHHHHHHHHHHHH		26051181
44	Ubiquitination	RRFQFLQKARALLDL HHHHHHHHHHHHHHH		23000965
157	Acetylation	RGGSFITKVFRSRDY CCCHHHHHHHHCCCC		25825284
157	Ubiquitination	RGGSFITKVFRSRDY CCCHHHHHHHHCCCC		23000965
181	Phosphorylation	LFRRVQATKPQASRH HHHHHHCCCCCCCCC		21406692
182	Acetylation	FRRVQATKPQASRHE HHHHHCCCCCCCCCC		26051181
182	Ubiquitination	FRRVQATKPQASRHE HHHHHCCCCCCCCCC		24816145
186	Phosphorylation	QATKPQASRHESAEI HCCCCCCCCCCCCEE		21406692
205	Acetylation	QGFLAPDKVDSKFFD ECCCCCCCCCCCCCC		26051181
209	Ubiquitination	APDKVDSKFFDPKFA CCCCCCCCCCCCCCC		23000965
214	Acetylation	DSKFFDPKFAFKEVE CCCCCCCCCCCEEEE		25953088
214	Ubiquitination	DSKFFDPKFAFKEVE CCCCCCCCCCCEEEE		23000965
218	Acetylation	FDPKFAFKEVEVQAK CCCCCCCEEEEEEEE		26051181
218	Ubiquitination	FDPKFAFKEVEVQAK CCCCCCCEEEEEEEE		23000965
226	Phosphorylation	EVEVQAKTVTELVTK EEEEEEEEHHHHHHC		-
228	Phosphorylation	EVQAKTVTELVTKKK EEEEEEHHHHHHCCC		-
232	Phosphorylation	KTVTELVTKKKPKAE EEHHHHHHCCCCCCC		20860994
233	2-Hydroxyisobutyrylation	TVTELVTKKKPKAEG EHHHHHHCCCCCCCC		-
233	Acetylation	TVTELVTKKKPKAEG EHHHHHHCCCCCCCC		23749302
233	Ubiquitination	TVTELVTKKKPKAEG EHHHHHHCCCCCCCC		33845483
234	Ubiquitination	VTELVTKKKPKAEGY HHHHHHCCCCCCCCC		-
241	Phosphorylation	KKPKAEGYAEGDLTL CCCCCCCCCCCCEEE		-
247	Phosphorylation	GYAEGDLTLYHRTSV CCCCCCEEEEEECCH		28152594
249	Phosphorylation	AEGDLTLYHRTSVTD CCCCEEEEEECCHHH		28152594
252	Phosphorylation	DLTLYHRTSVTDFLR CEEEEEECCHHHHHH		23186163
253	Phosphorylation	LTLYHRTSVTDFLRA EEEEEECCHHHHHHH		30108239
255	Phosphorylation	LYHRTSVTDFLRAAN EEEECCHHHHHHHHC		23186163
269	Ubiquitination	NPVDFLSKASEIMVD CHHHHHHHHHHHCCC		23503661
333	Phosphorylation	QAKALDISLSSGEED HHHHHCCCCCCCCCC		25159151
335	Phosphorylation	KALDISLSSGEEDEG HHHCCCCCCCCCCCC		25159151
336	Phosphorylation	ALDISLSSGEEDEGD HHCCCCCCCCCCCCC		23927012
347	Phosphorylation	DEGDEEDSTAGTTKQ CCCCCCCCCCCCCCC		30266825
348	Phosphorylation	EGDEEDSTAGTTKQP CCCCCCCCCCCCCCC		30266825
351	Phosphorylation	EEDSTAGTTKQPSKE CCCCCCCCCCCCCHH		23927012
352	Phosphorylation	EDSTAGTTKQPSKEE CCCCCCCCCCCCHHH		23927012
356	Phosphorylation	AGTTKQPSKEEEEEE CCCCCCCCHHHHHHH		30266825
357	Acetylation	GTTKQPSKEEEEEEE CCCCCCCHHHHHHHH		26051181
357	Sumoylation	GTTKQPSKEEEEEEE CCCCCCCHHHHHHHH		28112733
371	Phosphorylation	EEEQLNQTLAEMKAQ HHHHHHHHHHHHHHH		30266825
376	Ubiquitination	NQTLAEMKAQEVAEL HHHHHHHHHHHHHHH		29967540
384	Acetylation	AQEVAELKRKKKKLL HHHHHHHHHHHHHHH		26051181
384	Ubiquitination	AQEVAELKRKKKKLL HHHHHHHHHHHHHHH		-
392	Citrullination	RKKKKLLREQRKQRE HHHHHHHHHHHHHHH		-
392	Citrullination	RKKKKLLREQRKQRE HHHHHHHHHHHHHHH		-
422	Phosphorylation	EGETGMFSLSTIRGH CCCCCCEEEHHHHHH		-
425	Phosphorylation	TGMFSLSTIRGHQLL CCCEEEHHHHHHHHH		-
436	Phosphorylation	HQLLEEVTQGDMSAA HHHHHHHHHCCCCHH		24732914
441	Phosphorylation	EVTQGDMSAADTFLS HHHHCCCCHHHHHHH		24732914
445	Phosphorylation	GDMSAADTFLSDLPR CCCCHHHHHHHCCCC		24732914
448	Phosphorylation	SAADTFLSDLPRDDI CHHHHHHHCCCCCCE		24732914
456	Phosphorylation	DLPRDDIYVSDVEDD CCCCCCEEEECCCCC		25137130
458	Phosphorylation	PRDDIYVSDVEDDGD CCCCEEEECCCCCCC		17081983
467	Phosphorylation	VEDDGDDTSLDSDLD CCCCCCCCCCCCCCC		17081983
468	Phosphorylation	EDDGDDTSLDSDLDP CCCCCCCCCCCCCCH		17081983
471	Phosphorylation	GDDTSLDSDLDPEEL CCCCCCCCCCCHHHH		21082442
496	Phosphorylation	DQKRMRLTEVQDDKE HHHHCCCEECCCCCH		28555341
502	Acetylation	LTEVQDDKEEEEEEN CEECCCCCHHHHHCC		26051181
534	Phosphorylation	NLWFSKGSFAGIEDD HHHHCCCCCCCCCCC		23663014
549	Phosphorylation	ADEALEISQAQLLFE HHHHHHHHHHHHHHH		28176443
567	Ubiquitination	KGRQQQQKQQLPQTP HHHHHHHHHCCCCCC		29967540
573	Phosphorylation	QKQQLPQTPPSCLKT HHHCCCCCCCCHHHH		29255136
576	Phosphorylation	QLPQTPPSCLKTEIM CCCCCCCCHHHHHHC		30266825
579	Sumoylation	QTPPSCLKTEIMSPL CCCCCHHHHHHCCHH		-
579	Acetylation	QTPPSCLKTEIMSPL CCCCCHHHHHHCCHH		26051181
579	Sumoylation	QTPPSCLKTEIMSPL CCCCCHHHHHHCCHH		28112733
580	Phosphorylation	TPPSCLKTEIMSPLY CCCCHHHHHHCCHHH		21945579
584	Phosphorylation	CLKTEIMSPLYQDEA HHHHHHCCHHHCCCC		19664994
587	Phosphorylation	TEIMSPLYQDEAPKG HHHCCHHHCCCCCCC		21945579
595	Phosphorylation	QDEAPKGTEASSGTE CCCCCCCCCCCCCCC		28731282
598	Phosphorylation	APKGTEASSGTEAAT CCCCCCCCCCCCCCC		29255136
599	Phosphorylation	PKGTEASSGTEAATG CCCCCCCCCCCCCCC		29255136
601	Phosphorylation	GTEASSGTEAATGLE CCCCCCCCCCCCCCC		29255136
605	Phosphorylation	SSGTEAATGLEGEEK CCCCCCCCCCCCCCC		24732914
616	Phosphorylation	GEEKDGISDSDSSTS CCCCCCCCCCCCCCC		17081983
618	Phosphorylation	EKDGISDSDSSTSSE CCCCCCCCCCCCCCC		17081983
620	Phosphorylation	DGISDSDSSTSSEEE CCCCCCCCCCCCCCH		23909892
621	Phosphorylation	GISDSDSSTSSEEEE CCCCCCCCCCCCCHH		30576142
622	Phosphorylation	ISDSDSSTSSEEEES CCCCCCCCCCCCHHC		23909892
623	Phosphorylation	SDSDSSTSSEEEESW CCCCCCCCCCCHHCC		30576142
624	Phosphorylation	DSDSSTSSEEEESWE CCCCCCCCCCHHCCC		25814448
629	Phosphorylation	TSSEEEESWEPLRGK CCCCCHHCCCCCCCC		30576142
639	Phosphorylation	PLRGKKRSRGPKSDD CCCCCCCCCCCCCCC		25159151
643	Sumoylation	KKRSRGPKSDDDGFE CCCCCCCCCCCCCCE		28112733
643	Ubiquitination	KKRSRGPKSDDDGFE CCCCCCCCCCCCCCE		24816145
644	Phosphorylation	KRSRGPKSDDDGFEI CCCCCCCCCCCCCEE		23927012
659	2-Hydroxyisobutyrylation	VPIEDPAKHRILDPE ECCCCHHHCCCCCHH		-
659	Acetylation	VPIEDPAKHRILDPE ECCCCHHHCCCCCHH		26051181
659	Sumoylation	VPIEDPAKHRILDPE ECCCCHHHCCCCCHH		28112733
659	Ubiquitination	VPIEDPAKHRILDPE ECCCCHHHCCCCCHH		29967540
676	Phosphorylation	ALGAVIASSKKAKRD HHHHHHHCCHHHHHH		25159151
677	Phosphorylation	LGAVIASSKKAKRDL HHHHHHCCHHHHHHH		25159151
678	2-Hydroxyisobutyrylation	GAVIASSKKAKRDLI HHHHHCCHHHHHHHH		-
678	Acetylation	GAVIASSKKAKRDLI HHHHHCCHHHHHHHH		25953088
678	Sumoylation	GAVIASSKKAKRDLI HHHHHCCHHHHHHHH		28112733
678	Ubiquitination	GAVIASSKKAKRDLI HHHHHCCHHHHHHHH		33845483
679	Ubiquitination	AVIASSKKAKRDLID HHHHCCHHHHHHHHH		22505724
681	Ubiquitination	IASSKKAKRDLIDNS HHCCHHHHHHHHHCC		23503661
688	Phosphorylation	KRDLIDNSFNRYTFN HHHHHHCCCCCEECC		19664994
692	Phosphorylation	IDNSFNRYTFNEDEG HHCCCCCEECCCCCC		28450419
693	Phosphorylation	DNSFNRYTFNEDEGE HCCCCCEECCCCCCC		28450419
710	Acetylation	EWFVQEEKQHRIRQL HHHHHHHHHHHHHCC		26051181
710	Sumoylation	EWFVQEEKQHRIRQL HHHHHHHHHHHHHCC		28112733
710	Ubiquitination	EWFVQEEKQHRIRQL HHHHHHHHHHHHHCC		-
727	Phosphorylation	GKKEVEHYRKRWREI CHHHHHHHHHHHHHH		22210691
746	Ubiquitination	IKKVAEAKARKKRRM HHHHHHHHHHHHHHH		24816145
749	Methylation	VAEAKARKKRRMLKR HHHHHHHHHHHHHHH		23748837
762	Ubiquitination	KRLEQTRKKAEAVVN HHHHHHHHHHHHHHH		-
763	Methylation	RLEQTRKKAEAVVNT HHHHHHHHHHHHHHH		23748837
763	Ubiquitination	RLEQTRKKAEAVVNT HHHHHHHHHHHHHHH		33845483
778	Ubiquitination	VDISEREKVAQLRSL CCHHHHHHHHHHHHH		33845483
783	Citrullination	REKVAQLRSLYKKAG HHHHHHHHHHHHHCC		-
783	Citrullination	REKVAQLRSLYKKAG HHHHHHHHHHHHHCC		-
784	Phosphorylation	EKVAQLRSLYKKAGL HHHHHHHHHHHHCCC		28555341
788	Methylation	QLRSLYKKAGLGKEK HHHHHHHHCCCCCCH		-
793	Acetylation	YKKAGLGKEKRHVTY HHHCCCCCCHHCEEE		26051181
793	Ubiquitination	YKKAGLGKEKRHVTY HHHCCCCCCHHCEEE		24816145
799	Phosphorylation	GKEKRHVTYVVAKKG CCCHHCEEEEEECCC		28152594
800	Phosphorylation	KEKRHVTYVVAKKGV CCHHCEEEEEECCCC		28152594
804	Acetylation	HVTYVVAKKGVGRKV CEEEEEECCCCCCCC		26051181
822	2-Hydroxyisobutyrylation	AGVRGHFKVVDSRMK CCCCCCHHHHCHHHH		-
822	Acetylation	AGVRGHFKVVDSRMK CCCCCCHHHHCHHHH		26051181
822	Ubiquitination	AGVRGHFKVVDSRMK CCCCCCHHHHCHHHH		33845483
843	Ubiquitination	QRKEQKKKHKRK--- HHHHHHHHHHCC---		24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RRS1_HUMAN	RRS1	physical	22939629
UT14A_HUMAN	UTP14A	physical	22939629
BYST_HUMAN	BYSL	physical	24778252
DDB1_HUMAN	DDB1	physical	24778252
LTV1_HUMAN	LTV1	physical	24778252
NP1L4_HUMAN	NAP1L4	physical	24778252
NOB1_HUMAN	NOB1	physical	24778252
SET_HUMAN	SET	physical	24778252
TSR1_HUMAN	TSR1	physical	24778252
UBE2O_HUMAN	UBE2O	physical	24778252
DCAF1_HUMAN	VPRBP	physical	24778252
ZN622_HUMAN	ZNF622	physical	24778252
ABT1_HUMAN	ABT1	physical	26344197
BRX1_HUMAN	BRIX1	physical	26344197
DDX27_HUMAN	DDX27	physical	26344197
DKC1_HUMAN	DKC1	physical	26344197
EBP2_HUMAN	EBNA1BP2	physical	26344197
EI2BD_HUMAN	EIF2B4	physical	26344197
IF2P_HUMAN	EIF5B	physical	26344197
GNL3L_HUMAN	GNL3L	physical	26344197
MAK16_HUMAN	MAK16	physical	26344197
MPP10_HUMAN	MPHOSPH10	physical	26344197
MK67I_HUMAN	NIFK	physical	26344197
NOC2L_HUMAN	NOC2L	physical	26344197
NOP2_HUMAN	NOP2	physical	26344197
NOP58_HUMAN	NOP58	physical	26344197
NSA2_HUMAN	NSA2	physical	26344197
PRS7_HUMAN	PSMC2	physical	26344197
PWP1_HUMAN	PWP1	physical	26344197
RBM34_HUMAN	RBM34	physical	26344197
RPF2_HUMAN	RPF2	physical	26344197
RL31_HUMAN	RPL31	physical	26344197
RL39_HUMAN	RPL39	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RRS1_HUMAN	RRS1	physical	26344197
SRP68_HUMAN	SRP68	physical	26344197
SRP72_HUMAN	SRP72	physical	26344197
TBL3_HUMAN	TBL3	physical	26344197
UT14A_HUMAN	UTP14A	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.