LTV1_HUMAN - dbPTM
LTV1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LTV1_HUMAN
UniProt AC Q96GA3
Protein Name Protein LTV1 homolog
Gene Name LTV1
Organism Homo sapiens (Human).
Sequence Length 475
Subcellular Localization
Protein Description
Protein Sequence MPHRKKKPFIEKKKAVSFHLVHRSQRDPLAADESAPQRVLLPTQKIDNEERRAEQRKYGVFFDDDYDYLQHLKEPSGPSELIPSSTFSAHNRREEKEETLVIPSTGIKLPSSVFASEFEEDVGLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPDNLLEDDFILQANKATGEEEGMDIQKSENEDDSEWEDVDDEKGDSNDDYDSAGLLSDEDCMSVPGKTHRAIADHLFWSEETKSRFTEYSMTSSVMRRNEQLTLHDERFEKFYEQYDDDEIGALDNAELEGSIQVDSNRLQEVLNDYYKEKAENCVKLNTLEPLEDQDLPMNELDESEEEEMITVVLEEAKEKWDCESICSTYSNLYNHPQLIKYQPKPKQIRISSKTGIPLNVLPKKGLTAKQTERIQMINGSDLPKVSTQPRSKNESKEDKRARKQAIKEERKERRVEKKANKLAFKLEKRRQEKELLNLKKNVEGLKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationIEKKKAVSFHLVHRS
CHHHHHHEEEEECHH		16.2923401153
24PhosphorylationSFHLVHRSQRDPLAA
EEEEECHHHCCCCCC		18.0623186163
45SumoylationRVLLPTQKIDNEERR
CEECCCHHCCHHHHH		55.28-
45UbiquitinationRVLLPTQKIDNEERR
CEECCCHHCCHHHHH		55.2824816145
45SumoylationRVLLPTQKIDNEERR
CEECCCHHCCHHHHH		55.28-
45AcetylationRVLLPTQKIDNEERR
CEECCCHHCCHHHHH		55.2826051181
57UbiquitinationERRAEQRKYGVFFDD
HHHHHHHHHCCCCCC		46.1529967540
58UbiquitinationRRAEQRKYGVFFDDD
HHHHHHHHCCCCCCC		22.2529967540
66PhosphorylationGVFFDDDYDYLQHLK
CCCCCCCHHHHHHCC		17.3028796482
68PhosphorylationFFDDDYDYLQHLKEP
CCCCCHHHHHHCCCC		11.3028796482
73UbiquitinationYDYLQHLKEPSGPSE
HHHHHHCCCCCCCCC		66.5129967540
85PhosphorylationPSELIPSSTFSAHNR
CCCCCCCCCCCCCCC		28.2828555341
96UbiquitinationAHNRREEKEETLVIP
CCCCCHHHCCCEEEC		56.9829967540
99PhosphorylationRREEKEETLVIPSTG
CCHHHCCCEEECCCC		27.6725690035
104PhosphorylationEETLVIPSTGIKLPS
CCCEEECCCCCCCCC		28.3028555341
105PhosphorylationETLVIPSTGIKLPSS
CCEEECCCCCCCCCH		37.2625690035
108UbiquitinationVIPSTGIKLPSSVFA
EECCCCCCCCCHHHH		56.5429967540
116PhosphorylationLPSSVFASEFEEDVG
CCCHHHHHHHHHHHC		31.2128348404
124UbiquitinationEFEEDVGLLNKAAPV
HHHHHHCCCCCCCCC		4.8422817900
126UbiquitinationEEDVGLLNKAAPVSG
HHHHCCCCCCCCCCC		36.6422817900
127UbiquitinationEDVGLLNKAAPVSGP
HHHCCCCCCCCCCCC		45.9921906983
168UbiquitinationDDFILQANKATGEEE
CCHHHHHHHHCCCCC		22.8729967540
171PhosphorylationILQANKATGEEEGMD
HHHHHHHCCCCCCCC		46.8921815630
182PhosphorylationEGMDIQKSENEDDSE
CCCCCCCCCCCCCCC		29.3120164059
188PhosphorylationKSENEDDSEWEDVDD
CCCCCCCCCCCCCCC		57.8625159151
189UbiquitinationSENEDDSEWEDVDDE
CCCCCCCCCCCCCCC		62.9829967540
200PhosphorylationVDDEKGDSNDDYDSA
CCCCCCCCCCCCCHH		51.3222777824
202UbiquitinationDEKGDSNDDYDSAGL
CCCCCCCCCCCHHCC		60.8529967540
204PhosphorylationKGDSNDDYDSAGLLS
CCCCCCCCCHHCCCC		18.0528102081
206PhosphorylationDSNDDYDSAGLLSDE
CCCCCCCHHCCCCCH		20.2922777824
211PhosphorylationYDSAGLLSDEDCMSV
CCHHCCCCCHHHCCC		43.9522777824
217PhosphorylationLSDEDCMSVPGKTHR
CCCHHHCCCCCHHHH		31.3426074081
218UbiquitinationSDEDCMSVPGKTHRA
CCHHHCCCCCHHHHH		2.6329967540
222PhosphorylationCMSVPGKTHRAIADH
HCCCCCHHHHHHHHH		23.6226074081
233PhosphorylationIADHLFWSEETKSRF
HHHHHHCCHHHHHHH		20.4422199227
236PhosphorylationHLFWSEETKSRFTEY
HHHCCHHHHHHHCCC		30.2122199227
237UbiquitinationLFWSEETKSRFTEYS
HHCCHHHHHHHCCCC		42.8029967540
238PhosphorylationFWSEETKSRFTEYSM
HCCHHHHHHHCCCCC		39.7921945579
241PhosphorylationEETKSRFTEYSMTSS
HHHHHHHCCCCCHHH		32.6721945579
243PhosphorylationTKSRFTEYSMTSSVM
HHHHHCCCCCHHHHH		10.7321945579
244PhosphorylationKSRFTEYSMTSSVMR
HHHHCCCCCHHHHHH		14.8921945579
246PhosphorylationRFTEYSMTSSVMRRN
HHCCCCCHHHHHHHC		16.3521945579
247PhosphorylationFTEYSMTSSVMRRNE
HCCCCCHHHHHHHCC		16.5821945579
248PhosphorylationTEYSMTSSVMRRNEQ
CCCCCHHHHHHHCCC		15.6921945579
257PhosphorylationMRRNEQLTLHDERFE
HHHCCCCCCCHHHHH		23.0328555341
267PhosphorylationDERFEKFYEQYDDDE
HHHHHHHHHHCCCCC		17.1222817900
270PhosphorylationFEKFYEQYDDDEIGA
HHHHHHHCCCCCCCC		14.9222817900
282UbiquitinationIGALDNAELEGSIQV
CCCCCCCEEEECEEE		54.3229967540
301PhosphorylationLQEVLNDYYKEKAEN
HHHHHHHHHHHHHHH		18.5028796482
302PhosphorylationQEVLNDYYKEKAENC
HHHHHHHHHHHHHHC		18.6128796482
303UbiquitinationEVLNDYYKEKAENCV
HHHHHHHHHHHHHCE		46.6522817900
305UbiquitinationLNDYYKEKAENCVKL
HHHHHHHHHHHCEEC		57.7722817900
314PhosphorylationENCVKLNTLEPLEDQ
HHCEECCCCCCCCCC		42.8220873877
331PhosphorylationPMNELDESEEEEMIT
CHHHCCCCHHHHHHH		50.3930278072
338PhosphorylationSEEEEMITVVLEEAK
CHHHHHHHHHHHHHH		11.8420873877
347UbiquitinationVLEEAKEKWDCESIC
HHHHHHHHCCHHHHH		47.8529967540
352PhosphorylationKEKWDCESICSTYSN
HHHCCHHHHHHHHHH		34.9125159151
355PhosphorylationWDCESICSTYSNLYN
CCHHHHHHHHHHHHC		28.8025159151
356PhosphorylationDCESICSTYSNLYNH
CHHHHHHHHHHHHCC		26.9325159151
357PhosphorylationCESICSTYSNLYNHP
HHHHHHHHHHHHCCH		4.5425159151
358PhosphorylationESICSTYSNLYNHPQ
HHHHHHHHHHHCCHH		22.0523663014
361PhosphorylationCSTYSNLYNHPQLIK
HHHHHHHHCCHHHHH		18.7123663014
368UbiquitinationYNHPQLIKYQPKPKQ
HCCHHHHHCCCCCCE		46.5629967540
369PhosphorylationNHPQLIKYQPKPKQI
CCHHHHHCCCCCCEE		24.0526074081
374UbiquitinationIKYQPKPKQIRISSK
HHCCCCCCEEEEECC		65.56-
379PhosphorylationKPKQIRISSKTGIPL
CCCEEEEECCCCCCC		18.8826074081
380PhosphorylationPKQIRISSKTGIPLN
CCEEEEECCCCCCCC		31.6826074081
381AcetylationKQIRISSKTGIPLNV
CEEEEECCCCCCCCC		43.9425953088
381UbiquitinationKQIRISSKTGIPLNV
CEEEEECCCCCCCCC		43.9429967540
382PhosphorylationQIRISSKTGIPLNVL
EEEEECCCCCCCCCC		42.1430624053
397UbiquitinationPKKGLTAKQTERIQM
CCCCCCHHHHHEEEE		53.1429967540
408PhosphorylationRIQMINGSDLPKVST
EEEECCCCCCCCCCC		31.3321815630
449AcetylationRVEKKANKLAFKLEK
HHHHHHHHHHHHHHH		46.1625953088
453AcetylationKANKLAFKLEKRRQE
HHHHHHHHHHHHHHH		50.5625953088
461UbiquitinationLEKRRQEKELLNLKK
HHHHHHHHHHHHHHH		45.3729967540
467UbiquitinationEKELLNLKKNVEGLK
HHHHHHHHHHHCCCC		41.03-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LTV1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LTV1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LTV1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RCN1_HUMANRCN1physical
22939629
TBA1B_HUMANTUBA1Bphysical
22939629
BYST_HUMANBYSLphysical
22863883
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LTV1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-331, ANDMASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-188, ANDMASS SPECTROMETRY.

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