dbPTM

NOP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOP2_HUMAN
UniProt AC	P46087
Protein Name	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
Gene Name	NOP2
Organism	Homo sapiens (Human).
Sequence Length	812
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Involved in ribosomal large subunit assembly. [PubMed: 24120868 S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable]
Protein Sequence	MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVEAPKTNKSPEAKPLPGKLPKGISAGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDSEEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQWSEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVHKRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSETATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKGADSELSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPPKGTDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKGPQPPTVSPIRSSRPPPAKRKKSQSRGNSQLLLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MGRKLDPTKEK ----CCCCCCCCCCC	52.06	24816145
22	Methylation	GRKARKQKGAETELV CHHHHHHCCCCHHHH	64.22	116252317
22	Ubiquitination	GRKARKQKGAETELV CHHHHHHCCCCHHHH	64.22	33845483
36	Phosphorylation	VRFLPAVSDENSKRL HHHHHHCCCHHHHHH	41.11	25159151
36 (in isoform 2)	Phosphorylation	-	41.11	-
40	Phosphorylation	PAVSDENSKRLSSRA HHCCCHHHHHHHHHH	19.66	28464451
41	Acetylation	AVSDENSKRLSSRAR HCCCHHHHHHHHHHH	69.78	25953088
41	Ubiquitination	AVSDENSKRLSSRAR HCCCHHHHHHHHHHH	69.78	33845483
44	Phosphorylation	DENSKRLSSRARKRA CHHHHHHHHHHHHHH	23.08	28464451
45	Phosphorylation	ENSKRLSSRARKRAA HHHHHHHHHHHHHHH	34.25	24719451
45 (in isoform 2)	Phosphorylation	-	34.25	24719451
58	Phosphorylation	AAKRRLGSVEAPKTN HHHHHHCCCCCCCCC	22.75	29255136
58 (in isoform 2)	Phosphorylation	-	22.75	24719451
58 (in isoform 4)	Phosphorylation	-	22.75	27251275
64	Phosphorylation	GSVEAPKTNKSPEAK CCCCCCCCCCCCCCC	46.98	23927012
64 (in isoform 2)	Phosphorylation	-	46.98	-
67	Phosphorylation	EAPKTNKSPEAKPLP CCCCCCCCCCCCCCC	30.00	29255136
67 (in isoform 2)	Phosphorylation	-	30.00	29743597
67 (in isoform 3)	Phosphorylation	-	30.00	29743597
67 (in isoform 4)	Phosphorylation	-	30.00	27251275
71	Sumoylation	TNKSPEAKPLPGKLP CCCCCCCCCCCCCCC	45.48	-
71	Acetylation	TNKSPEAKPLPGKLP CCCCCCCCCCCCCCC	45.48	25953088
71	Sumoylation	TNKSPEAKPLPGKLP CCCCCCCCCCCCCCC	45.48	28112733
76	Acetylation	EAKPLPGKLPKGISA CCCCCCCCCCCCCCC	60.73	25953088
76	Ubiquitination	EAKPLPGKLPKGISA CCCCCCCCCCCCCCC	60.73	33845483
79	Acetylation	PLPGKLPKGISAGAV CCCCCCCCCCCCCCC	78.35	19816785
82	Phosphorylation	GKLPKGISAGAVQTA CCCCCCCCCCCCCCC	29.35	25159151
88	Phosphorylation	ISAGAVQTAGKKGPQ CCCCCCCCCCCCCCH	30.68	25159151
91	Acetylation	GAVQTAGKKGPQSLF CCCCCCCCCCCHHHH	52.68	25953088
92	Acetylation	AVQTAGKKGPQSLFN CCCCCCCCCCHHHHC	74.94	26051181
96	Phosphorylation	AGKKGPQSLFNAPRG CCCCCCHHHHCCCCC	37.75	25159151
96 (in isoform 4)	Phosphorylation	-	37.75	27251275
102	Citrullination	QSLFNAPRGKKRPAP HHHHCCCCCCCCCCC	68.12	-
102	Citrullination	QSLFNAPRGKKRPAP HHHHCCCCCCCCCCC	68.12	-
107 (in isoform 2)	Phosphorylation	-	52.25	-
111	Phosphorylation	KKRPAPGSDEEEEEE CCCCCCCCCHHHHHH	40.57	27362937
116 (in isoform 2)	Phosphorylation	-	70.71	-
120	Phosphorylation	EEEEEEDSEEDGMVN HHHHHHHCCCCCCCC	46.28	27362937
130 (in isoform 2)	Phosphorylation	-	31.53	-
134	Phosphorylation	NHGDLWGSEDDADTV CCHHCCCCCCCCCCC	26.69	22817900
136 (in isoform 2)	Phosphorylation	-	59.08	-
140	Phosphorylation	GSEDDADTVDDYGAD CCCCCCCCCCCCCCC	27.79	22817900
146 (in isoform 2)	Phosphorylation	-	15.72	-
148	Phosphorylation	VDDYGADSNSEDEEE CCCCCCCCCCCCHHH	41.54	27362937
150	Phosphorylation	DYGADSNSEDEEEGE CCCCCCCCCCHHHHH	50.83	27362937
164	Citrullination	EALLPIERAARKQKA HHHHHHHHHHHHHHH	33.98	-
164	Citrullination	EALLPIERAARKQKA HHHHHHHHHHHHHHH	33.98	-
177 (in isoform 2)	Phosphorylation	-	14.11	24719451
180 (in isoform 4)	Phosphorylation	-	13.04	22468782
181	Phosphorylation	AAAGIQWSEEETEDE HHHCCCCCHHHCCCH	20.82	22167270
181 (in isoform 2)	Phosphorylation	-	20.82	24719451
183 (in isoform 4)	Phosphorylation	-	65.78	22468782
185	Phosphorylation	IQWSEEETEDEEEEK CCCCHHHCCCHHHHC	52.60	22167270
187 (in isoform 4)	Phosphorylation	-	75.84	22468782
191 (in isoform 2)	Phosphorylation	-	58.77	-
194 (in isoform 2)	Phosphorylation	-	18.75	-
195	Phosphorylation	EEEEKEVTPESGPPK HHHHCCCCCCCCCCC	23.56	29255136
198	Phosphorylation	EKEVTPESGPPKVEE HCCCCCCCCCCCCEE	58.78	30266825
214 (in isoform 4)	Phosphorylation	-	11.93	27251275
218 (in isoform 4)	Phosphorylation	-	23.69	27251275
228 (in isoform 4)	Phosphorylation	-	40.79	27251275
258 (in isoform 2)	Phosphorylation	-	53.36	-
262	Phosphorylation	AQREEGRSRSEYLNR CCCHHCCCHHHHHHH	51.52	19691289
264	Phosphorylation	REEGRSRSEYLNRLK CHHCCCHHHHHHHHH	31.66	19691289
266	Phosphorylation	EGRSRSEYLNRLKKD HCCCHHHHHHHHHHH	15.55	26270265
272	Sumoylation	EYLNRLKKDLAIYYS HHHHHHHHHHHHEEH	63.67	28112733
336	Ubiquitination	INRGVNLDPLGKWSK HHCCCCCCCCCCCCC	31.04	21890473
336 (in isoform 2)	Ubiquitination	-	31.04	21890473
336	Ubiquitination	INRGVNLDPLGKWSK HHCCCCCCCCCCCCC	31.04	21890473
339	Ubiquitination	GVNLDPLGKWSKTGL CCCCCCCCCCCCCCE	34.47	22817900
340	Acetylation	VNLDPLGKWSKTGLV CCCCCCCCCCCCCEE	56.85	25953088
340	Ubiquitination	VNLDPLGKWSKTGLV CCCCCCCCCCCCCEE	56.85	22817900
343	Ubiquitination	DPLGKWSKTGLVVYD CCCCCCCCCCEEEEC	45.56	22817900
344	Phosphorylation	PLGKWSKTGLVVYDS CCCCCCCCCEEEECC	30.17	24043423
349	Phosphorylation	SKTGLVVYDSSVPIG CCCCEEEECCCCCCC	11.57	24043423
351	Phosphorylation	TGLVVYDSSVPIGAT CCEEEECCCCCCCCC	18.62	24043423
352	Phosphorylation	GLVVYDSSVPIGATP CEEEECCCCCCCCCH	29.08	24043423
358	Phosphorylation	SSVPIGATPEYLAGH CCCCCCCCHHHHCHH	16.07	24043423
361	Phosphorylation	PIGATPEYLAGHYML CCCCCHHHHCHHHHH	11.76	26074081
366	Phosphorylation	PEYLAGHYMLQGASS HHHHCHHHHHCCHHH	9.90	26074081
372	Phosphorylation	HYMLQGASSMLPVMA HHHHCCHHHHCCHHH	24.09	26074081
373	Phosphorylation	YMLQGASSMLPVMAL HHHCCHHHHCCHHHH	24.65	26074081
373	Ubiquitination	YMLQGASSMLPVMAL HHHCCHHHHCCHHHH	24.65	21890473
373 (in isoform 1)	Ubiquitination	-	24.65	21890473
373	Ubiquitination	YMLQGASSMLPVMAL HHHCCHHHHCCHHHH	24.65	21890473
376	Ubiquitination	QGASSMLPVMALAPQ CCHHHHCCHHHHCCC	12.75	22817900
398	Ubiquitination	MCCAPGGKTSYMAQL HHCCCCCHHHHHHHH	39.97	-
403	Ubiquitination	GGKTSYMAQLMKNTG CCHHHHHHHHHHHCC	7.36	21963094
407	Acetylation	SYMAQLMKNTGVILA HHHHHHHHHCCEEEE	61.01	26051181
407	Ubiquitination	SYMAQLMKNTGVILA HHHHHHHHHCCEEEE	61.01	21963094
419	Ubiquitination	ILANDANAERLKSVV EEECCCCHHHHHHHH	12.66	29967540
423	Acetylation	DANAERLKSVVGNLH CCCHHHHHHHHHHHH	47.64	25953088
423	Ubiquitination	DANAERLKSVVGNLH CCCHHHHHHHHHHHH	47.64	29967540
440	Ubiquitination	GVTNTIISHYDGRQF CCCCEEEECCCCCCC	16.49	21963094
442	Phosphorylation	TNTIISHYDGRQFPK CCEEEECCCCCCCCC	17.19	25839225
445	Ubiquitination	IISHYDGRQFPKVVG EEECCCCCCCCCEEC	31.88	29967540
449	Ubiquitination	YDGRQFPKVVGGFDR CCCCCCCCEECCCCE	51.33	29967540
456	Ubiquitination	KVVGGFDRVLLDAPC CEECCCCEEEEECCC	20.79	29967540
467	Ubiquitination	DAPCSGTGVISKDPA ECCCCCCCCCCCCCC	20.49	21963094
471	Acetylation	SGTGVISKDPAVKTN CCCCCCCCCCCCCCC	57.52	26051181
471	Ubiquitination	SGTGVISKDPAVKTN CCCCCCCCCCCCCCC	57.52	21963094
472	Ubiquitination	GTGVISKDPAVKTNK CCCCCCCCCCCCCCC	29.60	33845483
476	Ubiquitination	ISKDPAVKTNKDEKD CCCCCCCCCCCCHHH	48.78	33845483
479	Acetylation	DPAVKTNKDEKDILR CCCCCCCCCHHHHHH	72.93	26051181
482	Acetylation	VKTNKDEKDILRCAH CCCCCCHHHHHHHHH	61.27	23749302
482	Ubiquitination	VKTNKDEKDILRCAH CCCCCCHHHHHHHHH	61.27	29967540
488	Ubiquitination	EKDILRCAHLQKELL HHHHHHHHHHHHHHH	10.45	29967540
492	Acetylation	LRCAHLQKELLLSAI HHHHHHHHHHHHHHH	57.60	25953088
492	Ubiquitination	LRCAHLQKELLLSAI HHHHHHHHHHHHHHH	57.60	29967540
497	Phosphorylation	LQKELLLSAIDSVNA HHHHHHHHHHHHCCC	24.13	21601212
501	Phosphorylation	LLLSAIDSVNATSKT HHHHHHHHCCCCCCC	15.91	20068231
501 (in isoform 2)	Phosphorylation	-	15.91	-
502 (in isoform 2)	Phosphorylation	-	5.11	-
504	Ubiquitination	SAIDSVNATSKTGGY HHHHHCCCCCCCCCE	15.87	21963094
505	Phosphorylation	AIDSVNATSKTGGYL HHHHCCCCCCCCCEE	26.08	20068231
506	Phosphorylation	IDSVNATSKTGGYLV HHHCCCCCCCCCEEE	26.30	20068231
509	Ubiquitination	VNATSKTGGYLVYCT CCCCCCCCCEEEEEE	26.87	33845483
525	Ubiquitination	SITVEENEWVVDYAL EEEEECCCEEEEEHH	44.95	29967540
562	Phosphorylation	RERRFHPSLRSTRRF HHHCCCCCHHCCCCC	28.04	24719451
573	O-linked_Glycosylation	TRRFYPHTHNMDGFF CCCCCCCCCCCCCEE	15.50	31373491
588	Phosphorylation	IAKFKKFSNSIPQSQ EEEHHHHHCCCCHHH	38.25	22199227
590	Phosphorylation	KFKKFSNSIPQSQTG EHHHHHCCCCHHHCC	34.15	21815630
592 (in isoform 2)	Phosphorylation	-	27.82	-
594	Phosphorylation	FSNSIPQSQTGNSET HHCCCCHHHCCCCCC	25.10	25850435
596	Phosphorylation	NSIPQSQTGNSETAT CCCCHHHCCCCCCCC	43.51	25159151
599	Phosphorylation	PQSQTGNSETATPTN CHHHCCCCCCCCCCC	37.35	26657352
599 (in isoform 2)	Phosphorylation	-	37.35	24719451
601	Phosphorylation	SQTGNSETATPTNVD HHCCCCCCCCCCCCC	35.33	25850435
603	Phosphorylation	TGNSETATPTNVDLP CCCCCCCCCCCCCCC	37.76	25159151
605	Phosphorylation	NSETATPTNVDLPQV CCCCCCCCCCCCCCC	43.44	30576142
615	Sumoylation	DLPQVIPKSENSSQP CCCCCCCCCCCCCHH	60.31	28112733
616	Phosphorylation	LPQVIPKSENSSQPA CCCCCCCCCCCCHHH	36.33	-
619	Phosphorylation	VIPKSENSSQPAKKA CCCCCCCCCHHHHHH	26.71	-
620	Phosphorylation	IPKSENSSQPAKKAK CCCCCCCCHHHHHHH	52.33	-
627 (in isoform 4)	Phosphorylation	-	58.94	27251275
649	Acetylation	PKKASFQKLNGISKG CCHHHHHHHCCCCCC	41.74	19608861
654	Phosphorylation	FQKLNGISKGADSEL HHHHCCCCCCCCCCC	26.83	21601212
655	Acetylation	QKLNGISKGADSELS HHHCCCCCCCCCCCC	57.08	26051181
659	Phosphorylation	GISKGADSELSTVPS CCCCCCCCCCCCCCC	39.64	28555341
662	Phosphorylation	KGADSELSTVPSVTK CCCCCCCCCCCCCCC	24.25	29255136
662 (in isoform 2)	Phosphorylation	-	24.25	-
663	Phosphorylation	GADSELSTVPSVTKT CCCCCCCCCCCCCCC	49.40	30266825
666	Phosphorylation	SELSTVPSVTKTQAS CCCCCCCCCCCCCCC	37.77	30266825
668	O-linked_Glycosylation	LSTVPSVTKTQASSS CCCCCCCCCCCCCCC	32.48	31373491
668	Phosphorylation	LSTVPSVTKTQASSS CCCCCCCCCCCCCCC	32.48	30266825
669	Acetylation	STVPSVTKTQASSSF CCCCCCCCCCCCCCC	36.16	25953088
670	Phosphorylation	TVPSVTKTQASSSFQ CCCCCCCCCCCCCCC	21.72	24732914
670 (in isoform 2)	Phosphorylation	-	21.72	24719451
671 (in isoform 2)	Phosphorylation	-	40.58	-
673	Phosphorylation	SVTKTQASSSFQDSS CCCCCCCCCCCCCCC	19.39	19691289
674	Phosphorylation	VTKTQASSSFQDSSQ CCCCCCCCCCCCCCC	37.88	25159151
675	Phosphorylation	TKTQASSSFQDSSQP CCCCCCCCCCCCCCC	25.16	25159151
679	Phosphorylation	ASSSFQDSSQPAGKA CCCCCCCCCCCCCCC	21.79	24732914
680	Phosphorylation	SSSFQDSSQPAGKAE CCCCCCCCCCCCCCC	48.77	24732914
681	Neddylation	SSFQDSSQPAGKAEG CCCCCCCCCCCCCCC	35.50	32015554
681	Ubiquitination	SSFQDSSQPAGKAEG CCCCCCCCCCCCCCC	35.50	32015554
685	Acetylation	DSSQPAGKAEGIREP CCCCCCCCCCCCCCC	45.42	26051181
685	Neddylation	DSSQPAGKAEGIREP CCCCCCCCCCCCCCC	45.42	32015554
685	Ubiquitination	DSSQPAGKAEGIREP CCCCCCCCCCCCCCC	45.42	32015554
695	Ubiquitination	GIREPKVTGKLKQRS CCCCCCCCCCCCCCC	34.42	24816145
698 (in isoform 2)	Phosphorylation	-	6.38	24719451
699	Ubiquitination	PKVTGKLKQRSPKLQ CCCCCCCCCCCCCCC	47.34	24816145
702	Phosphorylation	TGKLKQRSPKLQSSK CCCCCCCCCCCCCCC	24.72	20860994
704	Acetylation	KLKQRSPKLQSSKKV CCCCCCCCCCCCCCH	61.48	25953088
707	Phosphorylation	QRSPKLQSSKKVAFL CCCCCCCCCCCHHHH	55.34	23909892
708	Phosphorylation	RSPKLQSSKKVAFLR CCCCCCCCCCHHHHH	24.43	23909892
709	Acetylation	SPKLQSSKKVAFLRQ CCCCCCCCCHHHHHC	57.42	26051181
710	Acetylation	PKLQSSKKVAFLRQN CCCCCCCCHHHHHCC	40.52	26051181
717	Ubiquitination	KVAFLRQNAPPKGTD CHHHHHCCCCCCCCC	48.24	24816145
718	Neddylation	VAFLRQNAPPKGTDT HHHHHCCCCCCCCCC	17.27	32015554
718	Ubiquitination	VAFLRQNAPPKGTDT HHHHHCCCCCCCCCC	17.27	32015554
719 (in isoform 2)	Phosphorylation	-	38.39	-
721	Ubiquitination	LRQNAPPKGTDTQTP HHCCCCCCCCCCCCC	73.68	24816145
723	Phosphorylation	QNAPPKGTDTQTPAV CCCCCCCCCCCCCCC	41.84	23927012
723 (in isoform 2)	Phosphorylation	-	41.84	-
725	Phosphorylation	APPKGTDTQTPAVLS CCCCCCCCCCCCCCC	33.89	23927012
727	Phosphorylation	PKGTDTQTPAVLSPS CCCCCCCCCCCCCCC	18.46	30266825
728	Phosphorylation	KGTDTQTPAVLSPSK CCCCCCCCCCCCCCC	15.56	32142685
728 (in isoform 2)	Phosphorylation	-	15.56	24719451
730 (in isoform 2)	Phosphorylation	-	5.99	-
732	Phosphorylation	TQTPAVLSPSKTQAT CCCCCCCCCCCCCCC	22.11	19664994
732	Ubiquitination	TQTPAVLSPSKTQAT CCCCCCCCCCCCCCC	22.11	24816145
734	Phosphorylation	TPAVLSPSKTQATLK CCCCCCCCCCCCCCC	44.98	29255136
735 (in isoform 2)	Phosphorylation	-	48.30	-
736	Phosphorylation	AVLSPSKTQATLKPK CCCCCCCCCCCCCCC	27.98	22167270
739	Phosphorylation	SPSKTQATLKPKDHH CCCCCCCCCCCCCCC	26.04	22167270
741	Acetylation	SKTQATLKPKDHHQP CCCCCCCCCCCCCCC	45.74	26051181
753	Acetylation	HQPLGRAKGVEKQQL CCCCCCCCCCCHHCC	63.23	25953088
754	Ubiquitination	QPLGRAKGVEKQQLP CCCCCCCCCCHHCCC	31.65	24816145
757	Acetylation	GRAKGVEKQQLPEQP CCCCCCCHHCCCCCH	40.72	25953088
763	Ubiquitination	EKQQLPEQPFEKAAF CHHCCCCCHHHHHHH	46.15	33845483
765	Phosphorylation	QQLPEQPFEKAAFQK HCCCCCHHHHHHHHH	17.56	32142685
765 (in isoform 4)	Phosphorylation	-	17.56	27251275
767	Acetylation	LPEQPFEKAAFQKQN CCCCHHHHHHHHHCC	45.45	25953088
767	Ubiquitination	LPEQPFEKAAFQKQN CCCCHHHHHHHHHCC	45.45	33845483
772	Acetylation	FEKAAFQKQNDTPKG HHHHHHHHCCCCCCC	44.61	26051181
772 (in isoform 2)	Phosphorylation	-	44.61	24719451
774	Ubiquitination	KAAFQKQNDTPKGPQ HHHHHHCCCCCCCCC	63.26	24816145
776	Phosphorylation	AFQKQNDTPKGPQPP HHHHCCCCCCCCCCC	34.15	23927012
778	Ubiquitination	QKQNDTPKGPQPPTV HHCCCCCCCCCCCCC	82.43	24816145
780 (in isoform 2)	Phosphorylation	-	50.02	24719451
782	Phosphorylation	DTPKGPQPPTVSPIR CCCCCCCCCCCCCCC	29.66	32142685
782 (in isoform 2)	Phosphorylation	-	29.66	24719451
784	Phosphorylation	PKGPQPPTVSPIRSS CCCCCCCCCCCCCCC	40.06	29255136
786	Phosphorylation	GPQPPTVSPIRSSRP CCCCCCCCCCCCCCC	19.65	29255136
790	Phosphorylation	PTVSPIRSSRPPPAK CCCCCCCCCCCCCCC	31.27	25159151
791	Phosphorylation	TVSPIRSSRPPPAKR CCCCCCCCCCCCCCC	38.67	26074081
797 (in isoform 2)	Phosphorylation	-	71.21	-
800	Ubiquitination	PPPAKRKKSQSRGNS CCCCCCCCCCCCCCC	58.73	33845483
801	Phosphorylation	PPAKRKKSQSRGNSQ CCCCCCCCCCCCCCC	36.10	25159151
803	Phosphorylation	AKRKKSQSRGNSQLL CCCCCCCCCCCCCCC	49.61	30576142
804	Methylation	KRKKSQSRGNSQLLL CCCCCCCCCCCCCCC	40.45	115385645
807	Phosphorylation	KSQSRGNSQLLLS-- CCCCCCCCCCCCC--	25.65	25159151
808 (in isoform 2)	Phosphorylation	-	39.88	24719451
811	Ubiquitination	RGNSQLLLS------ CCCCCCCCC------	8.52	24816145
812	Phosphorylation	GNSQLLLS------- CCCCCCCC-------	37.84	30266825
817 (in isoform 4)	Phosphorylation	-		27251275
819	Phosphorylation	S-------------- C--------------		32142685
845 (in isoform 4)	Phosphorylation	-		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCRS1_HUMAN	MCRS1	physical	9654073
FBRL_HUMAN	FBL	physical	9654073
NOP56_HUMAN	NOP56	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL11_HUMAN	RPL11	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RL19_HUMAN	RPL19	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
SPB1_HUMAN	FTSJ3	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL18_HUMAN	RPL18	physical	22939629
RL18A_HUMAN	RPL18A	physical	22939629
RRS1_HUMAN	RRS1	physical	22939629
RL15_HUMAN	RPL15	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
NOP58_HUMAN	NOP58	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RL1D1_HUMAN	RSL1D1	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
RL30_HUMAN	RPL30	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
SSRP1_HUMAN	SSRP1	physical	22939629
VPS52_HUMAN	VPS52	physical	25416956
IMA7_HUMAN	KPNA6	physical	25416956
CDA7L_HUMAN	CDCA7L	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
BRX1_HUMAN	BRIX1	physical	26344197
CSK22_HUMAN	CSNK2A2	physical	26344197
DDX47_HUMAN	DDX47	physical	26344197
DKC1_HUMAN	DKC1	physical	26344197
EBP2_HUMAN	EBNA1BP2	physical	26344197
PUM3_HUMAN	KIAA0020	physical	26344197
MINK1_HUMAN	MINK1	physical	26344197
MPP10_HUMAN	MPHOSPH10	physical	26344197
MK67I_HUMAN	NIFK	physical	26344197
NOC2L_HUMAN	NOC2L	physical	26344197
NOC3L_HUMAN	NOC3L	physical	26344197
NOL6_HUMAN	NOL6	physical	26344197
NOLC1_HUMAN	NOLC1	physical	26344197
NSA2_HUMAN	NSA2	physical	26344197
PRP8_HUMAN	PRPF8	physical	26344197
RPF2_HUMAN	RPF2	physical	26344197
SRSF3_HUMAN	SRSF3	physical	26344197
TOP1_HUMAN	TOP1	physical	26344197
TOP2A_HUMAN	TOP2A	physical	26344197
UT14A_HUMAN	UTP14A	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOP2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-649, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181; THR-185 ANDSER-732, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-58; SER-67;SER-181; THR-185; SER-666; SER-675; SER-732; THR-739; THR-776; SER-786AND SER-812, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-67; SER-181;THR-185; SER-732 AND SER-786, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-732 AND SER-786,AND MASS SPECTROMETRY.	18187866 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; THR-64; SER-67;THR-195; SER-675; SER-732 AND SER-786, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-732, AND MASSSPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67 AND SER-734, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181; THR-603 ANDSER-732, AND MASS SPECTROMETRY.	16565220 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-732, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-111; SER-120;SER-134; THR-140; SER-150; SER-181; THR-185 AND SER-732, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-195, AND MASSSPECTROMETRY.	15302935 [Abstract]