dbPTM

TOP2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TOP2A_HUMAN
UniProt AC	P11388
Protein Name	DNA topoisomerase 2-alpha
Gene Name	TOP2A
Organism	Homo sapiens (Human).
Sequence Length	1531
Subcellular Localization	Cytoplasm . Nucleus, nucleoplasm . Generally located in the nucleoplasm.
Protein Description	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity)..
Protein Sequence	MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEVSPLQP -------CCCCCCCC	47.60	22814378
4	Phosphorylation	----MEVSPLQPVNE ----CCCCCCCCCCC	24.16	25159151
17	Acetylation	NENMQVNKIKKNEDA CCCCCCCCCCCCHHH	57.98	25953088
17	Sumoylation	NENMQVNKIKKNEDA CCCCCCCCCCCCHHH	57.98	28112733
17	Ubiquitination	NENMQVNKIKKNEDA CCCCCCCCCCCCHHH	57.98	22505724
17 (in isoform 4)	Ubiquitination	-	57.98	-
19	Ubiquitination	NMQVNKIKKNEDAKK CCCCCCCCCCHHHHH	51.67	-
19 (in isoform 4)	Ubiquitination	-	51.67	-
20	Ubiquitination	MQVNKIKKNEDAKKR CCCCCCCCCHHHHHH	69.87	-
20 (in isoform 4)	Ubiquitination	-	69.87	-
29	Phosphorylation	EDAKKRLSVERIYQK HHHHHHHCHHHHHHH	26.43	30266825
76	Phosphorylation	GINYREVTFVPGLYK CCCCEEEEECCHHHH	17.73	21406692
82	Phosphorylation	VTFVPGLYKIFDEIL EEECCHHHHHHHHHH	14.14	20068231
84	Ubiquitination	FVPGLYKIFDEILVN ECCHHHHHHHHHHHH	3.12	21963094
96	Acetylation	LVNAADNKQRDPKMS HHHCCCCCCCCCCCC	47.46	26051181
96	Ubiquitination	LVNAADNKQRDPKMS HHHCCCCCCCCCCCC	47.46	21906983
96 (in isoform 1)	Ubiquitination	-	47.46	21890473
96 (in isoform 2)	Ubiquitination	-	47.46	21890473
96 (in isoform 3)	Ubiquitination	-	47.46	21890473
96 (in isoform 4)	Ubiquitination	-	47.46	21890473
101	Ubiquitination	DNKQRDPKMSCIRVT CCCCCCCCCCEEEEE	47.97	-
101 (in isoform 4)	Ubiquitination	-	47.97	-
111	Ubiquitination	CIRVTIDPENNLISI EEEEEECCCCCEEEE	42.22	21963094
123	Acetylation	ISIWNNGKGIPVVEH EEEEECCCCCCEEEC	56.65	26051181
123	Ubiquitination	ISIWNNGKGIPVVEH EEEEECCCCCCEEEC	56.65	21906983
123 (in isoform 1)	Ubiquitination	-	56.65	21890473
123 (in isoform 2)	Ubiquitination	-	56.65	21890473
123 (in isoform 3)	Ubiquitination	-	56.65	21890473
123 (in isoform 4)	Ubiquitination	-	56.65	21890473
131	Sumoylation	GIPVVEHKVEKMYVP CCCEEECCCCCCHHC	38.29	-
131	Acetylation	GIPVVEHKVEKMYVP CCCEEECCCCCCHHC	38.29	25953088
131	Sumoylation	GIPVVEHKVEKMYVP CCCEEECCCCCCHHC	38.29	-
131	Ubiquitination	GIPVVEHKVEKMYVP CCCEEECCCCCCHHC	38.29	21906983
131 (in isoform 1)	Ubiquitination	-	38.29	21890473
131 (in isoform 2)	Ubiquitination	-	38.29	21890473
131 (in isoform 3)	Ubiquitination	-	38.29	21890473
131 (in isoform 4)	Ubiquitination	-	38.29	21890473
134 (in isoform 4)	Ubiquitination	-	38.22	-
144	Ubiquitination	VPALIFGQLLTSSNY HCHHHHHHHHHCCCC	23.66	22817900
145	Ubiquitination	PALIFGQLLTSSNYD CHHHHHHHHHCCCCC	6.03	22817900
151	Phosphorylation	QLLTSSNYDDDEKKV HHHHCCCCCCCCCCC	23.77	-
156	Sumoylation	SNYDDDEKKVTGGRN CCCCCCCCCCCCCCC	60.58	28112733
156	Ubiquitination	SNYDDDEKKVTGGRN CCCCCCCCCCCCCCC	60.58	21906983
156 (in isoform 1)	Ubiquitination	-	60.58	21890473
156 (in isoform 2)	Ubiquitination	-	60.58	21890473
156 (in isoform 3)	Ubiquitination	-	60.58	21890473
156 (in isoform 4)	Ubiquitination	-	60.58	21890473
157	Sumoylation	NYDDDEKKVTGGRNG CCCCCCCCCCCCCCC	42.87	28112733
157	Ubiquitination	NYDDDEKKVTGGRNG CCCCCCCCCCCCCCC	42.87	22817900
157 (in isoform 4)	Ubiquitination	-	42.87	-
168	Acetylation	GRNGYGAKLCNIFST CCCCHHHHHHHHHHC	49.57	25953088
168	Ubiquitination	GRNGYGAKLCNIFST CCCCHHHHHHHHHHC	49.57	-
170	Glutathionylation	NGYGAKLCNIFSTKF CCHHHHHHHHHHCCE	3.46	22555962
176	Acetylation	LCNIFSTKFTVETAS HHHHHHCCEEHHHHC	37.53	26051181
176	Ubiquitination	LCNIFSTKFTVETAS HHHHHHCCEEHHHHC	37.53	32015554
179	Ubiquitination	IFSTKFTVETASREY HHHCCEEHHHHCHHH	7.47	22505724
191	Acetylation	REYKKMFKQTWMDNM HHHHHHHHHHHHHHC	43.23	25953088
191	Ubiquitination	REYKKMFKQTWMDNM HHHHHHHHHHHHHHC	43.23	22505724
191 (in isoform 4)	Ubiquitination	-	43.23	-
207	Acetylation	RAGEMELKPFNGEDY CCCCCEEECCCCCCC	33.97	26051181
213	Ubiquitination	LKPFNGEDYTCITFQ EECCCCCCCEEEEEC	45.50	23503661
215	Ubiquitination	PFNGEDYTCITFQPD CCCCCCCEEEEECCC	15.11	23000965
221	Ubiquitination	YTCITFQPDLSKFKM CEEEEECCCHHHHCC	40.08	21890473
225	Ubiquitination	TFQPDLSKFKMQSLD EECCCHHHHCCCCCC	57.19	23503661
225 (in isoform 2)	Ubiquitination	-	57.19	-
227	Sumoylation	QPDLSKFKMQSLDKD CCCHHHHCCCCCCHH	39.50	-
227	Sumoylation	QPDLSKFKMQSLDKD CCCHHHHCCCCCCHH	39.50	-
227	Ubiquitination	QPDLSKFKMQSLDKD CCCHHHHCCCCCCHH	39.50	23000965
227 (in isoform 2)	Ubiquitination	-	39.50	-
227 (in isoform 4)	Ubiquitination	-	39.50	-
230	Phosphorylation	LSKFKMQSLDKDIVA HHHHCCCCCCHHHHH	34.73	20068231
233	Acetylation	FKMQSLDKDIVALMV HCCCCCCHHHHHHHH	55.43	26051181
233	Ubiquitination	FKMQSLDKDIVALMV HCCCCCCHHHHHHHH	55.43	23000965
233 (in isoform 2)	Ubiquitination	-	55.43	21890473
233 (in isoform 3)	Ubiquitination	-	55.43	21890473
233 (in isoform 4)	Ubiquitination	-	55.43	21890473
235 (in isoform 1)	Ubiquitination	-	2.11	21890473
249	Phosphorylation	RAYDIAGSTKDVKVF HHHHCCCCCCEEEEE	24.22	-
249	Ubiquitination	RAYDIAGSTKDVKVF HHHHCCCCCCEEEEE	24.22	21890473
250	Phosphorylation	AYDIAGSTKDVKVFL HHHCCCCCCEEEEEE	30.28	-
251	Acetylation	YDIAGSTKDVKVFLN HHCCCCCCEEEEEEC	63.32	26051181
251	Ubiquitination	YDIAGSTKDVKVFLN HHCCCCCCEEEEEEC	63.32	32015554
251 (in isoform 4)	Ubiquitination	-	63.32	-
253	Ubiquitination	IAGSTKDVKVFLNGN CCCCCCEEEEEECCC	6.41	23000965
254	Acetylation	AGSTKDVKVFLNGNK CCCCCEEEEEECCCC	37.09	23749302
254	Sumoylation	AGSTKDVKVFLNGNK CCCCCEEEEEECCCC	37.09	-
261	Acetylation	KVFLNGNKLPVKGFR EEEECCCCCCCCCHH	56.41	25953088
261	Sumoylation	KVFLNGNKLPVKGFR EEEECCCCCCCCCHH	56.41	28112733
261	Ubiquitination	KVFLNGNKLPVKGFR EEEECCCCCCCCCHH	56.41	21890473
261 (in isoform 2)	Ubiquitination	-	56.41	21890473
261 (in isoform 3)	Ubiquitination	-	56.41	21890473
261 (in isoform 4)	Ubiquitination	-	56.41	21890473
263 (in isoform 1)	Ubiquitination	-	27.64	21890473
264	Ubiquitination	LNGNKLPVKGFRSYV ECCCCCCCCCHHHHH	15.97	22817900
265	Ubiquitination	NGNKLPVKGFRSYVD CCCCCCCCCHHHHHH	50.85	23000965
265 (in isoform 4)	Ubiquitination	-	50.85	-
266	Ubiquitination	GNKLPVKGFRSYVDM CCCCCCCCHHHHHHH	24.35	22817900
269	Phosphorylation	LPVKGFRSYVDMYLK CCCCCHHHHHHHHHH	27.52	26074081
270	Phosphorylation	PVKGFRSYVDMYLKD CCCCHHHHHHHHHHH	9.01	26074081
274	Phosphorylation	FRSYVDMYLKDKLDE HHHHHHHHHHHHHCC	13.21	26074081
275	Ubiquitination	RSYVDMYLKDKLDET HHHHHHHHHHHHCCC	4.67	21890473
276	Ubiquitination	SYVDMYLKDKLDETG HHHHHHHHHHHCCCC	35.02	32015554
276 (in isoform 4)	Ubiquitination	-	35.02	-
278	Sumoylation	VDMYLKDKLDETGNS HHHHHHHHHCCCCCC	57.14	-
278	Acetylation	VDMYLKDKLDETGNS HHHHHHHHHCCCCCC	57.14	21339330
278	Sumoylation	VDMYLKDKLDETGNS HHHHHHHHHCCCCCC	57.14	-
278	Ubiquitination	VDMYLKDKLDETGNS HHHHHHHHHCCCCCC	57.14	21906983
278 (in isoform 2)	Ubiquitination	-	57.14	21890473
278 (in isoform 3)	Ubiquitination	-	57.14	21890473
278 (in isoform 4)	Ubiquitination	-	57.14	21890473
280 (in isoform 1)	Ubiquitination	-	58.09	21890473
282	Phosphorylation	LKDKLDETGNSLKVI HHHHHCCCCCCCHHH	41.13	25159151
285	Phosphorylation	KLDETGNSLKVIHEQ HHCCCCCCCHHHHHH	30.80	19691289
287	Ubiquitination	DETGNSLKVIHEQVN CCCCCCCHHHHHHHC	38.68	21963094
287 (in isoform 2)	Ubiquitination	-	38.68	21890473
287 (in isoform 3)	Ubiquitination	-	38.68	21890473
287 (in isoform 4)	Ubiquitination	-	38.68	21890473
289 (in isoform 1)	Ubiquitination	-	2.57	21890473
309	Ubiquitination	TMSEKGFQQISFVNS EECCCCCCEEEEEHH	48.65	21890473
312	Phosphorylation	EKGFQQISFVNSIAT CCCCCEEEEEHHEEE	20.85	21712546
321	Ubiquitination	VNSIATSKGGRHVDY EHHEEECCCCCCHHH	62.11	23000965
321 (in isoform 2)	Ubiquitination	-	62.11	21890473
321 (in isoform 4)	Ubiquitination	-	62.11	21890473
325 (in isoform 3)	Phosphorylation	-	21.78	25690035
327 (in isoform 3)	Phosphorylation	-	26.51	25690035
328	Phosphorylation	KGGRHVDYVADQIVT CCCCCHHHHHHHHHH	9.10	28152594
328 (in isoform 3)	Phosphorylation	-	9.10	25690035
336	Ubiquitination	VADQIVTKLVDVVKK HHHHHHHHHHHHHHH	35.30	32015554
336 (in isoform 4)	Ubiquitination	-	35.30	-
340	Ubiquitination	IVTKLVDVVKKKNKG HHHHHHHHHHHCCCC	5.47	27667366
342	Ubiquitination	TKLVDVVKKKNKGGV HHHHHHHHHCCCCCE	58.86	29967540
343	Ubiquitination	KLVDVVKKKNKGGVA HHHHHHHHCCCCCEE	50.39	-
343 (in isoform 4)	Ubiquitination	-	50.39	-
352	Sumoylation	NKGGVAVKAHQVKNH CCCCEEEEEEECCCC	30.34	28112733
352	Ubiquitination	NKGGVAVKAHQVKNH CCCCEEEEEEECCCC	30.34	33845483
374	Ubiquitination	LIENPTFDSQTKENM HHHCCCCCCCCCCCC	42.17	21890473
382	Phosphorylation	SQTKENMTLQPKSFG CCCCCCCCCCCCCCC	33.55	23403867
385	Ubiquitination	KENMTLQPKSFGSTC CCCCCCCCCCCCCHH	37.05	23000965
386	Sumoylation	ENMTLQPKSFGSTCQ CCCCCCCCCCCCHHH	45.52	-
386	Acetylation	ENMTLQPKSFGSTCQ CCCCCCCCCCCCHHH	45.52	26051181
386	Sumoylation	ENMTLQPKSFGSTCQ CCCCCCCCCCCCHHH	45.52	28112733
386	Ubiquitination	ENMTLQPKSFGSTCQ CCCCCCCCCCCCHHH	45.52	23000965
386 (in isoform 2)	Ubiquitination	-	45.52	21890473
387	Phosphorylation	NMTLQPKSFGSTCQL CCCCCCCCCCCHHHC	41.33	20068231
388	Ubiquitination	MTLQPKSFGSTCQLS CCCCCCCCCCHHHCC	12.83	23000965
390	Phosphorylation	LQPKSFGSTCQLSEK CCCCCCCCHHHCCHH	24.81	25627689
392	S-palmitoylation	PKSFGSTCQLSEKFI CCCCCCHHHCCHHHH	4.03	26865113
395	Phosphorylation	FGSTCQLSEKFIKAA CCCHHHCCHHHHHHH	16.92	20068231
397	Acetylation	STCQLSEKFIKAAIG CHHHCCHHHHHHHHH	49.35	25825284
397	Sumoylation	STCQLSEKFIKAAIG CHHHCCHHHHHHHHH	49.35	28112733
397	Ubiquitination	STCQLSEKFIKAAIG CHHHCCHHHHHHHHH	49.35	23000965
400	Ubiquitination	QLSEKFIKAAIGCGI HCCHHHHHHHHHCCH	34.59	23000965
406	Ubiquitination	IKAAIGCGIVESILN HHHHHHCCHHHHHHH	23.05	21890473
413	Ubiquitination	GIVESILNWVKFKAQ CHHHHHHHHHHHHHH	39.56	27667366
414	Ubiquitination	IVESILNWVKFKAQV HHHHHHHHHHHHHHH	7.39	27667366
416	Sumoylation	ESILNWVKFKAQVQL HHHHHHHHHHHHHHH	32.53	28112733
418	Sumoylation	ILNWVKFKAQVQLNK HHHHHHHHHHHHHCC	31.99	28112733
418	Ubiquitination	ILNWVKFKAQVQLNK HHHHHHHHHHHHHCC	31.99	33845483
422 (in isoform 1)	Ubiquitination	-	27.51	21890473
422 (in isoform 3)	Ubiquitination	-	27.51	21890473
425	Acetylation	KAQVQLNKKCSAVKH HHHHHHCCCCHHCCC	64.84	25953088
425	Sumoylation	KAQVQLNKKCSAVKH HHHHHHCCCCHHCCC	64.84	28112733
425	Ubiquitination	KAQVQLNKKCSAVKH HHHHHHCCCCHHCCC	64.84	27667366
426	Ubiquitination	AQVQLNKKCSAVKHN HHHHHCCCCHHCCCC	32.14	27667366
428	Ubiquitination	VQLNKKCSAVKHNRI HHHCCCCHHCCCCCC	45.00	24816145
431	Ubiquitination	NKKCSAVKHNRIKGI CCCCHHCCCCCCCCC	34.57	29967540
440	Sumoylation	NRIKGIPKLDDANDA CCCCCCCCCCCCCCC	63.73	-
440	Acetylation	NRIKGIPKLDDANDA CCCCCCCCCCCCCCC	63.73	26051181
440	Sumoylation	NRIKGIPKLDDANDA CCCCCCCCCCCCCCC	63.73	28112733
440	Ubiquitination	NRIKGIPKLDDANDA CCCCCCCCCCCCCCC	63.73	24816145
452	Phosphorylation	NDAGGRNSTECTLIL CCCCCCCCCEEEEEE	24.99	21712546
454	Ubiquitination	AGGRNSTECTLILTE CCCCCCCEEEEEEEC	25.89	21963094
455	Glutathionylation	GGRNSTECTLILTEG CCCCCCEEEEEEECC	3.67	22555962
455	S-nitrosylation	GGRNSTECTLILTEG CCCCCCEEEEEEECC	3.67	24105792
464	Phosphorylation	LILTEGDSAKTLAVS EEEECCCCCCEEEEE	42.39	21712546
466	Sumoylation	LTEGDSAKTLAVSGL EECCCCCCEEEEEEE	48.28	28112733
466	Ubiquitination	LTEGDSAKTLAVSGL EECCCCCCEEEEEEE	48.28	21963094
467 (in isoform 4)	Ubiquitination	-	21.48	21890473
468	Ubiquitination	EGDSAKTLAVSGLGV CCCCCCEEEEEEEEC	4.34	21890473
471	Phosphorylation	SAKTLAVSGLGVVGR CCCEEEEEEEECCCC	23.77	21712546
477	Ubiquitination	VSGLGVVGRDKYGVF EEEEECCCCCCCCCC	29.66	21890473
478 (in isoform 4)	Ubiquitination	-	26.16	-
480	Acetylation	LGVVGRDKYGVFPLR EECCCCCCCCCCCCC	42.41	26051181
480	Sumoylation	LGVVGRDKYGVFPLR EECCCCCCCCCCCCC	42.41	28112733
480	Ubiquitination	LGVVGRDKYGVFPLR EECCCCCCCCCCCCC	42.41	23000965
481	Phosphorylation	GVVGRDKYGVFPLRG ECCCCCCCCCCCCCC	23.86	28152594
487	Ubiquitination	KYGVFPLRGKILNVR CCCCCCCCCEEECHH	44.59	23000965
489	Sumoylation	GVFPLRGKILNVREA CCCCCCCEEECHHHH	37.27	-
489	Sumoylation	GVFPLRGKILNVREA CCCCCCCEEECHHHH	37.27	-
489	Ubiquitination	GVFPLRGKILNVREA CCCCCCCEEECHHHH	37.27	23000965
499	Acetylation	NVREASHKQIMENAE CHHHHHHHHHHHCHH	38.74	26051181
499	Ubiquitination	NVREASHKQIMENAE CHHHHHHHHHHHCHH	38.74	23000965
499 (in isoform 4)	Ubiquitination	-	38.74	-
507	Ubiquitination	QIMENAEINNIIKIV HHHHCHHHHHHHHHH	4.43	22817900
508	Ubiquitination	IMENAEINNIIKIVG HHHCHHHHHHHHHHC	25.75	21890473
512	Ubiquitination	AEINNIIKIVGLQYK HHHHHHHHHHCEEEC	27.78	29967540
517	Ubiquitination	IIKIVGLQYKKNYED HHHHHCEEECCCCCC	41.91	23000965
518	Phosphorylation	IKIVGLQYKKNYEDE HHHHCEEECCCCCCH	29.04	21406692
519	Acetylation	KIVGLQYKKNYEDED HHHCEEECCCCCCHH	22.91	25953088
519	Malonylation	KIVGLQYKKNYEDED HHHCEEECCCCCCHH	22.91	26320211
519	Ubiquitination	KIVGLQYKKNYEDED HHHCEEECCCCCCHH	22.91	33845483
520	Acetylation	IVGLQYKKNYEDEDS HHCEEECCCCCCHHH	60.88	-
520	Ubiquitination	IVGLQYKKNYEDEDS HHCEEECCCCCCHHH	60.88	22817900
521 (in isoform 4)	Ubiquitination	-	41.07	-
522	Phosphorylation	GLQYKKNYEDEDSLK CEEECCCCCCHHHHH	33.37	29496907
523	Ubiquitination	LQYKKNYEDEDSLKT EEECCCCCCHHHHHH	65.40	21890473
525 (in isoform 2)	Ubiquitination	-	37.24	21890473
529	Acetylation	YEDEDSLKTLRYGKI CCCHHHHHHEEECEE	49.84	23236377
529	Sumoylation	YEDEDSLKTLRYGKI CCCHHHHHHEEECEE	49.84	28112733
529	Ubiquitination	YEDEDSLKTLRYGKI CCCHHHHHHEEECEE	49.84	23000965
530	Phosphorylation	EDEDSLKTLRYGKIM CCHHHHHHEEECEEE	23.04	23403867
535	Acetylation	LKTLRYGKIMIMTDQ HHHEEECEEEEEECC	21.84	27452117
535	Ubiquitination	LKTLRYGKIMIMTDQ HHHEEECEEEEEECC	21.84	23000965
535 (in isoform 1)	Ubiquitination	-	21.84	21890473
535 (in isoform 3)	Ubiquitination	-	21.84	21890473
546 (in isoform 2)	Ubiquitination	-	18.58	21890473
547 (in isoform 4)	Ubiquitination	-	30.26	-
555 (in isoform 2)	Ubiquitination	-	29.77	21890473
556 (in isoform 1)	Ubiquitination	-	4.45	21890473
556 (in isoform 3)	Ubiquitination	-	4.45	21890473
561 (in isoform 2)	Ubiquitination	-	4.58	21890473
561 (in isoform 4)	Ubiquitination	-	4.58	-
565 (in isoform 1)	Ubiquitination	-	5.20	21890473
565 (in isoform 3)	Ubiquitination	-	5.20	21890473
567	Ubiquitination	NWPSLLRHRFLEEFI CCHHHHHHHHHHHHC	25.47	21963094
570	Ubiquitination	SLLRHRFLEEFITPI HHHHHHHHHHHCHHH	6.59	22817900
570 (in isoform 4)	Ubiquitination	-	6.59	-
571 (in isoform 1)	Ubiquitination	-	48.42	21890473
571 (in isoform 3)	Ubiquitination	-	48.42	21890473
572	Ubiquitination	LRHRFLEEFITPIVK HHHHHHHHHCHHHEE	44.49	21963094
579	Ubiquitination	EFITPIVKVSKNKQE HHCHHHEEECCCCCE	41.32	21906983
580 (in isoform 4)	Ubiquitination	-	7.35	21890473
582	Ubiquitination	TPIVKVSKNKQEMAF HHHEEECCCCCEEEE	71.76	22817900
584	Acetylation	IVKVSKNKQEMAFYS HEEECCCCCEEEEEE	51.91	-
584	Sumoylation	IVKVSKNKQEMAFYS HEEECCCCCEEEEEE	51.91	28112733
584	Ubiquitination	IVKVSKNKQEMAFYS HEEECCCCCEEEEEE	51.91	21906983
597	Ubiquitination	YSLPEFEEWKSSTPN EECHHHHHHHCCCCC	66.58	23000965
599	Sumoylation	LPEFEEWKSSTPNHK CHHHHHHHCCCCCCC	37.50	28112733
599	Ubiquitination	LPEFEEWKSSTPNHK CHHHHHHHCCCCCCC	37.50	23000965
601	Phosphorylation	EFEEWKSSTPNHKKW HHHHHHCCCCCCCCE	44.12	27134283
601 (in isoform 4)	Ubiquitination	-	44.12	21890473
602	Ubiquitination	FEEWKSSTPNHKKWK HHHHHCCCCCCCCEE	34.89	23000965
605 (in isoform 2)	Ubiquitination	-	33.99	21890473
609	Ubiquitination	TPNHKKWKVKYYKGL CCCCCCEEEEEECCC	37.42	23000965
610	Ubiquitination	PNHKKWKVKYYKGLG CCCCCEEEEEECCCC	4.72	22817900
610 (in isoform 2)	Ubiquitination	-	4.72	21890473
610 (in isoform 4)	Ubiquitination	-	4.72	21890473
611	Ubiquitination	NHKKWKVKYYKGLGT CCCCEEEEEECCCCC	38.85	23000965
612	Phosphorylation	HKKWKVKYYKGLGTS CCCEEEEEECCCCCC	17.25	25884760
613	Phosphorylation	KKWKVKYYKGLGTST CCEEEEEECCCCCCC	7.89	23312004
613	Ubiquitination	KKWKVKYYKGLGTST CCEEEEEECCCCCCC	7.89	22817900
614	Sumoylation	KWKVKYYKGLGTSTS CEEEEEECCCCCCCC	44.57	28112733
614	Ubiquitination	KWKVKYYKGLGTSTS CEEEEEECCCCCCCC	44.57	23000965
615 (in isoform 1)	Ubiquitination	-	17.14	21890473
615 (in isoform 3)	Ubiquitination	-	17.14	21890473
616 (in isoform 4)	Ubiquitination	-	6.22	21890473
618	Phosphorylation	KYYKGLGTSTSKEAK EEECCCCCCCCHHHH	33.60	23312004
619	Phosphorylation	YYKGLGTSTSKEAKE EECCCCCCCCHHHHH	28.96	23312004
620	Phosphorylation	YKGLGTSTSKEAKEY ECCCCCCCCHHHHHH	43.59	23312004
620	Ubiquitination	YKGLGTSTSKEAKEY ECCCCCCCCHHHHHH	43.59	22505724
620 (in isoform 1)	Ubiquitination	-	43.59	21890473
620 (in isoform 3)	Ubiquitination	-	43.59	21890473
621	Phosphorylation	KGLGTSTSKEAKEYF CCCCCCCCHHHHHHH	28.41	23312004
622	Sumoylation	GLGTSTSKEAKEYFA CCCCCCCHHHHHHHH	62.88	28112733
622	Ubiquitination	GLGTSTSKEAKEYFA CCCCCCCHHHHHHHH	62.88	21906983
625	Sumoylation	TSTSKEAKEYFADMK CCCCHHHHHHHHHHH	54.78	-
625	Sumoylation	TSTSKEAKEYFADMK CCCCHHHHHHHHHHH	54.78	28112733
625	Ubiquitination	TSTSKEAKEYFADMK CCCCHHHHHHHHHHH	54.78	22817900
627	Ubiquitination	TSKEAKEYFADMKRH CCHHHHHHHHHHHHH	11.89	21963094
632	Sumoylation	KEYFADMKRHRIQFK HHHHHHHHHHEEEEE	45.67	-
632	Sumoylation	KEYFADMKRHRIQFK HHHHHHHHHHEEEEE	45.67	28112733
632	Ubiquitination	KEYFADMKRHRIQFK HHHHHHHHHHEEEEE	45.67	32015554
639	Sumoylation	KRHRIQFKYSGPEDD HHHEEEEECCCCCCC	23.33	-
639	Acetylation	KRHRIQFKYSGPEDD HHHEEEEECCCCCCC	23.33	26051181
639	Methylation	KRHRIQFKYSGPEDD HHHEEEEECCCCCCC	23.33	42373713
639	Sumoylation	KRHRIQFKYSGPEDD HHHEEEEECCCCCCC	23.33	28112733
639	Ubiquitination	KRHRIQFKYSGPEDD HHHEEEEECCCCCCC	23.33	21906983
643	Ubiquitination	IQFKYSGPEDDAAIS EEEECCCCCCCHHHH	35.58	21963094
644	Ubiquitination	QFKYSGPEDDAAISL EEECCCCCCCHHHHH	72.54	22817900
648 (in isoform 2)	Ubiquitination	-	10.01	21890473
650	Ubiquitination	PEDDAAISLAFSKKQ CCCCHHHHHHHHHHH	14.66	21890473
650 (in isoform 1)	Ubiquitination	-	14.66	21890473
650 (in isoform 3)	Ubiquitination	-	14.66	21890473
655	Acetylation	AISLAFSKKQIDDRK HHHHHHHHHHCCCHH	42.09	26051181
655	Sumoylation	AISLAFSKKQIDDRK HHHHHHHHHHCCCHH	42.09	28112733
655	Ubiquitination	AISLAFSKKQIDDRK HHHHHHHHHHCCCHH	42.09	21906983
656	Ubiquitination	ISLAFSKKQIDDRKE HHHHHHHHHCCCHHH	51.81	22817900
658 (in isoform 1)	Ubiquitination	-	9.03	21890473
658 (in isoform 2)	Ubiquitination	-	9.03	-
658 (in isoform 3)	Ubiquitination	-	9.03	21890473
660 (in isoform 4)	Ubiquitination	-	66.24	21890473
662	Sumoylation	KKQIDDRKEWLTNFM HHHCCCHHHHHHHHH	61.30	-
662	Neddylation	KKQIDDRKEWLTNFM HHHCCCHHHHHHHHH	61.30	32015554
662	Sumoylation	KKQIDDRKEWLTNFM HHHCCCHHHHHHHHH	61.30	28112733
662	Ubiquitination	KKQIDDRKEWLTNFM HHHCCCHHHHHHHHH	61.30	21890473
663 (in isoform 4)	Ubiquitination	-	48.92	-
664	Ubiquitination	QIDDRKEWLTNFMED HCCCHHHHHHHHHHH	16.12	22817900
665 (in isoform 2)	Ubiquitination	-	2.69	21890473
665 (in isoform 4)	Ubiquitination	-	2.69	21890473
672	Methylation	LTNFMEDRRQRKLLG HHHHHHHHHHHHHHC	24.27	-
675 (in isoform 1)	Ubiquitination	-	29.76	21890473
675 (in isoform 3)	Ubiquitination	-	29.76	21890473
676	Sumoylation	MEDRRQRKLLGLPED HHHHHHHHHHCCCHH	39.46	-
676	Sumoylation	MEDRRQRKLLGLPED HHHHHHHHHHCCCHH	39.46	28112733
676	Ubiquitination	MEDRRQRKLLGLPED HHHHHHHHHHCCCHH	39.46	21906983
681 (in isoform 2)	Ubiquitination	-	30.52	21890473
684	Phosphorylation	LLGLPEDYLYGQTTT HHCCCHHHCCCCCCE	10.52	24275569
686	Phosphorylation	GLPEDYLYGQTTTYL CCCHHHCCCCCCEEE	10.85	24275569
688 (in isoform 2)	Ubiquitination	-	23.32	21890473
691 (in isoform 1)	Ubiquitination	-	21.66	21890473
691 (in isoform 3)	Ubiquitination	-	21.66	21890473
692	Phosphorylation	LYGQTTTYLTYNDFI CCCCCCEEEEHHHCC	8.58	28064214
694	Phosphorylation	GQTTTYLTYNDFINK CCCCEEEEHHHCCCC	15.18	24275569
695 (in isoform 4)	Ubiquitination	-	15.33	-
698 (in isoform 1)	Ubiquitination	-	6.21	21890473
698 (in isoform 3)	Ubiquitination	-	6.21	21890473
702 (in isoform 2)	Ubiquitination	-	36.23	21890473
703 (in isoform 4)	Ubiquitination	-	4.38	21890473
706 (in isoform 4)	Ubiquitination	-	5.28	-
707	Phosphorylation	NKELILFSNSDNERS CCEEEEEECCCCCCC	31.79	20068231
709	Phosphorylation	ELILFSNSDNERSIP EEEEEECCCCCCCCC	40.38	20068231
711	Ubiquitination	ILFSNSDNERSIPSM EEEECCCCCCCCCHH	46.53	21890473
712 (in isoform 1)	Ubiquitination	-	53.44	21890473
712 (in isoform 3)	Ubiquitination	-	53.44	21890473
713 (in isoform 4)	Ubiquitination	-	46.25	-
714	Phosphorylation	SNSDNERSIPSMVDG ECCCCCCCCCHHCCC	32.45	-
716	Ubiquitination	SDNERSIPSMVDGLK CCCCCCCCHHCCCCC	20.02	23000965
717	Phosphorylation	DNERSIPSMVDGLKP CCCCCCCHHCCCCCC	29.75	-
720 (in isoform 4)	Ubiquitination	-	48.33	21890473
723	Ubiquitination	PSMVDGLKPGQRKVL CHHCCCCCCCCCEEE	53.27	23000965
728	Ubiquitination	GLKPGQRKVLFTCFK CCCCCCCEEEEEEEE	35.09	23000965
735	Acetylation	KVLFTCFKRNDKREV EEEEEEEECCCCCCE	53.06	25953088
735	Ubiquitination	KVLFTCFKRNDKREV EEEEEEEECCCCCCE	53.06	-
736 (in isoform 4)	Ubiquitination	-	36.01	21890473
737 (in isoform 4)	Ubiquitination	-	60.80	-
743 (in isoform 4)	Ubiquitination	-	27.40	21890473
749 (in isoform 2)	Ubiquitination	-	31.11	21890473
757 (in isoform 4)	Ubiquitination	-	7.19	21890473
759 (in isoform 1)	Ubiquitination	-	26.19	21890473
759 (in isoform 3)	Ubiquitination	-	26.19	21890473
798	Ubiquitination	GTRLHGGKDSASPRY CCCCCCCCCCCCHHH	53.77	33845483
800	Phosphorylation	RLHGGKDSASPRYIF CCCCCCCCCCHHHHH	33.85	27732954
802	Phosphorylation	HGGKDSASPRYIFTM CCCCCCCCHHHHHHH	17.54	24719451
804 (in isoform 4)	Ubiquitination	-	34.38	21890473
805	Phosphorylation	KDSASPRYIFTMLSS CCCCCHHHHHHHHHH	12.08	27732954
808	Phosphorylation	ASPRYIFTMLSSLAR CCHHHHHHHHHHHHH	13.98	27732954
809	Ubiquitination	SPRYIFTMLSSLARL CHHHHHHHHHHHHHH	2.08	21890473
809 (in isoform 4)	Ubiquitination	-	2.08	-
811	Phosphorylation	RYIFTMLSSLARLLF HHHHHHHHHHHHHHC	16.69	27732954
812	Phosphorylation	YIFTMLSSLARLLFP HHHHHHHHHHHHHCC	23.30	27732954
815	Ubiquitination	TMLSSLARLLFPPKD HHHHHHHHHHCCCCC	36.90	21890473
821	Ubiquitination	ARLLFPPKDDHTLKF HHHHCCCCCCCEEEE	75.84	21890473
825	Phosphorylation	FPPKDDHTLKFLYDD CCCCCCCEEEEEECC	38.34	-
827	Ubiquitination	PKDDHTLKFLYDDNQ CCCCCEEEEEECCCC	34.18	21890473
830	Phosphorylation	DHTLKFLYDDNQRVE CCEEEEEECCCCCCC	25.12	-
847 (in isoform 2)	Ubiquitination	-	2.42	21890473
853 (in isoform 2)	Ubiquitination	-	13.83	21890473
857 (in isoform 1)	Ubiquitination	-	29.09	21890473
857 (in isoform 3)	Ubiquitination	-	29.09	21890473
863 (in isoform 1)	Ubiquitination	-	56.53	21890473
863 (in isoform 3)	Ubiquitination	-	56.53	21890473
881	Ubiquitination	NNIRRLMDGEEPLPM HHHHHHCCCCCCCCC	66.98	22817900
884	Ubiquitination	RRLMDGEEPLPMLPS HHHCCCCCCCCCCCC	58.63	22817900
893	Ubiquitination	LPMLPSYKNFKGTIE CCCCCCCCCCCCCHH	61.31	22817900
896	Ubiquitination	LPSYKNFKGTIEELA CCCCCCCCCCHHHHC	65.62	22817900
898	Phosphorylation	SYKNFKGTIEELAPN CCCCCCCCHHHHCCC	26.30	-
902 (in isoform 4)	Ubiquitination	-	6.61	21890473
908 (in isoform 4)	Ubiquitination	-	1.70	21890473
919 (in isoform 2)	Ubiquitination	-	30.62	21890473
924	Ubiquitination	NSTTIEISELPVRTW ECCEEEEEECCCEEC	21.94	21963094
929 (in isoform 1)	Ubiquitination	-	23.70	21890473
929 (in isoform 3)	Ubiquitination	-	23.70	21890473
932	Phosphorylation	ELPVRTWTQTYKEQV ECCCEECCHHHHHHH	15.49	26657352
934	Phosphorylation	PVRTWTQTYKEQVLE CCEECCHHHHHHHHH	29.23	26657352
936	Acetylation	RTWTQTYKEQVLEPM EECCHHHHHHHHHHH	45.09	26051181
936	Methylation	RTWTQTYKEQVLEPM EECCHHHHHHHHHHH	45.09	42373725
936	Ubiquitination	RTWTQTYKEQVLEPM EECCHHHHHHHHHHH	45.09	21906983
937	Ubiquitination	TWTQTYKEQVLEPML ECCHHHHHHHHHHHH	35.19	21963094
949	Ubiquitination	PMLNGTEKTPPLITD HHHCCCCCCCCCCCC	67.19	21906983
950	Phosphorylation	MLNGTEKTPPLITDY HHCCCCCCCCCCCCC	24.73	20068231
955	Ubiquitination	EKTPPLITDYREYHT CCCCCCCCCCHHHCC	34.36	21890473
957	Phosphorylation	TPPLITDYREYHTDT CCCCCCCCHHHCCCC	9.19	20068231
962 (in isoform 2)	Ubiquitination	-	33.85	21890473
967	Ubiquitination	YHTDTTVKFVVKMTE HCCCCEEEEEEECCH	30.28	21890473
971	Acetylation	TTVKFVVKMTEEKLA CEEEEEEECCHHHHH	34.50	23236377
971	Ubiquitination	TTVKFVVKMTEEKLA CEEEEEEECCHHHHH	34.50	-
972 (in isoform 1)	Ubiquitination	-	3.73	21890473
972 (in isoform 3)	Ubiquitination	-	3.73	21890473
974 (in isoform 4)	Ubiquitination	-	50.03	21890473
975 (in isoform 2)	Ubiquitination	-	44.17	21890473
976	Acetylation	VVKMTEEKLAEAERV EEECCHHHHHHHHHH	46.92	26051181
976	Ubiquitination	VVKMTEEKLAEAERV EEECCHHHHHHHHHH	46.92	29967540
977 (in isoform 4)	Ubiquitination	-	6.19	-
985 (in isoform 1)	Ubiquitination	-	3.02	21890473
985 (in isoform 3)	Ubiquitination	-	3.02	21890473
987	Acetylation	AERVGLHKVFKLQTS HHHHCHHHHHHHCHH	55.18	26051181
987	Ubiquitination	AERVGLHKVFKLQTS HHHHCHHHHHHHCHH	55.18	33845483
998	Ubiquitination	LQTSLTCNSMVLFDH HCHHCCCCCEEEECC	28.09	23000965
999	Ubiquitination	QTSLTCNSMVLFDHV CHHCCCCCEEEECCC	16.65	21890473
1010	Ubiquitination	FDHVGCLKKYDTVLD ECCCCHHHHHHHHHH	54.05	23000965
1011	Acetylation	DHVGCLKKYDTVLDI CCCCHHHHHHHHHHH	35.10	27452117
1011	Ubiquitination	DHVGCLKKYDTVLDI CCCCHHHHHHHHHHH	35.10	23000965
1012	Phosphorylation	HVGCLKKYDTVLDIL CCCHHHHHHHHHHHH	18.43	24702127
1014	Phosphorylation	GCLKKYDTVLDILRD CHHHHHHHHHHHHHH	21.63	24702127
1016	Ubiquitination	LKKYDTVLDILRDFF HHHHHHHHHHHHHHH	3.53	21890473
1017 (in isoform 4)	Ubiquitination	-	33.27	21890473
1026	Methylation	LRDFFELRLKYYGLR HHHHHHHHHHHHCCC	23.18	115918729
1028	Acetylation	DFFELRLKYYGLRKE HHHHHHHHHHCCCHH	29.96	26051181
1028	Ubiquitination	DFFELRLKYYGLRKE HHHHHHHHHHCCCHH	29.96	21890473
1030 (in isoform 4)	Ubiquitination	-	14.22	21890473
1034	Acetylation	LKYYGLRKEWLLGML HHHHCCCHHHHHHHH	59.28	26051181
1037 (in isoform 2)	Ubiquitination	-	2.88	21890473
1045	Phosphorylation	LGMLGAESAKLNNQA HHHHCHHHHHCCHHH	30.12	-
1046	Ubiquitination	GMLGAESAKLNNQAR HHHCHHHHHCCHHHH	16.32	22817900
1047	Ubiquitination	MLGAESAKLNNQARF HHCHHHHHCCHHHHH	62.11	32015554
1047 (in isoform 1)	Ubiquitination	-	62.11	21890473
1047 (in isoform 3)	Ubiquitination	-	62.11	21890473
1048 (in isoform 4)	Ubiquitination	-	7.91	-
1050	Ubiquitination	AESAKLNNQARFILE HHHHHCCHHHHHHHH	47.53	22817900
1057 (in isoform 4)	Ubiquitination	-	43.05	-
1058	Acetylation	QARFILEKIDGKIII HHHHHHHEECCEEEE	42.52	26051181
1058	Ubiquitination	QARFILEKIDGKIII HHHHHHHEECCEEEE	42.52	22817900
1062	Acetylation	ILEKIDGKIIIENKP HHHEECCEEEECCCC	27.30	26051181
1062	Ubiquitination	ILEKIDGKIIIENKP HHHEECCEEEECCCC	27.30	21906983
1063	Ubiquitination	LEKIDGKIIIENKPK HHEECCEEEECCCCH	4.73	21890473
1068	Acetylation	GKIIIENKPKKELIK CEEEECCCCHHHHHH	45.48	25953088
1068	Ubiquitination	GKIIIENKPKKELIK CEEEECCCCHHHHHH	45.48	29967540
1070	Ubiquitination	IIIENKPKKELIKVL EEECCCCHHHHHHHH	61.56	29967540
1071	Ubiquitination	IIENKPKKELIKVLI EECCCCHHHHHHHHH	67.30	-
1075	Sumoylation	KPKKELIKVLIQRGY CCHHHHHHHHHHCCC	43.54	-
1075	Sumoylation	KPKKELIKVLIQRGY CCHHHHHHHHHHCCC	43.54	28112733
1075	Ubiquitination	KPKKELIKVLIQRGY CCHHHHHHHHHHCCC	43.54	33845483
1076	Ubiquitination	PKKELIKVLIQRGYD CHHHHHHHHHHCCCC	4.51	21890473
1084	Phosphorylation	LIQRGYDSDPVKAWK HHHCCCCCCHHHHHH	35.02	26074081
1088	Ubiquitination	GYDSDPVKAWKEAQQ CCCCCHHHHHHHHHH	54.65	21890473
1088 (in isoform 2)	Ubiquitination	-	54.65	21890473
1092 (in isoform 4)	Ubiquitination	-	40.80	21890473
1098 (in isoform 1)	Ubiquitination	-	50.78	21890473
1098 (in isoform 3)	Ubiquitination	-	50.78	21890473
1101 (in isoform 2)	Ubiquitination	-	73.78	21890473
1106	Phosphorylation	DEEENEESDNEKETE CHHHCCCCCCHHHHH	39.29	29255136
1109 (in isoform 4)	Ubiquitination	-	58.20	-
1111 (in isoform 1)	Ubiquitination	-	56.89	21890473
1111 (in isoform 3)	Ubiquitination	-	56.89	21890473
1112	Phosphorylation	ESDNEKETEKSDSVT CCCCHHHHHCCCCCC	60.83	22167270
1114	Sumoylation	DNEKETEKSDSVTDS CCHHHHHCCCCCCCC	67.97	28112733
1114	Ubiquitination	DNEKETEKSDSVTDS CCHHHHHCCCCCCCC	67.97	29967540
1115	Phosphorylation	NEKETEKSDSVTDSG CHHHHHCCCCCCCCC	28.96	22199227
1117	Phosphorylation	KETEKSDSVTDSGPT HHHHCCCCCCCCCCC	33.73	22199227
1119	Phosphorylation	TEKSDSVTDSGPTFN HHCCCCCCCCCCCHH	28.53	28387310
1121	Phosphorylation	KSDSVTDSGPTFNYL CCCCCCCCCCCHHHH	36.99	22199227
1124	Phosphorylation	SVTDSGPTFNYLLDM CCCCCCCCHHHHHHC	28.21	28464451
1127	Phosphorylation	DSGPTFNYLLDMPLW CCCCCHHHHHHCCHH	12.40	28464451
1135	Phosphorylation	LLDMPLWYLTKEKKD HHHCCHHHHCHHHHH	16.51	24144214
1137	Phosphorylation	DMPLWYLTKEKKDEL HCCHHHHCHHHHHHH	22.82	24144214
1139	Ubiquitination	PLWYLTKEKKDELCR CHHHHCHHHHHHHHH	61.17	24816145
1139 (in isoform 4)	Ubiquitination	-	61.17	-
1140	Acetylation	LWYLTKEKKDELCRL HHHHCHHHHHHHHHH	68.06	25953088
1143 (in isoform 4)	Ubiquitination	-	59.66	21890473
1147	Ubiquitination	KKDELCRLRNEKEQE HHHHHHHHHCHHHHH	7.23	21963094
1149	Ubiquitination	DELCRLRNEKEQELD HHHHHHHCHHHHHHH	70.09	22817900
1149 (in isoform 4)	Ubiquitination	-	70.09	-
1151	Acetylation	LCRLRNEKEQELDTL HHHHHCHHHHHHHHH	69.14	26051181
1151	Ubiquitination	LCRLRNEKEQELDTL HHHHHCHHHHHHHHH	69.14	24816145
1152 (in isoform 4)	Ubiquitination	-	43.01	-
1156 (in isoform 4)	Ubiquitination	-	49.60	21890473
1157	Phosphorylation	EKEQELDTLKRKSPS HHHHHHHHHHHCCHH	46.97	21815630
1159	Acetylation	EQELDTLKRKSPSDL HHHHHHHHHCCHHHH	60.93	25953088
1159	Ubiquitination	EQELDTLKRKSPSDL HHHHHHHHHCCHHHH	60.93	21906983
1161	Ubiquitination	ELDTLKRKSPSDLWK HHHHHHHCCHHHHHH	66.20	22817900
1162	Phosphorylation	LDTLKRKSPSDLWKE HHHHHHCCHHHHHHH	33.40	20873877
1164	Phosphorylation	TLKRKSPSDLWKEDL HHHHCCHHHHHHHHH	53.04	26546556
1169 (in isoform 4)	Ubiquitination	-	46.83	-
1174	Ubiquitination	WKEDLATFIEELEAV HHHHHHHHHHHHHHH	5.71	27667366
1184	Ubiquitination	ELEAVEAKEKQDEQV HHHHHHHHHHCCCCC	52.52	27667366
1185 (in isoform 2)	Ubiquitination	-	64.10	21890473
1186	Acetylation	EAVEAKEKQDEQVGL HHHHHHHHCCCCCCC	63.44	25953088
1186	Ubiquitination	EAVEAKEKQDEQVGL HHHHHHHHCCCCCCC	63.44	33845483
1187	Ubiquitination	AVEAKEKQDEQVGLP HHHHHHHCCCCCCCC	61.64	22817900
1189	Ubiquitination	EAKEKQDEQVGLPGK HHHHHCCCCCCCCCC	44.67	22817900
1191	Ubiquitination	KEKQDEQVGLPGKGG HHHCCCCCCCCCCCC	8.82	22817900
1192	Ubiquitination	EKQDEQVGLPGKGGK HHCCCCCCCCCCCCC	26.33	22817900
1195 (in isoform 1)	Ubiquitination	-	46.40	21890473
1195 (in isoform 3)	Ubiquitination	-	46.40	21890473
1196	Sumoylation	EQVGLPGKGGKAKGK CCCCCCCCCCCCCCC	63.65	-
1196	Acetylation	EQVGLPGKGGKAKGK CCCCCCCCCCCCCCC	63.65	134011
1196	Sumoylation	EQVGLPGKGGKAKGK CCCCCCCCCCCCCCC	63.65	28112733
1196	Ubiquitination	EQVGLPGKGGKAKGK CCCCCCCCCCCCCCC	63.65	21906983
1199	Acetylation	GLPGKGGKAKGKKTQ CCCCCCCCCCCCCCC	56.44	134007
1199	Ubiquitination	GLPGKGGKAKGKKTQ CCCCCCCCCCCCCCC	56.44	22817900
1201	Acetylation	PGKGGKAKGKKTQMA CCCCCCCCCCCCCCC	74.81	134003
1201	Ubiquitination	PGKGGKAKGKKTQMA CCCCCCCCCCCCCCC	74.81	22817900
1203	Ubiquitination	KGGKAKGKKTQMAEV CCCCCCCCCCCCCCC	52.52	22817900
1204	Sumoylation	GGKAKGKKTQMAEVL CCCCCCCCCCCCCCC	53.29	-
1204	Sumoylation	GGKAKGKKTQMAEVL CCCCCCCCCCCCCCC	53.29	28112733
1204	Ubiquitination	GGKAKGKKTQMAEVL CCCCCCCCCCCCCCC	53.29	21906983
1205	Phosphorylation	GKAKGKKTQMAEVLP CCCCCCCCCCCCCCC	27.36	25159151
1207	Sulfoxidation	AKGKKTQMAEVLPSP CCCCCCCCCCCCCCC	4.09	28183972
1213	Phosphorylation	QMAEVLPSPRGQRVI CCCCCCCCCCCCCCC	24.06	29255136
1222 (in isoform 2)	Ubiquitination	-	27.79	21890473
1228	Sumoylation	PRITIEMKAEAEKKN CEEEEEEHHHHHHHH	30.22	-
1228	Neddylation	PRITIEMKAEAEKKN CEEEEEEHHHHHHHH	30.22	32015554
1228	Sumoylation	PRITIEMKAEAEKKN CEEEEEEHHHHHHHH	30.22	28112733
1228	Ubiquitination	PRITIEMKAEAEKKN CEEEEEEHHHHHHHH	30.22	32015554
1230 (in isoform 2)	Ubiquitination	-	52.41	21890473
1232 (in isoform 1)	Ubiquitination	-	56.95	21890473
1232 (in isoform 3)	Ubiquitination	-	56.95	21890473
1233	Acetylation	EMKAEAEKKNKKKIK EEHHHHHHHHHHHCC	69.56	18529017
1234	Acetylation	MKAEAEKKNKKKIKN EHHHHHHHHHHHCCC	66.56	18529027
1237	Acetylation	EAEKKNKKKIKNENT HHHHHHHHHCCCCCC	69.95	18529037
1240	Sumoylation	KKNKKKIKNENTEGS HHHHHHCCCCCCCCC	68.06	-
1240	Acetylation	KKNKKKIKNENTEGS HHHHHHCCCCCCCCC	68.06	26051181
1240	Sumoylation	KKNKKKIKNENTEGS HHHHHHCCCCCCCCC	68.06	25114211
1240	Ubiquitination	KKNKKKIKNENTEGS HHHHHHCCCCCCCCC	68.06	33845483
1240 (in isoform 1)	Ubiquitination	-	68.06	21890473
1240 (in isoform 3)	Ubiquitination	-	68.06	21890473
1240 (in isoform 4)	Ubiquitination	-	68.06	21890473
1244	Phosphorylation	KKIKNENTEGSPQED HHCCCCCCCCCCCCC	35.23	22167270
1247	Phosphorylation	KNENTEGSPQEDGVE CCCCCCCCCCCCCCC	19.71	19664994
1247	Ubiquitination	KNENTEGSPQEDGVE CCCCCCCCCCCCCCC	19.71	23000965
1252	Ubiquitination	EGSPQEDGVELEGLK CCCCCCCCCCHHHHH	17.66	23000965
1253	Ubiquitination	GSPQEDGVELEGLKQ CCCCCCCCCHHHHHH	13.52	23000965
1259	Acetylation	GVELEGLKQRLEKKQ CCCHHHHHHHHHHHH	44.20	25953088
1259	Sumoylation	GVELEGLKQRLEKKQ CCCHHHHHHHHHHHH	44.20	28112733
1259	Ubiquitination	GVELEGLKQRLEKKQ CCCHHHHHHHHHHHH	44.20	23000965
1264	Ubiquitination	GLKQRLEKKQKREPG HHHHHHHHHHHCCCC	66.16	23000965
1265	Ubiquitination	LKQRLEKKQKREPGT HHHHHHHHHHCCCCC	52.23	23000965
1267 (in isoform 4)	Ubiquitination	-	68.55	-
1271	Ubiquitination	KKQKREPGTKTKKQT HHHHCCCCCCCCCCE	34.78	22817900
1272	Phosphorylation	KQKREPGTKTKKQTT HHHCCCCCCCCCCEE	46.38	-
1274	Phosphorylation	KREPGTKTKKQTTLA HCCCCCCCCCCEEEE	43.22	-
1274	Ubiquitination	KREPGTKTKKQTTLA HCCCCCCCCCCEEEE	43.22	21963094
1275	Ubiquitination	REPGTKTKKQTTLAF CCCCCCCCCCEEEEE	44.43	22817900
1276	Acetylation	EPGTKTKKQTTLAFK CCCCCCCCCEEEEEE	59.10	70611
1276	Sumoylation	EPGTKTKKQTTLAFK CCCCCCCCCEEEEEE	59.10	28112733
1276	Ubiquitination	EPGTKTKKQTTLAFK CCCCCCCCCEEEEEE	59.10	29967540
1277	Ubiquitination	PGTKTKKQTTLAFKP CCCCCCCCEEEEEEE	41.07	22817900
1277 (in isoform 4)	Ubiquitination	-	41.07	21890473
1278	Phosphorylation	GTKTKKQTTLAFKPI CCCCCCCEEEEEEEC	32.43	28555341
1278	Ubiquitination	GTKTKKQTTLAFKPI CCCCCCCEEEEEEEC	32.43	22817900
1279	Phosphorylation	TKTKKQTTLAFKPIK CCCCCCEEEEEEECC	17.37	28555341
1280 (in isoform 4)	Ubiquitination	-	6.31	-
1283	Acetylation	KQTTLAFKPIKKGKK CCEEEEEEECCCCCC	39.98	23236377
1283	Methylation	KQTTLAFKPIKKGKK CCEEEEEEECCCCCC	39.98	72604235
1283	Sumoylation	KQTTLAFKPIKKGKK CCEEEEEEECCCCCC	39.98	28112733
1283	Ubiquitination	KQTTLAFKPIKKGKK CCEEEEEEECCCCCC	39.98	32015554
1284 (in isoform 4)	Ubiquitination	-	36.86	-
1285 (in isoform 2)	Ubiquitination	-	8.10	21890473
1285 (in isoform 4)	Ubiquitination	-	8.10	21890473
1286	Acetylation	TLAFKPIKKGKKRNP EEEEEECCCCCCCCC	65.09	25953088
1286	Sumoylation	TLAFKPIKKGKKRNP EEEEEECCCCCCCCC	65.09	28112733
1286	Ubiquitination	TLAFKPIKKGKKRNP EEEEEECCCCCCCCC	65.09	21963094
1287	Acetylation	LAFKPIKKGKKRNPW EEEEECCCCCCCCCC	76.35	70603
1287	Ubiquitination	LAFKPIKKGKKRNPW EEEEECCCCCCCCCC	76.35	22817900
1289	Acetylation	FKPIKKGKKRNPWSD EEECCCCCCCCCCCC	58.39	70607
1289	Ubiquitination	FKPIKKGKKRNPWSD EEECCCCCCCCCCCC	58.39	22817900
1290	Ubiquitination	KPIKKGKKRNPWSDS EECCCCCCCCCCCCC	67.10	22817900
1295	Phosphorylation	GKKRNPWSDSESDRS CCCCCCCCCCCCCCC	32.30	30266825
1295 (in isoform 1)	Ubiquitination	-	32.30	21890473
1295 (in isoform 3)	Ubiquitination	-	32.30	21890473
1297	Phosphorylation	KRNPWSDSESDRSSD CCCCCCCCCCCCCCC	33.22	30266825
1299	Phosphorylation	NPWSDSESDRSSDES CCCCCCCCCCCCCCC	42.13	30266825
1302	Phosphorylation	SDSESDRSSDESNFD CCCCCCCCCCCCCCC	47.32	24461736
1303	Phosphorylation	DSESDRSSDESNFDV CCCCCCCCCCCCCCC	46.41	19691289
1306	Phosphorylation	SDRSSDESNFDVPPR CCCCCCCCCCCCCCC	48.03	19691289
1309 (in isoform 4)	Ubiquitination	-	57.15	-
1315	Phosphorylation	FDVPPRETEPRRAAT CCCCCCCCCCCCCCC	53.20	21406692
1324	Phosphorylation	PRRAATKTKFTMDLD CCCCCCCCEEEECCC	27.34	30576142
1327	Phosphorylation	AATKTKFTMDLDSDE CCCCCEEEECCCCCC	16.01	24461736
1332	Phosphorylation	KFTMDLDSDEDFSDF EEEECCCCCCCCHHC	50.63	26503892
1337	Phosphorylation	LDSDEDFSDFDEKTD CCCCCCCHHCCCCCC	50.09	26503892
1340 (in isoform 4)	Ubiquitination	-	62.57	21890473
1343	Phosphorylation	FSDFDEKTDDEDFVP CHHCCCCCCCCCCCC	46.78	20164059
1351	Phosphorylation	DDEDFVPSDASPPKT CCCCCCCCCCCCCCC	40.27	28355574
1351	Ubiquitination	DDEDFVPSDASPPKT CCCCCCCCCCCCCCC	40.27	27667366
1354	Phosphorylation	DFVPSDASPPKTKTS CCCCCCCCCCCCCCC	46.88	25159151
1358	Phosphorylation	SDASPPKTKTSPKLS CCCCCCCCCCCCCCC	45.38	19691289
1358	Ubiquitination	SDASPPKTKTSPKLS CCCCCCCCCCCCCCC	45.38	27667366
1360	Phosphorylation	ASPPKTKTSPKLSNK CCCCCCCCCCCCCCC	56.33	20068231
1361	Phosphorylation	SPPKTKTSPKLSNKE CCCCCCCCCCCCCCC	22.92	21254166
1363	Acetylation	PKTKTSPKLSNKELK CCCCCCCCCCCCCCC	65.40	25953088
1363	Sumoylation	PKTKTSPKLSNKELK CCCCCCCCCCCCCCC	65.40	28112733
1363	Ubiquitination	PKTKTSPKLSNKELK CCCCCCCCCCCCCCC	65.40	27667366
1365	Phosphorylation	TKTSPKLSNKELKPQ CCCCCCCCCCCCCCC	52.56	21254166
1367	Acetylation	TSPKLSNKELKPQKS CCCCCCCCCCCCCCC	62.13	23749302
1367	Sumoylation	TSPKLSNKELKPQKS CCCCCCCCCCCCCCC	62.13	28112733
1367	Ubiquitination	TSPKLSNKELKPQKS CCCCCCCCCCCCCCC	62.13	29967540
1370	Acetylation	KLSNKELKPQKSVVS CCCCCCCCCCCCCCC	46.63	25953088
1370	Ubiquitination	KLSNKELKPQKSVVS CCCCCCCCCCCCCCC	46.63	27667366
1373	Acetylation	NKELKPQKSVVSDLE CCCCCCCCCCCCCCC	54.46	25953088
1373	Sumoylation	NKELKPQKSVVSDLE CCCCCCCCCCCCCCC	54.46	28112733
1373	Ubiquitination	NKELKPQKSVVSDLE CCCCCCCCCCCCCCC	54.46	32015554
1374	O-linked_Glycosylation	KELKPQKSVVSDLEA CCCCCCCCCCCCCCC	23.62	30379171
1374	Phosphorylation	KELKPQKSVVSDLEA CCCCCCCCCCCCCCC	23.62	29255136
1377	Phosphorylation	KPQKSVVSDLEADDV CCCCCCCCCCCCCCC	34.03	19664994
1385	Sumoylation	DLEADDVKGSVPLSS CCCCCCCCCCCCCCC	53.08	-
1385	Acetylation	DLEADDVKGSVPLSS CCCCCCCCCCCCCCC	53.08	26051181
1385	Sumoylation	DLEADDVKGSVPLSS CCCCCCCCCCCCCCC	53.08	28112733
1385	Ubiquitination	DLEADDVKGSVPLSS CCCCCCCCCCCCCCC	53.08	29967540
1387	Phosphorylation	EADDVKGSVPLSSSP CCCCCCCCCCCCCCC	18.16	25159151
1391	Phosphorylation	VKGSVPLSSSPPATH CCCCCCCCCCCCCCC	23.77	22167270
1392	Phosphorylation	KGSVPLSSSPPATHF CCCCCCCCCCCCCCC	55.32	22167270
1393	Phosphorylation	GSVPLSSSPPATHFP CCCCCCCCCCCCCCC	31.37	22167270
1397	Phosphorylation	LSSSPPATHFPDETE CCCCCCCCCCCCCCC	29.80	22167270
1403	Phosphorylation	ATHFPDETEITNPVP CCCCCCCCCCCCCCC	39.82	22167270
1403 (in isoform 2)	Phosphorylation	-	39.82	18669648
1405	Ubiquitination	HFPDETEITNPVPKK CCCCCCCCCCCCCCC	6.19	27667366
1406	Phosphorylation	FPDETEITNPVPKKN CCCCCCCCCCCCCCC	27.51	22167270
1410	Ubiquitination	TEITNPVPKKNVTVK CCCCCCCCCCCEEEE	43.06	27667366
1412	Ubiquitination	ITNPVPKKNVTVKKT CCCCCCCCCEEEEEE	51.05	32015554
1417	Ubiquitination	PKKNVTVKKTAAKSQ CCCCEEEEEEECCCC	34.73	27667366
1418	Acetylation	KKNVTVKKTAAKSQS CCCEEEEEEECCCCC	38.77	26051181
1422	Acetylation	TVKKTAAKSQSSTST EEEEEECCCCCCCCC	46.71	25953088
1422	Sumoylation	TVKKTAAKSQSSTST EEEEEECCCCCCCCC	46.71	28112733
1422	Ubiquitination	TVKKTAAKSQSSTST EEEEEECCCCCCCCC	46.71	27667366
1423	Phosphorylation	VKKTAAKSQSSTSTT EEEEECCCCCCCCCC	30.48	21406692
1425	Phosphorylation	KTAAKSQSSTSTTGA EEECCCCCCCCCCCC	42.55	21406692
1426	Phosphorylation	TAAKSQSSTSTTGAK EECCCCCCCCCCCCC	20.81	21406692
1427	Phosphorylation	AAKSQSSTSTTGAKK ECCCCCCCCCCCCCC	35.03	21406692
1428	Phosphorylation	AKSQSSTSTTGAKKR CCCCCCCCCCCCCCC	26.39	21406692
1429	Phosphorylation	KSQSSTSTTGAKKRA CCCCCCCCCCCCCCC	29.36	21406692
1430	Phosphorylation	SQSSTSTTGAKKRAA CCCCCCCCCCCCCCC	34.60	21406692
1442	Sumoylation	RAAPKGTKRDPALNS CCCCCCCCCCHHHCC	64.57	-
1442	Acetylation	RAAPKGTKRDPALNS CCCCCCCCCCHHHCC	64.57	-
1442	Sumoylation	RAAPKGTKRDPALNS CCCCCCCCCCHHHCC	64.57	28112733
1442	Ubiquitination	RAAPKGTKRDPALNS CCCCCCCCCCHHHCC	64.57	32015554
1443	Methylation	AAPKGTKRDPALNSG CCCCCCCCCHHHCCC	55.79	9428365
1447	Ubiquitination	GTKRDPALNSGVSQK CCCCCHHHCCCCCCC	6.79	24816145
1448 (in isoform 4)	Ubiquitination	-	38.53	-
1449	Phosphorylation	KRDPALNSGVSQKPD CCCHHHCCCCCCCCC	41.23	30266825
1452	Phosphorylation	PALNSGVSQKPDPAK HHHCCCCCCCCCHHH	35.69	25159151
1454	Acetylation	LNSGVSQKPDPAKTK HCCCCCCCCCHHHCC	43.83	23749302
1454	Sumoylation	LNSGVSQKPDPAKTK HCCCCCCCCCHHHCC	43.83	28112733
1454	Ubiquitination	LNSGVSQKPDPAKTK HCCCCCCCCCHHHCC	43.83	32015554
1459	Acetylation	SQKPDPAKTKNRRKR CCCCCHHHCCCCCCC	66.47	26051181
1459	Sumoylation	SQKPDPAKTKNRRKR CCCCCHHHCCCCCCC	66.47	28112733
1459	Ubiquitination	SQKPDPAKTKNRRKR CCCCCHHHCCCCCCC	66.47	24816145
1461	Ubiquitination	KPDPAKTKNRRKRKP CCCHHHCCCCCCCCC	47.99	-
1467	Acetylation	TKNRRKRKPSTSDDS CCCCCCCCCCCCCCC	46.48	30593053
1469	Phosphorylation	NRRKRKPSTSDDSDS CCCCCCCCCCCCCCC	43.51	29255136
1470	Phosphorylation	RRKRKPSTSDDSDSN CCCCCCCCCCCCCCH	44.71	29255136
1471	Phosphorylation	RKRKPSTSDDSDSNF CCCCCCCCCCCCCHH	43.70	29255136
1474	Phosphorylation	KPSTSDDSDSNFEKI CCCCCCCCCCHHHHH	48.18	25159151
1476	Phosphorylation	STSDDSDSNFEKIVS CCCCCCCCHHHHHHH	47.58	21955146
1480	Acetylation	DSDSNFEKIVSKAVT CCCCHHHHHHHHHHH	44.25	30593059
1484	Acetylation	NFEKIVSKAVTSKKS HHHHHHHHHHHCCCC	35.66	25953088
1484	Sumoylation	NFEKIVSKAVTSKKS HHHHHHHHHHHCCCC	35.66	28112733
1484	Ubiquitination	NFEKIVSKAVTSKKS HHHHHHHHHHHCCCC	35.66	33845483
1487	Phosphorylation	KIVSKAVTSKKSKGE HHHHHHHHCCCCCCC	39.42	29214152
1488	O-linked_Glycosylation	IVSKAVTSKKSKGES HHHHHHHCCCCCCCC	31.33	30379171
1488	Phosphorylation	IVSKAVTSKKSKGES HHHHHHHCCCCCCCC	31.33	29214152
1491	Phosphorylation	KAVTSKKSKGESDDF HHHHCCCCCCCCCCC	50.02	30266825
1492	Sumoylation	AVTSKKSKGESDDFH HHHCCCCCCCCCCCC	75.48	-
1492	Acetylation	AVTSKKSKGESDDFH HHHCCCCCCCCCCCC	75.48	26051181
1492	Sumoylation	AVTSKKSKGESDDFH HHHCCCCCCCCCCCC	75.48	28112733
1492	Ubiquitination	AVTSKKSKGESDDFH HHHCCCCCCCCCCCC	75.48	32015554
1495	Phosphorylation	SKKSKGESDDFHMDF CCCCCCCCCCCCCCH	51.66	30266825
1504	Phosphorylation	DFHMDFDSAVAPRAK CCCCCHHHHHHCHHH	25.33	30266825
1512	Phosphorylation	AVAPRAKSVRAKKPI HHHCHHHCCCCCCCC	18.82	26074081
1521	Phosphorylation	RAKKPIKYLEESDED CCCCCCCCCCCCCCC	21.77	28176443
1521 (in isoform 2)	Phosphorylation	-	21.77	18669648
1525	Phosphorylation	PIKYLEESDEDDLF- CCCCCCCCCCCCCC-	36.60	25159151
1535 (in isoform 4)	Ubiquitination	-		-
1573 (in isoform 4)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
29	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
29	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
1106	S	Phosphorylation	Kinase	CK1	-	Uniprot
1213	S	Phosphorylation	Kinase	CDC7	O00311	PSP
1213	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1213	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
1213	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1213	S	Phosphorylation	Kinase	CDK12	Q9NYV4	GPS
1213	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1247	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1247	S	Phosphorylation	Kinase	CDK12	Q9NYV4	GPS
1247	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1247	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
1247	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1337	S	Phosphorylation	Kinase	PLK1	P53350	PSP
1343	T	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
1343	T	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
1343	T	Phosphorylation	Kinase	PLK3	Q9H4B4	Uniprot
1343	T	Phosphorylation	Kinase	PLK1	P53350	PSP
1343	T	Phosphorylation	Kinase	KPCB	P05771	PhosphoELM
1343	T	Phosphorylation	Kinase	PRKCB	P05126-2	GPS
1354	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1354	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1354	S	Phosphorylation	Kinase	CDK12	Q9NYV4	GPS
1354	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
1354	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1361	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1361	S	Phosphorylation	Kinase	CDK12	Q9NYV4	GPS
1361	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1361	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1361	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
1361	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
1365	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1377	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
1377	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1377	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
1393	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1393	S	Phosphorylation	Kinase	CDK12	Q9NYV4	GPS
1393	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1393	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
1393	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1469	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1469	S	Phosphorylation	Kinase	CK2	-	Uniprot
1525	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
1525	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
1525	S	Phosphorylation	Kinase	CDC7	O00311	PSP
1525	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1525	S	Phosphorylation	Kinase	PLK1	P53350	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	BRCA1	P38398	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF2	Q9HAU4	PMID:28611047

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1106	S	Phosphorylation
However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TOP2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	11136718
TOP2B_HUMAN	TOP2B	physical	8710863
AIRE_HUMAN	AIRE	physical	20085707
BRCA1_HUMAN	BRCA1	physical	15965487
SETMR_HUMAN	SETMAR	physical	19458360
BMI1_HUMAN	BMI1	physical	19956605
RING1_HUMAN	RING1	physical	19956605
CUL2_HUMAN	CUL2	physical	19695223
ELOC_HUMAN	TCEB1	physical	19695223
VHL_HUMAN	VHL	physical	19695223
FBXW7_HUMAN	FBXW7	physical	21254166
CSN5_HUMAN	COPS5	physical	21254166
CSK21_HUMAN	CSNK2A1	physical	21254166
GSK3B_HUMAN	GSK3B	physical	21254166
CSN5_HUMAN	COPS5	physical	15126503
BLM_HUMAN	BLM	physical	19329795
TERF2_HUMAN	TERF2	physical	19329795
TOP2B_HUMAN	TOP2B	physical	22939629
RB_HUMAN	RB1	physical	10393912
CSK2B_HUMAN	CSNK2B	physical	26344197
GLYR1_HUMAN	GLYR1	physical	26344197
PATL1_HUMAN	PATL1	physical	26344197
RBP2_HUMAN	RANBP2	physical	26344197
SSRP1_HUMAN	SSRP1	physical	26344197
TOP1_HUMAN	TOP1	physical	26344197
CHK1_HUMAN	CHEK1	genetic	27453043
BRCA2_HUMAN	BRCA2	genetic	27453043
WEE1_HUMAN	WEE1	genetic	27453043
PALB2_HUMAN	PALB2	genetic	27453043
RAD17_HUMAN	RAD17	genetic	27453043
L2GL1_HUMAN	LLGL1	genetic	27453043
MSH2_HUMAN	MSH2	genetic	27453043
NF1_HUMAN	NF1	genetic	27453043
RS11_HUMAN	RPS11	genetic	27453043
CDC73_HUMAN	CDC73	genetic	27453043
CDC6_HUMAN	CDC6	genetic	27453043
M3K4_HUMAN	MAP3K4	genetic	27453043
TITIN_HUMAN	TTN	genetic	27453043
FUMH_HUMAN	FH	genetic	27453043
RN168_HUMAN	RNF168	physical	27558965
SMUF2_HUMAN	SMURF2	physical	28611047

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00276	Amsacrine
DB00537	Ciprofloxacin
DB00970	Dactinomycin
DB00694	Daunorubicin
DB00380	Dexrazoxane
DB00997	Doxorubicin
DB00467	Enoxacin
DB00445	Epirubicin
DB00773	Etoposide
DB04576	Fleroxacin
DB01177	Idarubicin
DB01137	Levofloxacin
DB00978	Lomefloxacin
DB04967	Lucanthone
DB01204	Mitoxantrone
DB00218	Moxifloxacin
DB01059	Norfloxacin
DB01165	Ofloxacin
DB00487	Pefloxacin
DB01179	Podofilox
DB01208	Sparfloxacin
DB00444	Teniposide
DB00685	Trovafloxacin
DB00385	Valrubicin

Regulatory Network of TOP2A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-1106 AND SER-1247, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1213; SER-1247;SER-1374; SER-1377; SER-1387; SER-1393; SER-1504 AND SER-1525, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha atserine-1106 and modulates DNA cleavage activity."; Grozav A.G., Chikamori K., Kozuki T., Grabowski D.R., Bukowski R.M.,Willard B., Kinter M., Andersen A.H., Ganapathi R., Ganapathi M.K.; Nucleic Acids Res. 37:382-392(2009). Cited for: PHOSPHORYLATION AT SER-1106 BY CSNK1D/CK1.	19043076 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-1106 AND SER-1247, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106; SER-1213;THR-1244; SER-1247; SER-1332; SER-1337; THR-1343; SER-1351; SER-1354;SER-1374; SER-1377; SER-1392; SER-1393; SER-1449; SER-1469; THR-1470;SER-1471; SER-1474; SER-1491; SER-1495; SER-1504 AND SER-1525, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-29; SER-1213;SER-1247; SER-1332; SER-1337 AND SER-1377, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1213; SER-1393 ANDSER-1504, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT MET-1; SER-4; SER-29;SER-1106; SER-1213; SER-1247; SER-1302; SER-1354; SER-1377; SER-1393AND SER-1525, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106; SER-1247; SER-1374AND SER-1377, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1247, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106; SER-1213;SER-1247; SER-1295; SER-1297; SER-1351; SER-1354; SER-1387; SER-1393AND SER-1525, AND MASS SPECTROMETRY.	16565220 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1213; SER-1374; SER-1377AND SER-1525, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-29; SER-1106;SER-1213; SER-1247; SER-1332; SER-1337; THR-1343; SER-1351; SER-1354;SER-1374; SER-1377; SER-1469; THR-1470; SER-1471; SER-1474 ANDSER-1525, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106; SER-1213;SER-1247; SER-1354; SER-1377; SER-1469 AND SER-1474, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Mitotic phosphorylation of DNA topoisomerase II alpha by proteinkinase CK2 creates the MPM-2 phosphoepitope on Ser-1469."; Escargueil A.E., Plisov S.Y., Filhol O., Cochet C., Larsen A.K.; J. Biol. Chem. 275:34710-34718(2000). Cited for: PHOSPHORYLATION AT SER-1469, AND MUTAGENESIS OF SER-1469.	10942766 [Abstract]
"Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site thatis not recognized by Plk1."; Iida M., Matsuda M., Komatani H.; Biochem. J. 411:27-32(2008). Cited for: PHOSPHORYLATION AT THR-1343.	18062778 [Abstract]

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