dbPTM

CSK2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CSK2B_HUMAN
UniProt AC	P67870
Protein Name	Casein kinase II subunit beta
Gene Name	CSNK2B
Organism	Homo sapiens (Human).
Sequence Length	215
Subcellular Localization
Protein Description	Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit..
Protein Sequence	MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSSEEVSW ------CCCHHHHHH	42.44	25159151
2	Acetylation	------MSSSEEVSW ------CCCHHHHHH	42.44	19369195
3	Phosphorylation	-----MSSSEEVSWI -----CCCHHHHHHH	40.23	25159151
4	Phosphorylation	----MSSSEEVSWIS ----CCCHHHHHHHH	30.39	25159151
8	Phosphorylation	MSSSEEVSWISWFCG CCCHHHHHHHHHHHC	23.21	19369195
11	Phosphorylation	SEEVSWISWFCGLRG HHHHHHHHHHHCCCC	14.08	20068231
33	Ubiquitination	DEDYIQDKFNLTGLN CHHHHHHHHCCCCHH	21.56	-
37	Phosphorylation	IQDKFNLTGLNEQVP HHHHHCCCCHHCCCC	40.50	23186163
69	Phosphorylation	LEDNPNQSDLIEQAA HCCCCCHHHHHHHHH	40.81	17192257
92	Methylation	ARYILTNRGIAQMLE HHHHHHHHHHHHHHH	32.43	-
97	Sulfoxidation	TNRGIAQMLEKYQQG HHHHHHHHHHHHHCC	3.74	21406390
100	Ubiquitination	GIAQMLEKYQQGDFG HHHHHHHHHHCCCCC	44.38	-
100	Acetylation	GIAQMLEKYQQGDFG HHHHHHHHHHCCCCC	44.38	26051181
101	Phosphorylation	IAQMLEKYQQGDFGY HHHHHHHHHCCCCCC	9.19	28152594
108	Phosphorylation	YQQGDFGYCPRVYCE HHCCCCCCCCEEEEC	10.16	28152594
109	Glutathionylation	QQGDFGYCPRVYCEN HCCCCCCCCEEEECC	1.45	22555962
114	Glutathionylation	GYCPRVYCENQPMLP CCCCEEEECCCCCCC	3.47	22555962
131	Ubiquitination	LSDIPGEAMVKLYCP CCCCCCCHHHHHHCC	17.62	-
134	Ubiquitination	IPGEAMVKLYCPKCM CCCCHHHHHHCCCCC	22.21	-
136	Acetylation	GEAMVKLYCPKCMDV CCHHHHHHCCCCCEE	10.86	-
136	Ubiquitination	GEAMVKLYCPKCMDV CCHHHHHHCCCCCEE	10.86	-
139	Acetylation	MVKLYCPKCMDVYTP HHHHHCCCCCEEECC	38.33	25825284
139	Ubiquitination	MVKLYCPKCMDVYTP HHHHHCCCCCEEECC	38.33	21890473
139	Ubiquitination	MVKLYCPKCMDVYTP HHHHHCCCCCEEECC	38.33	21890473
142	Phosphorylation	LYCPKCMDVYTPKSS HHCCCCCEEECCCCC	39.48	-
144	Acetylation	CPKCMDVYTPKSSRH CCCCCEEECCCCCCC	17.04	-
144	Ubiquitination	CPKCMDVYTPKSSRH CCCCCEEECCCCCCC	17.04	-
144	Phosphorylation	CPKCMDVYTPKSSRH CCCCCEEECCCCCCC	17.04	-
145	Phosphorylation	PKCMDVYTPKSSRHH CCCCEEECCCCCCCC	24.88	22817900
147	Ubiquitination	CMDVYTPKSSRHHHT CCEEECCCCCCCCCC	53.95	-
147	Acetylation	CMDVYTPKSSRHHHT CCEEECCCCCCCCCC	53.95	23749302
148	Phosphorylation	MDVYTPKSSRHHHTD CEEECCCCCCCCCCC	33.53	-
149	Phosphorylation	DVYTPKSSRHHHTDG EEECCCCCCCCCCCC	41.58	-
175	Methylation	FMVHPEYRPKRPANQ EECCCCCCCCCCHHH	28.71	-
177	Ubiquitination	VHPEYRPKRPANQFV CCCCCCCCCCHHHCC	63.11	-
178	Methylation	HPEYRPKRPANQFVP CCCCCCCCCHHHCCC	37.94	-
183	Methylation	PKRPANQFVPRLYGF CCCCHHHCCCHHHCC	9.07	-
186	Methylation	PANQFVPRLYGFKIH CHHHCCCHHHCCEEE	34.93	-
188	Ubiquitination	NQFVPRLYGFKIHPM HHCCCHHHCCEEECC	23.07	-
191	Ubiquitination	VPRLYGFKIHPMAYQ CCHHHCCEEECCCHH	35.42	-
195	Sulfoxidation	YGFKIHPMAYQLQLQ HCCEEECCCHHHHHH	3.16	30846556
197	Phosphorylation	FKIHPMAYQLQLQAA CEEECCCHHHHHHHH	11.96	23927012
202	Phosphorylation	MAYQLQLQAASNFKS CCHHHHHHHHHCCCC	23.17	-
205	Phosphorylation	QLQLQAASNFKSPVK HHHHHHHHCCCCCCC	45.90	22167270
205	Methylation	QLQLQAASNFKSPVK HHHHHHHHCCCCCCC	45.90	-
205	Ubiquitination	QLQLQAASNFKSPVK HHHHHHHHCCCCCCC	45.90	-
206	Phosphorylation	LQLQAASNFKSPVKT HHHHHHHCCCCCCCC	43.57	17081983
208	Ubiquitination	LQAASNFKSPVKTIR HHHHHCCCCCCCCCC	59.09	21890473
208	Ubiquitination	LQAASNFKSPVKTIR HHHHHCCCCCCCCCC	59.09	21890473
208	Methylation	LQAASNFKSPVKTIR HHHHHCCCCCCCCCC	59.09	-
209	Acetylation	QAASNFKSPVKTIR- HHHHCCCCCCCCCC-	30.68	-
209	Ubiquitination	QAASNFKSPVKTIR- HHHHCCCCCCCCCC-	30.68	-
209	Sumoylation	QAASNFKSPVKTIR- HHHHCCCCCCCCCC-	30.68	-
209	Phosphorylation	QAASNFKSPVKTIR- HHHHCCCCCCCCCC-	30.68	22167270
210	Phosphorylation	AASNFKSPVKTIR-- HHHCCCCCCCCCC--	32.01	-
212	Sumoylation	SNFKSPVKTIR---- HCCCCCCCCCC----	41.43	25755297
212	Ubiquitination	SNFKSPVKTIR---- HCCCCCCCCCC----	41.43	21890473
212	Ubiquitination	SNFKSPVKTIR---- HCCCCCCCCCC----	41.43	21890473
212	Sumoylation	SNFKSPVKTIR---- HCCCCCCCCCC----	41.43	-
212	Acetylation	SNFKSPVKTIR---- HCCCCCCCCCC----	41.43	19608861
213	Phosphorylation	NFKSPVKTIR----- CCCCCCCCCC-----	23.40	24732914

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
2	S	Phosphorylation	Kinase	CSNK2A2	P19784	GPS
2	S	Phosphorylation	Kinase	CSK2B	P67870	PhosphoELM
2	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
2	S	Phosphorylation	Kinase	CSNK2B	-	GPS
2	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
3	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
3	S	Phosphorylation	Kinase	CSNK2A2	P19784	GPS
3	S	Phosphorylation	Kinase	CSK2B	P67870	PhosphoELM
3	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
3	S	Phosphorylation	Kinase	CSNK2B	-	GPS
3	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
209	S	Phosphorylation	Kinase	CDK1	P06493	PSP
209	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
209	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
213	T	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CSK2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CSK2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSK22_HUMAN	CSNK2A2	physical	14667819
LYN_HUMAN	LYN	physical	14667819
CSK2B_HUMAN	CSNK2B	physical	14667819
RL5_HUMAN	RPL5	physical	14667819
MBD4_HUMAN	MBD4	physical	14667819
BRCA1_HUMAN	BRCA1	physical	10403822
CSK2B_HUMAN	CSNK2B	physical	9571630
CSK22_HUMAN	CSNK2A2	physical	9571630
CSK21_HUMAN	CSNK2A1	physical	9188720
CSK22_HUMAN	CSNK2A2	physical	9188720
CSK2B_HUMAN	CSNK2B	physical	9188720
ROA2_HUMAN	HNRNPA2B1	physical	10381337
FGF2_HUMAN	FGF2	physical	12145206
CDN1A_HUMAN	CDKN1A	physical	10679299
RL5_HUMAN	RPL5	physical	9042965
ARAF_HUMAN	ARAF	physical	9042965
UB2R1_HUMAN	CDC34	physical	11546811
RL5_HUMAN	RPL5	physical	8806611
CSK21_HUMAN	CSNK2A1	physical	11710515
RBX2_HUMAN	RNF7	physical	11710515
TOP2B_HUMAN	TOP2B	physical	11710515
G45IP_HUMAN	GADD45GIP1	physical	11710515
RL5_HUMAN	RPL5	physical	11710515
FAF1_HUMAN	FAF1	physical	10094392
NOLC1_HUMAN	NOLC1	physical	9013635
TRIB3_HUMAN	TRIB3	physical	18276110
HIRP3_HUMAN	HIRIP3	physical	17391060
IKBA_HUMAN	NFKBIA	physical	20797629
MK14_HUMAN	MAPK14	physical	20797629
IKKB_HUMAN	IKBKB	physical	20797629
FBW1A_HUMAN	BTRC	physical	20797629
BCCIP_HUMAN	BCCIP	physical	21900206
SARNP_HUMAN	SARNP	physical	21900206
ADDA_HUMAN	ADD1	physical	21900206
CO4A2_HUMAN	COL4A2	physical	21900206
ATGA1_HUMAN	ATG101	physical	21900206
RXRA_HUMAN	RXRA	physical	21900206
SUMO2_HUMAN	SUMO2	physical	21900206
HEXB_HUMAN	HEXB	physical	21900206
DEN5A_HUMAN	DENND5A	physical	21900206
KIF2C_HUMAN	KIF2C	physical	21900206
SYNE4_HUMAN	SYNE4	physical	21900206
LRP5L_HUMAN	LRP5L	physical	21900206
ABHD4_HUMAN	ABHD4	physical	21900206
SDHA_HUMAN	SDHA	physical	21900206
PPID_HUMAN	PPID	physical	21900206
DACT1_HUMAN	DACT1	physical	21900206
LMO4_HUMAN	LMO4	physical	21900206
GBP2_HUMAN	GBP2	physical	21900206
ZNF71_HUMAN	ZNF71	physical	21900206
ARP5_HUMAN	ACTR5	physical	21900206
NOTC3_HUMAN	NOTCH3	physical	21900206
ASPP2_HUMAN	TP53BP2	physical	21900206
BAG6_HUMAN	BAG6	physical	21900206
DNMT1_HUMAN	DNMT1	physical	21900206
PLXA3_HUMAN	PLXNA3	physical	21900206
ITSN1_HUMAN	ITSN1	physical	21900206
PTPRK_HUMAN	PTPRK	physical	21900206
ERCC8_HUMAN	ERCC8	physical	21900206
VDAC1_HUMAN	VDAC1	physical	21900206
DCOR_HUMAN	ODC1	physical	21900206
SEN54_HUMAN	TSEN54	physical	21900206
VRK3_HUMAN	VRK3	physical	21900206
FBXL5_HUMAN	FBXL5	physical	21900206
STK16_HUMAN	STK16	physical	21900206
WFKN1_HUMAN	WFIKKN1	physical	21900206
CI114_HUMAN	C9orf114	physical	21900206
PROC_HUMAN	PROC	physical	21900206
TLE1_HUMAN	TLE1	physical	21900206
TCAL7_HUMAN	TCEAL7	physical	21900206
RFC1_HUMAN	RFC1	physical	21900206
ACTY_HUMAN	ACTR1B	physical	21900206
ZN784_HUMAN	ZNF784	physical	21900206
UT14A_HUMAN	UTP14A	physical	21900206
PYRD2_HUMAN	PYROXD2	physical	21900206
DALD3_HUMAN	DALRD3	physical	21900206
CENPB_HUMAN	CENPB	physical	21900206
RN126_HUMAN	RNF126	physical	21900206
CC115_HUMAN	CCDC115	physical	21900206
RL13_HUMAN	RPL13	physical	21900206
APLP1_HUMAN	APLP1	physical	21900206
IF6_HUMAN	EIF6	physical	21900206
ARBK1_HUMAN	ADRBK1	physical	21900206
GNB5_HUMAN	GNB5	physical	21900206
OGA_HUMAN	MGEA5	physical	21900206
CPNE7_HUMAN	CPNE7	physical	21900206
SIMC1_HUMAN	SIMC1	physical	21900206
MOXD1_HUMAN	MOXD1	physical	21900206
CF136_HUMAN	C6orf136	physical	21900206
ANGP2_HUMAN	ANGPT2	physical	21900206
INT11_HUMAN	CPSF3L	physical	21900206
KDM6B_HUMAN	KDM6B	physical	21900206
F264_HUMAN	PFKFB4	physical	21900206
IR3IP_HUMAN	IER3IP1	physical	21900206
STAU1_HUMAN	STAU1	physical	21900206
TC1D2_HUMAN	TCTEX1D2	physical	21900206
ACL6B_HUMAN	ACTL6B	physical	21900206
LCK_HUMAN	LCK	physical	21900206
WDR1_HUMAN	WDR1	physical	21900206
CIC_HUMAN	CIC	physical	21900206
WDR18_HUMAN	WDR18	physical	21900206
LEPR_HUMAN	LEPR	physical	21900206
NMT2_HUMAN	NMT2	physical	21900206
RFA1_HUMAN	RPA1	physical	21900206
PDS5A_HUMAN	PDS5A	physical	21900206
RENT1_HUMAN	UPF1	physical	21900206
NP1L1_HUMAN	NAP1L1	physical	21900206
ACHA4_HUMAN	CHRNA4	physical	21900206
MPP2_HUMAN	MPP2	physical	21900206
TBB2B_HUMAN	TUBB2B	physical	21900206
BGAL_HUMAN	GLB1	physical	21900206
PIPNA_HUMAN	PITPNA	physical	21900206
NRBP_HUMAN	NRBP1	physical	21900206
SIR1_HUMAN	SIRT1	physical	21968188
CSK2B_HUMAN	CSNK2B	physical	21675959
MAPK2_HUMAN	MAPKAPK2	physical	21675959
CASA1_HUMAN	CSN1S1	physical	11827172
ATX3_HUMAN	ATXN3	physical	18839019
WEE1_HUMAN	WEE1	physical	18560763
CSK21_HUMAN	CSNK2A1	physical	18560763
BACD2_HUMAN	TNFAIP1	physical	19851886
RBX2_HUMAN	RNF7	physical	10512750
CSK21_HUMAN	CSNK2A1	physical	10512750
SP16H_HUMAN	SUPT16H	physical	22939629
SSRP1_HUMAN	SSRP1	physical	22939629
CSK21_HUMAN	CSNK2A1	physical	12901717
IF2B_HUMAN	EIF2S2	physical	12901717
CASB_HUMAN	CSN2	physical	12901717
CSK2B_HUMAN	CSNK2B	physical	11574463
CSK21_HUMAN	CSNK2A1	physical	11574463
CBX4_HUMAN	CBX4	physical	21282530
RING2_HUMAN	RNF2	physical	21282530
BMI1_HUMAN	BMI1	physical	21282530
CSK2B_HUMAN	CSNK2B	physical	21282530
RAD_HUMAN	RRAD	physical	9677319
IKBA_HUMAN	NFKBIA	physical	10398585
LA_HUMAN	SSB	physical	19039329
ACVL1_HUMAN	ACVRL1	physical	19592636
SNX2_HUMAN	SNX2	physical	21988832
PHF11_HUMAN	PHF11	physical	21988832
KS6A2_HUMAN	RPS6KA2	physical	21988832
FRIH_HUMAN	FTH1	physical	21988832
CSK2B_HUMAN	CSNK2B	physical	21988832
PHC2_HUMAN	PHC2	physical	21988832
EPS8_HUMAN	EPS8	physical	21988832
FIBB_HUMAN	FGB	physical	21988832
GAMT_HUMAN	GAMT	physical	21988832
PP2BC_HUMAN	PPP3CC	physical	21988832
AAKB2_HUMAN	PRKAB2	physical	21988832
HTRA1_HUMAN	HTRA1	physical	21988832
KS6B2_HUMAN	RPS6KB2	physical	21988832
STA5A_HUMAN	STAT5A	physical	21988832
KS6A5_HUMAN	RPS6KA5	physical	21988832
SC11A_HUMAN	SEC11A	physical	21988832
POTE1_HUMAN	POT1	physical	21988832
PHRF1_HUMAN	PHRF1	physical	21988832
SHAN3_HUMAN	SHANK3	physical	21988832
SPSB3_HUMAN	SPSB3	physical	21988832
AMPD2_HUMAN	AMPD2	physical	22863883
CSK22_HUMAN	CSNK2A2	physical	22863883
NAP1_YEAST	NAP1	physical	18086883
DEC1_HUMAN	DEC1	physical	23555304
BHE41_HUMAN	BHLHE41	physical	23555304
EZH2_HUMAN	EZH2	physical	23555304
FXL15_HUMAN	FBXL15	physical	23555304
NPAS2_HUMAN	NPAS2	physical	23555304
PER1_HUMAN	PER1	physical	23555304
PER2_HUMAN	PER2	physical	23555304
PP1A_HUMAN	PPP1CA	physical	23555304
PP1B_HUMAN	PPP1CB	physical	23555304
PP1G_HUMAN	PPP1CC	physical	23555304
2AAA_HUMAN	PPP2R1A	physical	23555304
2AAB_HUMAN	PPP2R1B	physical	23555304
2A5D_HUMAN	PPP2R5D	physical	23555304
2A5E_HUMAN	PPP2R5E	physical	23555304
PP2AA_HUMAN	PPP2CA	physical	23555304
CSK2B_HUMAN	CSNK2B	physical	23555304
GSK3B_HUMAN	GSK3B	physical	23555304
CLOCK_HUMAN	CLOCK	physical	23555304
PI42A_HUMAN	PIP4K2A	physical	26344197
PI42C_HUMAN	PIP4K2C	physical	26344197
WDR12_HUMAN	WDR12	physical	26344197
AP2A_HUMAN	TFAP2A	physical	21777522
CSK21_HUMAN	CSNK2A1	physical	21777522
DPF3_HUMAN	DPF3	physical	26582913
CE170_HUMAN	CEP170	physical	27173435
MDM2_HUMAN	MDM2	physical	10561590
CSK2B_HUMAN	CSNK2B	physical	10561590

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CSK2B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-212, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-3; SER-4; SER-8;SER-69; THR-145; TYR-197; SER-205 AND SER-209, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-3; SER-4; SER-8;SER-69 AND SER-209, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-3; SER-4 ANDSER-209, AND MASS SPECTROMETRY.	17081983 [Abstract]