KDM6B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM6B_HUMAN
• UniProt AC: O15054
• Protein Name: Lysine-specific demethylase 6B
• Gene Name: KDM6B
• Organism: Homo sapiens (Human).
• Sequence Length: 1643
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. [PubMed: 17825402]
• Protein Sequence: MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPLPPSHGSSSGHPSKPYYAPGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESEHDSEEATRCYHSALRYGGSFAELGPRIGRLQQAQLWNFHTGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNLDLQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVVRASRNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAPASTSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	LSCAGAWSSCPPHPP CCCCCHHHCCCCCCC	22.87	26657352
30	Phosphorylation	SCAGAWSSCPPHPPP CCCCHHHCCCCCCCC	21.68	26657352
48	Phosphorylation	WLPGGRCSASIGQPP CCCCCCCCCCCCCCC	24.56	-
50	Phosphorylation	PGGRCSASIGQPPLP CCCCCCCCCCCCCCC	15.80	-
68	O-linked_Glycosylation	PPSHGSSSGHPSKPY CCCCCCCCCCCCCCC	42.70	29351928
72	O-linked_Glycosylation	GSSSGHPSKPYYAPG CCCCCCCCCCCCCCC	40.36	29351928
73	Ubiquitination	SSSGHPSKPYYAPGA CCCCCCCCCCCCCCC	41.30	29967540
215	Phosphorylation	PVPPAALSGPSGEEG CCCHHHHCCCCCCCC	43.88	29255136
218	Phosphorylation	PAALSGPSGEEGLSP HHHHCCCCCCCCCCC	63.46	29255136
224	Phosphorylation	PSGEEGLSPGGKRRR CCCCCCCCCCCCCCC	32.15	29255136
380	Phosphorylation	SVSPAATTACVPYAP CCCHHHCCCCCCCCC	17.21	-
399	O-linked_Glycosylation	GLPGTTTSSSSSSSS CCCCCCCCCCCCCCC	26.57	29351928
400	Phosphorylation	LPGTTTSSSSSSSSN CCCCCCCCCCCCCCC	31.95	-
402	O-linked_Glycosylation	GTTTSSSSSSSSNTG CCCCCCCCCCCCCCC	35.87	29351928
406	Phosphorylation	SSSSSSSSNTGLRGV CCCCCCCCCCCCCCC	40.12	-
456	Phosphorylation	FLGAPAATPHLSLPP CCCCCCCCCCCCCCC	17.22	25002506
460	Phosphorylation	PAATPHLSLPPGPSS CCCCCCCCCCCCCCC	35.48	25002506
466	Phosphorylation	LSLPPGPSSPPPPPC CCCCCCCCCCCCCCC	62.48	30108239
467	Phosphorylation	SLPPGPSSPPPPPCP CCCCCCCCCCCCCCC	44.55	30108239
487 (in isoform 1)	Ubiquitination	-	52.74	-
487	Ubiquitination	PPPPAWLKGPACRAA CCCCHHHCCHHHHHH	52.74	22505724
580	Phosphorylation	PPPYLARSIDPLPRP CCCCCCCCCCCCCCC	26.24	28122231
589	Phosphorylation	DPLPRPPSPAQNPQD CCCCCCCCCCCCCCC	35.23	26074081
603	Phosphorylation	DPPLVPLTLALPPAP CCCCCCEEEECCCCC	12.15	28122231
612	Phosphorylation	ALPPAPPSSCHQNTS ECCCCCCCCCCCCCC	44.53	22210691
613	Phosphorylation	LPPAPPSSCHQNTSG CCCCCCCCCCCCCCC	22.76	22210691
627	Phosphorylation	GSFRRPESPRPRVSF CCCCCCCCCCCCCCC	28.97	26657352
633	Phosphorylation	ESPRPRVSFPKTPEV CCCCCCCCCCCCCCC	36.79	28450419
637	Phosphorylation	PRVSFPKTPEVGPGP CCCCCCCCCCCCCCC	25.56	29255136
689	Acetylation	FEEPAEFKILPDGLA CCCCCHHCCCCHHHH	34.53	18530213
700	Acetylation	DGLANIMKMLDESIR HHHHHHHHHHHHHHH	32.30	18530223
705	Phosphorylation	IMKMLDESIRKEEEQ HHHHHHHHHHHHHHH	27.62	26074081
799	Phosphorylation	PPPPPPPSPASLLKS CCCCCCCCHHHHHHH	38.58	25627689
802	Phosphorylation	PPPPSPASLLKSLAS CCCCCHHHHHHHHHH	37.30	24719451
816	Phosphorylation	SVLEGQKYCYRGTGA HHHCCCCEEECCCCC	6.19	22210691
821	Phosphorylation	QKYCYRGTGAAVSTR CCEEECCCCCCEECC	18.04	22210691
835	O-linked_Glycosylation	RPGPLPTTQYSPGPP CCCCCCCCCCCCCCC	24.46	29351928
894	Phosphorylation	EPVPGPMTPTQPPPP CCCCCCCCCCCCCCC	26.73	29255136
896	Phosphorylation	VPGPMTPTQPPPPLS CCCCCCCCCCCCCCC	44.54	29255136
941	Phosphorylation	DPADPVDTAEPADSG CCCCCCCCCCCCCCC	32.90	30108239
947	Phosphorylation	DTAEPADSGTERLLP CCCCCCCCCCCCCCC	50.12	30108239
949	Phosphorylation	AEPADSGTERLLPPA CCCCCCCCCCCCCHH	23.14	30108239
969	Phosphorylation	AGGVAAVSGSCKRRQ HCCEEECCCCHHHHH	21.91	26434776
971	Phosphorylation	GVAAVSGSCKRRQKE CEEECCCCHHHHHHH	14.68	26434776
1025	Phosphorylation	LGNLDLQSEEIQGRE HCCCCCCCHHHCCCH	44.48	-
1034	Phosphorylation	EIQGREKSRPDLGGA HHCCCHHCCCCCCCC	44.27	-
1042	Phosphorylation	RPDLGGASKAKPPTA CCCCCCCCCCCCCCC	36.10	-
1063	Phosphorylation	PAPSAQPTPPSASVP CCCCCCCCCCCCCCC	35.43	26714015
1072	Acetylation	PSASVPGKKAREEAP CCCCCCCHHHHHCCC	36.87	26051181
1085	Phosphorylation	APGPPGVSRADMLKL CCCCCCCCHHHHHHH	27.89	-
1091	Ubiquitination	VSRADMLKLRSLSEG CCHHHHHHHHHCCCC	34.91	29967540
1109	Sumoylation	ELKIRLIKVESGDKE CCEEEEEEEECCCCC	44.54	28112733
1109	Sumoylation	ELKIRLIKVESGDKE CCEEEEEEEECCCCC	44.54	-
1115	Ubiquitination	IKVESGDKETFIASE EEEECCCCCEEEEHH	63.28	29967540
1121	Phosphorylation	DKETFIASEVEERRL CCCEEEEHHHHHHHH	37.04	23403867
1154	Ubiquitination	RNAKVKGKFRESYLS CCCCCCCCCHHHHCC	35.21	-
1221	Phosphorylation	VIRGLAGSLRLNLGL HHHHHHHHHHHEEEE	12.52	27251275
1273	Phosphorylation	WPCESSRSHTTIAKY ECCCCCCCCCHHHHH	27.42	27251275
1275	Phosphorylation	CESSRSHTTIAKYAQ CCCCCCCCHHHHHHH	22.57	27251275
1276	Phosphorylation	ESSRSHTTIAKYAQY CCCCCCCHHHHHHHH	17.32	27251275
1280	Phosphorylation	SHTTIAKYAQYQASS CCCHHHHHHHHHHHH	7.01	27251275
1283	Phosphorylation	TIAKYAQYQASSFQE HHHHHHHHHHHHHHH	9.62	27251275
1286	Phosphorylation	KYAQYQASSFQESLQ HHHHHHHHHHHHHHH	19.03	27251275
1287	Phosphorylation	YAQYQASSFQESLQE HHHHHHHHHHHHHHH	33.68	27251275
1338 (in isoform 1)	Ubiquitination	-	64.88	-
1338	Ubiquitination	NIDLSDAKRWKPQLQ CCCHHHHHHHHHHHH	64.88	29967540
1341 (in isoform 1)	Ubiquitination	-	27.24	-
1341	Ubiquitination	LSDAKRWKPQLQELL HHHHHHHHHHHHHHH	27.24	-
1358	Phosphorylation	PAFMRVTSTGNMLSH CCEEEECCCCCCHHH	31.31	25072903
1359	Phosphorylation	AFMRVTSTGNMLSHV CEEEECCCCCCHHHH	24.18	25072903
1364	Phosphorylation	TSTGNMLSHVGHTIL CCCCCCHHHHCCEEE	12.83	25072903
1369	Phosphorylation	MLSHVGHTILGMNTV CHHHHCCEEECCCEE	16.39	25072903
1375	Phosphorylation	HTILGMNTVQLYMKV CEEECCCEEEEEEEC	10.75	25072903
1379	Phosphorylation	GMNTVQLYMKVPGSR CCCEEEEEEECCCCC	4.27	25072903
1398	Phosphorylation	QENNNFCSVNINIGP CCCCCEEEEEEEECC	17.67	27251275
1524	Phosphorylation	VSWNVARTVKISDPD EEECEECCCCCCCHH	19.20	20068231
1528	Phosphorylation	VARTVKISDPDLFKM EECCCCCCCHHHHHH	37.06	20068231
1534	Ubiquitination	ISDPDLFKMIKFCLL CCCHHHHHHHHHHHH	47.19	29967540
1563	Phosphorylation	RAGKKIAYQGRVKDE HHCCCEEECCCCCCC	18.25	18083107
1610	Phosphorylation	EGCARRRSAGLQGVV HHHHHHHCCCCCCEE	25.52	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM6B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM6B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM6B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMAD4_HUMAN	SMAD4	physical	20667911
SMAD1_HUMAN	SMAD1	physical	20667911
SMAD2_HUMAN	SMAD2	physical	20571128
SMAD3_HUMAN	SMAD3	physical	20571128
H31_HUMAN	HIST1H3A	physical	17713478
WDR5_HUMAN	WDR5	physical	17825402
ASH2L_HUMAN	ASH2L	physical	17825402
RBBP5_HUMAN	RBBP5	physical	17825402

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.