DEN5A_HUMAN - dbPTM
DEN5A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DEN5A_HUMAN
UniProt AC Q6IQ26
Protein Name DENN domain-containing protein 5A
Gene Name DENND5A
Organism Homo sapiens (Human).
Sequence Length 1287
Subcellular Localization Golgi apparatus membrane .
Protein Description Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity)..
Protein Sequence MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationGGGGGGGSAPSRFAD
CCCCCCCCCCCHHCC		40.0422210691
13PhosphorylationGGGGSAPSRFADYFV
CCCCCCCCHHCCEEE		39.4822210691
52PhosphorylationSKARDGASPFISSTT
HHCCCCCCCCCCCCC		26.3525159151
123PhosphorylationQFHAFIITREDGSRT
CEEEEEEECCCCCEE		24.1624719451
193PhosphorylationTKLQRFNSYDISRDT
CCHHHCCCCCCCCCH		22.8225159151
194PhosphorylationKLQRFNSYDISRDTL
CHHHCCCCCCCCCHH		20.5729978859
197PhosphorylationRFNSYDISRDTLYVS
HCCCCCCCCCHHHHE		22.6228450419
200PhosphorylationSYDISRDTLYVSKCI
CCCCCCCHHHHEEEE		20.9126074081
202PhosphorylationDISRDTLYVSKCICL
CCCCCHHHHEEEEHH		12.5526074081
204PhosphorylationSRDTLYVSKCICLIT
CCCHHHHEEEEHHHC		14.3026074081
441PhosphorylationKLKRLRASELVSDKR
HHHHHHHHHHHCCCC		25.6528555341
455PhosphorylationRNGNIAGSPLHSYEL
CCCCCCCCCCHHHHH		18.4425159151
459PhosphorylationIAGSPLHSYELLKEN
CCCCCCHHHHHHHCC		28.16-
460PhosphorylationAGSPLHSYELLKENE
CCCCCHHHHHHHCCH		10.39-
468PhosphorylationELLKENETIARLQAL
HHHHCCHHHHHHHHH		31.36-
477UbiquitinationARLQALVKRTGVSLE
HHHHHHHHHHCCCHH		45.1329967540
479PhosphorylationLQALVKRTGVSLEKL
HHHHHHHHCCCHHEE		35.9026437602
479O-linked_GlycosylationLQALVKRTGVSLEKL
HHHHHHHHCCCHHEE		35.9055831413
482O-linked_GlycosylationLVKRTGVSLEKLEVR
HHHHHCCCHHEEEEE		31.9655831419
482PhosphorylationLVKRTGVSLEKLEVR
HHHHHCCCHHEEEEE		31.9626437602
485UbiquitinationRTGVSLEKLEVREDP
HHCCCHHEEEEECCC		56.0629967540
544PhosphorylationQPSQDKESWFTNREQ
CCCCCHHHCCCCHHH		32.9828985074
547PhosphorylationQDKESWFTNREQMQN
CCHHHCCCCHHHHHC		27.4028985074
557UbiquitinationEQMQNFDKASFLSDQ
HHHHCCCHHHHCCCC		41.6221963094
559PhosphorylationMQNFDKASFLSDQPE
HHCCCHHHHCCCCCC		32.2528985074
618PhosphorylationIRLLNVRTPTLRTSM
EEEECCCCCCCCHHH		19.1524719451
686UbiquitinationSTGPASNKWTKRNAP
CCCCCCCCCCCCCCC		54.4629967540
719PhosphorylationDNDQREKYIQEARTM
CHHHHHHHHHHHHHH		11.7722817900
725PhosphorylationKYIQEARTMGSTIRQ
HHHHHHHHHCCCCCC		32.6917081983
736PhosphorylationTIRQPKLSNLSPSVI
CCCCCCHHCCCHHHH		41.6828122231
739PhosphorylationQPKLSNLSPSVIAQT
CCCHHCCCHHHHHHC		21.2722199227
741PhosphorylationKLSNLSPSVIAQTNW
CHHCCCHHHHHHCCH		23.8427732954
755PhosphorylationWKFVEGLLKECRNKT
HHHHHHHHHHHCHHH		6.8932142685
827PhosphorylationHLLHYQDNRQRKLTS
HHHHHCCCCCCCCCC		26.8532142685
833PhosphorylationDNRQRKLTSGSLSTS
CCCCCCCCCCCCCCC		33.7929978859
834PhosphorylationNRQRKLTSGSLSTSG
CCCCCCCCCCCCCCC		36.5029978859
836PhosphorylationQRKLTSGSLSTSGIL
CCCCCCCCCCCCCEE		20.9329978859
838PhosphorylationKLTSGSLSTSGILLD
CCCCCCCCCCCEEEC		23.4029978859
839PhosphorylationLTSGSLSTSGILLDS
CCCCCCCCCCEEECC		35.9423312004
840PhosphorylationTSGSLSTSGILLDSE
CCCCCCCCCEEECCC		22.0627251275
846PhosphorylationTSGILLDSERRKSDA
CCCEEECCCCCCCCH		32.7329978859
851PhosphorylationLDSERRKSDASSLMP
ECCCCCCCCHHHHCC		36.2823927012
854PhosphorylationERRKSDASSLMPPLR
CCCCCCHHHHCCCHH		29.0623927012
855PhosphorylationRRKSDASSLMPPLRI
CCCCCHHHHCCCHHH		30.3323927012
878UbiquitinationIQNIGEIKTDVGKAR
HCCHHCEECCHHHHH		34.08-
972PhosphorylationKLGGSMFTANPWICI
HHCCCCCCCCCEEEE		19.5133259812
983PhosphorylationWICISGELGETQIMQ
EEEEECCCCCCEEEE		9.5432645325
989PhosphorylationELGETQIMQIPRNVL
CCCCCEEEECCHHHH		1.8132142685
1044PhosphorylationGHTYKFPCGRWLGKG
CCEEECCCCCCCCCC		6.9533259812
1050UbiquitinationPCGRWLGKGMDDGSL
CCCCCCCCCCCCCCC		49.22-
1055PhosphorylationLGKGMDDGSLERILV
CCCCCCCCCCHHHHH		29.8432645325
1056PhosphorylationGKGMDDGSLERILVG
CCCCCCCCCHHHHHH		33.7726091039
1061PhosphorylationDGSLERILVGELLTS
CCCCHHHHHHHHHHC		5.1932142685
1067PhosphorylationILVGELLTSQPEVDE
HHHHHHHHCCCCCCC		37.6330266825
1068PhosphorylationLVGELLTSQPEVDER
HHHHHHHCCCCCCCC		43.6430266825
1079PhosphorylationVDERPCRTPPLQQSP
CCCCCCCCCCCCCCH		35.6630266825
1085PhosphorylationRTPPLQQSPSVIRRL
CCCCCCCCHHHHHHH		13.2430266825
1087PhosphorylationPPLQQSPSVIRRLVT
CCCCCCHHHHHHHEE		35.1130266825
1094PhosphorylationSVIRRLVTISPNNKP
HHHHHHEEECCCCCC		21.9629396449
1096PhosphorylationIRRLVTISPNNKPKL
HHHHEEECCCCCCCC		16.5310470851
1100UbiquitinationVTISPNNKPKLNTGQ
EEECCCCCCCCCHHH		50.6129967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DEN5A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DEN5A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DEN5A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
XRN2_HUMANXRN2physical
22939629
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DEN5A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, AND MASSSPECTROMETRY.

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