| UniProt ID | ERCC8_HUMAN | |
|---|---|---|
| UniProt AC | Q13216 | |
| Protein Name | DNA excision repair protein ERCC-8 | |
| Gene Name | ERCC8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 396 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.. | |
| Protein Sequence | MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MLGFLSARQTGLE --CCCCCCCCCCCCC | 21.10 | 28355574 | |
| 71 | Phosphorylation | SDGVIVLYDLENSSR CCEEEEEEECCCCCC | 13.95 | 22817900 | |
| 77 | Phosphorylation | LYDLENSSRQSYYTC EEECCCCCCCEEEEE | 46.01 | 25332170 | |
| 125 | Ubiquitination | SSFDKTLKVWDTNTL CCCCCCEEEEECCCC | 46.65 | - | |
| 154 | Phosphorylation | HHMSPVSTKHCLVAV CCCCCCCCCCEEEEE | 25.66 | - | |
| 167 | Ubiquitination | AVGTRGPKVQLCDLK EECCCCCCEEEEECC | 45.50 | - | |
| 195 | Phosphorylation | EILAVSWSPRYDYIL EEEEEEECCCCCEEE | 7.62 | 24719451 | |
| 212 | Acetylation | ASADSRVKLWDVRRA CCCCCCEEHHHHHHC | 42.63 | 23749302 | |
| 212 | Malonylation | ASADSRVKLWDVRRA CCCCCCEEHHHHHHC | 42.63 | 26320211 | |
| 212 | Ubiquitination | ASADSRVKLWDVRRA CCCCCCEEHHHHHHC | 42.63 | - | |
| 220 | Phosphorylation | LWDVRRASGCLITLD HHHHHHCCCCEEEEE | 28.38 | 29083192 | |
| 225 | Phosphorylation | RASGCLITLDQHNGK HCCCCEEEEECCCCE | 16.01 | 29083192 | |
| 233 (in isoform 1) | Ubiquitination | - | 49.55 | 21906983 | |
| 233 | Ubiquitination | LDQHNGKKSQAVESA EECCCCEEEHHHHHC | 49.55 | 2190698 | |
| 247 | Ubiquitination | ANTAHNGKVNGLCFT CCCCCCCCCCEEEEE | 37.53 | - | |
| 286 | Ubiquitination | NTLVNYGKVCNNSKK CCEEEEEECCCCCCC | 33.00 | - | |
| 286 | Acetylation | NTLVNYGKVCNNSKK CCEEEEEECCCCCCC | 33.00 | 25953088 | |
| 390 | Phosphorylation | PAFEDAWSSSDEEG- HHHHHHHCCCCCCC- | 22.99 | 20363803 | |
| 391 | Phosphorylation | AFEDAWSSSDEEG-- HHHHHHCCCCCCC-- | 30.98 | 20363803 | |
| 392 | Phosphorylation | FEDAWSSSDEEG--- HHHHHCCCCCCC--- | 43.45 | 20363803 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERCC8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERCC8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERCC8_HUMAN !! | ||||||
loading...
