| UniProt ID | OGG1_HUMAN | |
|---|---|---|
| UniProt AC | O15527 | |
| Protein Name | N-glycosylase/DNA lyase | |
| Gene Name | OGG1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 345 | |
| Subcellular Localization |
Nucleus, nucleoplasm . Nucleus speckle . Nucleus matrix . Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion. |
|
| Protein Description | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.. | |
| Protein Sequence | MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 115 | Phosphorylation | QLYHHWGSVDSHFQE HHHHHHCCCCHHHHH | 19.98 | - | |
| 183 | Phosphorylation | VTYHGFPSLQALAGP CEECCCCCHHHHHCH | 30.74 | - | |
| 198 (in isoform 4) | Ubiquitination | - | 53.95 | - | |
| 198 | Ubiquitination | EVEAHLRKLGLGYRA HHHHHHHHCCCCHHH | 53.95 | - | |
| 203 | Phosphorylation | LRKLGLGYRARYVSA HHHCCCCHHHHHHCH | 13.22 | 20049867 | |
| 207 | Phosphorylation | GLGYRARYVSASARA CCCHHHHHHCHHHHH | 9.58 | 20049867 | |
| 231 | Phosphorylation | WLQQLRESSYEEAHK HHHHHHHCCHHHHHH | 31.61 | 19674107 | |
| 232 | Phosphorylation | LQQLRESSYEEAHKA HHHHHHCCHHHHHHH | 31.63 | 19674107 | |
| 248 | Phosphorylation | CILPGVGTKVADCIC HCCCCCCHHHHHHHH | 21.68 | 23532336 | |
| 280 | Phosphorylation | HIAQRDYSWHPTTSQ EEECCCCCCCCCCCC | 24.17 | 19674107 | |
| 289 | Ubiquitination | HPTTSQAKGPSPQTN CCCCCCCCCCCCCCH | 64.81 | - | |
| 289 (in isoform 4) | Ubiquitination | - | 64.81 | - | |
| 297 | Ubiquitination | GPSPQTNKELGNFFR CCCCCCHHHHHHHHH | 58.67 | - | |
| 297 (in isoform 4) | Ubiquitination | - | 58.67 | - | |
| 326 | Phosphorylation | FSADLRQSRHAQEPP HHHHHHHCHHCCCCC | 21.43 | 19674107 | |
| 335 | Acetylation | HAQEPPAKRRKGSKG HCCCCCCCCCCCCCC | 59.52 | 16478987 | |
| 338 | Acetylation | EPPAKRRKGSKGPEG CCCCCCCCCCCCCCC | 72.13 | 16478987 | |
| 341 | Acetylation | AKRRKGSKGPEG--- CCCCCCCCCCCC--- | 83.56 | 16478987 | |
| 400 (in isoform 3) | Phosphorylation | - | 28634120 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OGG1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OGG1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OGG1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RUXF_HUMAN | SNRPF | physical | 17353931 | |
| XRCC1_HUMAN | XRCC1 | physical | 12933815 | |
| SCG1_HUMAN | CHGB | physical | 16169070 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 144700 | Renal cell carcinoma (RCC) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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