UVSSA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UVSSA_HUMAN
• UniProt AC: Q2YD98
• Protein Name: UV-stimulated scaffold protein A
• Gene Name: UVSSA
• Organism: Homo sapiens (Human).
• Sequence Length: 709
• Subcellular Localization: Chromosome . Accumulates at UV DNA damage sites.
• Protein Description: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage..
• Protein Sequence: MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREMQEMSGEIESCLTEVESCFRLLVPFDFDPNPETESLGMASGMSDALRSSCAGQVGPCRSGTPDPRDGEQPCCSRDLPASAGHPRAGGGAQPSQTATGDPSDEDEDSDLEEFVRSHGLGSHKYTLDVELCSEGLKVQENEDNLALIHAARDTLKLIRNKFLPAVCSWIQRFTRVGTHGGCLKRAIDLKAELELVLRKYKELDIEPEGGERRRTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLRDHLPPPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDLHYWGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRAPRPDGRLCERQDRLKCPFHGKIVPRDDEGRPLDPEDRAREQRRQLQKQERPEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQADTARARIGRKVFAKAAVRRVVAAMNRMDQKKHEKFSNQFNYALN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
153	Phosphorylation	FQDTNARSLAERKRE CCCCCHHHHHHHHHH	29.53	24719451
230	Phosphorylation	MSDALRSSCAGQVGP HHHHHHHHHCCCCCC	11.10	27251275
240	Phosphorylation	GQVGPCRSGTPDPRD CCCCCCCCCCCCCCC	54.45	22617229
242	Phosphorylation	VGPCRSGTPDPRDGE CCCCCCCCCCCCCCC	26.26	30576142
260	Phosphorylation	CSRDLPASAGHPRAG CCCCCCCCCCCCCCC	32.61	28674419
273	Phosphorylation	AGGGAQPSQTATGDP CCCCCCCCCCCCCCC	28.25	29255136
275	Phosphorylation	GGAQPSQTATGDPSD CCCCCCCCCCCCCCC	30.44	29255136
277	Phosphorylation	AQPSQTATGDPSDED CCCCCCCCCCCCCCC	45.57	23663014
281	Phosphorylation	QTATGDPSDEDEDSD CCCCCCCCCCCCCCC	59.37	29255136
287	Phosphorylation	PSDEDEDSDLEEFVR CCCCCCCCCHHHHHH	41.89	29255136
311	Phosphorylation	TLDVELCSEGLKVQE EEEHHHHCCCCCEEE	47.53	-
378	Phosphorylation	LELVLRKYKELDIEP HHHHHHHHHHCCCCC	11.85	-
414	Ubiquitination	DFVEVPEKEGYEPHI CCCCCCHHHCCCCCC	50.82	-
475	Phosphorylation	RDHLPPPSSASPSRA HHHCCCCCCCCCCCC	44.29	30266825
476	Phosphorylation	DHLPPPSSASPSRAL HHCCCCCCCCCCCCC	38.24	30266825
478	Phosphorylation	LPPPSSASPSRALPE CCCCCCCCCCCCCCC	25.92	30266825
480	Phosphorylation	PPSSASPSRALPEPQ CCCCCCCCCCCCCHH	27.91	30266825
526	Phosphorylation	GKIVKSDSQHRFWKP CEEECCCCCCCCCCH	34.67	24719451
635	Phosphorylation	MRDVEAATGQDLGSS HHHHHHHHCCCCCCC	42.28	21214269
644	Phosphorylation	QDLGSSRYSGKGRGK CCCCCCCCCCCCCCC	24.59	21214269
645	Phosphorylation	DLGSSRYSGKGRGKK CCCCCCCCCCCCCCC	32.68	21214269
647	Acetylation	GSSRYSGKGRGKKRR CCCCCCCCCCCCCCC	39.22	19829899
652	Acetylation	SGKGRGKKRRYPSLT CCCCCCCCCCCCCHH	44.95	19829907
655	Phosphorylation	GRGKKRRYPSLTNLK CCCCCCCCCCHHHHH	10.95	23312004
657	Phosphorylation	GKKRRYPSLTNLKAQ CCCCCCCCHHHHHHH	38.60	23403867
659	Phosphorylation	KRRYPSLTNLKAQAD CCCCCCHHHHHHHHH	42.73	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UVSSA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UVSSA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UVSSA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP7_HUMAN	USP7	physical	22902626
DDB1_HUMAN	DDB1	physical	22902626
TF2H1_HUMAN	GTF2H1	physical	22902626
ERCC8_HUMAN	ERCC8	physical	22902626
ERCC3_HUMAN	ERCC3	physical	22902626
ERCC2_HUMAN	ERCC2	physical	22902626
SET1A_HUMAN	SETD1A	physical	22902626
SIR1_HUMAN	SIRT1	physical	22902626
CDK7_HUMAN	CDK7	physical	22902626
UBP7_HUMAN	USP7	physical	27129218

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614640: UV-sensitive syndrome 3 (UVSS3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281 AND SER-287, ANDMASS SPECTROMETRY.
PubMed: 19690332