WFKN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WFKN1_HUMAN
• UniProt AC: Q96NZ8
• Protein Name: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
• Gene Name: WFIKKN1
• Organism: Homo sapiens (Human).
• Sequence Length: 548
• Subcellular Localization: Secreted.
• Protein Description: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)..
• Protein Sequence: MPALRPLLPLLLLLRLTSGAGLLPGLGSHPGVCPNQLSPNLWVDAQSTCERECSRDQDCAAAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPETTARPTPGAAPVPPALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPARDAAPSIPAPAECLPDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFHSRESCEDACPVPRTPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSYVRAASEKRVKKILELLEKQACELLNRFQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Phosphorylation	TCASDGLTYYNRCYM EECCCCCEEECCHHC	29.50	22210691
135	Phosphorylation	CASDGLTYYNRCYMD ECCCCCEEECCHHCC	12.09	22210691
136	Phosphorylation	ASDGLTYYNRCYMDA CCCCCEEECCHHCCH	7.30	22210691
162	Phosphorylation	VPCKHVLSWPPSSPG EECCCEECCCCCCCC	36.13	-
166	Phosphorylation	HVLSWPPSSPGPPET CEECCCCCCCCCCCC	45.12	-
173	Phosphorylation	SSPGPPETTARPTPG CCCCCCCCCCCCCCC	31.37	-
328	Phosphorylation	PQRGGCMTFPARGCD CCCCCEEEECCCCCC	30.46	-
404	Phosphorylation	NNFHSRESCEDACPV CCCCCCCCCCCCCCC	23.00	-
475	Phosphorylation	MGLKFLGTKYLEVTL CCCCCCCEEEEEEEE	20.75	24505115
493	N-linked_Glycosylation	DWACPCPNMTAGDGP CEECCCCCCCCCCCC	47.34	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WFKN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WFKN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WFKN1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of WFKN1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.