ATGA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATGA1_HUMAN
• UniProt AC: Q9BSB4
• Protein Name: Autophagy-related protein 101
• Gene Name: ATG101
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm . Preautophagosomal structure . Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome format
• Protein Description: Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation..
• Protein Sequence: MNCRSEVLEVSVEGRQVEEAMLAVLHTVLLHRSTGKFHYKKEGTYSIGTVGTQDVDCDFIDFTYVRVSSEELDRALRKVVGEFKDALRNSGGDGLGQMSLEFYQKKKSRWPFSDECIPWEVWTVKVHVVALATEQERQICREKVGEKLCEKIINIVEVMNRHEYLPKMPTQSEVDNVFDTGLRDVQPYLYKISFQITDALGTSVTTTMRRLIKDTLAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RSEVLEVSVEGRQVE CCEEEEEEECCHHHH	12.69	22985185
78	Ubiquitination	ELDRALRKVVGEFKD HHHHHHHHHHHHHHH	41.96	-
84	Acetylation	RKVVGEFKDALRNSG HHHHHHHHHHHHHCC	37.48	132905
84	Ubiquitination	RKVVGEFKDALRNSG HHHHHHHHHHHHHCC	37.48	-
105	Ubiquitination	MSLEFYQKKKSRWPF CHHHHHHHHHCCCCC	51.28	21906983
106	Ubiquitination	SLEFYQKKKSRWPFS HHHHHHHHHCCCCCC	40.22	-
151	Ubiquitination	VGEKLCEKIINIVEV HHHHHHHHHHHHHHH	48.14	-
164	Phosphorylation	EVMNRHEYLPKMPTQ HHHCCCCCCCCCCCH	23.37	25884760
167	Ubiquitination	NRHEYLPKMPTQSEV CCCCCCCCCCCHHHH	55.72	-
203	Phosphorylation	ITDALGTSVTTTMRR EECCCCCCHHHHHHH	18.70	-
213	Ubiquitination	TTMRRLIKDTLAL-- HHHHHHHHHHHCC--	49.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
11	S	Phosphorylation	Kinase	ULK1	O75385	PSP
203	S	Phosphorylation	Kinase	ULK1	O75385	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATGA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATGA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG13_HUMAN	ATG13	physical	20562859
MYH4_HUMAN	MYH4	physical	20562859
FOXO3_HUMAN	FOXO3	physical	20562859
ANFY1_HUMAN	ANKFY1	physical	20562859
UBA5_HUMAN	UBA5	physical	20562859
FKBP4_HUMAN	FKBP4	physical	20562859
LONM_HUMAN	LONP1	physical	20562859
SYTC_HUMAN	TARS	physical	20562859
ASNS_HUMAN	ASNS	physical	20562859
PGK1_HUMAN	PGK1	physical	20562859
HXK1_HUMAN	HK1	physical	20562859
ECHB_HUMAN	HADHB	physical	20562859
PA2G4_HUMAN	PA2G4	physical	20562859
SYLC_HUMAN	LARS	physical	20562859
SSRP1_HUMAN	SSRP1	physical	20562859
SYVC_HUMAN	VARS	physical	20562859
ECHA_HUMAN	HADHA	physical	20562859
CBR1_HUMAN	CBR1	physical	20562859
COPA_HUMAN	COPA	physical	20562859
LPPRC_HUMAN	LRPPRC	physical	20562859
PRKDC_HUMAN	PRKDC	physical	20562859
RFA1_HUMAN	RPA1	physical	20562859
ETFA_HUMAN	ETFA	physical	20562859
MYH2_HUMAN	MYH2	physical	20562859
DSC1_HUMAN	DSC1	physical	20562859
ARGI1_HUMAN	ARG1	physical	20562859
PFKAL_HUMAN	PFKL	physical	20562859
COPG1_HUMAN	COPG1	physical	20562859
CDC37_HUMAN	CDC37	physical	20562859
AL9A1_HUMAN	ALDH9A1	physical	20562859
ODPA_HUMAN	PDHA1	physical	20562859
MYL3_HUMAN	MYL3	physical	21988832
ATG13_HUMAN	ATG13	physical	24100292
RBCC1_HUMAN	RB1CC1	physical	19597335
ATG13_HUMAN	ATG13	physical	19597335
ULK1_HUMAN	ULK1	physical	19597335

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.